If you made any changes in Pure these will be visible here soon.

Research Output 2005 2019

Filter
Article
2019
2 Citations (Scopus)

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018
2 Citations (Scopus)

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction

Sheybani-Deloui, S., Chi, L., Staite, M. V., Cain, J. E., Nieman, B. J., Mark Henkelman, R., Wainwright, B. J., Steven Potter, S., Bagli, D. J., Lorenzo, A. J. & Rosenblum, N. D., 1 Feb 2018, In : Journal of the American Society of Nephrology. 29, 2, p. 532-544 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, Szczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2018, In : Oncogene. 38, 10, p. 1661-1675 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

Lim, C. H., Sun, Q., Ratti, K., Lee, S. H., Zheng, Y., Takeo, M., Lee, W., Rabbani, P., Plikus, M. V., Cain, J. E., Wang, D. H., Watkins, D. N., Millar, S., Taketo, M. M., Myung, P., Cotsarelis, G. & Ito, M., 21 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4903.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 others, Lorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N., 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma

Sun, X., Vaghjiani, V., Jayasekara, W. S. N., Cain, J. E. & St John, J. C., 17 Dec 2018, In : Clinical Epigenetics. 10, 1, 17 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In : Oncogene. 37, p. 1939-1948 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017
1 Citation (Scopus)

Modulation of mitochondrial DNA copy number to induce hepatocytic differentiation of human Amniotic Epithelial cells

Vaghjiani, V., Cain, J. E., Lee, W., Vaithilingam, V., Tuch, B. E. & St John, J. C., 15 Oct 2017, In : Stem Cells and Development. 26, 20, p. 1505-1519 15 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Phosphoproteomic profiling reveals ALK and MET as novel actionable targets across synovial sarcoma subtypes

Fleuren, E. D. G., Vlenterie, M., Van Der Graaf, W. T. A., Hillebrandt-Roeffen, M. H. S., Blackburn, J., Ma, X., Chan, H., Magias, M. C., Van Erp, A., Van Houdt, L., Cebeci, S. A. S., Van De Ven, A., Flucke, U. E., Heyer, E. E., Thomas, D. M., Lord, C. J., Marini, K. D., Vaghjiani, V., Mercer, T. R., Cain, J. E. & 3 others, Wu, J., Versleijen-Jonkers, Y. M. H. & Daly, R. J., 15 Aug 2017, In : Cancer Research. 77, 16, p. 4279-4292 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo

Akladios, B., Mendoza Reinoso, V., Cain, J. E., Wang, T., Lambie, D. L., Watkins, D. N. & Beverdam, A., 1 Aug 2017, In : PLoS ONE. 12, 8, 15 p., e0183178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer

Szczepny, A., Rogers, S., Jayasekara, W. S. N., Park, K., McCloy, R. A., Cochrane, C. R., Ganju, V., Cooper, W. A., Sage, J., Peacock, C. D., Cain, J. E., Burgess, A. & Watkins, D. N., 28 Sep 2017, In : Oncogene. 36, 39, p. 5544-5550 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Topoisomerase 1 inhibition promotes cyclic GMP-AMP synthase-dependent antiviral responses

Pépin, G., Nejad, C., Ferrand, J., Thomas, B. J., Stunden, H. J., Sanij, E., Foo, C. H., Stewart, C. R., Cain, J. E., Bardin, P. G., Williams, B. R. G. & Gantier, M. P., 1 Sep 2017, In : mBio. 8, 5, 9 p., e01611-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016
4 Citations (Scopus)

Activating transcription factor 3 expression as a marker of response to the histone deacetylase inhibitor pracinostat

Sooraj, D., Xu, D., Cain, J. E., Gold, D. P. & Williams, B. R. G., 1 Jul 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1726-1739 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Cre-dependent DNA recombination activates a STING-dependent innate immune response

Pépin, G., Ferrand, J., Höning, K., Jayasekara, W. S. N., Cain, J. E., Behlke, M. A., Gough, D. J., Williams, B. R. G., Hornung, V. & Gantier, M. P., 20 Jun 2016, In : Nucleic Acids Research. 44, 11, p. 5356-5364 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Low-dose histone deacetylase inhibitor treatment leads to tumor growth arrest and multi-lineage differentiation of malignant rhabdoid tumors

Muscat, A., Popovski, D., Jayasekara, W. S. N., Rossello, F. J., Ferguson, M., Marini, K. D., Alamgeer, M., Algar, E. M., Downie, P., Watkins, D. N., Cain, J. E. & Ashley, D., 15 Jul 2016, In : Clinical Cancer Research. 22, 14, p. 3560-3570 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
54 Citations (Scopus)

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, WTY., Cain, JE., Cuddihy, AR., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, TG., Watkins, DN., Spencer, A., St John, JC. & Johnson, J., 2016, In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase

Deane, J. A., Ong, Y. R., Cain, J., Jayasekara, W. S. N., Tiwari, A., Carlone, D. L., Breault, D. T. & Gargett, C. E., 1 Apr 2016, In : Molecular Human Reproduction. 22, 4, p. 272-284 13 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis

Ramaswamy, V., Hielscher, T., Mack, S. C., Lassaletta, A., Lin, T., Pajtler, K. W., Jones, D. T. W., Luu, B., Cavalli, F. M. G., Aldape, K., Remke, M., Mynarek, M., Rutkowski, S., Gururangan, S., McLendon, R. E., Lipp, E. S., Dunham, C., Hukin, J., Eisenstat, D. D., Fulton, D. & 95 others, Van Landeghem, F. K. H., Santi, M., Van Veelen, M. L. C., Van Meir, E. G., Osuka, S., Fan, X., Muraszko, K. M., Tirapelli, D. P. C., Oba-Shinjo, S. M., Marie, S. K. N., Carlotti, C. G., Lee, J. Y., Rao, A. A. N., Giannini, C., Faria, C. C., Nunes, S., Mora, J., Hamilton, R. L., Hauser, P., Jabado, N., Petrecca, K., Jung, S., Massimi, L., Zollo, M., Cinalli, G., Bognár, L., Klekner, A., Hortobágyi, T., Leary, S., Ermoian, R. P., Olson, J. M., Leonard, J. R., Gardner, C., Grajkowska, W. A., Chambless, L. B., Cain, J., Eberhart, C. G., Ahsan, S., Massimino, M., Giangaspero, F., Buttarelli, F. R., Packer, R. J., Emery, L., Yong, W. H., Soto, H., Liau, L. M., Everson, R., Grossbach, A., Shalaby, T., Grotzer, M. A., Karajannis, M. A., Zagzag, D. S., Wheeler, H., Von Hoff, K., Alonso, M. M., Tuñon, T., Schüller, U., Zitterbart, K., Sterba, J., Chan, J. A., Guzman, M., Elbabaa, S. K., Colman, H., Dhall, G., Fisher, P. G., Fouladi, M., Gajjar, A., Goldman, S., Hwang, E., Kool, M., Ladha, H., Vera-Bolanos, E., Wani, K., Lieberman, F., Mikkelsen, T., Omuro, A. M., Pollack, I. F., Prados, M., Robins, H. I., Soffietti, R., Wu, J., Metellus, P., Tabori, U., Bartels, U., Bouffet, E., Hawkins, C. E., Rutka, J. T., Dirks, P., Pfister, S. M., Merchant, T. E., Gilbert, M. R., Armstrong, T. S., Korshunov, A., Ellison, D. W. & Taylor, M. D., 20 Jul 2016, In : Journal of Clinical Oncology. 34, 21, p. 2468-2477 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor

Blake, J., Hu, D., Cain, J. E. & Rosenblum, N. D., 1 Feb 2016, In : Human Molecular Genetics. 25, 3, p. 437-447 11 p., ddv483.

Research output: Contribution to journalArticleResearchpeer-review

2015
66 Citations (Scopus)

Hedgehog signaling in the maintenance of cancer stem cells

Cochrane, C. R., Szczepny, A., Watkins, N. & Cain, J., 2015, In : Cancers. 7, 3, p. 1554 - 1585 32 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014
247 Citations (Scopus)

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Buczkowicz, P., Hoeman, C., Rakopoulos, P., Pajovic, S., Letourneau, L., Dzamba, M., Morrison, A., Lewis, P. W., Bouffet, E., Bartels, U., Zuccaro, J., Agnihotri, S., Ryall, S., Barszczyk, M., Chornenkyy, Y., Bourgey, M., Bourque, G., Montpetit, A., Cordero, F., Caselo-Branco, P. & 32 others, Mangerel, J., Tabori, U., Ho, K. C., Huang, A., Taylor, K. R., MacKay, A., Bendel, A. E., Nazarian, J., Fangusaro, J. R., Karajannis, M. A., Zagzag, D. S., Foreman, N. O. K., Donson, A. M., Hegert, J. V., Smith, A. A., Chan, J. A., Lafay-Cousin, L., Dunn, S. E., Hukin, J., Dunham, C., Scheinemann, K., Michaud, J., Zelcer, S., Ramsay, D. B., Cain, J., Brennan, C. W., Souweidane, M. M., Jones, C. M., Allis, C. D., Brudno, M., Becher, O. J. & Hawkins, C., 2014, In : Nature Genetics. 46, 5, p. 451 - 456 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens

Leong, T., Marini, K. D., Rossello, F. J., Jayasekara, W. S. N., Russell, P. A., Prodanovic, Z., Kumar, B., Ganju, V., Alamgeer, M., Irving, L. B., Steinfort, D. P., Peacock, C. D., Cain, J., Szczepny, A. & Watkins, D. N., 2014, In : PLoS ONE. 9, 9 , 11 p., e106862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013
18 Citations (Scopus)

Deletions in 16q24.2 are associated with autism spectrum disorder, intellectual disability and congenital renal malformation

Handrigan, G. R., Chitayat, D. A., Lionel, A. C., Pinsk, M., Vaags, A. K., Marshall, C. R., Dyack, S., Escobar, L. F., Fernandez, B. A., Stegman, J. C., Rosenfeld, J. A., Shaffer, L. G., Goodenberger, M., Hodge, J. C., Cain, J. E., Babul-Hirji, R., Stavropoulos, D. J., Yiu, V., Scherer, S. W. & Rosenblum, N. D., 2013, In : Journal of Medical Genetics. 50, 3, p. 163-173 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Barakat, B. M., Yu, L., Lo, C. Y-W., Vu, D. T., De Luca, E., Cain, J., Martelotto, L. G., Dedhar, S., Sadler, A. J., Wang, D., Watkins, D. N. & Hannigan, G., 2013, In : EMBO Reports. 14, 9, p. 837 - 944 108 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Sustained low-dose treatment with the Histone deacetylase inhibitor LBH589 induces terminal differentiation of osteosarcoma cells

Cain, J. E., McCaw, A. S., Jayasekara, W. S. N., Rossello, F. J., Marini, K. D., Irving, A. T., Kansara, M., Thomas, D. M., Ashley, D. M. & Watkins, D. N., 2013, In : Sarcoma. 2013, p. 1 - 11 11 p., 608964.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Visualizing renal primary cilia

Deane, J. A., Verghese, E., Martelotto, L. G., Cain, J., Galtseva, A., Rosenblum, N. D., Watkins, D. N. & Ricardo, S. D., 2013, In : Nephrology. 18, 3, p. 161 - 168 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
24 Citations (Scopus)

Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma

Kelleher, F. C., Cain, J., Healy, J. M., Watkins, D. N. & Thomas, D. M., 2012, In : Pharmacology and Therapeutics. 136, 2, p. 153 - 168 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
25 Citations (Scopus)

beta-catenin causes renal dysplasia via upregulation of Tgfbeta2 and Dkk1

Bridgewater, D., di Giovanni, V., Cain, J., Cox, B., Jakobson, M., Sainio, K. & Rosenblum, N., 2011, In : Journal of the American Society of Nephrology. 22, 4, p. 718 - 731 14 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Control of mammalian kidney development by the Hedgehog signaling pathway

Cain, J. & Rosenblum, N., 2011, In : Pediatric Nephrology. 26, 9, p. 1365 - 1371 7 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

GLI3 repressor controls functional development of the mouse ureter

Cain, J., Islam, E., Haxho, F., Blake, J. & Rosenblum, N., 2011, In : Journal of Clinical Investigation. 121, 3, p. 1199 - 1206 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
44 Citations (Scopus)

GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells

Cain, J., Islam, E., Haxho, F., Chen, L., Bridgewater, D., Nieuwenhuis, E., Hui, C-C. & Rosenblum, N., 2009, In : PLoS ONE. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
43 Citations (Scopus)

BMP receptor ALK3 controls collecting system development

Hartwig, S., Bridgewater, D., di Giovanni, V., Cain, J., Mishina, Y. & Rosenblum, N., 2008, In : Journal of the American Society of Nephrology. 19, 1, p. 117 - 124 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Bone morphogenetic protein signaling in the developing kidney: Present and future

Cain, J., Hartwig, S., Bertram, J. F. & Rosenblum, N. D., 2008, In : Differentiation. 76, 8, p. 831 - 842 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Canonical WNT/beta-catenin signaling is required for ureteric branching

Bridgewater, D., Cox, B., Cain, J., Lau, A., Athaide, V., Gill, P., Kuure, S., Sainio, K. & Rosenblum, N., 2008, In : Developmental Biology. 317, 1, p. 83 - 94 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
17 Citations (Scopus)

Ureteric branching morphogenesis in BMP4 heterozygous mutant mice

Cain, J. & Bertram, J. F., 2006, In : Journal of Anatomy. 209, 6, p. 745 - 755 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
36 Citations (Scopus)

Exogenous BMP-4 amplifies asymmetric ureteric branching in the developing mouse kidney in vitro

Cain, J. E., Nion, T., Jeulin, D. & Bertram, J. F., 2005, In : Kidney International. 67, 2, p. 420 - 431 12 p.

Research output: Contribution to journalArticleResearchpeer-review