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Personal profile


Jason is Head of the Developmental and Cancer Biology research group in Hudson Institute's Centre for Cancer Research. A developmental biologist, Jason is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease, including paediatric brain tumours (atypical teratoid rhabdoid tumours, diffuse intrinsic pontine glioma, and medulloblastoma), paediatric connective tissue cancers (sarcomas), and lung cancer.


Dr Jason Cain is a developmental biologist involved in full time basic research. After completing his BSc (2000), BSc(Hons) (2001) and PhD (2006) in the Department of Anatomy and Cell Biology at Monash University, Jason moved to The Hospital for Sick Children in Toronto, Canada to undertake his post-doctoral training. During his postdoctoral training in the Program of Developmental and Stem Cell Biology under the supervision of Dr Norman Rosenblum (Professor of Paediatrics, Senior Scientist, and Staff Nephrologist at Sickkids), Jason focused on the role of the Hedgehog signalling pathway in normal and abnormal kidney development. In late 2010, Jason returned to Australia to take up a position as a Research Fellow with Prof Neil Watkins (Professor of Cancer and Developmental Biology, NHMRC Senior Research Fellow, and Consultant Physician) at Hudson Institute of Medical Research. In 2014, Jason was appointed Head of the Developmental and Cancer Biology laboratory, continuing his work in developmental biology and paediatric brain and solid cancers.


Education/Academic qualification

Anatomy and Developmental Biology, PhD


Award Date: 20 Jun 2020



Award Date: 17 Nov 2000

Postdoctoral Research Fellow, Hospital for Sick Children




Research area keywords

  • Cancer biology
  • Cancer epigenetics
  • Childhood Disease
  • Brain Cancer
  • Lung Cancer
  • mouse models

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Research Output

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, Szczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2019, In : Oncogene. 38, 10, p. 1661-1675 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury

Verghese, E., Martelotto, L. G., Cain, J. E., Williams, T. M., Wise, A. F., Hill, P. A., Langham, R. G., Watkins, D. N., Ricardo, S. D. & Deane, J. A., 1 Nov 2019, In : BMC Research Notes. 12, 1, 5 p., 718.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction

Sheybani-Deloui, S., Chi, L., Staite, M. V., Cain, J. E., Nieman, B. J., Mark Henkelman, R., Wainwright, B. J., Steven Potter, S., Bagli, D. J., Lorenzo, A. J. & Rosenblum, N. D., 1 Feb 2018, In : Journal of the American Society of Nephrology. 29, 2, p. 532-544 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

Lim, C. H., Sun, Q., Ratti, K., Lee, S. H., Zheng, Y., Takeo, M., Lee, W., Rabbani, P., Plikus, M. V., Cain, J. E., Wang, D. H., Watkins, D. N., Millar, S., Taketo, M. M., Myung, P., Cotsarelis, G. & Ito, M., 21 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4903.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)