1989 …2017

Research output per year

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2017

Reduced PU.1 expression underlies aberrant neutrophil maturation and function in b-Thalassemia mice and patients

Siwaponanan, P., Siegers, J. Y., Ghazali, R., Ng, T., Mccoll, B., Ng, G. Z. W., Sutton, P., Wang, N., Ooi, I., Thiengtavor, C., Fucharoen, S., Chaichompoo, P., Svasti, S., Wijburg, O. & Vadolas, J., 8 Jun 2017, In : Blood. 129, 23, p. 3087-3099 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2016

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

Howden, S. E., McColl, B. K., Glaser, A., Vadolas, J., Petrou, S., Little, M. H., Elefanty, A. G. & Stanley, E. G., 13 Sep 2016, In : Stem Cell Reports. 7, 3, p. 508-517 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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42 Citations (Scopus)

Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: Reciprocal phenomenon of Fe2+ and Ca2+ absorption

Kraidith, K., Svasti, S., Teerapornpuntakit, J., Vadolas, J., Chaimana, R., Lapmanee, S., Suntornsaratoon, P., Krishnamra, N., Fucharoen, S. & Charoenphandhu, N., 1 Jul 2016, In : American Journal of Physiology - Endocrinology and Metabolism. 311, 1, p. E214-E223

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2015

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin

Wienert, B., Funnell, A. P. W., Norton, L. J., Pearson, R. C. M., Wilkinson-White, L. E., Lester, K., Vadolas, J., Porteus, M. H., Matthews, J. M., Quinlan, K. G. R. & Crossley, M., 14 May 2015, In : Nature Communications. 6, 7085.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
49 Citations (Scopus)
2014

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation

McColl, B., Kao, B. R., Lourthai, P., Chan, K., Wardan, H., Roosjen, M., Delagneau, O., Gearing, L. J., Blewitt, M. E., Svasti, S., Fucharoen, S. & Vadolas, J., 1 Jan 2014, In : The FASEB Journal. 28, 5, p. 2306-2317 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes

Roosjen, M., McColl, B., Kao, B., Gearing, L. J., Blewitt, M. E. & Vadolas, J., 1 Jan 2014, In : The FASEB Journal. 28, 4, p. 1610-1620 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2013

A reduced curcuminoid analog as a novel inducer of fetal hemoglobin

Chaneiam, N., Changtam, C., Mungkongdee, T., Suthatvoravut, U., Winichagoon, P., Vadolas, J., Suksamrarn, A., Fucharoen, S. & Svasti, S., 1 Mar 2013, In : Annals of Hematology. 92, 3, p. 379-386 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level

Brown, F., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., Whitelaw, N. C., Whitelaw, E., Kile, B., Jane, S. M. & Curtis, D. J., 2013, In : Blood Cells, Molecules, and Diseases. 50, 2, p. 86-92 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Phenotypic comparison of four thalassemia model mice reconstructed from cryo-banked embryos

Boonkusol, D., Dinnyés, A., Sa-Ardrit, M., Svasti, S., Faisaikarm, T., Vadolas, J., Fucharoen, S. & Kitiyanant, Y., 1 Dec 2013, In : Acta Biologica Hungarica. 64, 4, p. 453-461 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation

Chan, K. S. K., Xu, J., Wardan, H., McColl, B., Orkin, S. & Vadolas, J., 1 Apr 2012, In : The FASEB Journal. 26, 4, p. 1736-1744 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)
2011

Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids

Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J. B. & Srichairatanakool, S., 1 Jan 2011, In : Medicinal Chemistry. 7, 1, p. 62-69 8 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2010

Effect of human β-globin bacterial artificial chromosome transgenesis on embryo cryopreservation in mouse models

Boonkusol, D., Dinnyes, A., Faisaikarm, T., Sangsuwan, P., Pratipnatalang, N., Sa-Ardrit, M., Saikhun, K., Svasti, S., Vadolas, J., Winichagoon, P., Fucharoen, S. & Kitiyanant, Y., 10 May 2010, In : Reproduction, Fertility and Development. 22, 5, p. 788-795 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Labdane diterpenes from the aerial parts of curcuma comosa enhance fetal hemoglobin production in an erythroid cell line

Chokchaisiri, R., Chaneiam, N., Svasti, S., Fucharoen, S., Vadolas, J. & Suksamrarn, A., 23 Apr 2010, In : Journal of Natural Products. 73, 4, p. 724-728 5 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2009

Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: Comparison with levels in the lymphocytes of thalassemia patients

Meerang, M., Nair, J., Sirankapracha, P., Thephinlap, C., Srichairatanakool, S., Arab, K., Kalpravidh, R., Vadolas, J., Fucharoen, S. & Bartsch, H., 15 Aug 2009, In : International Journal of Cancer. 125, 4, p. 759-766 8 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

ErythRED, a hESC line enabling identification of erythroid cells

Hatzistavrou, T., Micallef, S. J., Ng, E. S. S., Vadolas, J., Stanley, E. G. & Elefanty, A. G., 2009, In : Nature Methods. 6, 9, p. 659 - 662 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Gene induction for the treatment of methylmalonic aciduria

Hu, R., Buck, N. E., Khaniani, M. S., Wood, L., Wardan, H., Benoist, J. F., Li, L., Vadolas, J., Sarsero, J. P., Ioannou, P. A. & Peters, H. L., 1 Jun 2009, In : Journal of Gene Medicine. 11, 4, p. 361-369 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice

Srinoun, K., Svasti, S., Chumworathayee, W., Vadolas, J., Vattanaviboon, P., Fucharoen, S. & Winichagoon Fucharoen, P., 1 Sep 2009, In : Haematologica. 94, 9, p. 1211-1219 9 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Integration of functional bacterial artificial chromosomes into human cord blood-derived multipotent stem cells

Zaibak, F., Kozlovski, J., Vadolas, J., Sarsero, J. P., Williamson, R. & Howden, S. E., 30 Jan 2009, In : Gene Therapy. 16, 3, p. 404-414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2008

siRNA-mediated reduction of α-globin results in phenotypic improvements in β-thalassemic cells

Voon, H. P. J., Wardan, H. & Vadolas, J., 1 Aug 2008, In : Haematologica. 93, 8, p. 1238-1242 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Site-specific, Rep-mediated integration of the intact β-globin locus in the human erythroleukaemic cell line K562

Howden, S. E., Voullaire, L., Wardan, H., Williamson, R. & Vadolas, J., 18 Jul 2008, In : Gene Therapy. 15, 20, p. 1372-1383 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The transient expression of mRNA coding for Rep protein from AAV facilitates targeted plasmid integration

Howden, S. E., Voullaire, L. & Vadolas, J., 1 Jan 2008, In : Journal of Gene Medicine. 10, 1, p. 42-50 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2007

Co-inheritance of α- and β-thalassaemia in mice ameliorates thalassaemic phenotype

Voon, H. P. J., Wardan, H. & Vadolas, J., 1 Sep 2007, In : Blood Cells, Molecules, and Diseases. 39, 2, p. 184-188 5 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2006

A humanized BAC transgenic/knockout mouse model for HbE/beta-thalassemia

Jamsai, D., Zaibak, F., Vadolas, J., Voullaire, L., Fowler, K. J., Gazeas, S., Peters, H., Fucharoen, S., Williamson, R. & Ioannou, P. A., 2006, In : Genomics. 88, 3, p. 309 - 315 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
38 Citations (Scopus)

Chromatin-binding regions of EBNA1 protein facilitate the enhanced transfection of Epstein-Barr virus-based vectors

Howden, S. E., Wardan, H., Voullaire, L., McLenachan, S., Williamson, R., Ioannou, P. & Vadolas, J., 1 Aug 2006, In : Human Gene Therapy. 17, 8, p. 833-844 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Humanized β-thalassemia mouse model containing the common IVSI-110 splicing mutation

Vadolas, J., Nefedov, M., Wardan, H., Mansooriderakshan, S., Voullaire, L., Jamsai, D., Williamson, R. & Ioannou, P. A., 2006, In : The Journal of Biological Chemistry. 281, 11, p. 7399 - 7405 7 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2005

A 191-kb genomic fragment containing the human α-globin locus can rescue α-thalassemic mice

Al-Hasani, K., Vadolas, J., Knaupp, A. S., Wardan, H., Voullaire, L., Williamson, R. & Ioannou, P. A., 1 Nov 2005, In : Mammalian Genome. 16, 11, p. 847-853 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

A humanized mouse model for a common β0-thalassemia mutation

Jamsai, D., Zaibak, F., Khongnium, W., Vadolas, J., Voullaire, L., Fowler, K. J., Gazeas, S., Fucharoen, S., Williamson, R. & Ioannou, P. A., 2005, In : Genomics. 85, 4, p. 453 - 461 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Transgene copy number-dependent rescue of murine β-globin knockout mice carrying a 183 kb human β-globin BAC genomic fragment

