Jian Li

Personal profile

Biography

Professor Jian Li (PhD 2002) is an elected Fellow of the American Academy of Microbiology and Head of the Antimicrobial Systems Pharmacology Laboratory at the Biomedicine Discovery Institute, Monash University. He is a Web of Science 2015 - 2017 Highly Cited Researcher in Pharmacology & Toxicology. Dr Li has an internationally recognised track record in the pharmacology of polymyxins and the discovery of novel, safer polymyxins. He has 337 publications (including 266 on polymyxins alone) with 17,324 citations and an h-index of 65. Dr Li is an Editor of the International Journal of Antimicrobial Agents and an Associate Editor of BMC Microbiology and Frontiers in Microbiology. He is an invited reviewer for 167 international journals and grant/fellowship applications for 18 international funding bodies. His research is funded by NIH, Australian National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), pharmaceutical companies and other grant bodies. Dr Li has received numerous awards, including Australian Leadership Award (2013), Australian National Health and Medical Research Council’s Ten of the Best Research Projects (2014) and Australian Academy of Science Jacques Miller Medal (2017).

Monash teaching commitment

Supervisor of PhD, Masters and Honours students

Research area keywords

Antimicrobial Resistance
Drug Discovery
Antimicrobial Pharmacology
Systems Pharmacology
Computational Biology
Bioinformatics
Polymyxin
Colistin
Pharmacodynamics
Pharmacokinetics
Acinetobacter baumannii
Klebsiella pneumoniae
Pseudomonas aeruginosa

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Projects

1 Curtailed
7 Active
27 Finished

Integrating AI, Big Data and Smart Drug Design against 'Superbugs'

Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.

1/01/20 → 31/12/22

Project: Research

A systems approach to combat the significant antibiotic resistance challenge: Novel therapeutic strategies, mechanistic discoveries, and drug development

Li, J.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

Integrative systems pharmacology, neutron reflectometry and molecular dynamics approaches to unravelling the interaction between polymyxins and bacterial membranes

Li, J., Shen, H., Velkov, T., Song, J. & Schreiber, F.

1/01/18 → 31/12/22

Project: Research

Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach

Li, J. & Velkov, T.

National Institutes of Health (NIH US) United States

1/08/17 → 31/07/21

Project: Research

Targeting the Urgent Need for New Antibiotics against Gram-negative ‘Superbugs’

Li, J., Velkov, T., Roberts, K., Thompson, P. & Nation, R.

1/08/17 → 31/07/22

Project: Research

Research Output

278 Article
15 Letter
12 Review Article
8 Chapter (Book)
8 More

Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606

Zhu, Y., Lu, J., Zhao, J., Zhang, X., Yu, H. H., Velkov, T. & Li, J., Apr 2020, In : International Journal of Medical Microbiology. 310, 3, 11 p., 151412.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Graphene encapsulation enabled high-throughput atom probe tomography of liquid specimens

Qiu, S., Garg, V., Zhang, S., Chen, Y., Li, J., Taylor, A., Marceau, R. K. W. & Fu, J., Sep 2020, In : Ultramicroscopy. 216, 7 p., 113036.

Research output: Contribution to journal › Article › Research › peer-review

iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data

Chen, Z., Zhao, P., Li, F., Marquez-Lago, T. T., Leier, A., Revote, J., Zhu, Y., Powell, D. R., Akutsu, T., Webb, G. I., Chou, K-C., Smith, A. I., Daly, R. J., Li, J. & Song, J., 21 May 2020, In : Briefings in Bioinformatics. 21, 3, p. 1047-1057 11 p., bbz041.

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Zhou, Q. T., Lin, Y-W., Hancock, R. E. W., Hoyer, D., Creek, D. J., Li, J. & Velkov, T., Jan 2020, In : Antimicrobial Agents and Chemotherapy. 64, 1, 16 p., e01587-19.

Research output: Contribution to journal › Article › Research › peer-review