• Ground floor, 19 Innovation walk, Monash university

    3800 Clayton campus

    Australia

19962019
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Personal profile

Biography

Prof. Jamie Rossjohn

Academic Qualifications - FAA FAHMS FLSW FMedSci

Professor Jamie Rossjohn's research is centered on an understanding immunity.

He is currently an ARC Australian Laureate Fellow (2017-2021) and previously a NHMRC Australia Fellow (2011-2016) and ARC Federation Fellow (2007-11). He is the Head of the Infection and Immunity Program of the Biomedicine Discovery Institute.

Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.  Collectively, he has published > 365 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.

 

 

 

Keywords

  • X-Ray Crystallography
  • Structural Biology
  • Immunology
  • Infection and Immunity
  • Protein structure
  • Autoimmunity
  • T cells
  • immune recognition
  • MHC
  • MAIT cells

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Research Output 1996 2019

A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells

Dey, S., Vaidyanathan, R., Reza, K. K., Wang, J., Wang, Y., Nel, H. J., Law, S. C., Tyler, J., Rossjohn, J., Reid, H. H., Ibn Sina, A. A., Thomas, R. & Trau, M., 1 Apr 2019, In : Sensors and Actuators, B: Chemical. 284, p. 281-288 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T. Y., Minnaard, A. J., Altman, J. D., Lenz, S., Prandi, J., Kubler-Kielb, J., Moody, D. B., Rossjohn, J. & Van Rhijn, I., 4 Jan 2019, In : Nature Communications. 10, 1, 12 p., 56.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Discriminative T-cell receptor recognition of highly homologous HLA-DQ2– bound gluten epitopes

Dahal-Koirala, S., Ciacchi, L., Petersen, J., Risnes, L. F., Neumann, R. S., Christophersen, A., Lundin, K. E. A., Reid, H. H., Qiao, S. W., Rossjohn, J. & Sollid, L. M., 18 Jan 2019, In : Journal of Biological Chemistry. 294, 3, p. 941-952 12 p.

Research output: Contribution to journalArticleResearchpeer-review

H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

Schinkelshoek, M. S., Fronczek, R., Kooy-Winkelaar, E. M. C., Petersen, J., Reid, H. H., van der Heide, A., Drijfhout, J. W., Rossjohn, J., Lammers, G. J. & Koning, F., 15 Jul 2019, In : Journal of Neuroimmunology. 332, p. 167-175 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 othersJackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 2019, (Accepted/In press) In : Nature Immunology. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2017 2017

  • 1 ​Hosting an academic or industry visitor

Roeland Lameris

Adam Shahine (Host), Jamie Rossjohn (Host)
2 Feb 201718 Jun 2017

Activity: Hosting a visitor types​Hosting an academic or industry visitor

Press / Media

Paper: A molecule with more to say in autoimmune diseases

Adam Shahine, Jamie Rossjohn & D Branch Moody

23/10/17

1 media contribution

Press/Media: Expert Comment