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Jason Cain

Dr

20052022
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Personal profile

Biography

Jason is a Research Fellow and Co-Head of the Developmental and Cancer Biology research group in Hudson Institute's Centre for Cancer Research. A developmental biologist, Jason is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease. In particular Jason's focus is on paediatric cancers including osteosarcoma, medulloblastoma, diffuse intrinsic pontine glioma and malignant rhabdoid tumours.



Dr Jason Cain is a developmental biologist involved in full time basic research. After completing his BSc (2000), BSc(Hons) (2001) and PhD (2006) in the Department of Anatomy and Cell Biology at Monash University, Jason moved to The Hospital for Sick Children in Toronto, Canada to undertake his post-doctoral training. During his postdoctoral training in the Program of Developmental and Stem Cell Biology under the supervision of Dr Norman Rosenblum (Professor of Paediatrics, Senior Scientist, and Staff Nephrologist at Sickkids), Jason focused on the role of the Hedgehog signalling pathway in normal and abnormal kidney development. In late 2010, Jason returned to Australia to take up a position as a Research Fellow with Prof Neil Watkins (Professor of Cancer and Developmental Biology, NHMRC Senior Research Fellow, and Consultant Physician) at Hudson Institute and accepted an appointment of Co-Head of the group in 2014.

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Projects 2011 2022

Project 220: My Room Clinical Research Fellowship

Cain, J., Firestein, R. & Downie, P.

1/02/19 → 31/01/22

Project: Research

Identification of Epigenetic Therapeutic Targets in Malignant Rhabdoid Tumour

Cain, J.

9/03/18 → 8/03/22

Project: Research

Paediatric Cancer Precision Medicine Pilot Program

Firestein, R., Cain, J., Downie, P., Gough, D., Williams, B., Abud, H., Rosenbluh, S., Algar, E. & Wood, P.

1/09/17 → 30/08/19

Project: Research

A Phase II Study of continuous, low-dose LBH 589 (Panobinostat) in Patients with Refractory Solid Tumors, including CNS tumors

Desai, J., Ashley, D. M., Cain, J., Gottardo, N. G., Wood, P. & Strong, R.

The Kids' Cancer Project, National Health & Medical Research Council (NHMRC)

1/07/17 → 31/12/21

Project: Research

AIM-BRAIN PROject: The AIM Brain PROject - Access to Innovative Molecular diagnostic PROfiling for paediatric brain tumours

Gottardo, N., Hansford, J., Downie, P., Cain, J., Ziegler, D., Strong, R. & Jones, J.

1/03/17 → 28/02/21

Project: Research

Research Output 2005 2019

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 othersRuwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., 4 Mar 2019, (Accepted/In press) In : EMBO Molecular Medicine. 19 p., e9976.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 othersSzczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2018, In : Oncogene. 38, 10, p. 1661-1675 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing

Lim, C. H., Sun, Q., Ratti, K., Lee, S. H., Zheng, Y., Takeo, M., Lee, W., Rabbani, P., Plikus, M. V., Cain, J. E., Wang, D. H., Watkins, D. N., Millar, S., Taketo, M. M., Myung, P., Cotsarelis, G. & Ito, M., 21 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4903.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 othersLorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N., 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.

Research output: Contribution to journal › Article › Research › peer-review

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In : Oncogene. 37, p. 1939-1948 10 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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