Joanne Ryan

Dr

  • Senior Research Fellow, ASPREE

Accepting PhD Students

20012022

Research output per year

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Research Output

2020

Aromatase (CYP19A1) gene variants, sex steroid levels, and late-life depression

Ancelin, M. L., Norton, J., Canonico, M., Scarabin, P. Y., Ritchie, K. & Ryan, J., Feb 2020, In : Depression and Anxiety. 37, 2, p. 146-155 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic variation, intrauterine growth, and adverse pregnancy conditions predict leptin gene DNA methylation in blood at birth and 12 months of age

Mansell, T., Ponsonby, A. L., Collier, F., Burgner, D., Vuillermin, P., Lange, K., Ryan, J., Saffery, R. & Barwon Infant Study Investigator Team, Jan 2020, In : International Journal of Obesity. 44, 1, p. 45-56 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Is Peripheral BDNF Promoter Methylation a Preclinical Biomarker of Dementia?

Fransquet, P. D., Ritchie, K., Januar, V., Saffery, R., Ancelin, M. L. & Ryan, J., Jan 2020, In : Journal of Alzheimer's Disease. 73, 2, p. 645-655 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Normative performance of older individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) according to ethno-racial group, gender, age and education level

Ryan, J., Woods, R. L., Murray, A. M., Shah, R. C., Britt, C. J., Reid, C. M., Wolfe, R., Nelson, M. R., Lockery, J. E., Orchard, S. G., Trevaks, R. E., Chong, T. J., McNeil, J. J., Storey, E. & on behalf of the ASPREE Investigator Group, 26 Feb 2020, (Accepted/In press) In : The Clinical Neuropsychologist. 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The extent to which childhood adversity and recent stress influence all-cause mortality risk in older adults

Johnson, J., Chaudieu, I., Ritchie, K., Scali, J., Ancelin, M. L. & Ryan, J., Jan 2020, In : Psychoneuroendocrinology. 111, 8 p., 104492.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation

Galbally, M., Wilson, S. J., IJzendoorn, M. V., Saffery, R., Ryan, J., De Kloet, E. R., Oberlander, T. F., Lappas, M. & Lewis, A. J., May 2020, In : Psychoneuroendocrinology. 115, 31 p., 104611.

Research output: Contribution to journalArticleResearchpeer-review

2019

Association between DNA methylation of the KITLG gene and cortisol levels under stress: a replication study

Wrigglesworth, J., Ancelin, M-L., Ritchie, K. & Ryan, J., 2 Jan 2019, In : Stress-The International Journal on the Biology of Stress. 22, 1, p. 162-168 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A systematic review and meta-analysis of environmental, lifestyle and health factors associated with DNA methylation age

Ryan, J., Wrigglesworth, J., Loong, J., Fransquet, P. D. & Woods, R., 17 Apr 2019, (Accepted/In press) In : Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 60 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure

Wrigglesworth, J., Ryan, J., Vijayakumar, N. & Whittle, S., 30 Mar 2019, In : Psychiatry Research - Neuroimaging. 285, p. 51-57 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Correction to: Prenatal alcohol exposure and infant gross motor development: A prospective cohort study (BMC Pediatrics (2019) 19 (149) DOI: 10.1186/s12887-019-1516-5)

Hutchinson, D., Youssef, G. J., McCormack, C., Wilson, J., Allsop, S., Najman, J., Elliott, E., Burns, L., Jacobs, S., Honan, I., Rossen, L., Fiedler, H., Teague, S., Ryan, J., Olsson, C. A. & Mattick, R. P., 4 Jul 2019, In : BMC Pediatrics. 19, 1, 2 p., 222.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
1 Citation (Scopus)

Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: A birth cohort study

Mansell, T., Ponsonby, A. L., Januar, V., Novakovic, B., Collier, F., Burgner, D., Vuillermin, P., Ryan, J., Saffery, R. & Barwon Infant Study Investigator Team, 1 Jul 2019, In : Clinical Epigenetics. 11, 1, 12 p., 96.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic and Epigenetic Regulation of the Serotonin Transporter Gene in Late-Life Depression

Ryan, J. & Ancelin, M-L., 1 Jul 2019, In : Journal of Geriatric Psychiatry and Neurology. 32, 4, p. 175-177 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review

