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Personal profile


Professor D. James Cooper AO 


Professor Jamie Cooper is Director of the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University; Director of the NHMRC Centre of Research Excellence for Patient Blood Management in Critical Illness and Trauma (Blood-CRE), Monash University; Director of Critical Care Research in the School of Public Health and Preventive Medicine (SPHPM), Monash University; and Head of Research and Deputy Director of the Department of Intensive Care at The Alfred Hospital, Melbourne.  In 2017, he was awarded an Officer of the Order of Australia (AO) for distinguished service to intensive care medicine in the field of traumatic brain injury as a clinician, and to medical education as an academic, researcher and author. He is a National Health and Medical Research Council (NHMRC) Practitioner Fellow, full Professor of Intensive Care Medicine at Monash University and Hon. Professorial Fellow in the Critical Care and Trauma Division at The George Institute, University of Sydney. He has published >300 journal papers including 18 in New England Journal of Medicine (NEJM), Lancet, and Journal of the American Medical Association (JAMA). He has been a Principal or Co-investigator on peer reviewed research grants exceeding $70m including 30 NHMRC grants. Research foci include randomised clinical trials in traumatic brain injury (TBI), sepsis, acute lung injury, resuscitation fluids, and blood transfusion.

He has published three landmark trials including the DECRA trial (CIA NHMRC#314502), which demonstrated unexpectedly inferior long-term outcomes for an increasingly popular neurosurgical intervention (early decompressive craniectomy) that was opposite to apparent short-term benefits, and has initiated international TBI practice review. The trial results were fast tracked for NEJM publication (Cooper DJ, et al. 2011) and were editorialised in the Lancet as “one of the most important clinical trials of a therapy for severe TBI ever conducted”. The trial results have been a watershed in changing current practice and have proved invaluable from both an individual patient and community perspective. This was the first Level I evidence in this area and has been incorporated into the international Brain Trauma Foundation practice guidelines. Using alternative therapies will improve TBI patient outcomes and substantially reduce health care spending on lifetime care of severe disability survivors. DECRA was included in Yale University’s 50 most important papers of all time “that shaped the current clinical practice of neurology” and was also included in the “50 of the most important studies in Critical Care Medicine” by Harvard University and Oxford University Press.

Research area keywords

  • Acute lung injury
  • Blood transfusion
  • Decompressive craniectomy
  • Resuscitation fluids
  • Sepsis
  • Traumatic brain injury

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Projects 2000 2024

Research Output 1986 2020

Early osmotherapy in severe traumatic brain injury: An international multicenter study

Anstey, J. R., Taccone, F. S., Udy, A. A., Citerio, G., Duranteau, J., Ichai, C., Badenes, R., Prowle, J. R., Ercole, A., Oddo, M., Schneider, A. G., Van Der Jagt, M., Wolf, S., Helbok, R., Nelson, D. W., Skrifvars, M. B., Harrois, A., Presneill, J., Cooper, D. J., Bailey, M. & 2 others, Bellomo, R. & on behalf of The TBI Collaborative, 1 Jan 2020, In : Journal of Neurotrauma. 37, 1, p. 178-184 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Age of Red Blood Cells for Transfusion in Critically Ill Pediatric Patients

McQuilten, Z. K. & Cooper, D. J., 10 Dec 2019, In : JAMA. 322, 22, p. 2175-2176 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

3 Citations (Scopus)

Aspirin in coronary artery surgery: 1-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery trial

Myles, P. S., Smith, J. A., Kasza, J., Silbert, B., Jayarajah, M., Painter, T., Cooper, D. J., Marasco, S., McNeil, J., Bussières, J. S., McGuinness, S., Chan, M. T. V., Wallace, S., Forbes, A. & for the ATACAS investigators and the ANZCA Clinical Trials Network, Feb 2019, In : Journal of Thoracic and Cardiovascular Surgery. 157, 2, p. 633-640

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study

Steyerberg, E. W., Wiegers, E., Sewalt, C., Buki, A., Citerio, G., De Keyser, V., Ercole, A., Kunzmann, K., Lanyon, L., Lecky, F., Lingsma, H., Manley, G., Nelson, D., Peul, W., Stocchetti, N., von Steinbüchel, N., Vande Vyvere, T., Verheyden, J., Wilson, L., Maas, A. I. R. & 2 others, Menon, D. K. & CENTER-TBI Investigators and Participants, Oct 2019, In : The Lancet Neurology. 18, 10, p. 923-934 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury: Consensus statement

Hutchinson, P. J., Kolias, A. G., Tajsic, T., Adeleye, A., Aklilu, A. T., Apriawan, T., Bajamal, A. H., Barthélemy, E. J., Devi, B. I., Bhat, D., Bulters, D., Chesnut, R., Citerio, G., Cooper, D. J., Czosnyka, M., Edem, I., El-Ghandour, N. M. F., Figaji, A., Fountas, K. N., Gallagher, C. & 31 others, Hawryluk, G. W. J., Iaccarino, C., Joseph, M., Khan, T., Laeke, T., Levchenko, O., Liu, B., Liu, W., Maas, A., Manley, G. T., Manson, P., Mazzeo, A. T., Menon, D. K., Michael, D. B., Muehlschlegel, S., Okonkwo, D. O., Park, K. B., Rosenfeld, J. V., Rosseau, G., Rubiano, A. M., Shabani, H. K., Stocchetti, N., Timmons, S. D., Timofeev, I., Uff, C., Ullman, J. S., Valadka, A., Waran, V., Wells, A., Wilson, M. H. & Servadei, F., 1 Jul 2019, In : Acta Neurochirurgica. 161, 7, p. 1261-1274 14 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access


AMREP (Alfred Research and Medical Education Precinct) Research Prize

Jamie Cooper (Recipient), Oct 2016

Prize: Prize (including medals and awards)

AMREP (Alfred Research and Medical Education Precinct) Research Prize

Jamie Cooper (Recipient), Oct 2011

Prize: Prize (including medals and awards)

David Sloane Prize to DJ Cooper for the Best Free Paper

Jamie Cooper (Recipient), Jul 2004

Prize: Prize (including medals and awards)