Projects per year
Personal profile
Biography
Dr. Jha is a research fellow in the Department of Diabetes, where he leads projects focused on identifying novel therapeutic targets and biomarkers for diabetes and kidney disease. He completed his PhD at Monash University in 2014, and the outcomes of his thesis provided the rationale for clinical trials of NOX inhibitors in diabetic kidney disease. In 2015, he began his postdoctoral research at the Baker Heart and Diabetes Institute. In 2016, he received the prestigious Juvenile Diabetes Research Foundation (JDRF) International Postdoctoral Fellowship to continue his work on diabetes and kidney disease. In 2017, he was awarded the highly prestigious NHMRC Early Career Research Fellowship, at which point he transitioned to the newly established Monash Diabetes Department. Additionally, he spent three months as a visiting scholar at the German Diabetes Centre in Düsseldorf in 2022.
Dr. Jha is a member of the Australian Diabetes Society (ADS), the Australian and New Zealand Society of Nephrology (ANZSN), the American Society of Nephrology (ASN), and the European Association for the Study of Diabetes (EASD). The quality of his research outputs is reflected in his highly cited publications in leading journals in diabetes and nephrology, as well as in securing fellowships and grants, including recent grants from Diabetes Australia (2020, 2022, 2023, 2024). These achievements underscore the significance of his work in the field.
Research interests
- Oxidative stress – inflammation – fibrosis axis in diabetes and related complications
- Human 3D kidney organoids
- Translation of novel therapeutic targets
- NOX pathways
- Predictive tools and biomarkers of diabetes and kidney disease
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Diabetes
- Kidney Disease
- Oxidative stress
- NADPH oxidases
- Inflammation
- Fibrosis
- Kidney organoids
- Biomarkers
Collaborations and top research areas from the last five years
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Translational Kidney Fibrosis Imaging in Diabetes
Alt, K., Jandeleit-Dahm, K. & Jha, J.
1/01/24 → 31/07/25
Project: Research
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Diabetes and Renal Complications: An Overview on Pathophysiology, Biomarkers and Therapeutic Interventions
Jha, R., Lopez-Trevino, S., Kankanamalage, H. R. & Jha, J. C., May 2024, In: Biomedicines. 12, 5, 23 p., 1098.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access12 Citations (Scopus) -
Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes
Jandeleit-Dahm, K. A. M., Kankanamalage, H. R., Dai, A., Meister, J., Lopez-Trevino, S., Cooper, M. E., Touyz, R. M., Kennedy, C. R. J. & Jha, J. C., Apr 2024, In: Antioxidants. 13, 4, 18 p., 396.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Elucidating NOX5 as a Potential Therapeutic Target and a Biomarker of Kidney Disease in Diabetes FR-PO376
Jha, J., Kankanamalage, H. R., Jaquet, V., Cooper, M. E. & Jandeleit-Dahm, K. A. M., Nov 2023, In: Journal of the American Society of Nephrology. 34, 11S, p. 507 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Nox5: a promising therapeutic target for diabetic kidney disease
Jha, J. C., Dai, A., Kankanamalage, H. R., Meister, J., Vincent, J., Cooper, M. E. & Jandeleit-Dahm, K., Sept 2023, In: Diabetologia. 66, Suppl 1, p. S71 1 p., 132.Research output: Contribution to journal › Meeting Abstract › peer-review
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Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease
Østergaard, J. A., Jha, J. C., Sharma, A., Dai, A., Choi, J. S. Y., de Haan, J. B., Cooper, M. E. & Jandeleit-Dahm, K., Jan 2022, In: Clinical Science. 136, 2, p. 167-180 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access29 Citations (Scopus)
Prizes
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AMREP best paper award and prizes, Melbourne, Australia
Jha, Jay (Recipient), 2015
Prize: Prize (including medals and awards)
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Basic Science Finalist Award and Prize, APCN/ANZSN, Perth, Australia
Jha, Jay (Recipient), 2016
Prize: Prize (including medals and awards)
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Basic Science Runner up Award, Australian New Zealand Society of Nephrology, Sydney, Australia
Jha, Jay (Recipient), 2018
Prize: Prize (including medals and awards)
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Basic Science Runner Up Award, Australian New Zealand Society of Nephrology (ANZSN), Australia
Jha, Jay (Recipient), 2020
Prize: Prize (including medals and awards)
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Best Abstracts Award, Asia pacific congress of Nephrology (APCN) & CSN 2018, Beijing, China
Jha, Jay (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
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Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD) 2024
Jay Jha (Speaker)
2024Activity: Participating in or organising an event types › Contribution to conference
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Honours Student Supervision
Jay Jha (Supervisor)
1 Mar 2024 → 30 Nov 2024Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Research in Action (HUP3990) Student Supervision
Jay Jha (Supervisor)
1 Mar 2024 → 31 Jul 2024Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Annual Scientific Meeting of the Australian-and-New-Zealand-Society-of-Nephrology 2023
Jay Jha (Speaker)
2023Activity: Participating in or organising an event types › Contribution to conference
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Honours Student Supervision
Jay Jha (Supervisor)
Mar 2023 → Nov 2023Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Press/Media
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https://www.monash.edu/medicine/news/latest/2022-articles/new-diabetic-kidney-disease-target-raises-hopes.
1/07/22
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Social Media Article
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https://www.monash.edu/medicine/news/latest/2022-articles/new-anti-inflammatory-approach-may-damage-kidneys,-monash-scientists-find
2/02/22
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Social Media Article
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http://ccsmonash.blogspot.com/2019/11/answering-fundamental-question-about.html
1/11/19
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Social Media Article
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STM diabetes researcher honoured by award
6/09/19
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Blogs
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http://ccsmonash.blogspot.com/2018/06/amrep-student-journal-club-kicks-off.html
11/06/18
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Blogs