Huq, A. J., Fransquet, P., Laws, S. M., Ryan, J., Sebra, R., Masters, C. L., Winship, I. M., James, P. A. & Lacaze, P., 7 Sep 2019, (Accepted/In press) In : Alzheimer's and Dementia. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Lifetime major depression and grey-matter volume

Ancelin, M-L., Carriere, I., Artero, S., Maller, J., Meslin, C., Ritchie, K., Ryan, J. & Chaudieu, I., 1 Jan 2019, In : Journal of Psychiatry & Neuroscience. 44, 1, p. 45-53 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Maternal mental health and infant emotional reactivity: a 20-year two-cohort study of preconception and perinatal exposures.

Spry, E., Moreno-Betancur, M., Becker, D., Romaniuk, H., Carlin, J. B., Molyneaux, E., Howard, L. M., Ryan, J., Letcher, P., McIntosh, J. E., Macdonald, J. A., Greenwood, C. J., Thomson, K. C., McAnally, H., Hancox, R., Hutchinson, D. M., Youssef, G. J., Olsson, C. A. & Patton, G. C., 10 Apr 2019, (Accepted/In press) In : Psychological Medicine. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Mental health trajectories among women in Australia as they age

Tran, T., Hammarberg, K., Ryan, J., Lowthian, J., Freak-Poli, R., Owen, A., Kirkman, M., Curtis, A., Rowe, H., Brown, H., Ward, S., Britt, C. & Fisher, J., 2019, In : Aging and Mental Health. 23, 7, p. 887-896 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level

Ryan, J., Woods, R. L., Britt, C., Murray, A. M., Shah, R. C., Reid, C. M., Kirpach, B., Wolfe, R. S., Nelson, M. R., Lockery, J. E., Orchard, S. G., Trevaks, R. E., McNeil, J. J., Storey, E. & on behalf of the ASPREE Investigator Group, 19 May 2019, In : The Clinical Neuropsychologist. 33, 4, p. 779–797 19 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Prenatal alcohol exposure and infant gross motor development: A prospective cohort study

Hutchinson, D., Youssef, G. J., McCormack, C., Wilson, J., Allsop, S., Najman, J., Elliott, E., Burns, L., Jacobs, S., Honan, I., Rossen, L., Fiedler, H., Teague, S., Ryan, J., Olsson, C. A. & Mattick, R. P., 14 May 2019, In : BMC Pediatrics. 19, 1, 14 p., 149.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

The current status of blood epigenetic biomarkers for dementia

Fransquet, P. D. & Ryan, J., Jul 2019, (Accepted/In press) In : Critical Reviews in Clinical Laboratory Sciences. 23 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The epigenetic clock as a predictor of disease and mortality risk: A systematic review and meta-analysis

Fransquet, P. D., Wrigglesworth, J., Woods, R. L., Ernst, M. E. & Ryan, J., 11 Apr 2019, In : Clinical Epigenetics. 11, 1, 17 p., 62.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

The impact of psychological stress and trauma on later-life cognitive function and dementia

Nilaweera, D., Freak-Poli, R. & Ryan, J., 2019, In : Journal of Gerontology and Geriatrics. 2019, 2, p. 114-122 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2018

5-HTTLPR × stress hypothesis: is the debate over?

Ancelin, M-L. & Ryan, J., 1 Nov 2018, In : Molecular Psychiatry. 23, 11, p. 2116-2117 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access
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5 Citations (Scopus)

Blood DNA methylation as a potential biomarker of dementia: A systematic review

Fransquet, P. D., Lacaze, P., Saffery, R., McNeil, J., Woods, R. & Ryan, J., Jan 2018, In : Alzheimer's and Dementia. 14, 1, p. 81-103 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Cognitive Impairment, Sexual Activity and Physical Tenderness in Community-Dwelling Older Adults: A Cross-Sectional Exploration

Freak-Poli, R., Licher, S., Ryan, J., Ikram, M. A. & Tiemeier, H., Oct 2018, In : Gerontology. 64, 6, p. 589–602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cohort profile: The Triple B Pregnancy Cohort Study: A longitudinal study of the relationship between alcohol, tobacco and other substance use during pregnancy and the health and well-being of Australian children and families

Hutchinson, D., Wilson, J., Allsop, S., Elliott, E., Najman, J., Burns, L., Bartu, A., Jacobs, S., Honan, I., McCormack, C., Rossen, L., Fiedler, H., Stone, C., Khor, S., Ryan, J., Youssef, G. J., Olsson, C. A., Mattick, R. P. & The Triple B Research Consortium, 1 Feb 2018, In : International Journal of Epidemiology. 47, 1, p. 26-27m 15 p., dyx218.

