• Ground floor, 19 Innovation walk, Monash university

    3800 Clayton campus

    Australia

Accepting PhD Students

1996 …2024

Research activity per year

Personal profile

Biography

Prof. Jamie Rossjohn, FAA FAHMS FLSW FMedSci FRS

Professor Jamie Rossjohn's research is centered on an understanding immunity.

He is currently a NHMRC Investigator L3 Fellow (2022-26) and previously an ARC Australian Laureate Fellow (2017-21), NHMRC Australia Fellow (2011-16) and ARC Federation Fellow (2007-11). He was the former Head of the Infection and Immunity Program (2016-19) of the Biomedicine Discovery Institute.

Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.  Collectively, he has published > 465 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.

In 2022, Prof. Rossjohn was elected as a Fellow of the Royal Society and Associate Member of EMBO.

 

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 14 - Life Below Water

Research area keywords

  • X-Ray Crystallography
  • Structural Biology
  • Immunology
  • Infection and Immunity
  • Protein structure
  • Autoimmunity
  • T cells
  • immune recognition
  • MHC
  • MAIT cells

Collaborations and top research areas from the last five years

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