Projects per year
Personal profile
Biography
Dr Jane Bourke is Associate Professor in Pharmacology at Monash University, where she leads the Respiratory Pharmacology Group. Her research focuses on identifying improved therapeutic strategies in chronic lung diseases. She has unique expertise in Australia with an innovative technique in which changes in intrapulmonary airway and artery lumen area can be visualized in situ in lung slices. With numerous local and international collaborators, she has applied this approach in preclinical studies in animal models of asthma, COPD, infection, pulmonary hypertension and bronchopulmonary dysplasia to study disease mechanisms and test novel therapeutic interventions. More recently, she has commenced studies using human tissues to facilitate clinical translation.
Jane has published her research in specialist respiratory and pharmacology journals (Thorax, European Respiratory Journal, American Journal of Respiratory Cell and Molecular Biology, American Journal of Physiology (Lung), Respiratory Research, Trends in Pharmacological Sciences, British Journal of Pharmacology) as well as multidisciplinary journals (Nature Communications, Clinical Science, Scientific Reports). She regularly reviews manuscripts and is currently an Editorial Board Member for Frontiers in Physiology and Scientific Reports.
Jane has completed several terms as an elected member of the Board of the Thoracic Society of Australia and New Zealand (TSANZ), where she chaired the Education and Research Subcommittee and Conference Committee. She was also President of the Asia Pacific Society of Respirology Congress, held in Sydney in 2017. Jane is currently a member of the Executive Committee of the Respiratory Structure and Function Assembly of the American Thoracic Society (ATS). She was made a Fellow of TSANZ in 2019 and Fellow of ATS in 2020 in recognitions of her contributions to respiratory research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Asthma
- COPD
- Pulmonary Hypertension
- Lung
- Airway
- Artery
- Smooth Muscle
- Calcium
- Bronchodilator
- Vasodilator
Network
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Blocking harmful lung damage during acute exacerbations of chronic obstructive pulmonary disease (COPD) caused by infections
Bourke, J., Bardin, P., Thomas, B., Payne, J., Chen, Y., Montgomery, B., Gosens, R., King, P., Dousha, L. & Royce, S.
1/01/23 → 31/12/25
Project: Research
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Establishing a novel human model for anti-fibrotic drug screening in silicosis
Bourke, J., Royce, S., Leong, T., Corrie, S., Harris, J., Sim, C., Hoy, R., Westall, G., Bardin, P. & Chen, Y.
iCare NSW (Insurance and Care NSW) (New South Wales)
1/01/23 → 27/03/26
Project: Research
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Investigating the effect of FXII and CSL312 in ILD precision cut lung slice (PCLS)
13/04/22 → 19/06/23
Project: Research
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SCIREQ inExpose system
Winship, A., Carroll, J., Bourke, J., Simonds, S., Heng, T., Hutt, K., Stringer, J., Western, P., Coelho Marques, F. & Abud, H.
1/10/21 → 31/12/22
Project: Research
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Targeting fibrosis with relaxin – a new therapeutic strategy for IPF and silicosis
Bourke, J. & Sim, C.
1/04/21 → 31/03/22
Project: Research
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The Role of the Interleukin-1 Family in Complications of Prematurity
Green, E. A., Garrick, S. P., Peterson, B., Berger, P. J., Galinsky, R., Hunt, R. W., Cho, S. X., Bourke, J. E., Nold, M. F. & Nold-Petry, C. A., Feb 2023, In: International Journal of Molecular Sciences. 24, 3, 29 p., 2795.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Bimodal fibrosis in a novel mouse model of bleomycin-induced usual interstitial pneumonia
Miura, Y., Lam, M., Bourke, J. E. & Kanazawa, S., Jan 2022, In: Life Science Alliance. 5, 1, 14 p., 101059.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Nurturing respiratory clinician-scientists—An important priority in the Asia-Pacific and for the Asia-Pacific Society of Respirology (APSR)
Bardin, P. G. & Bourke, J., Jul 2022, In: Respirology. 27, 7, p. 490-492 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung
Miura, Y., Ohkubo, H., Nakano, A., Bourke, J. E. & Kanazawa, S., 4 Nov 2022, In: Frontiers in Immunology. 13, 14 p., 1028613.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms
Royce, S. G., Licciardi, P. V., Beh, R. C., Bourke, J. E., Donovan, C., Hung, A., Khurana, I., Liang, J. J., Maxwell, S., Mazarakis, N., Pitsillou, E., Siow, Y. Y., Snibson, K. J., Tobin, M. J., Ververis, K., Vongsvivut, J., Ziemann, M., Samuel, C. S., Tang, M. L. K., El-Osta, A., & 1 others , Nov 2022, In: Cellular and Molecular Life Sciences. 79, 11, 22 p., 579.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)
Prizes
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American Thoracic Society Neonatal and Developing Lung Abstract Award
Bourke, Jane (Recipient), 2016
Prize: Prize (including medals and awards)
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Fellow of the American Thoracic Society (ATSF)
Bourke, Jane (Recipient), 29 Nov 2019
Prize: Election to learned society
File -
Fellow of the Thoracic Society of Australia and New Zealand (FThorSoc)
Bourke, Jane (Recipient), 2019
Prize: Election to learned society
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Vice Chancellor's Diversity and Inclusion Award
Bourke, Jane (Recipient), 2017
Prize: Other distinction
File
Press/Media
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Monash Lens - Silicosis: Hormone hope in fight against deadly disease
2/08/19
1 item of Media coverage
Press/Media: Article/Feature
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thelimbic Respiratory - Holy Grail: Looking for a drug that reverses lung fibrosis
24/06/19
1 Media contribution
Press/Media: Profile/Interview
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American Thoracic Society - invited research profile
26/12/18
1 item of Media coverage
Press/Media: Profile/Interview