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Research Output 1997 2019

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2010
53 Citations (Scopus)

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates

Kennan, R. M., Wong, W., Dhungyel, O., Han, X., Wong, D. M., Parker, D., Rosado, C. J., Law, R. HP., McGowan, S., Reeve, S. B., Levina, V., Powers, G. A., Pike, R. N., Bottomley, S. P., Smith, A. I., Marsh, I., Whittington, R. J., Whisstock, J., Porter, C. J. & Rood, J. I., 2010, In : PLoS Pathogens. 6, 11, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., 2010, In : PLoS Pathogens. 6, 5 (e1000898), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions

Langendorf, C., Key, T., Fenalti, G., Kan, W-T., Buckle, A. M., Caradoc-Davies, T. T., Tuck, K. L., Law, R. H. P. & Whisstock, J., 2010, In : PLoS ONE. 5, 2, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
3 Citations (Scopus)

Conformational change in the chromatin remodelling protein MENT

Ong, P. C., Golding, S. J., Pearce, M. C., Irving, J. A., Grigoryev, S. A., Pike, D., Langendorf, C. G., Bashtannyk-Puhalovich, T. A., Bottomley, S. P., Whisstock, J. C., Pike, R. N. & McGowan, S., 2009, In : PLoS ONE. 4, 3 (e4727), p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Modulation of the proteolytic activity of the complement protease C1s by polyanions: Implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

Murray-Rust, T. A., Kerr, F. K., Thomas, A. R., Wu, T. J-T., Yongqing, T., Ong, P. C., Quinsey, N. S., Whisstock, J. C., Wagenaar-Bos, I. C., Freeman, C. & Pike, R. N., 2009, In : Biochemical Journal. 422, 2, p. 295 - 303 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Prodepth: Predict residue depth by support vector regression approach from protein sequences only

Song, J., Tan, H., Mahmood, K., Law, R. H. P., Buckle, A. M., Webb, G., Akutsu, T. & Whisstock, J., 2009, In : PLoS ONE. 4, 9 (e7072), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

McGowan, S., Porter, C. J., Lowther, J., Stack, C. M., Golding, S. J., Skinner-Adams, T. S., Trenholme, K. R., Teuscher, F., Donnelly, S. M., Grembecka, J., Mucha, A., Kafarski, P., DeGori, R., Buckle, A. M., Gardiner, D. L., Whisstock, J. C. & Dalton, J. P., 2009, In : Proceedings of the National Academy of Sciences. 106, 8, p. 2537 - 2542 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural determinants of GAD antigenicity

Arafat, Y., Fenalti, G., Whisstock, J., Mackay, I. R., Garcia De La Banda, M. J., Rowley, M. J. & Buckle, A. M., 2009, In : Molecular Immunology. 47, 2-3, p. 493 - 505 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Structural mechanisms of inactivation in scabies mite serine protease paralogues

Fischer, K., Langendorf, C., Irving, J. A., Reynolds, S., Willis, C., Beckham, S. A., Law, R. H. P., Yang, S., Bashtannyk-Puhalovich, T. A., McGowan, S., Whisstock, J., Pike, R. N., Kemp, D. J. & Buckle, A. M., 2009, In : Journal of Molecular Biology. 390, 4, p. 635 - 645 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

Kaiserman, D., Buckle, A. M., Van Damme, P., Irving, J. A., Law, R. H. P., Matthews, A. Y., Bashtannyk-Puhalovich, T. A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J. C. & Bird, P. I., 2009, In : Proceedings of the National Academy of Sciences. 106, 14, p. 5587 - 5592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

Chia, J., Yeo, K. P., Whisstock, J., Dunstone, M. A., Trapani, J. A. & Voskoboinik, I., 2009, In : Proceedings of the National Academy of Sciences. 106, 24, p. 9809 - 9814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

The molecular basis for perforin oligomerization and transmembrane pore assembly

Baran, K., Dunstone, M. A., Chia, J., Ciccone, A., Browne, K. A., Clarke, C. J. P., Lukoyanova, N., Saibil, H., Whisstock, J., Voskoboinik, I. & Trapani, J. A., 2009, In : Immunity. 30, 5, p. 684 - 695 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The performance of perforin-like proteins

Whisstock, J., May 2009, In : Australian Life Scientist. 6, 3, p. 34-35 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
23 Citations (Scopus)

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2

Steenbakkers, P. JM., Irving, J. A., Harhangi, H. R., Swinkels, W. JC., Akhmanova, A., Dijkerman, R., Jetten, M. SM., Van Der Drift, C., Whisstock, J. & Op Den Camp, H. JM., 2008, In : Mycological Research. 112, 8, p. 999 - 1006 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A structural basis for Loop C-sheet polymerization in serpins

Zhang, Q., Law, R. H. P., Bottomley, S. P., Whisstock, J. & Buckle, A. M., 2008, In : Journal of Molecular Biology. 376, 5, p. 1348 - 1359 12 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity

Fenalti, G., Hampe, C. S., Arafat, Y., Law, R. H. P., Banga, J. P., Mackay, I. R., Whisstock, J., Buckle, A. M. & Rowley, M. J., 2008, In : Diabetes. 57, 5, p. 1293 - 1301 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

