Jian Li

Personal profile

Biography

Professor Jian Li (PhD 2002) is Head of the Antimicrobial Systems Pharmacology Laboratory at the Biomedicine Discovery Institute, Monash University. He is a Web of Science 2015 - 2017 Highly Cited Researcher in Pharmacology & Toxicology. Dr Li has an internationally recognised track record in the pharmacology of polymyxins and the discovery of novel, safer polymyxins. He has 317 publications (including 252 on polymyxins alone) with 15,109 citations and an h-index of 60. Dr Li is an Editor of the International Journal of Antimicrobial Agents and an Associate Editor of BMC Microbiology and Frontiers in Microbiology. He is an invited reviewer for 167 international journals and grant/fellowship applications for 18 international funding bodies. His research is funded by NIH, Australian National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), pharmaceutical companies and other grant bodies. Dr Li has received numerous awards, including Australian Leadership Award (2013), Australian National Health and Medical Research Council’s Ten of the Best Research Projects (2014) and Australian Academy of Science Jacques Miller Medal (2017).

Monash teaching commitment

Supervisor of PhD, Masters and Honours students

Research area keywords

Antimicrobial Resistance
Drug Discovery
Antimicrobial Pharmacology
Systems Pharmacology
Computational Biology
Bioinformatics
Polymyxin
Colistin
Pharmacodynamics
Pharmacokinetics
Acinetobacter baumannii
Klebsiella pneumoniae
Pseudomonas aeruginosa

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Projects 2004 2023

1 Curtailed
7 Active
26 Finished

Advancing innovative therapies against pandrug-resistant Gram-negative superbugs

Li, J., Zhou, T. Q., Rao, G. G., Kaye, K. S. & Velkov, T.

National Institutes of Health (NIH US)

1/07/19 → 30/06/20

Project: Other

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Li, J.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interaction between polymyxins and bacterial membranes

Li, J., Shen, H., Velkov, T., Song, J. & Schreiber, F.

1/01/18 → 31/12/22

Project: Research

Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach

Li, J. & Velkov, T.

National Institutes of Health (NIH US)

1/08/17 → 31/07/21

Project: Research

Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’

Li, J., Velkov, T., Roberts, K., Thompson, P. & Nation, R.

1/08/17 → 31/07/22

Project: Research

Research Output 2001 2019

267 Article
15 Letter
11 Review Article
5 Chapter (Book)
8 More

A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction

Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., 14 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bbz051.

Research output: Contribution to journal › Review Article › Research › peer-review

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Schneider-Futschik, E. K., Hoyer, D., Khromykh, A. A., Baell, J. B., Marsh, G. A., Baker, M. A., Li, J. & Velkov, T., 1 Nov 2019, In : ACS Infectious Diseases. 5, 1, p. 35-48 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections

Mangal, S., Huang, J., Shetty, N., Park, H., Lin, Y., Yu, H. H., Zemlyanov, D., Velkov, T., Li, J. & Zhou, Q. T., 20 Apr 2019, In : International Journal of Pharmaceutics. 561, p. 102-113 12 p.

Research output: Contribution to journal › Article › Research › peer-review

iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data

Chen, Z., Zhao, P., Li, F., Marquez-Lago, T. T., Leier, A., Revote, J., Zhu, Y., Powell, D. R., Akutsu, T., Webb, G. I., Chou, K-C., Smith, A. I., Daly, R. J., Li, J. & Song, J., 24 Apr 2019, (Accepted/In press) In : Briefings in Bioinformatics. 11 p., bbz041.

Research output: Contribution to journal › Article › Research › peer-review