• Ground floor, 19 Innovation walk, Monash university

    3800 Clayton campus

    Australia

19972018
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Personal profile

Biography

Prof. Jamie Rossjohn

Academic Qualifications - FAA FAHMS FLSW FMedSci

Professor Jamie Rossjohn's research is centered on an understanding immunity.

He is currently an ARC Australian Laureate Fellow (2017-2021) and previously a NHMRC Australia Fellow (2011-2016) and ARC Federation Fellow (2007-11). He is the Head of the Infection and Immunity Program of the Biomedicine Discovery Institute.

Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.  Collectively, he has published > 365 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.

 

 

 

Keywords

  • X-Ray Crystallography
  • Structural Biology
  • Immunology
  • Infection and Immunity
  • Protein structure
  • Autoimmunity
  • T cells
  • immune recognition
  • MHC
  • MAIT cells

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Research Output 1997 2018

An overview on the identification of MAIT cell antigens

Kjer-Nielsen, L., Corbett, A. J., Chen, Z., Liu, L., Mak, J. Y., Godfrey, D. I., Rossjohn, J., Fairlie, D. P., Mccluskey, J. & Eckle, S. B. Jul 2018 In : Immunology and Cell Biology. 96, 6, p. 573-587 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function

Sundararaj, S., Zhang, J., Krovi, S. H., Bedel, R., Tuttle, K. D., Veerapen, N., Besra, G. S., Khandokar, Y., Praveena, T., Le Nours, J., Matsuda, J. L., Rossjohn, J. & Gapin, L. 6 Feb 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. E1204-E1213 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Chan, K. F., Gully, B. S., Gras, S., Beringer, D. X., Kjer-Nielsen, L., Cebon, J., McCluskey, J., Chen, W. & Rossjohn, J. 1 Dec 2018 In : Nature Communications. 9, 1, 13 p., 1026

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity

Chennamadhavuni, D., Saavedra-Avila, N. A., Carreño, L. J., Guberman-Pfeffer, M. J., Arora, P., Yongqing, T., Koay, H. F., Godfrey, D. I., Keshipeddy, S., Richardson, S. K., Sundararaj, S., Lo, J. H., Wen, X., Gascón, J. A., Yuan, W., Rossjohn, J., Le Nours, J., Porcelli, S. A. & Howell, A. R. 17 May 2018 In : Cell Chemical Biology. 25, 5, p. 571-584 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Flow cytometric clinical immunomonitoring using peptide-MHC class II tetramers: Optimization of methods and protocol development

Jansen, D. T. S. L., Ramnoruth, N., Loh, K. L., Rossjohn, J., Reid, H. H., Nel, H. J. & Thomas, R. 22 Jan 2018 In : Frontiers in Immunology. 9, 10 p., 8

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2017 2017

  • 1 ​Hosting an academic or industry visitor

Roeland Lameris

Shahine, A. (Host), Rossjohn, J. (Host)
2 Feb 201718 Jun 2017

Activity: ​Hosting an academic or industry visitor

Press / Media

Paper: A molecule with more to say in autoimmune diseases

Adam Shahine, Jamie Rossjohn & D Branch Moody

23/10/17

1 media contribution

Press/Media: Expert Comment