• Ground floor, 19 Innovation walk, Monash university

    3800 Clayton campus



Research output per year

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Personal profile


Prof. Jamie Rossjohn, FAA FAHMS FLSW FMedSci

Professor Jamie Rossjohn's research is centered on an understanding immunity.

He is currently an ARC Australian Laureate Fellow (2017-2021) and previously a NHMRC Australia Fellow (2011-2016) and ARC Federation Fellow (2007-11). 

Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.  Collectively, he has published > 387 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.




Research area keywords

  • X-Ray Crystallography
  • Structural Biology
  • Immunology
  • Infection and Immunity
  • Protein structure
  • Autoimmunity
  • T cells
  • immune recognition
  • MHC
  • MAIT cells

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease

Ting, Y. T., Dahal-Koirala, S., Kim, H. S. K., Qiao, S. W., Neumann, R. S., Lundin, K. E. A., Petersen, J., Reid, H. H., Sollid, L. M. & Rossjohn, J., 11 Feb 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3063-3073 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Fugger, L., Jensen, L. T. & Rossjohn, J., 2 Apr 2020, In : Cell. 181, 1, p. 63-80 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

Crowther, M. D., Dolton, G., Legut, M., Caillaud, M. E., Lloyd, A., Attaf, M., Galloway, S. A. E., Rius, C., Farrell, C. P., Szomolay, B., Ager, A., Parker, A. L., Fuller, A., Donia, M., McCluskey, J., Rossjohn, J., Svane, I. M., Phillips, J. D. & Sewell, A. K., Feb 2020, In : Nature Immunology. 21, 2, p. 178-185 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Human mucosal-associated invariant t cells in older individuals display expanded tcrαβ clonotypes with potent antimicrobial responses

Loh, L., Gherardin, N. A., Sant, S., Grzelak, L., Crawford, J. C., Bird, N. L., Koay, H. F., Van De Sandt, C. E., Moreira, M. L., Lappas, M., Allen, E. K., Crowe, J., Loudovaris, T., Flanagan, K. L., Quinn, K. M., Rossjohn, J., Thomas, P. G., Eckle, S. B. G., McCluskey, J., Godfrey, D. I. & 1 others, Kedzierska, K., 1 Mar 2020, In : Journal of Immunology. 204, 5, p. 1119-1133 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products

Nicolai, S., Wegrecki, M., Cheng, T. Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., Monnot, G. C., Le Nours, J., Van Rhijn, I., Rossjohn, J., Moody, D. B. & de Jong, A., 3 Jan 2020, In : Science Immunology. 5, 43, 13 p., eaax5430.

Research output: Contribution to journalArticleResearchpeer-review


  • 1 ​Hosting an academic or industry visitor

Roeland Lameris

Adam Shahine (Host), & Jamie Rossjohn (Host)

2 Feb 201718 Jun 2017

Activity: Hosting a visitor types​Hosting an academic or industry visitor

Press / Media

Paper: A molecule with more to say in autoimmune diseases

Adam Shahine, Jamie Rossjohn & D Branch Moody


1 Media contribution

Press/Media: Expert Comment