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression

Lam, D., Ancelin, M. L., Ritchie, K., Saffery, R. & Ryan, J., 1 Feb 2018, In : Psychoneuroendocrinology. 88, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Effect of aspirin on all-cause mortality in the healthy elderly

McNeil, J. J., Nelson, M. R., Woods, R. L., Lockery, J. E., Wolfe, R., Reid, C. M., Kirpach, B. R., Shah, R. C., Ives, D. G., Storey, E., Ryan, J., Tonkin, A. M., Newman, A. B., Williamson, J. D., Margolis, K. L., Ernst, M. E., Abhayaratna, W. P., Stocks, N., Fitzgerald, S. M., Orchard, S. G. & 9 others, Trevaks, R. E., Beilin, L. J., Donnan, G. A., Gibbs, P., Johnston, C. I., Radziszewska, B., Grimm, R., Murray, A. M. & for the ASPREE Investigator Group, 18 Oct 2018, In : New England Journal of Medicine. 379, 16, p. 1519-1528 10 p.

Research output: Contribution to journalArticleResearchpeer-review

149 Citations (Scopus)

Effect of aspirin on cardiovascular events and bleeding in the healthy elderly

McNeil, J. J., Wolfe, R., Woods, R. L., Tonkin, A. M., Donnan, G. A., Nelson, M. R., Reid, C. M., Lockery, J. E., Kirpach, B. R., Storey, E., Shah, R. C., Williamson, J. D., Margolis, K. L., Ernst, M. E., Abhayaratna, W. P., Stocks, N., Fitzgerald, S. M., Orchard, S. G., Trevaks, R. E., Beilin, L. J. & 14 others, Johnston, C. I., Ryan, J., Radziszewska, B., Jelinek, M., Malik, M. A., Eaton, C. B., Brauer, D., Cloud, G., Wood, E. M., Mahady, S. E., Satterfield, S. A., Grimm, R., Murray, A. M. & for the ASPREE Investigator Group, 18 Oct 2018, In : New England Journal of Medicine. 379, 16, p. 1509-1518 10 p.

Research output: Contribution to journalArticleResearchpeer-review

192 Citations (Scopus)

Effect of aspirin on disability-free survival in the healthy elderly

McNeil, J. J., Woods, R. L., Nelson, M. R., Reid, C. M., Kirpach, B. R., Wolfe, R., Storey, E., Shah, R. C., Lockery, J. E., Tonkin, A. M., Newman, A. B., Williamson, J. D., Margolis, K. L., Ernst, M. E., Abhayaratna, W. P., Stocks, N., Ives, D. G., Fitzgerald, S. M., Orchard, S. G., Trevaks, R. E. & 9 others, Beilin, L. J., Donnan, G. A., Gibbs, P., Johnston, C. I., Ryan, J., Radziszewska, B., Grimm, R., Murray, A. M. & for the ASPREE Investigator Group, 18 Oct 2018, In : New England Journal of Medicine. 379, 16, p. 1499-1508 10 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Epigenetics: a missing link in understanding psychiatric disorders?

Ryan, J., Saffery, R. & Patton, G., 1 Jan 2018, In : The Lancet Psychiatry. 5, 1, p. 65-78 14 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

3 Citations (Scopus)

Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression

Lam, D., Ancelin, M. L., Ritchie, K., Freak-Poli, R., Saffery, R. & Ryan, J., 4 Sep 2018, In : BMC Psychiatry. 18, 1, 10 p., 282.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Maternal depression, antidepressant use and placental oxytocin receptor DNA methylation: Findings from the MPEWS study

Galbally, M., Ryan, J., van IJzendoorn, M., Watson, S. J., Spigset, O., Lappas, M., Saffery, R., de Kloet, R. & Lewis, A. J., 1 Apr 2018, In : Psychoneuroendocrinology. 90, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer's disease

