Personal profile

Biography

Our research is focused on understanding the mechanisms of oocyte development, maturation and fertilization in mammals. Early embryo development in mammals is driven and underpinned by a healthy fertile oocyte. How the oocyte acquires this developmental potential is not understood and problems in oocyte quality are largely responsible for the high rates of infertility and miscarriage in the population.

 

Our work focuses on understanding how the oocyte undergoes the meiotic cell divisions and why the rate of chromosome abnormalities is so high in women in their late 30s and early 40s. A major factor in determining oocyte quality is the ability of mitochondria to generate ATP. We are studying mitochondrial dynamics and function in oocytes with the aim of modulating mitochondrial activity in order to improve oocyte quality. We have established a new collaboration with Monash IVF in order to translate our findings to the clinic. Our research has been funded by long term MRC Programme Grants and the ARC and the results are published in leading journal including Nature Cell Biology, Science, Developmental Cell, Development and Journal of Cell Biology.

Career Summary:

John obtained his PhD in 1991 from the University of Adelaide before moving to the MRC Experimental Embryology Unit in London. John moved to University College London (UCL) in 1996 where he held an MRC Fellowship and an academic position. In 2004 John was appointed Professor and Head of Department of Physiology, becoming the Associate Dean and Director of the UCL Division of Biosciences in 2007.

Prof John Carroll joined Monash University in September 2012 to take up the position of Head of School of Biomedical Sciences.

Keywords

  • fertility
  • oocyte
  • meiosis
  • aneuploidy
  • cell cycle

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Projects 2013 2020

Research Output 2005 2017

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II

Nabti, I., Grimes, R., Sarna, H., Marangos, P. & Carroll, J. 18 May 2017 In : Nature Communications. 8, 9 p., 15346

Research output: Research - peer-reviewArticle

Open Access
File

Cytoplasmic determination of meiotic spindle size revealed by a unique inter-species germinal vesicle transfer model

Wang, Z-W., Zhang, G-L., Schatten, H., Carroll, J. & Sun, Q-Y. 27 Jan 2016 In : Scientific Reports. 6, 9 p., 19827

Research output: Research - peer-reviewArticle

Open Access
File

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies

Iyer, S., Anwari, K., Alsop, A. E., Yuen, W. S., Huang, D. C. S., Carroll, J., Smith, N. A., Smith, B. J., Dewson, G. & Kluck, R. M. 24 May 2016 In : Nature Communications. 7, 10 p., 11734

Research output: Research - peer-reviewArticle

Open Access
File

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

Marangos, P., Stevense, M., Niaka, K., Lagoudaki, M., Nabti, I., Jessberger, R. & Carroll, J. G. 2015 In : Nature Communications. 6, 10 p., 8706

Research output: Research - peer-reviewArticle

Open Access
File

Mitochondrial dysfunction in oocytes of obese mothers: Transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

Wu, L., Russell, D. L., Wong, S. L., Chen, M., Tsai, T-S., St John, J. C., Norman, R. J., Febbraio, M. A., Carroll, J. G. & Robker, R. 2015 In : Development. 142, 4, p. 681 - 691 11 p.

Research output: Research - peer-reviewArticle