Projects per year
Personal profile
Biography
I am a Research Fellow with the World Mosquito Program, Institute of Vector-borne Disease. My work is focussed on understanding the mechansims by which the symbiotic bacterium Wolbachia can disrupt arbovirus replication in Aedes aegypti mosquitoes. I am using molecular imaging and genomics techniques to better understand how Wolbachia modifies its host to create an antiviral environment.
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Projects 2013 2014
- 1 Finished
Characterisation and validation of retinoic acid p-hydroxanilide (4-HPR) as a potent anti-dengue agent.
Jans, D., Fraser, J. & Morton, C.
1/08/13 → 30/06/14
Project: Research
Research Output 2011 2019
- 8 Article
Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer
Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Novel Wolbachia-transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes
Fraser, J. E., De Bruyne, J. T., Iturbe-Ormaetxe, I., Stepnell, J., Burns, R. L., Flores, H. A. & O’Neill, S. L., 1 Dec 2017, In : PLoS Pathogens. 13, 12, 19 p., e1006751.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Dynamic nucleolar targeting of dengue virus polymerase NS5 in response to extracellular pH
Fraser, J. E., Rawlinson, S. M., Heaton, S. M. & Jans, D. A., Jun 2016, In : Journal of Virology. 90, 12, p. 5797-5807 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R–like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells
Fraser, J. E., Wang, C., Chan, K. W. K., Vasudevan, S. G. & Jans, D. A., Jun 2016, In : Antiviral Research. 130, 6 p.Research output: Contribution to journal › Article › Research › peer-review
A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection
Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.Research output: Contribution to journal › Article › Research › peer-review