20022020

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Article
2020

Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

Li, J., Sun, Y. B. Y., Chen, W., Fan, J., Li, S., Qu, X., Chen, Q., Chen, R., Zhu, D., Zhang, J., Wu, Z., Chi, H., Crawford, S., Oorschot, V., Puelles, V. G., Kerr, P. G., Ren, Y., Nilsson, S. K., Christian, M., Tang, H. & 4 others, Chen, W., Bertram, J. F., Nikolic-Paterson, D. J. & Yu, X., 5 Feb 2020, In : EMBO Reports. 21, 2, 20 p., e48781.

Research output: Contribution to journalArticleResearchpeer-review

2019

Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy

Jiang, M., Fan, J., Qu, X., Li, S., Nilsson, S. K., Sun, Y. B. Y., Chen, Y., Yu, D., Liu, D., Liu, B-C., Tang, M., Chen, W., Ren, Y., Nikolic-Paterson, D. J., Jiang, X., Li, J. & Yu, X., 9 Aug 2019, In : Frontiers in Pharmacology. 10, 17 p., 880.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury

Zhou, T., Zheng, Y., Sun, L., Badea, S. R., Jin, Y., Liu, Y., Rolfe, A. J., Sun, H., Wang, X., Cheng, Z., Huang, Z., Zhao, N., Sun, X., Li, J., Fan, J., Lee, C., Megraw, T. L., Wu, W., Wang, G. & Ren, Y., Mar 2019, In : Nature Neuroscience. 22, 3, p. 421-435 15 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

MTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans

Puelles, V. G., van der Wolde, J. W., Wanner, N., Scheppach, M. W., Cullen-McEwen, L. A., Bork, T., Lindenmeyer, M. T., Gernhold, L., Wong, M. N., Braun, F., Cohen, C. D., Kett, M. M., Kuppe, C., Kramann, R., Saritas, T., Van Roeyen, C. R., Moeller, M. J., Tribolet, L., Rebello, R., Sun, Y. B. Y. & 13 others, Li, J., Müller-Newen, G., Hughson, M. D., Hoy, W. E., Person, F., Wiech, T., Ricardo, S. D., Kerr, P. G., Denton, K. M., Furic, L., Huber, T. B., Nikolic-Paterson, D. J. & Bertram, J. F., 19 Sep 2019, In : JCI Insight. 4, 18, 18 p., e99271.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Passive stretch regulates skeletal muscle glucose uptake independent of nitric oxide synthase

Kerris, J. P., Betik, A. C., Li, J. & McConell, G. K., Jan 2019, In : Journal of Applied Physiology. 126, 1, p. 239-245 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
2018

Fine Tuning of Canonical Wnt Stimulation Enhances Differentiation of Pluripotent Stem Cells Independent of β-Catenin-Mediated T-Cell Factor Signaling

Chen, J., Nefzger, C. M., Rossello, F., Sun, Y. B. Y., Lim, S. M., Liu, X., De Boer, S., Knaupp, A. S., Li, J., Davidson, K. C., Polo, J. M. & Barberi, T., 1 Jun 2018, In : Stem Cells. 36, 6, p. 822-833 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2017

Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery

Cheng, Z., Bosco, D. B., Sun, L., Chen, X., Xu, Y., Tai, W., Didier, R., Li, J., Fan, J., He, X. & Ren, Y., 1 Mar 2017, In : Cell Transplantation: the regenerative medicine journal. 26, 3, p. 469-482 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)
2016

Endothelial nitric oxide synthase prevents heparanase induction and the development of proteinuria

Garsen, M., Rops, A. L., Li, J., Van Beneden, K., Van Den Branden, C., Berden, J. H. M., Rabelink, T. J. & Van Der Vlag, J., 1 Aug 2016, In : PLoS ONE. 11, 8, 8 p., e0160894.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Human podocyte depletion in association with older age and hypertension