Kerr, F. K., Thomas, A. R., Wijeyewickrema, L. C., Whisstock, J., Boyd, S. E., Kaiserman, D., Matthews, A. Y., Bird, P. I., Thielens, N. M., Rossi, V. & Pike, R. N., 2008, In : Molecular Immunology. 45, p. 670 - 677 7 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Federated repositories of X-ray diffraction images

Androulakis, S. G., Schmidberger, J., Bate, M. A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C. J., Harrison, A., Hunter, J., Martin, J. L., Kobe, B., Dobson, R. CJ., Parker, M. W., Whisstock, J., Gray, J., Treloar, A. E., Groenewegen, D., Dickson, N. & 1 others, Buckle, A. M., 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 7, p. 810 - 814 5 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Structural biology: Serpins' mystery solved

Whisstock, J. & Bottomley, S. P., 2008, In : Nature. 455, 7217, p. 1189 - 1190 2 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism

Schmidberger, J. W., Wilce, J. A., Weightman, A. J., Whisstock, J. & Wilce, M. C. J., 2008, In : Journal of Molecular Biology. 378, 1, p. 284 - 294 11 p.

Research output: Contribution to journalArticleResearchpeer-review

174 Citations (Scopus)

The MACPF/CDC family of pore-forming toxins

Rosado, C. J., Kondos, S., Bull, T. E., Kuiper, M., Law, R. H. P., Buckle, A. M., Voskoboinik, I., Bird, P. I., Trapani, J. A., Whisstock, J. & Dunstone, M. A., 2008, In : Cellular Microbiology. 10, 9, p. 1765 - 1774 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin

Law, R. H. P., Sofian, T., Kan, W-T., Horvath, A. J., Hitchen, C. R., Langendorf, C., Buckle, A. M., Whisstock, J. & Coughlin, P. B., 2008, In : Blood. 111, p. 2049 - 2052 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
190 Citations (Scopus)

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 others, Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Aeropin from the extremophile pyrobaculum aerophilum bypasses the serpin misfolding trap

Cabrita, L., Irving, J. A., Pearce, M. C., Whisstock, J. & Bottomley, S. P., 2007, In : Journal of Biological Chemistry. 282, 37, p. 26802 - 26809 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

DNA accelerates the inhibition of human cathepsin V by serpins

Ong, P. C., McGowan, S., Pearce, M. C., Irving, J. A., Kan, W-T., Grigoryev, S. A., Turk, B., Silverman, G. A., Brix, K., Bottomley, S. P., Whisstock, J. & Pike, R. N., 2007, In : Journal of Biological Chemistry. 282, 51, p. 36980 - 36986 7 p.

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

Fenalti, G., Law, R. H. P., Buckle, A. M., Langendorf, C., Tuck, K. L., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P., Wilce, M. C. J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I. R., Rowley, M. J. & Whisstock, J., 2007, In : Nature Structural and Molecular Biology. 14, 4, p. 280 - 286 7 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins

Faux, N. G., Huttley, G. A., Mahmood, K., Webb, G., Garcia De La Banda, M. J. & Whisstock, J., 2007, In : Genome Research. 17, 7, p. 1118 - 1127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

SERPINB11 is a new noninhibitory intracellular serpin: Common single nucleotide polymorphisms in the scaffold impair conformational change

Askew, D. J., Cataltepe, S., Kumar, V., Edwards, C., Pace, S. M., Howarth, R. N., Pak, S. C., Askew, Y. S., Bromme, D., Luke, C., Whisstock, J. & Silverman, G. A., 2007, In : Journal of Biological Chemistry. 282, 34, p. 24948 - 24960 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes

Scott, F. L., Sun, J. H., Whisstock, J., Kato, K. & Bird, P. I., 2007, In : Journal of Biochemistry. 142, 4, p. 435 - 442 8 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

The 1.6 angstrom crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis

Porter, C. J., Schuch, R., Pelzek, A. J., Buckle, A. M., McGowan, S., Wilce, M. C. J., Rossjohn, J., Russell, R., Nelson, D., Fischetti, V. A. & Whisstock, J. C., 2007, In : Journal of Molecular Biology. 366, 2, p. 540 - 550 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

The N terminus of the serpin, tengpin, functions to trap the metastable native state

Zhang, Q., Buckle, A. M., Law, R. H. P., Pearce, M. C., Cabrita, L., Lloyd, G., Irving, J. A., Smith, A. I., Ruzyla, K., Rossjohn, J., Bottomley, S. P. & Whisstock, J., 2007, In : EMBO Reports. 8, 7, p. 658 - 663 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
244 Citations (Scopus)

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

Paton, A. W., Beddoe, T. C., Thorpe, C. M., Whisstock, J., Wilce, M. C. J., Rossjohn, J., Talbot, U. M. & Paton, J. C., 2006, In : Nature. 443, 7111, p. 548 - 552 5 p.

Research output: Contribution to journalArticleResearchpeer-review

323 Citations (Scopus)

An overview of the serpin superfamily

Law, R. H. P., Zhang, Q., McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W., Rosado, C. J., Langendorf, C., Pike, R. N., Bird, P. I. & Whisstock, J., 2006, In : Genome Biology. 7, 5, p. 216-1 - 216-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis

Marland, Z., Beddoe, T. C., Zaker-Tabrizi, L., Lucet, I., Brammananth, R., Whisstock, J. C., Wilce, M. C. J., Coppel, R. L., Crellin, P. K. & Rossjohn, J., 2006, In : Journal of Molecular Biology. 359, 4, p. 983 - 997 15 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor

Shen, Y., Cranmer, S. L., Aprico, A., Whisstock, J., Jackson, S., Berndt, M. C. & Andrews, R. K., 2006, In : Journal of Biological Chemistry. 281, 36, p. 26419 - 26423 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Managing and mining protein crystallization data

Amin, A. A., Faux, N. G., Fenalti, G., Williams, G. N., Bernadou, A., Daglish, B., Keefe, K., Middleton, S., Rae, J., Tetis, K., Law, R. H. P., Fulton, K. F., Rossjohn, J., Whisstock, J. C. & Buckle, A. M., 2006, In : Proteins: Structure, Function, and Bioinformatics. 62, 1, p. 4 - 7 4 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Mechanisms of serpin dysfunction in disease

Kaiserman, D., Whisstock, J. C. & Bird, P. I., 2006, In : Expert Reviews in Molecular Medicine. 8, 31, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Molecular gymnastics: serpin structure, folding and misfolding

Whisstock, J. & Bottomley, S. P., 2006, In : Current Opinion in Structural Biology. 16, 6, p. 761 - 768 8 p.

Research output: Contribution to journalArticleResearchpeer-review

458 Citations (Scopus)

MUSTANG: a multiple structural alignment algorithm

Konagurthu, A. S., Whisstock, J. C., Stuckey, P. J. & Lesk, A. M., 2006, In : Proteins: Structure, Function, and Bioinformatics. 64, 3, p. 559 - 574 16 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

REFOLD: an analytical database of protein refolding methods

Chow, M. K. M., Amin, A. A., Fulton, K. F., Whisstock, J. C., Buckle, A. M. & Bottomley, S. P., 2006, In : Protein Expression and Purification. 46, 1, p. 166 - 171 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase

Hennebry, S. C., Law, R. H. P., Richardson, S. J., Buckle, A. M. & Whisstock, J. C., 2006, In : Journal of Molecular Biology. 359, 5, p. 1389 - 1399 11 p.

Research output: Contribution to journalArticleResearchpeer-review

135 Citations (Scopus)

The major human and mouse granzymes are structurally and functionally divergent

Kaiserman, D., Bird, C. H., Sun, J., Matthews, A. Y., Ung, K. S., Whisstock, J. C., Thompson, P. E., Trapani, J. A. & Bird, P. I., 2006, In : Journal of Cell Biology. 175, 4, p. 619 - 630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The REFOLD database: a tool for the optimization of protein expression and refolding.

Chow, M. K. M., Amin, A. A., Fulton, K. F., Fernando, T., Kamau, L., Batty, C., Louca, M., Ho, S., Whisstock, J. C., Bottomley, S. P. & Buckle, A. M., 2006, In : Nucleic Acids Research. 34, D-Base Issue, p. D207 - D212 6 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

McGowan, S., Buckle, A. M., Irving, J. A., Ong, P. C., Bashtannyk-Puhalovich, T. A., Kan, W-T., Henderson, K., Bulynko, Y. A., Popova, E. Y., Smith, A. I., Bottomley, S. P., Rossjohn, J., Grigoryev, S. A., Pike, R. N. & Whisstock, J. C., 2006, In : EMBO Journal. 25, 13, p. 3144 - 3155 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
58 Citations (Scopus)

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

Bird, C. H., Sun, J., Ung, K. S., Karambalis, D., Whisstock, J. C., Trapani, J. A. & Bird, P. I., 2005, In : Molecular and Cellular Biology. 25, 17, p. 7854 - 7867 14 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Elucidation of the substrate specificity of the C1s protease of the classical complement pathway

Kerr, F. K., O'Brien, G., Quinsey, N. S., Whisstock, J., Boyd, S. E., Garcia De La Banda, M. J., Kaiserman, D., Matthews, A. Y., Bird, P. I. & Pike, R. N., 2005, In : Journal of Biological Chemistry. 280, 47, p. 39510 - 39514 5 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

Functional insights from the distribution and role of homopeptide repeat-containing proteins

Faux, N. G., Bottomley, S. P., Lesk, A. M., Irving, J. A., Morrison, J. R., Garcia De La Banda, M. J. & Whisstock, J. C., 2005, In : Genome Research. 15, 4, p. 537 - 551 15 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

PoPS: A computational tool for modeling and predicting protease specificity

Boyd, S. E., Pike, R. N., Rudy, G. B., Whisstock, J. & Garcia De La Banda, M. J., 2005, In : Journal of Bioinformatics and Computational Biology. 3, 3, p. 551 - 585 35 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
209 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review