Projects per year
Personal profile
Biography
Jeff performs research on mitochondrial replacement therapy in the Biomedicine Discovery Institute. Previously, he led laboratories researching the role of epigenetics in mammalian germ cell development at the City of Hope National Medical Center in Los Angeles, The University of Melbourne, and the Murdoch Children’s Research Institute, Melbourne. For several years he instructed the 'Molecular Embryology of the Mouse Course' at the Cold Spring Harbor Laboratory, New York, and has directed institutional facilities for making preclinical models of disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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MitoHOPE: Introducing Mitochondrial Donation in AustraliaL The MitoHOPE (Healthy Outcomes Pilot and Evaluation) Program
Carroll, J. (Primary Chief Investigator (PCI)), Herbert, M. (Chief Investigator (CI)), Christodoulou, J. (Chief Investigator (CI)), Thorburn, D. R. (Chief Investigator (CI)), Mills, C. (Chief Investigator (CI)), Zander-Fox, D. L. (Chief Investigator (CI)), Robker, R. (Chief Investigator (CI)), Rombauts, L. (Chief Investigator (CI)), Sallevelt, S. (Chief Investigator (CI)), Ludlow, K. (Chief Investigator (CI)), Coman, D. J. (Chief Investigator (CI)), Ellaway, C. J. (Chief Investigator (CI)), Mackey, D. A. (Chief Investigator (CI)), Delatycki, M. B. (Chief Investigator (CI)), Yau, W. Y. (Chief Investigator (CI)), Tchan, M. C. (Chief Investigator (CI)), Long, J. C. (Chief Investigator (CI)), Hardy, T. (Chief Investigator (CI)), Adhikari, D. (Chief Investigator (CI)), Choudhary, M. (Chief Investigator (CI)), Hyslop, L. A. (Chief Investigator (CI)), Mann, J. (Chief Investigator (CI)), Ryan, M. (Chief Investigator (CI)), Hodges, R. (Chief Investigator (CI)), Hui, L. (Chief Investigator (CI)), Kamien, B. A. (Chief Investigator (CI)), Mallett, A. J. (Chief Investigator (CI)), Semsarian, C. (Chief Investigator (CI)), Wallis, M. J. (Chief Investigator (CI)), Wall, M. (Chief Investigator (CI)), Zoungas, S. (Chief Investigator (CI)), Goranitis, I. (Chief Investigator (CI)), Gyngell, C. (Chief Investigator (CI)), Hammarberg, K. (Chief Investigator (CI)), Sparrow, R. (Chief Investigator (CI)), Warren, N. (Chief Investigator (CI)), Fahey, M. (Chief Investigator (CI)), Stutterd, C. A. (Associate Investigator (AI)), Schweitzer, D. (Associate Investigator (AI)), McGillivray, G. (Associate Investigator (AI)), Savulescu, J. (Associate Investigator (AI)), Panetta, J. (Associate Investigator (AI)), Kava, M. P. (Associate Investigator (AI)), Freckmann, M.-L. (Associate Investigator (AI)), Lynch, M. (Associate Investigator (AI)), Lamont, P. J. (Associate Investigator (AI)), Scott, R. (Associate Investigator (AI)), Ware, T. (Associate Investigator (AI)), Mowat, D. (Associate Investigator (AI)), Jones, K. J. (Associate Investigator (AI)), Green, S. (Associate Investigator (AI)), Wolfe, R. (Associate Investigator (AI)), Hackett, A. (Associate Investigator (AI)), Bratkovic, D. (Associate Investigator (AI)), Horton, A. (Associate Investigator (AI)) & Blok, R. (Project Manager)
Monash University – Internal Faculty Contribution, Australian Genomics, Centenary Institute of Cancer Medicine & Cell Biology, James Cook University, Lyons Eye Institute Limited, Macquarie University, Murdoch Children's Research Institute, Australian Mitochondrial Disease Foundation Limited (trading as Mito Foundation), Monash IVF Group Limited, Perron Institute for Neurological and Translational Science Limited, Queensland Children's Hosptial , Tasmanian Clinical Genetics Service, University of Adelaide, Victorian Assisted Reproductive Treatment Authority (VARTA) (Victoria), Women's and Children's Health Care Network Incorporated, Western Sydney Local Health District (WSLHD)
