Projects per year
Personal profile
Biography
Jason is Head of the Developmental and Cancer Biology research group in Hudson Institute's Centre for Cancer Research, and Head of the Sarcoma Program. A developmental biologist, Jason is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease, including paediatric childhood and adolescent sarcomas, childhood brain tumours (diffuse intrinsic pontine glioma), and lung cancer.
Dr Jason Cain is a developmental biologist involved in full time basic research. After completing his BSc (2000), BSc(Hons) (2001) and PhD (2006) in the Department of Anatomy and Cell Biology at Monash University, Jason moved to The Hospital for Sick Children in Toronto, Canada to undertake his post-doctoral training. During his postdoctoral training in the Program of Developmental and Stem Cell Biology under the supervision of Dr Norman Rosenblum (Professor of Paediatrics, Senior Scientist, and Staff Nephrologist at Sickkids), Jason focused on the role of the Hedgehog signalling pathway in normal and abnormal kidney development. In late 2010, Jason returned to Australia to take up a position as a Research Fellow with Prof Neil Watkins (Professor of Cancer and Developmental Biology, NHMRC Senior Research Fellow, and Consultant Physician) at Hudson Institute of Medical Research. In 2014, Jason was appointed Head of the Developmental and Cancer Biology laboratory, continuing his work in developmental biology and paediatric brain and solid cancers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Anatomy and Developmental Biology, PhD, Bone morphogenetic protein 4 and ureteric branching morphogenesis in the developing mouse kidney
2002 → 2006
Award Date: 20 Jun 2020
BSc, MONASH UNIVERSITY
1998 → 2000
Award Date: 17 Nov 2000
Postdoctoral Research Fellow, Hospital for Sick Children
2006 → 2010
BSc(Hons), MONASH UNIVERSITY
2001
Research area keywords
- Cancer biology
- Cancer epigenetics
- Childhood Disease
- Brain Cancer
- Lung Cancer
- mouse models
- Sarcoma
- Osteosarcoma
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Advancing Differentiation Therapy and Immunotherapy for Paediatric High-Grade Gliomas Through Targeted Epigenome Regulation
Wong, L. (Primary Chief Investigator (PCI)), Firestein, R. (Chief Investigator (CI)), Faridi, P. (Chief Investigator (CI)), Cain, J. (Chief Investigator (CI)), Khuong-Quang, D.-A. (Chief Investigator (CI)), Geraldine, O. (Chief Investigator (CI)), Dolcetti, R. (Chief Investigator (CI)), Ashley, D. (Chief Investigator (CI)), Jones, C. (Chief Investigator (CI)), Collas, P. (Chief Investigator (CI)), Sun, C. (Chief Investigator (CI)), Daniel, P. (Chief Investigator (CI)), Ekert, P. (Associate Investigator (AI)), Eisenstat, D. D. (Associate Investigator (AI)), Lou, J. (Associate Investigator (AI)), Resnick, A. (Associate Investigator (AI)), Goldstein, R. (Associate Investigator (AI)), Danaher, T. (Associate Investigator (AI)), Lucas, D. D. (Associate Investigator (AI)), De Rose, R. (Associate Investigator (AI)), Jabado, N. (Associate Investigator (AI)) & Mazzieri, R. (Associate Investigator (AI))
1/04/25 → 31/03/28
Project: Research
-
My Room Children's Cancer Charity Fellowship
Cain, J. (Primary Chief Investigator (PCI))
1/01/24 → 31/12/28
Project: Research
-
Robert Connor Dawes Foundation Travel Grant
Parackal, S. G. (Primary Chief Investigator (PCI)) & Cain, J. (Supervisor)
Trustee for The Robert Connor Dawes Foundation
26/09/22 → 30/09/22
Project: Research
-
The Victorian Paediatric Cancer Consortium: A Multi-institutional Partnership to Catalyze Advances in Childhood Cancer Research and Clinical Implementation
Firestein, R. (Primary Chief Investigator (PCI)), Eisenstat, D. D. (Chief Investigator (CI)), Conyers, R. (Chief Investigator (CI)), Downie, P. (Chief Investigator (CI)), Hansford, J. (Chief Investigator (CI)), Rosenbluh, S. (Chief Investigator (CI)), McCarthy, M. (Chief Investigator (CI)), Cain, J. (Chief Investigator (CI)), Jenkins, M. R. (Chief Investigator (CI)), Danaher, T. (Chief Investigator (CI)), Wong, L. (Associate Investigator (AI)), Southey, M. (Associate Investigator (AI)), Powell, D. (Associate Investigator (AI)), Daly, R. (Associate Investigator (AI)), Khuong-Quang, D.-A. (Associate Investigator (AI)), Ekert, P. (Associate Investigator (AI)), Lunke, S. (Associate Investigator (AI)), Carleton, B. C. (Associate Investigator (AI)), Neeson, P. J. (Associate Investigator (AI)) & Carder, J. (Associate Investigator (AI))
1/07/21 → 31/05/25
Project: Research
-
The development of precision vaccines for devastating paediatric brain tumours
Faridi, P. (Primary Chief Investigator (PCI)), Purcell, A. (Chief Investigator (CI)), Nazarian, J. (Chief Investigator (CI)), Hansford, J. R. (Chief Investigator (CI)), Jabado, N. (Chief Investigator (CI)), Linette, G. (Associate Investigator (AI)), Behren, A. (Associate Investigator (AI)), Cain, J. (Associate Investigator (AI)) & Ludlow, L. (Chief Investigator (CI))
19/03/21 → 18/03/25
Project: Research
-
A Semiautomated Proteomics and Phosphoproteomics Protocol for the Identification of Novel Therapeutic Targets and Predictive Biomarkers in In Vivo Xenograft Models of Pediatric Cancers
Lim Kam Sian, T. C., Sun, C., Cain, J. E., Steele, J. R., Hanchapola, I., Stoychev, S., Schittenhelm, R. B. & Faridi, P., 2024, Patient-Derived Xenografts: Methods and Protocols. Saad, M. I. (ed.). New York NY USA: Humana Press, p. 229-242 14 p. (Methods in Molecular Biology; vol. 2806).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
1 Citation (Scopus) -
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to recision therapies
Germon, Z. P., Sillar, J. R., Mannan, A., Duchatel, R. J., Staudt, D., Murray, H. C., Findlay, I. J., Jackson, E. R., McEwen, H. P., Douglas, A. M., McLachlan, T., Schjenken, J. E., Skerrett-Byrne, D. A., Huang, H., Melo-Braga, M. N., Plank, M. W., Alvaro, F., Chamberlain, J., Iuliis, G. D. & John Aitken, R. & 12 others, , 28 Mar 2023, In: Science Signaling. 16, 778, 18 p., eabp9586.Research output: Contribution to journal › Article › Research › peer-review
15 Citations (Scopus) -
Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
Venneti, S., Kawakibi, A. R., Ji, S., Waszak, S. M., Sweha, S. R., Mota, M., Pun, M., Deogharkar, A., Chung, C., Tarapore, R. S., Ramage, S., Chi, A., Wen, P. Y., Arrillaga-Romany, I., Batchelor, T. T., Butowski, N. A., Sumrall, A., Shonka, N., Harrison, R. A. & de Groot, J. & 64 others, , Nov 2023, In: Cancer Discovery. 13, 11, p. 2370-2393 24 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access84 Citations (Scopus) -
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
Sun, C. X., Daniel, P., Bradshaw, G., Shi, H., Loi, M., Chew, N., Parackal, S., Tsui, V., Liang, Y., Koptyra, M., Adjumain, S., Sun, C., Chong, W. C., Fernando, D., Drinkwater, C., Tourchi, M., Habarakada, D., Sooraj, D., Carvalho, D. & Storm, P. B. & 36 others, , 10 Apr 2023, In: Cancer Cell. 41, 4, p. 660-677.e7 26 p.Research output: Contribution to journal › Article › Research › peer-review
29 Citations (Scopus) -
Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study
White, C. L., Kinross, K. M., Moore, M. K., Rasouli, E., Strong, R., Jones, J. M., Cain, J. E., Sturm, D., Sahm, F., Jones, D. T. W., Pfister, S. M., Robertson, T., D'Arcy, C., Rodriguez, M. L., Dyke, J. M., Junckerstorff, R., Bhuva, D. D., Davis, M. J., Wood, P. & Hassall, T. & 14 others, , Oct 2023, In: The Journal of Molecular Diagnostics. 25, 10, p. 709-728 20 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)