Projects per year
Personal profile
Biography
I am a Research Fellow with the Institute of Vector-borne Disease. I completed my PhD at the Burnet Institute in Melbourne (2011) in hepatitis C virus, then undertook postdoctoral research in the Department of Biochemistry and Molecular Biology, Monash University. There, I researched the pathogenic roles of the dengue virus NS5 protein and identified several potential antiviral therapeutics, including one that has now been licensed and has patents approved in multiple countries.
I joined the Institute of Vector-borne Disease in 2016, and currently run an NHMRC-funded research program focussed on understanding the molecular mechanisms that underpin Wolbachia-mediated virus inhibition in Aedes aegypti mosquitoes - the novel biocontrol tool established by Monash-based World Mosquito program. I am also using molecular virology techniques to determine the risk of viral resistance developing towards this technology. My research primarily uses molecular technologies including high resolution imaging, genomics and proteomics techniques to better understand how Wolbachia modifies this host to create an antiviral environment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dengue virus resistance to Wolbachia
Fraser, J. & Eyre, N.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/22
Project: Research
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Characterisation and validation of retinoic acid p-hydroxanilide (4-HPR) as a potent anti-dengue agent.
Jans, D., Fraser, J. & Morton, C. J.
1/08/13 → 30/06/14
Project: Research
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Erratum: Using Wolbachia to eliminate dengue: will the virus fight back? (Journal of Virology (2021) 95:13 (e02203-20) DOI:10.1128/JVI.02203-20)
Edenborough, K. M., Flores, H. A., Simmons, C. P. & Fraser, J. E., Sep 2021, In: Journal of Virology. 95, 18, 1 p., e00953-21.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Using Wolbachia to eliminate dengue: will the virus fight back?
Edenborough, K. M., Flores, H. A., Simmons, C. P. & Fraser, J. E., Jun 2021, In: Journal of Virology. 95, 13, 13 p., e02203-20.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile2 Citations (Scopus) -
Novel phenotype of Wolbachia strain wPip in Aedes aegypti challenges assumptions on mechanisms of Wolbachia-mediated dengue virus inhibition
Fraser, J. E., O'Donnell, T. B., Duyvestyn, J. M., O'Neill, S. L., Simmons, C. P. & Flores, H. A., 1 Jul 2020, In: PLoS Pathogens. 16, 7, 21 p., e1008410.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019
Helbig, K. J., Bull, R. A., Ambrose, R., Beard, M. R., Blanchard, H., Böcking, T., Chua, B., Colmant, A. M. G., Crosse, K. M., Purcell, D. F. J., Fraser, J., Hayward, J. A., Hamilton, S. T., Husain, M., MacDiarmid, R., Mackenzie, J. M., Moseley, G. W., Nguyen, T. H. O., Quiñones-Mateu, M. E., Robinson, K. & 10 others, , 6 Jun 2020, In: Viruses. 12, 6, 23 p., 621.Research output: Contribution to journal › Article › Other › peer-review
Open AccessFile -
Wolbachia's deleterious impact on aedes aegypti egg development: The potential role of nutritional parasitism
Allman, M. J., Fraser, J. E., Ritchie, S. A., Joubert, D. A., Simmons, C. P. & Flores, H. A., 27 Oct 2020, In: Insects. 11, 11, 14 p., 735.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile4 Citations (Scopus)
Activities
- 2 Patents
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MONASH UNIVERSITY (Organisational unit)
Johanna Elisabeth Fraser (Inventor), Jyotika Taneja Taneja De Bruyne (Inventor), Inaki Iturbe-Ormaeche (Inventor), Heather Ann Flores (Inventor) & Scott O'Neill (Inventor)
3 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Johanna Fraser (Inventor), David Jans (Inventor) & Kylie Wagstaff (Inventor)
31 Oct 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent