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Research Output 2001 2019

2019

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Schneider-Futschik, E. K., Hoyer, D., Khromykh, A. A., Baell, J. B., Marsh, G. A., Baker, M. A., Li, J. & Velkov, T., 1 Nov 2019, In : ACS Infectious Diseases. 5, 1, p. 35-48 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

Mangal, S., Xu, R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y-W., Morton, D., Chan, H-K., Li, J. & Zhou, T. Q., 1 Jan 2019, In : Pharmaceutical Research. 36, 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

Jasim, R., Baker, M. A., Zhu, Y., Han, M., Schneider-Futschik, E. K., Hussein, M., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, (Accepted/In press) In : ACS Infectious Diseases. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Assessment and modelling of antibacterial combination regimens

Rao, G. G., Li, J., Garonzik, S. M., Nation, R. L. & Forrest, A., Jul 2018, In : Clinical Microbiology and Infection. 24, 7, p. 689-696 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Nguyen, N., Wilson, D. W., Nagalingam, G., Triccas, J. A., Schneider, E. K., Li, J., Velkov, T. & Baell, J., 25 Mar 2018, In : European Journal of Medicinal Chemistry. 148, p. 507-518 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa

Wang, S., Yu, S., Lin, Y., Zou, P., Chai, G., Yu, H. H., Wickremasinghe, H., Shetty, N., Ling, J., Li, J. & Zhou, Q. T., 1 Oct 2018, In : Pharmaceutical Research. 35, 10, 13 p., 187.

Research output: Contribution to journalArticleResearchpeer-review

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across 10 clinically relevant Gram-negative bacteria

Huang, J., Zhu, Y., Han, M., Li, M., Song, J., Velkov, T., Li, C. & Li, J., 1 Apr 2018, In : International Journal of Antimicrobial Agents. 51, 4, p. 586-593 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of the composition and in vitro activity of polymyxin B products

Diep, J. K., Covelli, J., Sharma, R., Ruszaj, D. M., Kaye, K. S., Li, J., Straubinger, R. M. & Rao, G. G., 25 May 2018, (Accepted/In press) In : International Journal of Antimicrobial Agents. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation

Mangal, S., Park, H., Zeng, L., Yu, H. H., Lin, Y., Velkov, T., Denman, J. A., Zemlyanov, D., Li, J. & Zhou, Q. T., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 443-453 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlled graphene encapsulation: A nanoscale shield for characterising single bacterial cells in liquid

Li, J., Zheng, C., Liu, B., Chou, T., Kim, Y., Qiu, S., Li, J., Yan, W. & Fu, J., 2 Jul 2018, In : Nanotechnology. 29, 36, 11 p., 365705.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice (Archives of Toxicology, (2018), 92, 7, (2259-2271), 10.1007/s00204-018-2192-1)

Yun, B., Zhang, T., Azad, M. A. K., Wang, J., Nowell, C. J., Kalitsis, P., Velkov, T., Hudson, D. F. & Li, J., 1 Jul 2018, In : Archives of Toxicology. 92, 7, p. 2273-2274 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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Discovery of mcr-1-mediated colistin resistance in a highly virulent Escherichia coli lineage

Forde, B. M., Zowawi, H. M., Harris, P., Roberts, L., Ibrahim, E., Shaikh, N., Deshmukh, A., Ahmed, M. A. S., Maslamani, M. A., Cottrell, K., Trembizki, E., Sundac, L., Yu, H. H., Li, J., Schembri, M. A., Whiley, D. M., Paterson, D. L. & Beatson, S. A., 1 Sep 2018, In : mSphere. 3, 5, 11 p., e00486-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study

Lin, Y-W., Chen, K., Wang, J., Velkov, T., Zhou, Q. & Li, J., May 2018, In : Antimicrobial Agents and Chemotherapy. 62, 5, 5 p., e02527-17.

Research output: Contribution to journalArticleResearchpeer-review

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Chen, K., Onufrak, N. J., Wang, J., Turnidge, J. D., Howden, B. P., Forrest, A., Chan, H. K. & Li, J., 1 Feb 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, 9 p., e01790.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.

Research output: Contribution to journalArticleResearchpeer-review

Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers

Grace, J. L., Schneider-Futschik, E. K., Elliott, A. G., Amado, M., Truong, N. P., Cooper, M. A., Li, J., Davis, T. P., Quinn, J. F., Velkov, T. & Whittaker, M. R., 25 Oct 2018, (Accepted/In press) In : Biomacromolecules. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae

Nang, S. C., Morris, F. C., McDonald, M. J., Han, M., Wang, J., Strugnell, R. A., Velkov, T. & Li, J., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1604-1610 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa

Zhu, Y., Czauderna, T., Zhao, J., Klapperstueck, M., Mahamad Maifiah, M. H. B., Han, M-L., Lu, J., Sommer, B., Velkov, T., Lithgow, T., Song, J., Schreiber, F. & Li, J., 1 Apr 2018, In : GigaScience. 7, 4, 18 p., giy021.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Graphene-Enhanced 3D Chemical Mapping of Biological Specimens at Near-Atomic Resolution

Adineh, V. R., Zheng, C., Zhang, Q., Marceau, R. K. W., Liu, B., Chen, Y., Si, K. J., Weyland, M., Velkov, T., Cheng, W., Li, J. & Fu, J., 8 Aug 2018, In : Advanced Functional Materials. 28, 32, 9 p., 1801439.

