20112024

Research activity per year

Personal profile

Research interests

I am a Research Fellow within the Department of Microbiology,
Biomedicine Discovery Institute, and my team is co-located alongside
the World Mosquito Program (WMP) at Monash University, Clayton. My
team aims to develop and support the application of novel intervention
strategies for mosquito-borne viruses.

Over the last decade WMP has established the use of the insect
symbiotic bacterium, Wolbachia, as a biocontrol tool: Wolbachia
reduces the risk of transmission of important human pathogenic
viruses, like dengue, from the Aedes aegypti mosquito species to
humans. WMP has deployed Wolbachia in regions of 12 dengue-prone
countries to date. The efficacy of their approach was recently
demonstrated in a randomised controlled trial in Yogyakarta,
Indonesia, where a 77% reduction in dengue incidence was reported in
regions of the city where Wolbachia was established in Ae. aegypti
populations (Utarini et al., NEJM 2021).

I run an NHMRC- and ARC-funded research program focussed on
understanding the molecular mechanisms that underpin Wolbachia's
antiviral activity in Ae. aegypti. Using novel in vivo and in vitro
systems, we apply a range of molecular technologies including high
resolution imaging, transcriptomics, proteomics and deep sequencing,
to probe how Wolbachia modifies mosquito cells and how viruses like
dengue may adapt to this antiviral pressure. Building this knowledge
bank will help support the application and longevity of Wolbachia as
an intervention strategy and may guide development of new applications
for its use in other viral vector species.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • Enhancing the scalability of Wolbachia-based vector-borne disease management: time and temperature limits for storage and transport of Wolbachia-infected Aedes aegypti eggs for field releases

    Allman, M. J., Lin, Y-H., Joubert, D. A., Addley-Cook, J., Mejía-Torres, M. C., Simmons, C. P., Flores, H. A. & Fraser, J. E., 2023, In: Parasites & Vectors. 16, 13 p., 108.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    File
    1 Citation (Scopus)
  • Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”

    Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., Herrero, L., Helbig, K., Londrigan, S., Moseley, G., Prow, N., Hansman, G., Edwards, R., Ahlenstiel, C., Abendroth, A., Tscharke, D., Hobson-Peters, J., Kriiger-Loterio, R., Parry, R., Marsh, G., & 100 othersHarding, E., Jacques, D. A., Gartner, M. J., Lee, W. S., McAuley, J., Vaz, P., Sainsbury, F., Tate, M. D., Sinclair, J., Imrie, A., Rawlinson, S., Harman, A., Carr, J. M., Monson, E. A., Hibma, M., Mahony, T. J., Tu, T., Center, R. J., Shrestha, L. B., Hall, R., Warner, M., Ward, V., Anderson, D. E., Eyre, N. S., Netzler, N. E., Peel, A. J., Revill, P., Beard, M., Legione, A. R., Spencer, A. J., Idris, A., Forwood, J., Sarker, S., Purcell, D. F. J., Bartlett, N., Deerain, J. M., Brew, B. J., Asgari, S., Farrell, H., Khromykh, A., Tuipulotu, D. E., Anderson, D., Mese, S., Tayyar, Y., Edenborough, K., Uddin, J. M., Hussain, A., Daymond, C. J. I., Agius, J., Johnson, K. N., Shirmast, P., Abedinzadeshahri, M., MacDiarmid, R., Ashley, C. L., Laws, J., Furfaro, L. L., Burton, T. D., Johnson, S. M. R., Telikani, Z., Petrone, M., Roby, J. A., Samer, C., Suhrbier, A., Van Der Kamp, A., Cunningham, A., Donato, C., Mahar, J., Black, W. D., Vasudevan, S., Lenchine, R., Spann, K., Rawle, D. J., Rudd, P., Neil, J., Kingston, R., Newsome, T. P., Kim, K. W., Mak, J., Lowry, K., Bryant, N., Meers, J., Roberts, J. A., McMillan, N., Labzin, L. I., Slonchak, A., Hugo, L. E., Henzeler, B., Newton, N. D., David, C. T., Reading, P. C., Esneau, C., Briody, T., Nasr, N., McNeale, D., McSharry, B., Fakhri, O., Horsburgh, B. A., Logan, G., Howley, P. & Young, P., 31 May 2023, In: Journal of Virology. 97, 5, 3 p.

