• Ground floor, 19 Innovation walk, Monash university

    3800 Clayton campus


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Personal profile


Prof. Jamie Rossjohn, FAA FAHMS FLSW FMedSci

Professor Jamie Rossjohn's research is centered on an understanding immunity.

He is currently an ARC Australian Laureate Fellow (2017-2021) and previously a NHMRC Australia Fellow (2011-2016) and ARC Federation Fellow (2007-11). 

Prof. Rossjohn is known for his contributions to the understanding the molecular basis underpinning immunity. He has used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. He has unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. He has pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently he has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.  Collectively, he has published > 387 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.




Research area keywords

  • X-Ray Crystallography
  • Structural Biology
  • Immunology
  • Infection and Immunity
  • Protein structure
  • Autoimmunity
  • T cells
  • immune recognition
  • MHC
  • MAIT cells

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2020

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products

Nicolai, S., Wegrecki, M., Cheng, T. Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., Monnot, G. C., Le Nours, J., Van Rhijn, I., Rossjohn, J., Moody, D. B. & de Jong, A., 3 Jan 2020, In : Science Immunology. 5, 43, 13 p., eaax5430.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Petersen, J., Ciacchi, L., Tran, M. T., Loh, K. L., Kooy-Winkelaar, Y., Croft, N. P., Hardy, M. Y., Chen, Z., McCluskey, J., Anderson, R. P., Purcell, A. W., Tye-Din, J. A., Koning, F., Reid, H. H. & Rossjohn, J., Jan 2020, In : Nature Structural and Molecular Biology. 27, p. 49-61 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction

Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., 14 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bbz051.

Research output: Contribution to journalReview ArticleResearchpeer-review

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Lim Kam Sian, T. C. C., Indumathy, S., Halim, H., Greule, A., Cryle, M. J., Bowness, P., Rossjohn, J., Gras, S., Purcell, A. W. & Schittenhelm, R. B., 27 Dec 2019, In : Journal of Biological Chemistry. 294, 52, p. 20185-20195 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2017 2017

  • 1 ​Hosting an academic or industry visitor

Roeland Lameris

Adam Shahine (Host), Jamie Rossjohn (Host)
2 Feb 201718 Jun 2017

Activity: Hosting a visitor types​Hosting an academic or industry visitor

Press / Media

Paper: A molecule with more to say in autoimmune diseases

Adam Shahine, Jamie Rossjohn & D Branch Moody


1 Media contribution

Press/Media: Expert Comment