Vadolas, J., Wardan, H., Bosmans, M., Zaibak, F., Jamsai, D., Voullaire, L., Williamson, R. & Ioannou, P. A., 2005, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1728, 3, p. 150 - 162 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2004

Complementation of α-thalassaemia in α-globin knockout mice with a 191 kb transgene containing the human α-globin locus

Al-Hasani, K., Vadolas, J., Voullaire, L., Williamson, R. & Ioannou, P. A., 1 Jun 2004, In : Transgenic Research. 13, 3, p. 235-243 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The potential of bone marrow stem cells to correct liver dysfunction in a mouse model of Wilson's disease

Allen, K. J., Cheah, D. M. Y., Xiao, L. L., Pettigrew-Buck, N. E., Vadolas, J., Mercer, J. F. B., Ioannou, P. A. & Williamson, R., 1 Dec 2004, In : Cell Transplantation. 13, 7-8, p. 765-773 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2003

Development of a novel bacterial artificial chromosome cloning system for functional studies

Al-Hasani, K., Simpfendorfer, K., Wardan, H., Vadolas, J., Zaibak, F., Villain, R. & Ioannou, P. A., 1 Jan 2003, In : Plasmid. 49, 2, p. 184-187 4 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2002

Development of sensitive fluorescent assays for embryonic and fetal hemoglobin inducers using the human β-globin locus in erythropoietic cells

Vadolas, J., Wardan, H., Orford, M., Voullaire, L., Zaibak, F., Williamson, R. & Ioannou, P. A., 1 Dec 2002, In : Blood. 100, 12, p. 4209-4216 8 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Targeted gene correction in the mdx mouse using short DNA fragments: Towards application with bone marrow-derived cells for autologous remodeling of dystrophic muscle

Kapsa, R. M., Quigley, A. F., Vadolas, J., Steeper, K., Ioannou, P. A., Byrne, E. & Kornberg, A. J., 1 Jan 2002, In : Gene Therapy. 9, 11, p. 695-699 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2000

Engineering EGFP reporter constructs into a 200 kb human beta-globin BAC clone using GET Recombination.

Orford, M., Nefedov, M., Vadolas, J., Zaibak, F., Williamson, R. & Ioannou, P. A., 15 Sep 2000, In : Nucleic Acids Research. 28, 18, e84.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)
1998

Intranasal immunization with yeast-expressed 19 kD carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein-1 (yMSP119) induces protective immunity to blood stage malaria infection in mice

Hirunpetcharat, C., Stanisic, D., Liu, X. Q., Vadolas, J., Strugnell, R. A., Lee, R., Miller, L. H., Kaslow, D. C. & Good, M. F., 1 Oct 1998, In : Parasite Immunology. 20, 9, p. 413-420 8 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

The role of macrophages in the induction and regulation of immunity elicited by exogenous antigens

Wijburg, O. L. C., Van Den Dobbelsteen, G. P. J. M., Vadolas, J., Sanders, A., Strugnell, R. A. & Van Rooijen, N., 1 Feb 1998, In : European Journal of Immunology. 28, 2, p. 479-487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)
1997

Alveolar macrophages regulate the induction of primary cytotoxic T- lymphocyte responses during influenza virus infection

Wijburg, O. L. C., Dinatale, S., Vadolas, J., Van Rooijen, N. & Strugnell, R. A., 1 Dec 1997, In : Journal of Virology. 71, 12, p. 9450-9457 8 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Nucleic acid vaccination of sheep: Use in combination with a conventional adjuvanted vaccine against Taenia ovis

Rothel, J. S., Waterkeyn, J. G., Strugnell, R. A., Wood, P. R., Seow, H. F., Vadolas, J. & Lightowlers, M. W., 1 Jan 1997, In : Immunology and Cell Biology. 75, 1, p. 41-46 6 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
1995

Intranasal immunization with liposomes induces strong mucosal immune responses in mice

Vadolas, J., Davies, J. K., Wright, P. J. & Strugnell, R. A., 1 Jan 1995, In : European Journal of Immunology. 25, 4, p. 969-975 7 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)
1990

Neutralization epitopes of human rhinovirus type 2

Appleyard, G., Russell, S. M., Clarke, B. E., Speller, S. A., Trowbridge, R. & Vadolas, J., 1 Jun 1990, In : Journal of General Virology. 71, 6, p. 1275-1282 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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