Projects per year
Personal profile
Biography
I am a Research Fellow with the Institute of Vector-borne Disease. I completed my PhD at the Burnet Institute in Melbourne (2011) in hepatitis C virus, then undertook postdoctoral research in the Department of Biochemistry and Molecular Biology, Monash University. There, I researched the pathogenic roles of the dengue virus NS5 protein and identified several potential antiviral therapeutics, including one that has now been licensed and has patents approved in multiple countries.
I joined the Institute of Vector-borne Disease in 2016, and currently run an NHMRC-funded research program focussed on understanding the molecular mechanisms that underpin Wolbachia-mediated virus inhibition in Aedes aegypti mosquitoes - the novel biocontrol tool established by Monash-based World Mosquito program. I am also using molecular virology techniques to determine the risk of viral resistance developing towards this technology. My research primarily uses molecular technologies including high resolution imaging, genomics and proteomics techniques to better understand how Wolbachia modifies this host to create an antiviral environment.
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Projects
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Dengue virus resistance to Wolbachia
Fraser, J. & Eyre, N.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/22
Project: Research
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Characterisation and validation of retinoic acid p-hydroxanilide (4-HPR) as a potent anti-dengue agent.
Jans, D., Fraser, J. & Morton, C. J.
1/08/13 → 30/06/14
Project: Research
Research output
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Novel phenotype of Wolbachia strain wPip in Aedes aegypti challenges assumptions on mechanisms of Wolbachia-mediated dengue virus inhibition
Fraser, J. E., O'Donnell, T. B., Duyvestyn, J. M., O'Neill, S. L., Simmons, C. P. & Flores, H. A., 1 Jul 2020, In : PLoS Pathogens. 16, 7, 21 p., e1008410.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Tenth Scientific Biennial Meeting of the Australasian Virology Society-AVS10 2019
Helbig, K. J., Bull, R. A., Ambrose, R., Beard, M. R., Blanchard, H., Böcking, T., Chua, B., Colmant, A. M. G., Crosse, K. M., Purcell, D. F. J., Fraser, J., Hayward, J. A., Hamilton, S. T., Husain, M., MacDiarmid, R., Mackenzie, J. M., Moseley, G. W., Nguyen, T. H. O., Quiñones-Mateu, M. E., Robinson, K. & 10 others, , 6 Jun 2020, In : Viruses. 12, 6, 23 p., 621.Research output: Contribution to journal › Article › Other › peer-review
Open AccessFile -
Wolbachia's deleterious impact on aedes aegypti egg development: The potential role of nutritional parasitism
Allman, M. J., Fraser, J. E., Ritchie, S. A., Joubert, D. A., Simmons, C. P. & Flores, H. A., 27 Oct 2020, In : Insects. 11, 11, 14 p., 735.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile -
Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Novel Wolbachia-transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes
Fraser, J. E., De Bruyne, J. T., Iturbe-Ormaetxe, I., Stepnell, J., Burns, R. L., Flores, H. A. & O’Neill, S. L., 1 Dec 2017, In : PLoS Pathogens. 13, 12, 19 p., e1006751.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile36 Citations (Scopus)