Projects per year
Personal profile
Biography
Dr Jane Bourke is Associate Professor in Pharmacology at Monash University, where she leads the Respiratory Pharmacology Group. Her research focuses on identifying improved therapeutic strategies in chronic lung diseases. She has unique expertise in Australia with an innovative technique in which changes in intrapulmonary airway and artery lumen area can be visualized in situ in lung slices. With numerous local and international collaborators, she has applied this approach in preclinical studies in animal models of asthma, COPD, infection, pulmonary hypertension and bronchopulmonary dysplasia to study disease mechanisms and test novel therapeutic interventions. More recently, she has commenced studies using human tissues to facilitate clinical translation.
Jane has published her research in specialist respiratory and pharmacology journals (Thorax, European Respiratory Journal, American Journal of Respiratory Cell and Molecular Biology, American Journal of Physiology (Lung), Respiratory Research, Trends in Pharmacological Sciences, British Journal of Pharmacology) as well as multidisciplinary journals (Nature Communications, Clinical Science, Scientific Reports). She regularly reviews manuscripts and is currently an Editorial Board Member for Frontiers in Physiology and Scientific Reports.
Jane has completed several terms as an elected member of the Board of the Thoracic Society of Australia and New Zealand (TSANZ), where she chaired the Education and Research Subcommittee and Conference Committee. She was also President of the Asia Pacific Society of Respirology Congress, held in Sydney in 2017. Jane is currently a member of the Executive Committee of the Respiratory Structure and Function Assembly of the American Thoracic Society (ATS). She was made a Fellow of TSANZ in 2019 and Fellow of ATS in 2020 in recognitions of her contributions to respiratory research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Asthma
- COPD
- Pulmonary Hypertension
- Lung
- Airway
- Artery
- Smooth Muscle
- Calcium
- Bronchodilator
- Vasodilator
Collaborations and top research areas from the last five years
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Establishing non-invasive screening for early detection of silicosis
Bourke, J., Papagianis, P., Sim, C. T. K., Royce, S., Leong, T., Goh, N. S. L., Hoy, R., Harris, J. & Thomas, P. S.
21/06/23 → 21/06/25
Project: Research
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Blocking harmful lung damage during acute exacerbations of chronic obstructive pulmonary disease (COPD) caused by infections
Bourke, J., Bardin, P., Thomas, B., Payne, J., Chen, Y., Montgomery, B., Gosens, R., King, P., Dousha, L. & Royce, S.
1/01/23 → 31/12/25
Project: Research
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Establishing a novel human model for anti-fibrotic drug screening in silicosis
Bourke, J., Royce, S., Leong, T., Corrie, S., Harris, J., Sim, C. T. K., Hoy, R., Westall, G., Bardin, P. & Chen, Y.
iCare NSW (Insurance and Care NSW) (New South Wales)
1/01/23 → 27/03/26
Project: Research
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Assessing angiotensin type II receptor (AT2R) agonists as novel anti-fibrotics in the treatment of Idiopathic Pulmonary Fibrosis
Young, L., Bourke, J. & Widdop, R.
2/03/22 → 2/09/25
Project: Research
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Investigating the effect of FXII and CSL312 in ILD precision cut lung slice (PCLS)
13/04/22 → 19/06/23
Project: Research
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Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations
Haupt, S., Carcel, C., Halliday, L., Billiards, S., Carson, L., Redman, K., Lappan-Newton, S., Aubrey, K. R., Bickendorf, X., Bourke, J. E., Buchert, M., Duarte, J. D. G., Dasvarma, A., Drake-Brockman, T. F. E., Drysdale, K., Dymock, S. C. C., Eadie, L. N., Eckersley-Maslin, M., Eissmann, M. F., Fazio, J., & 25 others , 12 Feb 2025, In: Frontiers in Public Health. 12, 9 p., 1522213.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
The small-molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices
Studley, W. R., Lamanna, E., Martin, K. A., Nold-Petry, C. A., Royce, S. G., Woodman, O. L., Ritchie, R. H., Qin, C. X. & Bourke, J. E., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2287-2301 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways
Diao, J., Lam, M., Gregory, K. J., Leach, K. & Bourke, J. E., 1 Aug 2023, In: American Journal of Respiratory Cell and Molecular Biology. 69, 2, p. 182-196 15 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Catch your breath: The protective role of the angiotensin AT2 receptor for the treatment of idiopathic pulmonary fibrosis
Young, O. N., Bourke, J. E. & Widdop, R. E., Nov 2023, In: Biochemical Pharmacology. 217, 19 p., 115839.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Citations (Scopus) -
Perspectives on precision cut lung slices—powerful tools for investigation of mechanisms and therapeutic targets in lung diseases
Lam, M., Lamanna, E., Organ, L., Donovan, C. & Bourke, J. E., 2023, In: Frontiers in Pharmacology. 14, 14 p., 1162889.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access21 Citations (Scopus)
Prizes
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American Thoracic Society Neonatal and Developing Lung Abstract Award
Bourke, Jane (Recipient), 2016
Prize: Prize (including medals and awards)
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Fellow of the American Thoracic Society (ATSF)
Bourke, Jane (Recipient), 29 Nov 2019
Prize: Election to learned society
File -
Fellow of the Thoracic Society of Australia and New Zealand (FThorSoc)
Bourke, Jane (Recipient), 2019
Prize: Election to learned society
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Vice Chancellor's Diversity and Inclusion Award
Bourke, Jane (Recipient), 2017
Prize: Other distinction
File
Press/Media
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Monash Lens - Silicosis: Hormone hope in fight against deadly disease
2/08/19
1 item of Media coverage
Press/Media: Article/Feature
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thelimbic Respiratory - Holy Grail: Looking for a drug that reverses lung fibrosis
24/06/19
1 Media contribution
Press/Media: Profile/Interview
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American Thoracic Society - invited research profile
26/12/18
1 item of Media coverage
Press/Media: Profile/Interview