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Improving kidney health in diabetes by targeting NOX pathways

20072024

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Personal profile

Biography

Dr. Jay Jha is a biomedical researcher and an emerging leader in the field of diabetes and kidney disease.  His main focus of research is identifying novel therapeutic targets and biomarkers for diabetic kidney disease. He has been progressing on a highly promising career path with a steep upward trajectory of high-quality research outputs which is reflected through his seminal publications in the leading journals of diabetes (Diabetes, Diabetologia), nephrology (JASN, Kidney international) and oxidative stress (Antioxid Redox Signal). He has been awarded two highly competitive early career fellowships from NHMRC and JDRF as well as secured 3 Diabetes Australia (DARP) grants, highlighting the significance of his achievements in the field.

2017-2020: NHMRC-Early Career Research Fellow

2016-2017: International JDRF post-doctoral fellowship (Relinquished)    

2012-2014: Australian post graduate award (APA)                                   

2011-2012: Monash International postgraduate research scholarship

2011-2014: Baker Heart and Diabetes PhD Bright Spark Scholarship  

 

The significant aspect of Dr Jha's research contribution is the identification and validation of the NOX4-pathway which plays a detrimental role in diabetic kidney disease. This is reflected by translation of his preclinical work in diabetic kidney disease to clinical trials (ACTRN12617001187336). 

Research interests

Dr Jha research interest is to develop innovative approaches to substantially advance our knowledge about the pathways (pro-oxidant-inflammatory-fibrotic axis) implicated in diabetic kidney disease and translate novel therapies to human studies as well as clinically validate predictive tools and biomarkers.  His current research includes NOX5 inhibition program to combat kidney disease in diabetes. 

 

Monash teaching commitment

Dr Jha contributes to teaching by giving sessional tutorial lecture/practical class on diabetic complications including kidney disease to the Monash University 3rd year Biomedical students (HUP 3022) and research in action (IMM3990 / HUP3990) as well as an online lecture to Master students for the course entitled Translational Research and Medicine for Metabolic Disorders (TRM6007).

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Biomedical Science, PhD, Monash University

20112014

Research area keywords

  • Diabetes
  • Kidney Disease
  • Oxidative stress
  • reactive oxygen species
  • Inflammation
  • Fibrosis
  • Organoids
  • Biomarkers

Collaborations and top research areas from the last five years

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