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Research Output

2020

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses

Dowling, J. K., Tate, M. D., Rosli, S., Bourke, N. M., Bitto, N., Lauterbach, M. A., Cheung, S., Ve, T., Kobe, B., Golenbock, D. & Mansell, A., 15 Apr 2019, In : Journal of Immunology. 202, 8, p. 2384-2396 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes

Bitto, N. J., Baker, P. J., Dowling, J. K., Wray-McCann, G., De Paoli, A., Tran, L. S., Leung, P. L., Stacey, K. J., Mansell, A., Masters, S. L. & Ferrero, R. L., Nov 2018, In : Immunology and Cell Biology. 96, 10, p. 1120-1130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2017

PB1-F2 peptide derived from avian influenza A virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar, A., Dowling, J. K., Bitto, N. J., Robertson, A. A. B., Latz, E., Stewart, C. R., Drummond, G. R., Cooper, M. A., McAuley, J. L., Tate, M. D. & Mansell, A., 20 Jan 2017, In : The Journal of Biological Chemistry. 292, 3, p. 826-836 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)
2016

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Tate, M. D., Ong, J. DH., Dowling, J. K., McAuley, J. L., Robertson, A. B., Latz, E., Drummond, G. R., Cooper, M. A., Hertzog, P. J. & Mansell, A., 10 Jun 2016, In : Scientific Reports. 6, 8 p., 27912.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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59 Citations (Scopus)

Toll-like receptors: Ligands, cell-based models, and readouts for receptor action

Dowling, J. K. & Dellacasagrande, J., 1 Jan 2016, Toll-Like Receptors: Practice and Methods. McCoy, C. E. (ed.). 2nd ed. New York USA: Humana Press, Vol. 1390. p. 3-27 25 p. (Methods in Molecular Biology; vol. 1390).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

13 Citations (Scopus)

Toll-like receptors: the swiss army knife of immunity and vaccine development

Dowling, J. K. & Mansell, A., 2016, In : Clinical & Translational Immunology. 5, 10 p., e85.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2014

Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50

Canavan, M., McCarthy, C., Larbi, N. B., Dowling, J. K., Collins, L., O'Sullivan, F., Hurley, G., Murphy, C., Quinlan, A., Moloney, G., Darby, T., Macsharry, J., Kagechika, H., Moynagh, P., Melgar, S. & Loscher, C. E., Oct 2014, In : Innate Immunity. 20, 7, p. 675-687 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

Dowling, J. K., Becker, C., Bourke, N., Corr, S. C., Connolly, D. J., Quinn, S. R., Pandolfi, P. P., Mansell, A. S. & O'Neill, L. A. J., 2014, In : The Journal of Biological Chemistry. 289, 10, p. 6429 - 6437 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2013

Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14

Dowling, J. K., McCoy, C., Doyle, S. L., BenLarbi, N., Canavan, M., O'Neill, L. A. J. & Loscher, C. E., 2013, In : Journal of Nutritional Biochemistry. 24, 5, p. 920 - 928 9 p.

Research output: Contribution to journalLetterOther

5 Citations (Scopus)
2012

Biochemical regulation of the inflammasome

Dowling, J. K. & O'Neill, L. A. J., Sep 2012, In : Critical Reviews in Biochemistry and Molecular Biology. 47, 5, p. 424-443 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

86 Citations (Scopus)
2011

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins

Ryan, A., Lynch, M., Smith, S., Amu, S., Nel, H., McCoy, C., Dowling, J. K., Draper, E., O'Reilly, V., McCarthy, C., O'Brien, J., Eidhin, D., O'Connell, M., Keogh, B., Morton, C., Rogers, T., Fallon, P., O'Neill, L., Kelleher, D. & Loscher, C., 2011, In : PLoS Pathogens. 7, 6 (Art. No: e1002076), 13 p., e1002076.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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97 Citations (Scopus)

Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms

Court, N., Rose, S., Bourigault, M. L., Front, S., Martin, O. R., Dowling, J. K., Kenny, E. F., O'Neill, L., Erard, F. & Quesniaux, V. F. J., 16 Sep 2011, In : PLoS ONE. 6, 9, 12 p., e24631.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)
2007

Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: Role of receptor heterodimerization

Wilson, S. J., Dowling, J. K., Zhao, L., Carnish, E. & Smyth, E. M., Feb 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 2, p. 290-296 7 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)