• Ground floor, 19 Innovation walk, Monash university

    3800 Clayton campus

    Australia

19962019
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Personal profile

Biography

Prof. Jamie Rossjohn, FAA FAHMS FLSW FMedSci

Professor Jamie Rossjohn's research is centered on an understanding immunity.

He is currently an ARC Australian Laureate Fellow (2017-2021) and previously a NHMRC Australia Fellow (2011-2016) and ARC Federation Fellow (2007-11). 

Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.  Collectively, he has published > 387 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.

 

 

 

Research area keywords

  • X-Ray Crystallography
  • Structural Biology
  • Immunology
  • Infection and Immunity
  • Protein structure
  • Autoimmunity
  • T cells
  • immune recognition
  • MHC
  • MAIT cells

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction

Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., 14 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bbz051.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells

Dey, S., Vaidyanathan, R., Reza, K. K., Wang, J., Wang, Y., Nel, H. J., Law, S. C., Tyler, J., Rossjohn, J., Reid, H. H., Ibn Sina, A. A., Thomas, R. & Trau, M., 1 Apr 2019, In : Sensors and Actuators B: Chemical. 284, p. 281-288 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Ooi, J. D., Jiang, J-H., Eggenhuizen, P. J., Chua, L. L., van Timmeren, M., Loh, K. L., O’Sullivan, K. M., Gan, P. Y., Zhong, Y., Tsyganov, K., Shochet, L. R., Ryan, J., Stegeman, C. A., Fugger, L., Reid, H. H., Rossjohn, J., Heeringa, P., Holdsworth, S. R., Peleg, A. Y. & Kitching, A. R., 29 Jul 2019, In : Nature Communications. 10, 1, 14 p., 3392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44

Niehrs, A., Garcia-Beltran, W. F., Norman, P. J., Watson, G. M., Hölzemer, A., Chapel, A., Richert, L., Pommerening-Röser, A., Körner, C., Ozawa, M., Martrus, G., Rossjohn, J., Lee, J-H., Berry, R., Carrington, M. & Altfeld, M., 29 Jul 2019, In : Nature Immunology. 20, 9, p. 1129-1137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T. Y., Minnaard, A. J., Altman, J. D., Lenz, S., Prandi, J., Kubler-Kielb, J., Moody, D. B., Rossjohn, J. & Van Rhijn, I., 4 Jan 2019, In : Nature Communications. 10, 1, 12 p., 56.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2017 2017

  • 1 ​Hosting an academic or industry visitor

Roeland Lameris

Adam Shahine (Host), Jamie Rossjohn (Host)
2 Feb 201718 Jun 2017

Activity: Hosting a visitor types​Hosting an academic or industry visitor

Press / Media

Paper: A molecule with more to say in autoimmune diseases

Adam Shahine, Jamie Rossjohn & D Branch Moody

23/10/17

1 Media contribution

Press/Media: Expert Comment