Projects per year
Personal profile
Biography
Jhih-Hang is a postdoctoral research fellow in the Department of Infectious Diseases and Department of Microbiology, Monash University. He is a molecular microbiologist with specific interests in human bacterial pathogens. He joined Prof Anton Peleg’s laboratory since 2013. Dr Jiang leads the Translational Staphylococcal Research Program. His research focuses on the interface between antibiotic resistance and bacterial pathogenesis in Staphylococcus aureus and Coagulase-negative staphylococci. Using these findings, he aims to develop innovative therapeutic strategies to treat multi-drug resistant S. aureus infections. Jhih-Hang has a wealth of expertise in the biochemical, lipidomic and genetic manipulation approaches, as well as the in vivo models.
Research interests
S. aureus can cause serious infection of almost any human tissue and mortality from treated infections is up to 35 percent. It is estimated that around 7000 cases of S. aureus blood stream infections occur in Australia each year, and about 25 percent are caused by methicillin-resistant S. aureus (MRSA). Without the ability to use the antibiotic methicillin, treatment of MRSA infection increasingly relies on last-line antibiotics. The World Health Organization (WHO) has listed MRSA as a ‘high-priority’ pathogen that urgently requires the development of new antimicrobial agents. Daptomycin is one of the last-line antibiotics to treat MRSA infections but daptomycin resistance is emerging. Infections caused by daptomycin-resistant S. aureus are often complicated, with disseminated foci and persistent infection in humans. Our team investigate how S. aureus utilizes a stealth strategy during mammalian infection that includes evasion of antimicrobial action and host immune attack.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Microbiology and Immunology, Doctor of Philosophy, Neisserial pathogenesis: key factors in disease, University of Melbourne
2 Mar 2009 → 29 Nov 2012
Award Date: 22 Mar 2013
Master of Science, National Yang-Ming University
2005 → 2007
Award Date: 11 Jun 2007
Bachelor of Science, National Yang-Ming University
2001 → 2005
Award Date: 10 Jun 2005
Research area keywords
- antibiotic resistance
- S. aureus
- methicillin-resistant S. aureus
- bacterial pathogenesis
- Biochemistry, Lipids
- Biochemistry, Proteins
- Infectious Diseases/Agents
- toxins
- cell death
- Biology
- Coagulase-negative staphylococci
Collaborations and top research areas from the last five years
Projects
- 6 Finished
-
Deciphering the dynamic membrane lipid remodelling in Acinetobacter baumannii and the interaction with membrane-targeting peptides
Shen, H., Jiang, J., Lai, X. & Le Brun, A.
Australian Nuclear Science and Technology Organisation (ANSTO)
9/08/22 → 14/08/22
Project: Research
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Charge interference - how does increase of lysyl-phosphatidylglycerols in Staphylococcus aureus lead to daptomycin resistance?
23/05/22 → 26/05/22
Project: Research
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Charge-repulsion or trapping - how do lysyl-phosphatidylglycerols block actions of daptomycin on Staphylococcus aureus membrane?
Shen, H., Jiang, J. & Lim, C. X.
10/02/20 → 12/02/20
Project: Research
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Polysaccharide-targeting lipid nanoparticles to kill gram-negative bacteria
Lai, X., Chow, S. H., Le Brun, A. P., Muir, B. W., Bergen, P. J., White, J., Yu, H. H., Wang, J., Danne, J., Jiang, J. H., Short, F. L., Han, M. L., Strugnell, R. A., Song, J., Cameron, N. R., Peleg, A. Y., Li, J. & Shen, H. H., 8 Feb 2024, In: Small. 20, 6, 13 p., 230502.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology
Xu, L., Henriksen, C., Mebus, V., Guérillot, R., Petersen, A., Jacques, N., Jiang, J.-H., Derks, R. J. E., Sánchez-López, E., Giera, M., Leeten, K., Stinear, T. P., Oury, C., Howden, B. P., Peleg, A. Y. & Frees, D., Jun 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6, p. 1-18 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Characterisation of key genotypic and phenotypic traits of clinical cystic fibrosis Staphylococcus aureus isolates
Mossop, M., Robinson, L., Jiang, J.-H., Peleg, A. Y., Blakeway, L. V., Macesic, N., Perry, A., Bourke, S., Ulhuq, F. R. & Palmer, T., 2023, In: Journal of Medical Microbiology. 72, 6, 15 p., 001703.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages
Jiang, J.-H. (Leading Author), Cameron, D. R., Nethercott, C., Aires-de-Sousa, M. & Peleg, A. Y., 20 Dec 2023, In: Clinical Microbiology Reviews. 36, 4, 52 p., e0014822.Research output: Contribution to journal › Review Article › Research › peer-review
20 Citations (Scopus) -
A polytherapy based approach to combat antimicrobial resistance using cubosomes
Lai, X., Han, M.-L., Ding, Y., Chow, S. H., Le Brun, A. P., Wu, C.-M., Bergen, P. J., Jiang, J.-H., Hsu, H.-Y., Muir, B. W., White, J., Song, J., Li, J. & Shen, H.-H., Dec 2022, In: Nature Communications. 13, 1, 12 p., 343.Research output: Contribution to journal › Article › Research › peer-review
Open Access46 Citations (Scopus)