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Personal profile


Professor (DJ) Jamie Cooper AO BMBS MD FRACP FCICM FAHMS 

Professor Cooper is Director of the Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University; Director of the NHMRC Centre of Research Excellence for Patient Blood Management in Critical Illness and Trauma (Blood-CRE), Monash University; Director of Critical Care Research in the School of Public Health and Preventive Medicine (SPHPM), Monash University; and Interim Director of the Department of Intensive Care at The Alfred Hospital, Melbourne.  In 2017, he was awarded an Officer of the Order of Australia (AO) for distinguished service to intensive care medicine in the field of traumatic brain injury as a clinician, and to medical education as an academic, researcher and author. He is a National Health and Medical Research Council (NHMRC) Practitioner Fellow, full Professor of Intensive Care Medicine at Monash University and Hon. Professorial Fellow in the Critical Care and Trauma Division at The George Institute, University of Sydney. He has published more than 270 journal papers including 18 in New England Journal of Medicine (NEJM), Lancet, and Journal of the American Medical Association (JAMA). He has been a Principal or Co-investigator on peer reviewed research grants exceeding $58m including 26 NHMRC grants. Research foci include randomised clinical trials in traumatic brain injury (TBI), sepsis, acute lung injury, resuscitation fluids, and blood transfusion.

He has published three landmark trials including the DECRA trial (CIA NHMRC#314502), which demonstrated unexpectedly inferior long-term outcomes for an increasingly popular neurosurgical intervention (early decompressive craniectomy) that was opposite to apparent short-term benefits, and has initiated international TBI practice review. The trial results were fast tracked for NEJM publication (Cooper DJ, et al. 2011) and were editorialised in the Lancet as “one of the most important clinical trials of a therapy for severe TBI ever conducted”. The trial results have been a watershed in changing current practice and have proved invaluable from both an individual patient and community perspective. This was the first Level I evidence in this area and has been incorporated into the international Brain Trauma Foundation practice guidelines. Using alternative therapies will improve TBI patient outcomes and substantially reduce health care spending on lifetime care of severe disability survivors. DECRA was included by Yale University in the top 50 most important Neurological papers of all time.


  • Acute lung injury
  • Blood transfusion
  • Decompressive craniectomy
  • Resuscitation fluids
  • Sepsis
  • Traumatic brain injury

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Projects 2000 2022

Research Output 1998 2018

Cause and Timing of Death and Subgroup Differential Effects of Erythropoietin in the EPO-TBI Study

Skrifvars, M. B., French, C., Bailey, M., Presneill, J., Nichol, A., Little, L., Durantea, J., Huet, O., Haddad, S., Arabi, Y., McArthur, C., Cooper, D. J., Bellomo, R. & EPO-TBI Investigators and the ANZICS Clinical Trials Group, 15 Jan 2018, In : Journal of Neurotrauma. 35, 2, p. 333-340 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Day or overnight transfusion in critically ill patients: Does it matter?

The Blood Observational Study investigators & The ANZICS Clinical Trials Group, Apr 2018, In : Vox Sanguinis. 113, 3, p. 275-282 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of age of red cells for transfusion on patient outcomes: a systematic review and meta-analysis

McQuilten, Z. K., French, C. J., Nichol, A., Higgins, A. & Cooper, D. J., 1 Apr 2018, In : Transfusion Medicine Reviews. 32, 2, p. 77-88 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: A multinational prospective longitudinal cohort study

Shehabi, Y., Bellomo, R., Kadiman, S., Ti, L. K., Howe, B., Reade, M. C., Khoo, T. M., Alias, A., Wong, Y. L., Mukhopadhyay, A., McArthur, C., Seppelt, I., Webb, S. A., Green, M., Bailey, M. J. & for the Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, 1 Jan 2018, In : Critical Care Medicine. 46, 6, p. 850-859 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Statistical analysis plan for the POLAR-RCT: The Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial

Presneill, J., Gantner, D., Nichol, A., McArthur, C., Forbes, A., Kasza, J., Trapani, T., Murray, L., Bernard, S., Cameron, P., Capellier, G., Huet, O., Newby, L., Rashford, S., Rosenfeld, J. V., Smith, T., Stephenson, M., Varma, D., Vallance, S., Walker, T. & 2 othersWebb, S. & James Cooper, D., 27 Apr 2018, In : Trials. 19, 1, 10 p., 259.

Research output: Contribution to journalArticleResearchpeer-review

Open Access