Research output: Contribution to journalArticleResearchpeer-review

Lipidomic analysis of the outer membrane vesicles from paired polymyxin-susceptible and -resistant Klebsiella pneumoniae clinical isolates

Jasim, R., Han, M-L., Zhu, Y., Hu, X., Hussein, M. H., Lin, Y-W., Zhou, T. Q., Dong, C. Y. D., Li, J. & Velkov, T., 10 Aug 2018, In : International Journal of Molecular Sciences. 19, 8, 13 p., 2356.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mechanism-based pharmacokinetic/pharmacodynamic modeling of aerosolized colistin in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Onufrak, N. J., Chen, K., Wang, J., Forrest, A., Chan, H-K. & Li, J., 1 Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01965-17.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Schneider-Futschik, E. K., Hu, X., Zhou, Q. T., Lin, Y-W., Anderson, D., Creek, D. J., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, In : Computational and Structural Biotechnology Journal. 16, p. 587-599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Li, M., Yu, H. H., Zhou, Z., Creek, D. J., Zhang, J. & Li, J., 16 Nov 2018, In : Frontiers in Microbiology. 9, 12 p., 2776.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress

Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.

Research output: Contribution to journalArticleResearchpeer-review

Novel polymyxin combination with antineoplastic mitotane improved the bacterial killing against polymyxin-resistant multidrug-resistant gram-negative pathogens

Tran, T. B., Wang, J., Doi, Y., Velkov, T., Bergen, P. J. & Li, J., 12 Apr 2018, In : Frontiers in Microbiology. 9, 11 p., 721.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Personalizing Polymyxin B dosing using an adaptive feedback control algorithm

Lakota, E. A., Landersdorfer, C. B., Nation, R. L., Li, J., Kaye, K. S., Rao, G. G. & Forrest, A., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 9 p., e00483-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

Landersdorfer, C. B., Wang, J., Wirth, V., Chen, K., Kaye, K. S., Tsuji, B., Li, J. & Nation, R. L., Feb 2018, In : Journal of Antimicrobial Chemotherapy. 73, 2, p. 462-468 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics of colistin methanesulfonate (CMS) in healthy Chinese subjects after single and multiple intravenous doses

Zhao, M., Wu, X-J., Fan, Y-X., Zhang, Y., Guo, B-N., Yu, J., Cao, G., Chen, Y., Wu, J., Shi, Y., Li, J. & Zhang, J., 1 May 2018, In : International Journal of Antimicrobial Agents. 51, 5, p. 714-720 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin B and fosfomycin thwart KPC-producing Klebsiella pneumoniae in the hollow-fibre infection model

Bulman, Z. P., Zhao, M., Satlin, M. J., Chen, L., Kreiswirth, B. N., Walsh, T. J., Nation, R. L., Li, J. & Tsuji, B. T., 1 Jul 2018, In : International Journal of Antimicrobial Agents. 52, 1, p. 114-118 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin B causes DNA damage in HK-2 cells and mice

Yun, B., Zhang, T., Azad, M. A. K., Wang, J., Nowell, C. J., Kalitsis, P., Velkov, T., Hudson, D. F. & Li, J., Jul 2018, In : Archives of Toxicology. 92, 7, p. 2259-2271 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin b in combination with enrofloxacin exerts synergistic killing against extensively drug-resistant pseudomonas aeruginosa

Lin, Y-W., Yu, H. H., Zhao, J., Han, M-L., Zhu, Y., Akter, J., Wickremasinghe, H., Walpola, H., Wirth, V., Rao, G. G., Forrest, A., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 13 p., e00028-18.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance

Han, M-L., Velkov, T., Zhu, Y., Roberts, K. D., Le Brun, A. P., Chow, S. H., Gutu, A. D., Moskowitz, S. M., Shen, H-H. & Li, J., 19 Jan 2018, In : ACS Chemical Biology. 13, 1, p. 121-130 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxins for CNS infections: Pharmacology and neurotoxicity

Velkov, T., Dai, C., Ciccotosto, G. D., Cappai, R., Hoyer, D. & Li, J., Jan 2018, In : Pharmacology and Therapeutics. 181, p. 85-90 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Proof-of-principle study in a murine lung infection model of antipseudomonal activity of phage PEV20 in a dry-powder formulation

Chang, R. Y. K., Chen, K., Wang, J., Wallin, M., Britton, W., Morales, S., Kutter, E., Li, J. & Chan, H. K., 1 Feb 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, 8 p., e01714-17.