Fransquet, P. D. & Ryan, J., 1 Aug 2018, In : Clinical Biochemistry. 58, p. 5-14 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Phenotypic Heterogeneity in Dementia: A Challenge for Epidemiology and Biomarker Studies

Ryan, J., Fransquet, P., Wrigglesworth, J. & Lacaze, P., 19 Jun 2018, In : Frontiers in Public Health. 2018, 6 p., 00181.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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Pilot clinical quality registry for dementia in Australia

McNeil, J. J., Brodaty, H., Ahern, S., Storey, E., Earnest, A., Woods, R. L., Nelson, M. R., Krysinska, K., Dean, J. T., Liew, D. Y. H., Ryan, J. L., Ayton, D. R., Gardam, M., Pritchard, E. K., Robinson, S. & Ward, S. A., Oct 2018.

Research output: Contribution to conferencePoster

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: A systematic narrative review

Maud, C., Ryan, J., McIntosh, J. E. & Olsson, C. A., 29 May 2018, In : BMC Psychiatry. 18, 1, 13 p., 154.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Time- and sex-dependent associations between prenatal alcohol exposure and placental global DNA methylation

Loke, Y. J., Muggli, E., Nguyen, L., Ryan, J., Saffery, R., Elliott, E. J., Halliday, J. & Craig, J. M., 1 Jul 2018, In : Epigenomics. 10, 7, p. 981-991 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2017

Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4

Fransquet, P. D., Hutchinson, D. M., Olsson, C. A., Allsop, S., Elliott, E. J., Burns, L., Mattick, R., Saffery, R. & Ryan, J., 2017, In : American Journal of Drug and Alcohol Abuse. 43, 6, p. 671-677 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Chronic and remitting trajectories of depressive symptoms in the elderly. Characterisation and risk factors

Carrière, I., Farré, A., Proust-Lima, C., Ryan, J., Ancelin, M. L. & Ritchie, K., Apr 2017, In : Epidemiology and Psychiatric Sciences. 26, 2, p. 146-156 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Does maternal mental well-being in pregnancy impact the early human epigenome?

Ryan, J., Mansell, T., Fransquet, P. & Saffery, R., 1 Mar 2017, In : Epigenomics. 9, 3, p. 313-322 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Rao, S., Yao, Y., Ryan, J., Jin, C., Xu, Y., Huang, X., Guo, J., Wen, Y., Mao, C., Meyre, D. & Zhang, F., 25 Jan 2017, In : Scientific Reports. 7, 8 p., 41140.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression

Ancelin, M-L., Scali, J., Norton, J., Ritchie, K., Dupuy, A-M., Chaudieu, I. & Ryan, J., 1 Mar 2017, In : Psychoneuroendocrinology. 77, p. 90-94 5 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Hormone treatment

Ryan, J., 2017, The SAGE Encyclopedia of Abnormal and Clinical Psychology. Wenzel, A. (ed.). Thousand Oaks CA USA: SAGE Publications Ltd, p. 1696 - 1697 2 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Investigating direct links between depression, emotional control, and physical punishment with adolescent drive for thinness and bulimic behaviors, including possible moderation by the serotonin transporter 5-HTTLPR polymorphism

Rozenblat, V., Ryan, J., Wertheim, E. H., King, R., Olsson, C. A. & Krug, I., 9 Aug 2017, In : Frontiers in Psychology. 8, AUG, 1361.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression

Ryan, J., Pilkington, L., Neuhaus, K., Ritchie, K., Ancelin, M. L. & Saffery, R., 25 Oct 2017, In : BMC Psychiatry. 17, 1, 354.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Mercy Pregnancy and Emotional Well-being Study (MPEWS): Understanding maternal mental health, fetal programming and child development. Study design and cohort profile

Galbally, M., IJzendoorn, M. V., Permezel, M., Saffery, R., Lappas, M., Ryan, J., Van Rossum, E., Johnson, A. R., Teti, D. & Lewis, A. J., 1 Dec 2017, In : International Journal of Methods in Psychiatric Research. 26, 4, 10 p., e1558.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Pathogenic variants in the healthy elderly: Unique ethical and practical challenges

Lacaze, P., Ryan, J., Woods, R., Winship, I. & McNeil, J., Oct 2017, In : Journal of Medical Ethics. 43, 10, p. 714-722 9 p., 103967.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)