    Research output: Contribution to journalLetterOtherpeer-review

    Open Access
  • Statement in Support of: "Virology under the Microscope-a Call for Rational Discourse"

    Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., Herrero, L., Helbig, K., Londrigan, S., Moseley, G., Prow, N., Hansman, G., Edwards, R., Ahlenstiel, C., Abendroth, A., Tscharke, D., Hobson-Peters, J., Kriiger-Loterio, R., Parry, R., Marsh, G., & 100 othersHarding, E., Jacques, D. A., Gartner, M. J., Lee, W. S., McAuley, J., Vaz, P., Sainsbury, F., Tate, M. D., Sinclair, J., Imrie, A., Rawlinson, S., Harman, A., Carr, J. M., Monson, E. A., Hibma, M., Mahony, T. J., Tu, T., Center, R. J., Shrestha, L. B., Hall, R., Warner, M., Ward, V., Anderson, D. E., Eyre, N. S., Netzler, N. E., Peel, A. J., Revill, P., Beard, M., Legione, A. R., Spencer, A. J., Idris, A., Forwood, J., Sarker, S., Purcell, D. F. J., Bartlett, N., Deerain, J. M., Brew, B. J., Asgari, S., Farrell, H., Khromykh, A., Enosi Tuipulotu, D., Anderson, D., Mese, S., Tayyar, Y., Edenborough, K., Uddin, J. M., Hussain, A., Daymond, C. J. I., Agius, J., Johnson, K. N., Shirmast, P., Abedinzadeshahri, M., MacDiarmid, R., Ashley, C. L., Laws, J., Furfaro, L. L., Burton, T. D., Johnson, S. M. R., Telikani, Z., Petrone, M., Roby, J. A., Samer, C., Suhrbier, A., Van Der Kamp, A., Cunningham, A., Donato, C., Mahar, J., Black, W. D., Vasudevan, S., Lenchine, R., Spann, K., Rawle, D. J., Rudd, P., Neil, J., Kingston, R., Newsome, T. P., Kim, K. W., Mak, J., Lowry, K., Bryant, N., Meers, J., Roberts, J. A., McMillan, N., Labzin, L. I., Slonchak, A., Hugo, L. E., Henzeler, B., Newton, N. D., David, C. T., Reading, P. C., Esneau, C., Briody, T., Nasr, N., McNeale, D., McSharry, B., Fakhri, O., Horsburgh, B. A., Logan, G., Howley, P. & Young, P., 22 Jun 2023, In: mSphere. 8, 3, 3 p., e0016523.

    Research output: Contribution to journalLetterOtherpeer-review

    Open Access
  • Statement in Support of: "Virology under the Microscope-a Call for Rational Discourse"

    Speck, P., Mackenzie, J., Bull, R. A., Slobedman, B., Drummer, H., Fraser, J., Herrero, L., Helbig, K., Londrigan, S., Moseley, G., Prow, N., Hansman, G., Edwards, R., Ahlenstiel, C., Abendroth, A., Tscharke, D., Hobson-Peters, J., Kriiger-Loterio, R., Parry, R., Marsh, G., & 100 othersHarding, E., Jacques, D. A., Gartner, M. J., Lee, W. S., McAuley, J., Vaz, P., Sainsbury, F., Tate, M. D., Sinclair, J., Imrie, A., Rawlinson, S., Harman, A., Carr, J. M., Monson, E. A., Hibma, M., Mahony, T. J., Tu, T., Center, R. J., Shrestha, L. B., Hall, R., Warner, M., Ward, V., Anderson, D. E., Eyre, N. S., Netzler, N. E., Peel, A. J., Revill, P., Beard, M., Legione, A. R., Spencer, A. J., Idris, A., Forwood, J., Sarker, S., Purcell, D. F. J., Bartlett, N., Deerain, J. M., Brew, B. J., Asgari, S., Farrell, H., Khromykh, A., Enosi Tuipulotu, D., Anderson, D., Mese, S., Tayyar, Y., Edenborough, K., Uddin, J. M., Hussain, A., Daymond, C. J. I., Agius, J., Johnson, K. N., Shirmast, P., Abedinzadeshahri, M., MacDiarmid, R., Ashley, C. L., Laws, J., Furfaro, L. L., Burton, T. D., Johnson, S. M. R., Telikani, Z., Petrone, M., Roby, J. A., Samer, C., Suhrbier, A., Van Der Kamp, A., Cunningham, A., Donato, C., Mahar, J., Black, W. D., Vasudevan, S., Lenchine, R., Spann, K., Rawle, D. J., Rudd, P., Neil, J., Kingston, R., Newsome, T. P., Kim, K. W., Mak, J., Lowry, K., Bryant, N., Meers, J., Roberts, J. A., McMillan, N., Labzin, L. I., Slonchak, A., Hugo, L. E., Henzeler, B., Newton, N. D., David, C. T., Reading, P. C., Esneau, C., Briody, T., Nasr, N., McNeale, D., McSharry, B., Fakhri, O., Horsburgh, B. A., Logan, G., Howley, P. & Young, P., 27 Jun 2023, In: mBio. 14, 3, 3 p., e00815-23.

    Research output: Contribution to journalLetterOtherpeer-review

    Open Access
  • High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses

    Yang, S. N. Y., Maher, B., Wang, C., Wagstaff, K. M., Fraser, J. E. & Jans, D. A., 2 Feb 2022, In: Cells. 11, 4, 11 p., 730.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    6 Citations (Scopus)