Puelles, V. G., Cullen-McEwen, L. A., Taylor, G. E., Li, J., Hughson, M. D., Kerr, P. G., Hoy, W. E. & Bertram, J. F., 1 Apr 2016, In : American Journal of Physiology-Renal Physiology. 310, 7, p. F656-F668 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Anders, H. J., Rovin, B., Jayne, D., Brunetta, P., Coppo, R., Davidson, A., Devarapu, S. K., de Zeeuw, D., Duffield, J. S., Eulberg, D., Fierro, A., Floege, J., Frese, S., Guillevin, L., Holdsworth, S., Hughes, J., Kettritz, R., Kluger, M., Krebs, C., Lapteva, L. & 25 others, Levin, A., Li, J., Lightstone, L., Mack, M., Mansouri, L., McAdoo, S., McKinney, E., Panzer, U., Parikh, S., Pusey, C., Putterman, C., Rabelink, T. J., Radbruch, A., Rees, A., Reilly, M. M., Reinders, M., Remuzzi, G., Ruggenenti, P., Sacks, S., Schall, T. J., Meyer-Schwesinger, C., Sharma, S. K., Suzuki, Y., Tomas, N. M. & Zhao, M. H., 2016, In : Kidney International Reports. 1, 4, p. 327-339 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency

Fan, A., Jiang, X., Mo, Y., Tan, H., Jiang, M. & Li, J., Jan 2016, In : Pediatric Nephrology. 31, 1, p. 83-88 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media

Guo, L., Rolfe, A. J., Wang, X., Tai, W., Cheng, Z., Cao, K., Chen, X., Xu, Y., Sun, D., Li, J., He, X., Young, W., Fan, J. & Ren, Y., 6 May 2016, In : Molecular Brain. 9, 14 p., 48.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli

Puelles, V. G., van der Wolde, J. W., Schulze, K. E., Short, K. M., Wong, M. N., Bensley, J. G., Cullen-McEwen, L. A., Caruana, G., Hokke, S. N., Li, J., Firth, S. D., Harper, I. S., Nikolic-Paterson, D. J. & Bertram, J. F., 1 Oct 2016, In : Journal of the American Society of Nephrology. 27, 10, p. 3093-3104 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
2015

Continuously elevated serum matrix metalloproteinase-3 for 3~6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

Ma, J-D., Wei, X-N., Zheng, D-H., Mo, Y-Q., Chen, L-F., Zhang, X., Li, J. & Dai, L., 2015, In : Arthritis Research & Therapy. 17, 13 p., 289.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Erratum to: Continuously elevated serum matrix metalloproteinase-3 for 3 ~ 6 months predict one-year radiographic progression in rheumatoid arthritis: a prospective cohort study

Ma, J-D., Wei, X-N., Zheng, D-H., Mo, Y-Q., Chen, L-F., Zhang, X., Li, J. & Dai, L., 2015, In : Arthritis Research & Therapy. 17, Article #311, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

4 Citations (Scopus)

Podocyte number in children and adults: Associations with glomerular size and numbers of other glomerular resident cells

Puelles Rodriguez, V. G., Douglas-Denton, R. N., Cullen-McEwen, L. A., Li, J., Hughson, M. D., Hoy, W. E., Kerr, P. G. & Bertram, J. F., 2015, In : Journal of the American Society of Nephrology. 26, 9, p. 2277 - 2288 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance

Sun, Y. B. Y., Qu, X., Howard, V., Dai, L., Jiang, X., Ren, Y., Fu, P., Puelles, V. G., Nikolic-Paterson, D. J., Caruana, G., Bertram, J. F., Sleeman, M. W. & Li, J., Aug 2015, In : Kidney International. 88, 2, p. 286 - 298 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction

Qu, X., Jiang, M., Sun, Y. B. Y., Jiang, X., Fu, P., Ren, Y., Wang, D., Dai, L., Caruana, G., Bertram, J. F., Nikolic-Paterson, D. J. & Li, J., 2015, In : Kidney International. 88, 6, p. 1323 - 1335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2014

Design-based stereological methods for estimating numbers of glomerular podocytes

Puelles Rodriguez, V. G., Douglas-Denton, R. N., Cullen-McEwen, L. A., McNamara, B. J., Salih, F., Li, J., Hughson, M. D., Hoy, W. E., Nyengaard, J. R. & Bertram, J. F., 2014, In : Annals of Anatomy. 196, 1, p. 48 - 56 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Embryonic stem cells promoting macrophage survival and function are crucial for teratoma development

Chen, T., Wang, X., Guo, L., Wu, M., Duan, Z., Lv, J., Tai, W., Renganathan, H., Didier, R., Li, J., Sun, D., Chen, X., He, X., Fan, J., Young, W. & Ren, Y., 2014, In : Frontiers in Immunology. 5, (Art. No: 275), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
18 Citations (Scopus)