Research output: Contribution to journalArticleResearchpeer-review

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Schneider-Futschik, E. K., Paulin, O. K. A., Hoyer, D., Roberts, K. D., Ziogas, J., Baker, M. A., Karas, J., Li, J. & Velkov, T., 11 May 2018, In : ACS Infectious Diseases. 4, 5, p. 646-655 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 othersOwen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic killing of polymyxin B in combination with the antineoplastic drug mitotane against polymyxin-susceptible and -resistant Acinetobacter baumannii: A metabolomic study

Tran, T. B., Bergen, P. J., Creek, D. J., Velkov, T. & Li, J., 16 Apr 2018, In : Frontiers in Pharmacology. 9, 14 p., 359.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models

Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q. T., Li, J., Chan, H. K. & Zhou, F., 30 Mar 2018, In : European Journal of Pharmaceutical Sciences. 115, p. 132-143 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites

Schneider, E. K., McQuade, R. M., Carbone, V. C., Reyes-Ortega, F., Wilson, J. W., Button, B., Saito, A., Poole, D. P., Hoyer, D. & Li, J., 1 Jan 2018, In : ERJ Open Research. 4, 1, 10 p., 00127-2017.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

3D-stereoscopic immersive analytics projects at Monash University and University of Konstanz

Sommer, B., Barnes, D. G., Boyd, S., Chandler, T., Cordeil, M., Czauderna, T., Klapperstueck, M., Klein, K., Nguyen, T. D., Nim, H., Stephens, K., Vohl, D., Wang, S., Wilson, E., Zhu, Y., Li, J., McCormack, J., Marriott, K. & Schreiber, F., 2017, Stereoscopic Displays and Applications XXVIII (SD&A 2017): 30 January - 1 February 2017, Burlingame, California, USA, part of IS&T's International Symposium on Electronic Imaging: Science and Technology [Proceedings]. Springfield VA USA: Society for Imaging Science and Technology, p. 1-9 9 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Aerosolized polymyxin B for treatment of respiratory tract infections: Determination of pharmacokinetic-pharmacodynamic indices for aerosolized polymyxin B against Pseudomonas aeruginosa in a mouse lung infection model

Lin, Y. W., Zhou, Q., Onufrak, N. J., Wirth, V., Chen, K., Wang, J., Forrest, A., Chan, H-K. & Li, J., 1 Aug 2017, In : Antimicrobial Agents and Chemotherapy. 61, 8, 15 p., e00211-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A fresh shine on cystic fibrosis inhalation therapy: Antimicrobial synergy of polymyxin B in combination with silver nanoparticles

Jasim, R., Schneider, E. K., Han, M., Azad, M. A. K., Hussein, M., Nowell, C., Baker, M. A., Wang, J., Li, J. & Velkov, T., 1 Apr 2017, In : Journal of Biomedical Nanotechnology. 13, 4, p. 447-457 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A hydrogel-based localized release of colistin for antimicrobial treatment of burn wound infection

Zhu, C., Zhao, J., Kempe, K., Wilson, P., Wang, J., Velkov, T., Li, J., Davis, T. P., Whittaker, M. R. & Haddleton, D. M., 2017, In : Macromolecular Bioscience. 17, 2, 7 p., 1600320.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule

Mularski, A., Wilksch, J., Hanssen, E., Li, J., Tomita, T., Pidot, S. J., Stinear, T., Separovic, F. & Strugnell, D., 1 May 2017, In : European Biophysics Journal. 46, 4, p. 351-361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'

Schneider, E. K., Reyes Ortega, F., Velkov, T. & Li, J., 3 Mar 2017, In : Essays in Biochemistry. 61, 1, p. 115-125 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

A portrait of the sialyl glycan receptor specificity of the H10 influenza virus hemagglutinin—a picture of an avian virus on the verge of becoming a pandemic?

Schneider, E. K., Li, J. & Velkov, T., 13 Dec 2017, In : Vaccines. 5, 4, 15 p., 51.

Research output: Contribution to journalReview ArticleResearchpeer-review

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria

Zhu, C., Schneider, E. K., Wang, J., Kempe, K., Wilson, P., Velkov, T., Li, J., Davis, T., Whittaker, M. R. & Haddleton, D. M., 2017, In : Journal of Controlled Release. 259, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Automated patterning and probing with multiple nanoscale tools for single-cell analysis

Li, J., Kim, Y., Liu, B., Qin, R., Li, J. & Fu, J., 1 Oct 2017, In : Micron. 101, p. 132-137 6 p.

Research output: Contribution to journalArticleResearchpeer-review