Jian Li — Monash University

Personal profile

Biography

Professor Jian Li (PhD 2002) is Head of the Antimicrobial Systems Pharmacology Laboratory at the Biomedicine Discovery Institute, Monash University. He is a Web of Science 2015 - 2017 Highly Cited Researcher in Pharmacology & Toxicology. Dr Li has an internationally recognised track record in the pharmacology of polymyxins and the discovery of novel, safer polymyxins. He has 285 publications (including 225 on polymyxins alone) with 12,500 citations and an h-index of 55. Dr Li is an Editor of the International Journal of Antimicrobial Agents and an Associate Editor of BMC Microbiology. He is an invited reviewer for 152 international journals and grant/fellowship applications for 14 international funding bodies. His research is funded by NIH, Australian National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), pharmaceutical companies and other grant bodies. Dr Li has received numerous awards, including Australian Leadership Award (2013), Australian National Health and Medical Research Council’s Ten of the Best Research Projects (2014) and Australian Academy of Science Jacques Miller Medal (2017).

Monash teaching commitment

Supervisor of PhD, Masters and Honours students

Keywords

Antimicrobial Resistance
Drug Discovery
Antimicrobial Pharmacology
Systems Pharmacology
Computational Biology
Bioinformatics
Polymyxin
Colistin
Pharmacodynamics
Pharmacokinetics
Acinetobacter baumannii
Klebsiella pneumoniae
Pseudomonas aeruginosa

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2004 2023

1 Curtailed
6 Active
26 Finished

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Li, J.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interaction between polymyxins and bacterial membranes

Li, J., Shen, H., Velkov, T., Song, J. & Schreiber, F.

1/01/18 → 31/12/22

Project: Research

Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach

Li, J. & Velkov, T.

National Institutes of Health (NIH US)

1/08/17 → 31/07/21

Project: Research

Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’

Li, J., Velkov, T., Roberts, K., Thompson, P. & Nation, R.

1/08/17 → 31/07/22

Project: Research

An integrated virtual cell approach towards elucidating the systems pharmacology of antibiotics against Pseudomonas aeruginosa

Li, J., Song, J. & Schreiber, F.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/20

Project: Research

Research Output 2001 2019

260 Article
13 Letter
10 Review Article
4 Chapter (Book)
9 More

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Schneider-Futschik, E. K., Hoyer, D., Khromykh, A. A., Baell, J. B., Marsh, G. A., Baker, M. A., Li, J. & Velkov, T., 1 Nov 2019, In : ACS Infectious Diseases. 5, 1, p. 35-48 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

Mangal, S., Xu, R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y-W., Morton, D., Chan, H-K., Li, J. & Zhou, T. Q., 1 Jan 2019, In : Pharmaceutical Research. 36, 15 p.

Research output: Contribution to journal › Article › Research › peer-review

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

Jasim, R., Baker, M. A., Zhu, Y., Han, M., Schneider-Futschik, E. K., Hussein, M., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, (Accepted/In press) In : ACS Infectious Diseases. 13 p.

Research output: Contribution to journal › Article › Research › peer-review