Projects per year
Personal profile
Biography
Joel is a proud Palawa man and Proteomics Lead Expert at the Monash University Proteomics & Metabolomics Platform. His expertise in biological mass spectrometry and proteomics has focused on the identification of novel proteins and their post-translational modifications, which are crucial for understanding disease mechanisms and therapeutic targets.
Academic Background:
- PhD in Medical Science (Proteomics) from the University of Technology Sydney, focusing on mass spectrometry analysis of non-protein amino acid misincorporation and proteomic changes in neurotoxicity-related cellular pathways.
- Honours First Class in Medical Science from the University of Technology Sydney, with research on non-protein amino acids' effects on mammalian cells.
- Bachelor of Medical Science from the University of Technology Sydney, specializing in medical, neuroscience, advanced immunology, and molecular biochemistry.
Professional Experience:
- Proteomics Lead at Monash University (Mar 2021 - Present):
Responsible for leading proteomic research, method development, experimental design, and project management. He collaborates with government, academic, and commercial sectors to provide quantitative solutions to biological questions across medical and life sciences. - Analysis Working Group Member at NASA GeneLab (Aug 2022 - Present):
Contributing to maximizing knowledge generation from complex spaceflight-relevant omics datasets. - Fulbright Future Scholar at NASA Ames Research Center (May 2022 - Sep 2022):
Conducted research on bacterial mutation rates due to spaceflight radiation exposure and on mouse muscle proteomes. - Casual Academic at the University of Technology Sydney (May 2016 - Feb 2021):
Taught courses in proteomics, pharmacology, physiological systems, principles of scientific practice, and metabolic biochemistry. - Research Affiliate at the University of Sydney (Feb 2018 - Aug 2019):
Involved in the study of E-Cigarette's effects on the brain in combination with other dietary factors.
Honours and Awards:
- Fulbright Future Scholarship (2021): Awarded for research at NASA’s Jet Propulsion Laboratory, focusing on microbes that can survive extreme conditions.
- NASA-JPL Internship Program (2020): accepted into the summer internship programs at NASA's Jet Propulsion Laboratory.
- Dean's Merit List for Academic Excellence (2017): Recognition for first-class honours at the University of Technology Sydney.
- Poster Prize at Australasian Proteomic Society (2017): For research on proteomic analysis of non-protein amino acids.
Contributions and Collaborations:
Joel has led over 500 proteomic experiments and processed more than 7,000 samples during his three years at Monash. Collaborative efforts span institutions such as the NSW Department of Primary Industries, CSIRO, Australian Defence DSTG, University College London, Stanford University, US-ARMY, Oxford, NASA, and Johns Hopkins University. His research has notably contributed to studies in women's reproductive health and various proteomic analyses related to diseases and space biology.
Research Interests:
Joel's research interests include proteomics, mass spectrometry, analytical biochemistry, and bioinformatics. He is actively involved in developing bioassays, investigating protein misincorporation, and exploring biomarkers for neurodegenerative and infectious diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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NHMRC Equipment Grant - PIXUL Multi-Sample Megasonicator (ProtiFi)
Schittenhelm, R., Faridi, P., Creek, D., Steele, J., Li, J., Traven, A., Lahoud, M., Daly, R. & Lim, T.
1/11/23 → 31/12/24
Project: Research
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Establishing a Clinical Single-Cell Proteomics Facility
Schittenhelm, R., Nishtala, T., de Marco, A., Neild, A. & Steele, J.
Ian Potter Foundation, Monash University, Bioplatforms Australia Ltd
1/09/23 → 31/08/24
Project: Research
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Analysis and visualization of quantitative proteomics data using FragPipe-Analyst
Hsiao, Y., Zhang, H., Li, G. X., Deng, Y., Yu, F., Kahrood, H. V., Steele, J. R., Schittenhelm, R. B. & Nesvizhskii, A. I., 11 Mar 2024, 33 p. bioRxiv.Research output: Other contribution › Research
Open Access -
A Semiautomated Proteomics and Phosphoproteomics Protocol for the Identification of Novel Therapeutic Targets and Predictive Biomarkers in In Vivo Xenograft Models of Pediatric Cancers
Lim Kam Sian, T. CC., Sun, C., Cain, J. E., Steele, J. R., Hanchapola, I., Stoychev, S., Schittenhelm, R. B. & Faridi, P., 2024, Patient-Derived Xenografts: Methods and Protocols. Saad, M. I. (ed.). New York NY USA: Humana Press, p. 229-242 14 p. (Methods in Molecular Biology; vol. 2806).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Siew, K., Nestler, K. A., Nelson, C., D’Ambrosio, V., Zhong, C., Li, Z., Grillo, A., Wan, E. R., Patel, V., Overbey, E., Kim, J. K., Yun, S., Vaughan, M. B., Cheshire, C., Cubitt, L., Broni-Tabi, J., Al-Jaber, M. Y., Boyko, V., Meydan, C., Barker, P., & 85 others , Dec 2024, In: Nature Communications. 15, 1, 20 p., 4923.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit
Strange, N., Luu, L., Ong, V., Wee, B. A., Phillips, M. J. A., McCaughey, L., Steele, J. R., Barlow, C. K., Cranfield, C. G., Myers, G., Mazraani, R., Rock, C., Timms, P. & Huston, W. M., 18 Apr 2024, In: Journal of Bacteriology. 206, 4, 21 p., e00371-23.Research output: Contribution to journal › Article › Research › peer-review
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Loss of endogenous estrogen alters mitochondrial metabolism and muscle clock-related protein Rbm20 in female mdx mice
Timpani, C. A., Debrincat, D., Kourakis, S., Boyer, R., Formosa, L. E., Steele, J. R., Zhang, H., Schittenhelm, R. B., Russell, A. P., Rybalka, E. & Lindsay, A., 12 Feb 2024, 26 p. bioRxiv.Research output: Other contribution › Research
Open Access