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Personal profile

Biography

I am a Research Fellow with the World Mosquito Program, Institute of Vector-borne Disease. My work is focussed on understanding the mechansims by which the symbiotic bacterium Wolbachia can disrupt arbovirus replication in Aedes aegypti mosquitoes. I am using molecular imaging and genomics techniques to better understand how Wolbachia modifies its host to create an antiviral environment.

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Projects 2013 2014

Research Output 2011 2019

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Novel Wolbachia-transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes

Fraser, J. E., De Bruyne, J. T., Iturbe-Ormaetxe, I., Stepnell, J., Burns, R. L., Flores, H. A. & O’Neill, S. L., 1 Dec 2017, In : PLoS Pathogens. 13, 12, 19 p., e1006751.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Dynamic nucleolar targeting of dengue virus polymerase NS5 in response to extracellular pH

Fraser, J. E., Rawlinson, S. M., Heaton, S. M. & Jans, D. A., Jun 2016, In : Journal of Virology. 90, 12, p. 5797-5807 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection

Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.

Research output: Contribution to journalArticleResearchpeer-review