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20032018
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Personal profile

Biography

Jerome works in the Faculty of Medicine, Nursing and Health Sciences (Biomedicine Discovery Institute) at Monash University as an Australian Research Council (ARC) Future Fellow. Jerome was initially trained as a chemist at the University of Brest (France) prior to the completion of his PhD in structural biology at the University of Copenhagen (Denmark) in 2005. During his PhD, he acquired a set of skills and expertise in a range of biophysical techniques that enabled him to complete a very successful PhD with the publication of a total of five peer-review articles (four as first author). He then pursued his scientific career as a research fellow at the University of Auckland (New Zealand) where he studied the protein structures of Mycobacterium tuberculosis. In 2008, Jerome relocated to Australia and accepted a research fellow position at Monash  in the Department of Biochemistry and Molecular Biology, where he expanded his interest and skills in immunity and structural biology. Since then, he has established an impressive track record with the publication in top-tier generalist journals such as Nature and Nature Communications, and in very prestigious high impact journals in the field of immunology such as Nature Immunology, Immunity and The Journal of Experimental Medicine. Of particular significance are Jerome’s contributions to the field of non-classical MHC (Major Histocompatibility Complex)-mediated T-cell immunity. In 2016, Jerome was awarded a prestigious ARC Future fellowship, and in 2017, he was appointed as an independent group leader within the Biomedicine Discovery Institute (Monash University). By applying a multi-disciplinary and highly innovative approaches that include comparative immunology, chemistry, structural biology, cell immunology, advanced atomic and molecular imaging, his research program aims to provide comprehensive and fundamental insights into molecular recognition of non-peptidic antigens (Ags), and gain an evolutionary perspective on the structure and function of MHC-like Ag-presenting molecules.

Keywords

  • Structural Biology
  • Comparative immunology
  • T cell receptors
  • MHC
  • immune recognition

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Research Output 2003 2018

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

Sundararaj, S., Zhang, J., Krovi, S. H., Bedel, R., Tuttle, K. D., Veerapen, N., Besra, G. S., Khandokar, Y., Praveena, T., Le Nours, J., Matsuda, J. L., Rossjohn, J. & Gapin, L. 6 Feb 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. E1204-E1213 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity

Chennamadhavuni, D., Saavedra-Avila, N. A., Carreño, L. J., Guberman-Pfeffer, M. J., Arora, P., Yongqing, T., Koay, H. F., Godfrey, D. I., Keshipeddy, S., Richardson, S. K., Sundararaj, S., Lo, J. H., Wen, X., Gascón, J. A., Yuan, W., Rossjohn, J., Le Nours, J., Porcelli, S. A. & Howell, A. R. 17 May 2018 In : Cell Chemical Biology. 25, 5, p. 571-584 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity (Cell Chemical Biology (2018) 25(5) (571–584.e8) (S2451945618300734) (10.1016/j.chembiol.2018.02.009))

Chennamadhavuni, D., Saavedra-Avila, N. A., Carreño, L. J., Guberman-Pfeffer, M. J., Arora, P., Yongqing, T., Pryce, R., Koay, H. F., Godfrey, D. I., Keshipeddy, S., Richardson, S. K., Sundararaj, S., Lo, J. H., Wen, X., Gascón, J. A., Yuan, W., Rossjohn, J., Le Nours, J., Porcelli, S. A. & Howell, A. R. 19 Jul 2018 In : Cell Chemical Biology. 25, 7, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Molecular recognition of microbial lipid-based antigens by T cells

Gras, S., van Rhijn, I., Shahine, A. & Le Nours, J. May 2018 In : Cellular and Molecular Life Sciences. 75, 9, p. 1623-1639 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Mucosal-associated invariant T cell receptor recognition of small molecules presented by MR1

Awad, W., Le Nours, J., Kjer-Nielsen, L., Mccluskey, J. & Rossjohn, J. Jul 2018 In : Immunology and Cell Biology. 96, 6, p. 588-597 10 p.

Research output: Contribution to journalArticleOtherpeer-review