Projects per year
Personal profile
Biography
I am a Research Fellow with the Department of Microbiology, Biomedicine Discovery Institute. I completed my PhD at the Burnet Institute in Melbourne (2011) in hepatitis C virus, then undertook postdoctoral research in the Department of Biochemistry and Molecular Biology, Monash University. There, I researched the pathogenic roles of the dengue virus NS5 protein and identified several potential antiviral therapeutics, including one that has now been licensed and has patents approved in multiple countries.
I currently run an NHMRC- and ARC-funded research program focussed on understanding the molecular mechanisms that underpin Wolbachia-mediated virus inhibition in Aedes aegypti mosquitoes - the novel biocontrol tool established by Monash-based World Mosquito program. I am also using molecular virology techniques to determine the risk of viral resistance developing towards this technology. My research primarily uses molecular technologies including high resolution imaging, genomics and proteomics techniques to better understand how Wolbachia modifies this host to create an antiviral environment.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Defining the antiviral effects of Wolbachia in Aedes aegypti mosquitoes
Fraser, J., Mackenzie, J. & Simmons, C.
Australian Research Council (ARC)
1/01/23 → 31/12/25
Project: Research
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Dengue virus resistance to Wolbachia
Fraser, J. & Eyre, N. S.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/23
Project: Research
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Characterisation and validation of retinoic acid p-hydroxanilide (4-HPR) as a potent anti-dengue agent.
Jans, D., Fraser, J. & Morton, C. J.
1/08/13 → 30/06/14
Project: Research
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High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses
Yang, S. N. Y., Maher, B., Wang, C., Wagstaff, K. M., Fraser, J. E. & Jans, D. A., 2 Feb 2022, In: Cells. 11, 4, 11 p., 730.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Transient introgression of Wolbachia into Aedes aegypti populations does not elicit an antibody response to Wolbachia surface protein in community members
Lee, E., Nguyen, T. H., Nguyen, T. Y., Vu, S. N., Tran, N. D., Nghia, L. T., Vien, Q. M., Nguyen, T. D., Loterio, R. K., Iturbe-Ormaetxe, I., Flores, H. A., O’neill, S. L., Dang, D. A., Simmons, C. P. & Fraser, J. E., 2022, In: Pathogens. 11, 5, 13 p., 535.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Erratum: Using Wolbachia to eliminate dengue: will the virus fight back? (Journal of Virology (2021) 95:13 (e02203-20) DOI:10.1128/JVI.02203-20)
Edenborough, K. M., Flores, H. A., Simmons, C. P. & Fraser, J. E., Sep 2021, In: Journal of Virology. 95, 18, 1 p., e00953-21.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Using Wolbachia to eliminate dengue: will the virus fight back?
Edenborough, K. M., Flores, H. A., Simmons, C. P. & Fraser, J. E., Jun 2021, In: Journal of Virology. 95, 13, 13 p., e02203-20.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile9 Citations (Scopus) -
Novel phenotype of Wolbachia strain wPip in Aedes aegypti challenges assumptions on mechanisms of Wolbachia-mediated dengue virus inhibition
Fraser, J. E., O'Donnell, T. B., Duyvestyn, J. M., O'Neill, S. L., Simmons, C. P. & Flores, H. A., 1 Jul 2020, In: PLoS Pathogens. 16, 7, 21 p., e1008410.Research output: Contribution to journal › Article › Research › peer-review
Open Access21 Citations (Scopus)
Activities
- 2 Patents
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MONASH UNIVERSITY (Organisational unit)
Johanna Elisabeth Fraser (Inventor), Jyotika Taneja Taneja De Bruyne (Inventor), Inaki Iturbe-Ormaeche (Inventor), Heather Ann Flores (Inventor) & Scott O'Neill (Inventor)
3 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Johanna Fraser (Inventor), David Jans (Inventor) & Kylie Wagstaff (Inventor)
31 Oct 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent