Projects per year
Personal profile
Biography
Jason is Head of the Developmental and Cancer Biology research group in Hudson Institute's Centre for Cancer Research. A developmental biologist, Jason is driving cutting-edge research to understand the role of critical embryonic signalling pathways and epigenetic mechanisms in normal and abnormal development and disease, including paediatric brain tumours (atypical teratoid rhabdoid tumours, diffuse intrinsic pontine glioma, and medulloblastoma), paediatric connective tissue cancers (sarcomas), and lung cancer.
Dr Jason Cain is a developmental biologist involved in full time basic research. After completing his BSc (2000), BSc(Hons) (2001) and PhD (2006) in the Department of Anatomy and Cell Biology at Monash University, Jason moved to The Hospital for Sick Children in Toronto, Canada to undertake his post-doctoral training. During his postdoctoral training in the Program of Developmental and Stem Cell Biology under the supervision of Dr Norman Rosenblum (Professor of Paediatrics, Senior Scientist, and Staff Nephrologist at Sickkids), Jason focused on the role of the Hedgehog signalling pathway in normal and abnormal kidney development. In late 2010, Jason returned to Australia to take up a position as a Research Fellow with Prof Neil Watkins (Professor of Cancer and Developmental Biology, NHMRC Senior Research Fellow, and Consultant Physician) at Hudson Institute of Medical Research. In 2014, Jason was appointed Head of the Developmental and Cancer Biology laboratory, continuing his work in developmental biology and paediatric brain and solid cancers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Anatomy and Developmental Biology, PhD
2002 → 2006
Award Date: 20 Jun 2020
BSc, MONASH UNIVERSITY
1998 → 2000
Award Date: 17 Nov 2000
Postdoctoral Research Fellow, Hospital for Sick Children
2006 → 2010
BSc(Hons), MONASH UNIVERSITY
2001
Research area keywords
- Cancer biology
- Cancer epigenetics
- Childhood Disease
- Brain Cancer
- Lung Cancer
- mouse models
Network
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The Victorian Paediatric Cancer Consortium: A Multi-institutional Partnership to Catalyze Advances in Childhood Cancer Research and Clinical Implementation
Firestein, R., Eisenstat, D. D., Conyers, R. K., Downie, P., Hansford, J., Rosenbluh, S., McCarthy, M., Cain, J., Jenkins, M. R., Danaher, T., Wong, L., Southey, M., Powell, D., Daly, R., Khuong-Quang, D., Ekert, P. G., Lunke, S., Carleton, B. C., Neeson, P. J. & Carder, J.
1/07/21 → 30/06/24
Project: Research
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The development of precision vaccines for devastating paediatric brain tumours
Faridi, P., Purcell, A., Nazarian, J., Hansford, J. R., Jabado, N., Linette, G., Behren, A. & Cain, J.
19/03/21 → 18/03/25
Project: Research
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Exploiting therapeutic vulnerability of Hedgehog activated osteosarcoma
Vaghjiani, V., Cain, J., Watkins, N., Desai, J. R., Sweet-Cordero, E. A., Rosenbluh, S., Ganju, V., Downie, P., Mudge, S., Wong, N. & Wilson, T.
19/03/21 → 18/03/24
Project: Research
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AIM BRAIN PROject: Access to Innovative Molecular diagnostic PROfiling for paediatric brain tumours
Gottardo, N. G., Hansford, J. R., Downie, P., Cain, J., Ziegler, D., Strong, R., Jones, J. & May, K.
Carrie Bickmore's Beanies 4 Brain Cancer Foundation
1/01/19 → 30/06/23
Project: Research
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A Phase II Study of continuous, low-dose LBH 589 (Panobinostat) in Patients with Refractory Solid Tumors, including CNS tumors
Desai, J. R., Ashley, D. M., Cain, J., Gottardo, N. G., Wood, P., Strong, R. & May, K.
Kids' Cancer Project, National Health and Medical Research Council (NHMRC) (Australia)
1/07/17 → 30/06/24
Project: Research
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Distinctive molecular features of regenerative stem cells in the damaged male germline
La, H. M., Liao, J., Legrand, J. M. D., Rossello, F. J., Chan, A-L., Vaghjiani, V., Cain, J. E., Papa, A., Lee, T. L. & Hobbs, R. M., 2022, In: Nature Communications. 13, 1, 17 p., 2500.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas
Przystal, J. M., Cianciolo Cosentino, C., Yadavilli, S., Zhang, J., Laternser, S., Bonner, E. R., Prasad, R., Dawood, A. A., Lobeto, N., Chin Chong, W., Biery, M. C., Myers, C., Olson, J. M., Panditharatna, E., Kritzer, B., Mourabit, S., Vitanza, N. A., Filbin, M. G., de Iuliis, G. N., Dun, M. D., & 6 others , 1 Sep 2022, In: Neuro-Oncology. 24, 9, p. 1438-1451 14 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium
Chen, J., Guanizo, A., Luong, Q., Jayasekara, W. S. N., Jayasinghe, D., Inampudi, C., Szczepny, A., Garama, D. J., Russell, P. A., Ganju, V., Cain, J. E., Watkins, D. N. & Gough, D. J., 3 Jan 2022, In: Oncogene. 41, 1, p. 138-145 8 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Findlay, I. J., De Iuliis, G. N., Duchatel, R. J., Jackson, E. R., Vitanza, N. A., Cain, J. E., Waszak, S. M. & Dun, M. D., Jan 2022, In: Oncogene. 41, 4, p. 461-475 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access15 Citations (Scopus) -
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
Rajal, A. G., Marzec, K. A., McCloy, R. A., Nobis, M., Chin, V., Hastings, J. F., Lai, K., Kennerson, M., Hughes, W. E., Vaghjiani, V., Timpson, P., Cain, J. E., Watkins, D. N., Croucher, D. R. & Burgess, A., May 2021, In: eLife. 10, 28 p., e65234.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus)