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Research Output 1997 2019

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2000
77 Citations (Scopus)

Cleaved antitrypsin polymers at atomic resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B. F., Parker, M. W. & Bottomley, S. P., 13 Mar 2000, In : Protein Science. 9, 2, p. 417-420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cleaved antitrypsin polymers at atominc resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B., Parker, M. W. & Bottomley, S. P., 2000, In : Protein Science. p. 417 - 420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Conformational changes in serpins: 1. The native and cleaved conformations of alpha1-antitrypsin

Whisstock, J. C., Skinner, R., Carrell, R. W. & Lesk, A. M., 2000, In : Journal of Molecular Biology. p. 685 - 699 15 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin

Whisstock, J. C., Pike, R. N., Jin, L., Skinner, R., Pei, X. Y., Carrell, R. W. & Lesk, A. M., 2000, In : Journal of Molecular Biology. p. 1287 - 1305 19 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling

Myers, M., Davies, J. M., Tong, J. C., Whisstock, J. C., Scealy, M., Mackay, I. R. & Rowley, M. J., 2000, In : Journal of Immunology. p. 3830 - 3838 9 p.

Research output: Contribution to journalArticleResearchpeer-review

459 Citations (Scopus)

Phylogeny of the serpin superfamily: Implications of patterns of amino acid conservation for structure and function

Irving, J., Pike, R. N., Lesk, A. M. & Whisstock, J. C., 2000, In : Genome Research. p. 1845 - 1864 20 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Prediction of the immunodominant epitope of the pyruvate dehydrogenase complex E2 in primary biliary cirrhosis using phage display

Rowley, M. J., Scealy, M., Whisstock, J. C., Jois, J. A., Wijeyewickrema, L. C. & Mackay, I. R., 2000, In : Journal of Immunology. p. 3413 - 3419 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Requirement of leucine-rich repeats of glycoprotein (GP) Ibalpha for shear-dependent and static binding of von Willebrand factor to the platelet membrane GP Ib-IX-V complex

Shen, Y., Romo, G. M., Dong, J., Schade, A., McIntire, L. V., Kenny, D., Whisstock, J. C., Berndt, M. C., Lopez, J. A. & Andrews, R. K., 2000, In : Blood. 95, p. 903* - 910 8 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Requirement of leucine-rich repeats of glycoprotein (GP) Ibα for shear- dependent and static binding of von willebrand factor to the platelet membrane GP Ib-IX-V complex

Shen, Y., Romo, G. M., Dong, J. F., Schade, A., McIntire, L. V., Kenny, D., Whisstock, J. C., Berndt, M. C., López, J. A. & Andrews, R. K., 1 Feb 2000, In : Blood. 95, 3, p. 903-910 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Simple modifications of the serpin reactive site loop convert SCCA2 into a cystein proteinase inhibitor: A critical role for the P3' proline in facilitating RSL cleavage

Luke, C., Schick, C., Tsu, C., Whisstock, J. C., Irving, J., Bromme, D., Juliano, L., Shi, G-P., Chapman, H. A. & Silverman, G. A., 2000, In : Biochemistry. p. 7081 - 7091 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Structure and function of the von Willebrand factor A1 domain: analysis with monoclonal antibodies reveals distinct binding sites involved in recognition of the platelet membrane glycoprotein Ib-IX-V complex and ristocetin-dependent activation

De Luca, M., Facey, D. A., Favaloro, E. J., Hertzberg, M. S., Whisstock, J. C., McNally, T., Andrews, R. K. & Berndt, M. C., 2000, In : Blood. p. 164 - 172 9 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)
1999
5 Citations (Scopus)
51 Citations (Scopus)

Expression and purification of recombinant human granzyme B from Pichia pastoris

Sun, J., Bird, C., Buzza, M. S., McKee, K. E., Whisstock, J. C. & Bird, P. I., 1999, In : Biochemical and Biophysical Research Communications. p. 251-255 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of functional regions of the thyrotropin beta-subunit recognised by two monoclonal antibodies mAb

Gomme, P. T., Thompson, P. E., Whisstock, J. C., Stanton, P. & Hearn, M. T. W., 1999, In : Journal of Peptide Research. p. 218 - 229 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Multiple alignment and sorting of peptides derived from phage-displayed random peptide libraries with polyclonal sera allows discrimination of relevant phagotopes

Davies, J. M., Scealy, M., Cai, Y. P., Whisstock, J. C., Mackay, I. R. & Rowley, M. J., 1999, In : Molecular Immunology. p. 659 - 667 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the unfolding pathway of alpha1-antitrypsin

James, E. L., Whisstock, J. C., Gore, M. G. & Bottomley, S. P., 1999, In : Journal of Biological Chemistry. p. 9482 - 9488 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Serpins in the "Caenorhabditis elegans" genome

Whisstock, J. C., Irving, J., Bottomley, S. P., Pike, R. N. & Lesk, A. M., 1999, In : Proteins: Structure, Function, and Bioinformatics. p. 31 - 41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

SH3 domains in prokaryotes

Whisstock, J. C. & Lesk, A. M., 1999, In : Trends in Biochemical Sciences. p. 132 - 133 2 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
1998

a1 - antitrypsin polymerisation can occur by both Loop A and C sheet mechanisms

Bottomley, S. P., Hopkins, P. & Whisstock, J. C., 1998, In : Biochemical and Biophysical Research Communications. p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes

de Veer, M. J., Sim, H., Whisstock, J. C., Devenish, R. J. & Ralph, S. J., 1998, In : Genomics. p. 267 - 277 11 p.

Research output: Contribution to journalArticleResearchpeer-review