Projects per year
Personal profile
Biography
Jason is Head of the Developmental and Cancer Biology research group in Hudson Institute's Centre for Cancer Research. A developmental biologist, Jason is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease, including paediatric brain tumours (atypical teratoid rhabdoid tumours, diffuse intrinsic pontine glioma, and medulloblastoma), paediatric connective tissue cancers (sarcomas), and lung cancer.
Dr Jason Cain is a developmental biologist involved in full time basic research. After completing his BSc (2000), BSc(Hons) (2001) and PhD (2006) in the Department of Anatomy and Cell Biology at Monash University, Jason moved to The Hospital for Sick Children in Toronto, Canada to undertake his post-doctoral training. During his postdoctoral training in the Program of Developmental and Stem Cell Biology under the supervision of Dr Norman Rosenblum (Professor of Paediatrics, Senior Scientist, and Staff Nephrologist at Sickkids), Jason focused on the role of the Hedgehog signalling pathway in normal and abnormal kidney development. In late 2010, Jason returned to Australia to take up a position as a Research Fellow with Prof Neil Watkins (Professor of Cancer and Developmental Biology, NHMRC Senior Research Fellow, and Consultant Physician) at Hudson Institute of Medical Research. In 2014, Jason was appointed Head of the Developmental and Cancer Biology laboratory, continuing his work in developmental biology and paediatric brain and solid cancers.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2011 2022
Project 220: My Room Clinical Research Fellowship
Cain, J., Firestein, R. & Downie, P.
1/02/19 → 31/01/22
Project: Research
Identification of Epigenetic Therapeutic Targets in Malignant Rhabdoid Tumour
9/03/18 → 8/03/22
Project: Research
A Phase II Study of continuous, low-dose LBH 589 (Panobinostat) in Patients with Refractory Solid Tumors, including CNS tumors
Desai, J., Ashley, D. M., Cain, J., Gottardo, N. G., Wood, P. & Strong, R.
The Kids' Cancer Project, National Health & Medical Research Council (NHMRC)
1/07/17 → 31/12/21
Project: Research
AIM-BRAIN PROject: The AIM Brain PROject - Access to Innovative Molecular diagnostic PROfiling for paediatric brain tumours
Gottardo, N., Hansford, J. R., Downie, P., Cain, J., Ziegler, D., Strong, R. & Jones, J.
1/03/17 → 28/02/21
Project: Research
Mediator kinase as a therapeutic target for Wnt/B-catenin dependent malignancies
Firestein, R., Williams, B., Mathivanan, S. & Cain, J.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/20
Project: Research
Research Output 2005 2019
ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer
Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, , Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction
Sheybani-Deloui, S., Chi, L., Staite, M. V., Cain, J. E., Nieman, B. J., Mark Henkelman, R., Wainwright, B. J., Steven Potter, S., Bagli, D. J., Lorenzo, A. J. & Rosenblum, N. D., 1 Feb 2018, In : Journal of the American Society of Nephrology. 29, 2, p. 532-544 13 p.Research output: Contribution to journal › Article › Research › peer-review
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, , 7 Mar 2018, In : Oncogene. 38, 10, p. 1661-1675 15 p.Research output: Contribution to journal › Article › Research › peer-review
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Lim, C. H., Sun, Q., Ratti, K., Lee, S. H., Zheng, Y., Takeo, M., Lee, W., Rabbani, P., Plikus, M. V., Cain, J. E., Wang, D. H., Watkins, D. N., Millar, S., Taketo, M. M., Myung, P., Cotsarelis, G. & Ito, M., 21 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4903.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 others, , 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.Research output: Contribution to journal › Article › Research › peer-review