Prof Botha completed his undergraduate and post graduate training at Stellenbosch University South Africa. He subsequently completed further training at the Hammersmith Hospital in nephrology and a Critical Care fellowship at the Vancouver General Hospital, University of British Columbia. He has been working in Australia since 1996 and has been Director of ICU at Peninsula Health since 1999. He has diverse interests including medical education, nephrology and clinical research. He has been site investigator for numerous pharmaceutical and CTG trials and has published over a wide range of topics including critical care nephrology, sedative practice, ventilation and futility of care. He is an examiner for the College of Intensive Care Medicine and has delivered numerous BASIC and beyond BASIC mechanical ventilation courses.

He is an active member of ANZICS having convened the 2010 ANZICS ASM in Melbourne and was the scientific convenor for the CICM ASM in 2011.He has previously served on the Intensive Care Advisory Committee to DHS and as secretary for the College Victorian State Committee.