Establishment of bovine trophoblast stem-like cells from in vitro-produced blastocyst-stage embryos using two inhibitors

Huang, X., Han, X., Uyunbilig, B., Zhang, M., Duo, S., Zuo, Y., Zhao, Y., Yun, T., Tai, D., Wang, C., Li, J., Li, X. & Li, R., 2014, In : Stem Cells and Development. 23, 13, p. 1501 - 1514 14 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Regulation of renal fibrosis by Smad3 Thr388 phosphorylation

Qu, X., Li, X., Zheng, Y., Ren, Y., Puelles Rodriguez, V. G., Caruana, G., Nikolic-Paterson, D. J. & Li, J., 2014, In : American Journal of Pathology. 184, 4, p. 944 - 952 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2013

Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney

Sun, Y. B. Y., Qu, X., Li, X., Nikolic-Paterson, D. J. & Li, J., 2013, In : PLoS ONE. 8, 12 (Art. ID: e84063), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Glomerular endothelial cell injury and damage precedes that of podocytes in adriamycin-induced nephropathy

Sun, Y. B. Y., Qu, X., Zhang, X., Caruana, G., Bertram, J. F. & Li, J., 2013, In : PLoS ONE. 8, 1, 12 p., e55027.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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58 Citations (Scopus)

Polymyxin B induces apoptosis in kidney proximal tubular cells

Azad, M. A. K., Finnin, B. A. L., Poudyal, A., Davis, K. E., Li, J., Hill, P. A., Nation, R. L., Velkov, T. & Li, J., 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4329 - 4335 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
39 Citations (Scopus)

Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3beta acetylation

Zhang, X., Qu, X., Sun, Y. B. Y., Caruana, G., Bertram, J. F., Nikolic-Paterson, D. J. & Li, J., 2013, In : PLoS ONE. 8, 6 (e67471), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)
2012

Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis

Iqbal, J., Tonta, M. A., Mitsui, R., Li, Q., Kett, M. M., Li, J., Parkington, H. C., Hashitani, H. & Lang, R. J., 2012, In : British Journal of Pharmacology. 165, 7, p. 2389 - 2408 20 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

Qu, X., Zhang, X., Yao, J. J., Song, J., Nikolic-Paterson, D. J. & Li, J., 2012, In : Journal of Pathology. 228, 4, p. 506 - 519 14 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
2011

Betaglycan is required for the establishment of nephron endowment in the mouse

Walker, K., Sims-Lucas, S., Caruana, G., Cullen-McEwen, L., Li, J., Sarraj, M., Bertram, J. & Stenvers, K., 2011, In : PLoS ONE. 6, 4, 10 p., e18723.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

The protective role of Smad7 in diabetic kidney disease: Mechanism and therapeutic potential

Chen, H. Y., Huang, X. R., Wang, W., Li, J., Heuchel, R. L., Chung, A. CK. & Lan, H. Y., 2011, In : Diabetes. 60, 2, p. 590 - 601 12 p.

Research output: Contribution to journalArticleResearchpeer-review

160 Citations (Scopus)
2010

Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy

Li, J., Qu, X., Yao, J. J., Caruana, G., Ricardo, S. D., Yamamoto, Y., Yamamoto, H. & Bertram, J. F., 2010, In : Diabetes. 59, 10, p. 2612 - 2624 13 p.

Research output: Contribution to journalArticleResearchpeer-review

147 Citations (Scopus)

Resveratrol inhibits renal fibrosis in the obstructed kidney: Potential role in deacetylation of Smad3

Li, J., Qu, X., Ricardo, S. D., Bertram, J. F. & Nikolic-Paterson, D. J., 2010, In : American Journal of Pathology. 177, 3, p. 1065 - 1071 7 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Review: Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis

Li, J. & Bertram, J. F., 2010, In : Nephrology. 15, 5, p. 507 - 512 6 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

SCUBE1, a novel developmental gene involved in renal regeneration and repair

Zhuang, J., Deane, J. A., Yang, R-B., Li, J. & Ricardo, S. D., 2010, In : Nephrology Dialysis Transplantation. 25, p. 1421 - 1428 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2009
195 Citations (Scopus)
2007

