Projects per year
Developing diet strategies to treat functional gut disorders
Dr Jane Muir is currently Head of Translational Nutrition Science in the Department of Gastroenterology, Central Clinical School, Monash University.She is a trained dietitian with a PhD in biochemistry and has over 20 years experience in the area of nutrition research.Her major research focus has been on the important role of fermentable carbohydrates in the health of the gastrointestinal tract.
Jane has made a major contribution to understanding the role of resistant starch (RS) (starch that escapes digestion in the small intestine) in gastrointestinal health. In 1990, she developed an assay for measuring levels of resistant starch in food. This assay was then validated and used to construct diets which differ greatly in levels of starch escaping digestion (ie. low and high in resistant starch). These diets were used in subsequent studies to investigate the physiological significance of including resistant starch in the diet.
Since 2001, Jane has worked in collaboration with the Gastroenterologist- Prof Peter Gibson.
This position provided her with the opportunity to develop and extend her research in the area of carbohydrates in the gut further, while strengthening the role of Nutrition and Dietetic research in the clinical setting.
Her primary focus has been assisting with the development of new diet therapies to treat and control diet-related gastrointestinal dysfunction.
A major focus of their research involved a new area of carbohydrate research involving poorly absorbed short chain carbohydrates (called FODMAPs).
FODMAPs stands for Fermentable Oligo- Di- and Mono-saccharides And Polyols). FODMAPs are found in a wide variety of foods and include; excess fructose (in pears, apples), sugar polyols (sorbitol and mannitol in stone fruits and artificial sweeteners), lactose (in milk), fructans and fructo-oligosaccharides (FOS) (rye, artichoke, garlic, onions) and galacto-oligosaccharides (GOS) (stachyose, raffinose, in legumes and nuts).
Jane has helped to establish the laboratory techniques to quantify the FODMAP sugars in foods.
The group have now started assembling, for the first time, comprehensive FODMAP food composition tables, which has been essential for their research into studying the physiological effects of these sugars in the gastrointestinal tract.
These FODMAP food composition tables are also essential for designing new diet strategies for the treatment of gastrointestinal symptoms associated with Irritable Bowel Syndrome (IBS). Irritable bowel syndrome (IBS) is the most common disorder seen in gastroenterological practices and affects 1 in 7 Australians.
Research area keywords
- Gastrointestinal Function
- Dietary Fibre
- Irritable Bowel Syndrome
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Creating an evidence base for clinical care: A randomized controlled study examining the efficacy of the low FODMAP diet for the relief of gastrointestinal symptoms in endometriosis.
1/06/20 → 31/05/25
FODMAP: Changing therapeutic paradigms for intestinal health: Diet as a therapeutic strategy in Gastroenterology.
1/01/18 → 31/12/22
The impact of day-time and night-time endurance exercise on gastrointestinal integrity, functional responses, symptoms, and systemic endotoxin and cytokine profiles - A laboratory controlled mechanistic exploration of circadian variation influences in ultra-endurance athletes.
4/02/19 → 31/12/19
Comparing Costs and Outcomes of Treatments for Irritable Bowel Syndrome With Diarrhea: Cost-Benefit AnalysisShah, E. D., Salwen-Deremer, J. K., Gibson, P. R., Muir, J. G., Eswaran, S. & Chey, W. D., Jan 2022, In: Clinical Gastroenterology and Hepatology. 20, 1, p. 136-144.e31 40 p.
Research output: Contribution to journal › Article › Research › peer-review
Gibson, P. R., Halmos, E. P., So, D., Yao, C. K., Varney, J. E. & Muir, J. G., Apr 2022, In: Journal of Gastroenterology and Hepatology. 37, 4, p. 644-652 9 p.
Research output: Contribution to journal › Review Article › Research › peer-reviewOpen Access
Evaluating tolerability of resistant starch 2, alone and in combination with minimally fermented fibre for patients with irritable bowel syndrome: A pilot randomised controlled cross-over trialSo, D., Yao, C. K., Gibson, P. R. & Muir, J. G., 21 Feb 2022, In: Journal of Nutritional Science. 11, 7 p., e15.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access
Xiong, W., Devkota, L., Zhang, B., Muir, J. & Dhital, S., Mar 2022, In: Comprehensive Reviews in Food Science and Food Safety. 21, 2, p. 1198-1217 20 p.
Research output: Contribution to journal › Review Article › Other › peer-review
Letter: progressive weakening of the concept that gluten has a detrimental effect on mental health and gut symptoms in the absence of coeliac diseasePeters, S. L., Muir, J. G. & Gibson, P. R., Jul 2022, In: Alimentary Pharmacology & Therapeutics. 56, 2, p. 363-364 2 p.
Research output: Contribution to journal › Letter › Other › peer-reviewOpen Access