1/06/23 → 31/05/28
Project: Research
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Understanding non-genetic inheritance in health and disease
Western, P. (Primary Chief Investigator (PCI)), Adelson, D. L. (Chief Investigator (CI)), Gibson, W. (Chief Investigator (CI)), Blewitt, M. (Associate Investigator (AI)), Lee, H. J. (Associate Investigator (AI)), Sims, N. A. (Associate Investigator (AI)), Gouil, Q. (Associate Investigator (AI)) & Mann, J. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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(1) FemtoJet 4i microinjector (Eppendorf). (2) IVF Cube (Astec) tri-gas incubator (regulated carbon dioxide and oxygen)
Carroll, J. (Primary Chief Investigator (PCI)), Mann, J. (Chief Investigator (CI)), Herbert, M. (Chief Investigator (CI)) & Zander-Fox, D. (Chief Investigator (CI))
Australian Mitochondrial Disease Foundation Limited (trading as Mito Foundation)
1/02/21 → 1/12/22
Project: Research
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NHOMD: Mitigating the risks of mitochondrial donation
Carroll, J. (Primary Chief Investigator (PCI)), Mann, J. (Chief Investigator (CI)), Herbert, M. (Chief Investigator (CI)) & Zander-Fox, D. L. (Chief Investigator (CI))
1/01/21 → 31/12/24
Project: Research
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Investigation into epigenetic defects and new therapeutic strategy in ATRX mutated gliomas
Wong, L., Voon, H. P. J. & Mann, J.
1/09/18 → 31/08/20
Project: Research
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Development of Mitochondrial Replacement Therapies
Mann, J. R., Herbert, M., Zander-Fox, D. L., Adhikari, D. & Carroll, J., Feb 2023, Reproduction Reborn: How Science, Ethics, and Law Shape Mitochondrial Replacement Therapies. Bowman, D. (ed.). United States: Oxford University Press, USA, p. 17-31 15 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
2 Citations (Scopus) -
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
Voon, H. P. J., Hii, L., Garvie, A., Udugama, M., Krug, B., Russo, C., Chüeh, A. C., Daly, R. J., Morey, A., Bell, T. D. M., Turner, S. J., Rosenbluh, J., Daniel, P., Firestein, R., Mann, J. R., Collas, P., Jabado, N. & Wong, L. H., Dec 2023, In: Genome Biology. 24, 1, 27 p., 284.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development
Adhikari, D., Lee, I. W., Al-Zubaidi, U., Liu, J., Zhang, Q. H., Yuen, W. S., He, L., Winstanley, Y., Sesaki, H., Mann, J. R., Robker, R. L. & Carroll, J., Jun 2022, In: Science Advances. 8, 24, 15 p., eabl8070.Research output: Contribution to journal › Article › Research › peer-review
Open Access26 Citations (Scopus) -
Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase
Udugama, M., Vinod, B., Chan, F. L., Hii, L., Garvie, A., Collas, P., Kalitsis, P., Steer, D., Das, P. P., Tripathi, P., Mann, J. R., Voon, H. P. J. & Wong, L. H., 6 May 2022, In: Nucleic Acids Research. 50, 8, p. 4500-4514 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access19 Citations (Scopus) -
HENMT1 is involved in the maintenance of normal female fertility in the mouse
Hutt, K. J., Lim, S. L., Zhang, Q.-H., Gonzalez, M., O'Connor, A. E., Jo Merriner, D., Liew, S. H., Al-Zubaidi, U., Yuen, W. S., Adhikari, D., Robker, R. L., Mann, J. R., Carroll, J. & O'Bryan, M. K., Nov 2021, In: Molecular Human Reproduction. 27, 11, p. 1-12 12 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus)