• B112, Pharmacology, 9 Ancora Imparo Way

    3800 Clayton

    Australia

1987 …2021
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Personal profile

Biography

Dr Jane Bourke is a Senior Lecturer in Pharmacology at Monash University, where she leads the Respiratory Pharmacology Group. She has a long-standing interest in the regulation of smooth muscle function in the lung and cardiovascular system. Her research focuses on identifying improved therapeutic strategies in chronic lung diseases, including asthma, COPD and pulmonary hypertension.

Jane has unique expertise in Australia with a novel lung slice technique in which changes in airway and artery lumen area and calcium signalling can be visualised. She has applied this to mouse, rat and sheep models that mimic key features of human lung diseases in both early and adult life. She discovered that ligands of an intracellular receptor, called peroxisome-proliferator activated receptor gamma (PPARandgamma) cause airways to relax under conditions where current drugs are ineffective. Her research group is now examining multiple novel bronchodilators and vasodilators targeting the lung to support their future clinical development.

 

Research area keywords

  • Asthma
  • COPD
  • Pulmonary Hypertension
  • Lung
  • Airway
  • Artery
  • Smooth Muscle
  • Calcium
  • Bronchodilator
  • Vasodilator

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2013 2021

Research Output 1987 2019

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults

Aldakheel, F. M., Bourke, J. E., Thomas, P. S., Matheson, M. C., Abramson, M. J., Hamilton, G. S., Lodge, C. J., Thompson, B. R., Haydn Walters, E., Allen, K. J., Erbas, B., Perret, J. L., Dharmage, S. C. & Lowe, A. J., Feb 2019, In : Clinical and Experimental Allergy. 49, 2, p. 171-179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Regulation of Airway Smooth Muscle Contraction in Health and Disease

Lam, M., Lamanna, E. & Bourke, J. E., 24 Jun 2019, Smooth Muscle Spontaneous Activity: Physiological and Pathological Modulation. Hashitani, H. & Lang, R. J. (eds.). Singapore: Springer, p. 381-422 42 p. (Advances in Experimental Medicine and Biology; vol. 1124).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases

Lam, M., Royce, S. G., Samuel, C. S. & Bourke, J. E., Jul 2018, In : Pharmacology and Therapeutics. 187, p. 61-70 10 p.

Research output: Contribution to journalArticleOtherpeer-review