• 19 innovation walk, Biomedicine Discovery Institute - Building 76

    3800 Clayton


Research output per year

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Personal profile


Jerome works in the Faculty of Medicine, Nursing and Health Sciences (Biomedicine Discovery Institute) at Monash University as an Australian Research Council (ARC) Future Fellow. Jerome was initially trained as a chemist at the University of Brest (France) prior to the completion of his PhD in structural biology at the University of Copenhagen (Denmark) in 2005. During his PhD, he acquired a set of skills and expertise in a range of biophysical techniques that enabled him to complete a very successful PhD with the publication of a total of five peer-review articles (four as first author). He then pursued his scientific career as a research fellow at the University of Auckland (New Zealand) where he studied the protein structures of Mycobacterium tuberculosis. In 2008, Jerome relocated to Australia and accepted a research fellow position at Monash  in the Department of Biochemistry and Molecular Biology, where he expanded his interest and skills in immunity and structural biology. Since then, he has established an impressive track record with the publication in top-tier generalist journals such as Nature and Nature Communications, and in very prestigious high impact journals in the field of immunology such as Nature Immunology, Immunity and The Journal of Experimental Medicine. Of particular significance are Jerome’s contributions to the field of non-classical MHC (Major Histocompatibility Complex)-mediated T-cell immunity. In 2016, Jerome was awarded a prestigious ARC Future fellowship, and in 2017, he was appointed as an independent group leader within the Biomedicine Discovery Institute (Monash University). By applying a multi-disciplinary and highly innovative approaches that include comparative immunology, chemistry, structural biology, cell immunology, advanced atomic and molecular imaging, his research program aims to provide comprehensive and fundamental insights into molecular recognition of non-peptidic antigens (Ags), and gain an evolutionary perspective on the structure and function of MHC-like Ag-presenting molecules.

Research area keywords

  • Structural Biology
  • Comparative immunology
  • T cell receptors
  • MHC
  • immune recognition

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Research Output

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products

Nicolai, S., Wegrecki, M., Cheng, T. Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., Monnot, G. C., Le Nours, J., Van Rhijn, I., Rossjohn, J., Moody, D. B. & de Jong, A., 3 Jan 2020, In : Science Immunology. 5, 43, 13 p., eaax5430.

Research output: Contribution to journalArticleResearchpeer-review

The molecular basis underpinning the potency and specificity of MAIT cell antigens

Awad, W., Ler, G. J. M., Xu, W., Keller, A. N., Mak, J. Y. W., Lim, X. Y., Liu, L., Eckle, S. B. G., Le Nours, J., McCluskey, J., Corbett, A. J., Fairlie, D. P. & Rossjohn, J., Apr 2020, In : Nature Immunology. 12 p., s41590.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A TCR β-chain motif biases toward recognition of human CD1 proteins

Reinink, P., Shahine, A., Gras, S., Cheng, T. Y., Farquhar, R., Lopez, K., Suliman, S. A., Reijneveld, J. F., Le Nours, J., Tan, L. L., León, S. R., Jimenez, J., Calderon, R., Lecca, L., Murray, M. B., Rossjohn, J., Moody, D. B. & Van Rhijn, I., 15 Dec 2019, In : Journal of Immunology. 203, 12, p. 3395-3406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Almeida, C. F., Sundararaj, S., Le Nours, J., Praveena, T., Cao, B., Burugupalli, S., Smith, D. G. M., Patel, O., Brigl, M., Pellicci, D. G., Williams, S. J., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Nov 2019, In : Nature Communications. 10, 1, 14 p., 5242.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)