The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis

Li, J., Deane, J. A., Campanale, N. V., Bertram, J. F. & Ricardo, S. D., 2007, In : Stem Cells. 25, 3, p. 697 - 706 10 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)
73 Citations (Scopus)

Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene

Li, H., Xu, D., Li, J., Berndt, M. C. & Liu, J-P., 2006, In : The Journal of Biological Chemistry. 281, 35, p. 25588 - 25600 13 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)
2005

Signaling mechanism of TGF-beta1 in prevention of renal inflammation: Role of Smad7

Wang, W., Huang, X. R., Li, A. G., Liu, F., Li, J., Truong, L. D., Wang, X. J. & Lan, H. Y., 2005, In : Journal of the American Society of Nephrology. 16, p. 1371 - 1383 13 p.

Research output: Contribution to journalArticleResearchpeer-review

182 Citations (Scopus)

Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling

Li, H., Pinto, A. R. I., Duan, W., Li, J., Toh, B-H. & Liu, J-P., 2005, In : Journal of Neurochemistry. 95, 3, p. 891 - 901 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2004

Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease.

Li, J. H., Huang, X. R., Zhu, H. J., Oldfield, M., Cooper, M., Truong, L. D., Johnson, R. J. & Lan, H. Y., Jan 2004, In : The FASEB Journal. 18, 1, p. 176-178 3 p.

Research output: Contribution to journalArticleResearchpeer-review

189 Citations (Scopus)

Advanced glycation end products activate Smad signaling via TGF--dependent and -independent mechanisms: implications for diabetic renal and vascular disease

Li, J., Huang, X. R., Zhu, H-J., Oldfield, M. D., Cooper, M. E., Truong, L. D., Johnson, R. J. & Lan, H. Y., 2004, In : The FASEB Journal. 18, 1, p. 176 - 178 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Advanced Glycation End Products Induce Tubular Epithelial-Myofibroblast Transition through the RAGE-ERK1/2 MAP Kinase Signaling Pathway

Li, J. H., Wang, W., Huang, X. R., Oldfield, M., Schmidt, A. M., Cooper, M. E. & Lan, H. Y., Apr 2004, In : American Journal of Pathology. 164, 4, p. 1389-1397 9 p.

Research output: Contribution to journalArticleResearchpeer-review

179 Citations (Scopus)

Advanced glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK 1/2 MAP kinase signaling pathway

Li, J., Wang, W., Huang, X. R., Oldfield, M. D., Schmidt, A. M., Cooper, M. E. & Lan, H. Y., 2004, In : American Journal of Pathology. 164, 4, p. 1389 - 1397 9 p.

Research output: Contribution to journalArticleResearchpeer-review

TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways

Nakagawa, T., Li, J., Garcia, G., Mu, W., Piek, E., Bottinger, E. P., Chen, Y., Zhu, H. J., Kang, D-H., Schreiner, G. F., Lan, H. Y. & Johnson, R. J., 2004, In : Kidney International. 66, 2, p. 605 - 613 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

Lan, H. Y., Mu, W., Tomita, N., Huang, X. R., Li, J., Zhu, H-J., Morishita, R. & Johnson, R. J., 2003, In : Journal of the American Society of Nephrology. 14, 6, p. 1535 - 1548 14 p.

Research output: Contribution to journalArticleResearchpeer-review

293 Citations (Scopus)

Role of TGF-beta signaling in extracellular matrix production under high glucose conditions

Li, J., Huang, X. R., Zhu, H-J., Johnson, R. J. & Lan, H. Y., 2003, In : Kidney International. 63, p. 2010 - 2019 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2

Kanellis, J., Watanabe, S., Li, J., Kang, D. H., Li, P., Nakagawa, T., Wamsley, A., Sheikh-Hamad, D., Lan, H. Y., Feng, L. & Johnson, R. J., 2003, In : Hypertension. 41, 6, p. 1287 - 1293 7 p.

Research output: Contribution to journalArticleResearchpeer-review

552 Citations (Scopus)
2002

Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation

Li, J., Zhu, H-J., Huang, X. R., Lai, K. N., Johnson, R. J. & Lan, H. Y., 2002, In : Journal of the American Society of Nephrology. 13, 6, p. 1464 - 1472 9 p.

Research output: Contribution to journalArticleResearchpeer-review