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Research Output 1997 2019

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Article
2014
17 Citations (Scopus)

The perforin pore facilitates the delivery of cationic cargos

Stewart, S. E., Kondos, S., Matthews, A. Y., D'Angelo, M., Dunstone, M. A., Whisstock, J., Trapani, J. A. & Bird, P. I., 2014, In : Journal of Biological Chemistry. 289, 13, p. 9172 - 9181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori

Pang, S. S., Nguyen, T. S., Perry, A. J., Day, C. J., Panjikar, S., Tiralongo, J., Whisstock, J. & Kwok, T., 2014, In : Journal of Biological Chemistry. 289, 10, p. 6332 - 6340 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like

Henstridge, M. A., Johnson, T. K., Warr, C. G. & Whisstock, J., 2014, In : Nature Communications. 5, 3419, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013
17 Citations (Scopus)

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Perry, A. J., Wijeyewickrema, L. C., Wilmann, P. G., Gunzburg, M. J., D'Andrea, L. P., Irving, J., Pang, S. S., Duncan, R. C., Wilce, J. A., Whisstock, J. & Pike, R. N., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15821 - 15829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Byrne, H., Conroy, P., Whisstock, J. & O'Kennedy, R., 2013, In : Trends in Biotechnology. 31, 11, p. 621 - 632 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

Li, S-H., Reinke, A. A., Sanders, K. L., Emal, C. D., Whisstock, J., Stuckey, J. A. & Lawrence, D. A., 2013, In : Proceedings of the National Academy of Sciences. 110, 51, p. 4941 - 4949 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
54 Citations (Scopus)

New insights into the structure and function of the plasminogen/plasmin system

Law, R. H. P., Abu-ssaydeh, D. & Whisstock, J., 2013, In : Current Opinion in Structural Biology. 23, 6, p. 836 - 841 6 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Lopez, J., Susanto, O., Jenkins, M., Lukoyanova, N., Sutton, V. R., Law, R. H. P., Johnston, A., Bird, C. H., Bird, P. I., Whisstock, J., Trapani, J. A., Saibil, H. & Voskoboinik, I., 2013, In : Blood. 121, 14, p. 2659 - 2668 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Structural and functional analysis of the pore-forming toxin NetB from clostridium perfringens

Yan, X., Porter, C. J., Hardy, S. P., Steer, D., Smith, A. I., Quinsey, N. S., Hughes, V., Cheung, J. K., Keyburn, A. L., Kaldhusdal, M., Moore, R. J., Bannam, T. L., Whisstock, J. C. & Rood, J. I., 2013, In : mBio. 4, 1, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural biology: Torqueing about pores

Whisstock, J. & Dunstone, M. A., 2013, In : Nature Chemical Biology. 9, 10, p. 605 - 606 2 p.

Research output: Contribution to journalArticleOther

6 Citations (Scopus)

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Langendorf, C. G., Tuck, K. L., Key, T., Fenalti, G., Pike, R. N., Rosado, C. J., Wong, A. SM., Buckle, A. M., Law, R. H. P. & Whisstock, J., 2013, In : Bioscience Reports. 33, 1 (Art # A13), p. 137 - 149 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome

Yongqing, T., Wilmann, P. G., Reeve, S. B., Coetzer, T. H., Smith, A. I., Whisstock, J., Pike, R. N. & Wijeyewickrema, L. C., 2013, In : Journal of Biological Chemistry. 288, 31, p. 22399 - 22407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing

Johnson, T. K., Crossman, T., Foote, K., Henstridge, M. A., Saligari, M. J., Forbes Beadle, L. J., Herr, A., Whisstock, J. & Warr, C. G., 2013, In : Proceedings of the National Academy of Sciences. 110, 36, p. 14688 - 14692 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012
2 Citations (Scopus)

A versatile monoclonal antibody specific to human SERPINB5

Teoh, S. SY., Wang, H., Risbridger, G. P., Whisstock, J. C. & Bird, P. I., 2012, In : Hybridoma. 31, 5, p. 333 - 339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs

Mahmood, K., Webb, G. I., Song, J., Whisstock, J. C. & Konagurthu, A. S., 2012, In : Nucleic Acids Research. 40, 6 (Art. ID: e44), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
42 Citations (Scopus)

Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum

Poreba, M., McGowan, S., Skinner-Adams, T. S., Trenholme, K. R., Gardiner, D. L., Whisstock, J. C., To, J., Salvesen, G. S., Dalton, J. P. & Drag, M., 2012, In : PLoS ONE. 7, 2, 8 p., e31938.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

D'Angelo, M., Dunstone, M. A., Whisstock, J. C., Trapani, J. & Bird, P. I., 2012, In : BMC Evolutionary Biology. 12, Art. ID: 59, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
18 Citations (Scopus)

Predicting giant transmembrane beta-barrel architecture

Reboul, C. F., Mahmood, K., Whisstock, J. C. & Dunstone, M. A., 2012, In : Bioinformatics. 28, 10, p. 1299 - 1302 4 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites

Song, J., Tan, H., Perry, A. J., Akutsu, T., Webb, G. I., Whisstock, J. C. & Pike, R. N., 2012, In : PLoS ONE. 7, 11, 23 p., e50300.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
42 Citations (Scopus)

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Lopez, J. A., Brennan, A. J., Whisstock, J. C., Voskoboinik, I. & Trapani, J. A., 2012, In : Trends in Immunology. 33, 8, p. 406 - 412 7 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

Lo, C. Y. J., Jamsai, D., O'Connor, A. E., Borg, C. L., Clark, B., Whisstock, J. C., Field, M. C., Adams, V., Ishikawa, T., Aitken, R. J., Whittle, B., Goodnow, C. C., Ormandy, C. J. & O'Bryan, M. K., 2012, In : PLoS Genetics. 8, 10 (Art. No.: e1002969), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus

Han, X. Y., Kennan, R. M., Steer, D. L., Smith, A. I., Whisstock, J. C. & Rood, J. I., 2012, In : PLoS ONE. 7, 10, 8 p., e47932.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
53 Citations (Scopus)

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria

Porter, C. J., Bantwal, R., Bannam, T. L., Rosado, C. J., Pearce, M. C., Adams, V. M., Lyras, D., Whisstock, J. C. & Rood, J. I., 2012, In : Molecular Microbiology. 83, 2, p. 275 - 288 14 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an n-terminal domain containing a carbohydrate-binding module

Linke, C., Siemens, N., Oehmcke, S., Radjainia, M., Law, R. HP., Whisstock, J. C., Baker, E. N. & Kreikemeyer, B., 2012, In : Journal of Biological Chemistry. 287, 45, p. 38178 - 38189 12 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

The x-ray crystal structure of full-length human plasminogen

Law, R. HP., Caradoc-Davies, T. T., Cowieson, N. P., Horvath, A. J., Quek, A. J., Amarante Da Encarnacao, J., Steer, D. L., Cowan, A. D., Zhang, Q., Lu, B. GC., Pike, R. N., Smith, A. I., Coughlin, P. B. & Whisstock, J. C., 2012, In : Cell Reports. 1, 3, p. 185 - 190 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

Kannan Sivaraman, K., Oellig, C. A., Huynh, K., Atkinson, S. C., Poreba, M., Perugini, M. A., Trenholme, K. R., Gardiner, D. L., Salvesen, G. S., Drag, M., Dalton, J. P., Whisstock, J. C. & McGowan, S., 2012, In : Journal of Molecular Biology. 422, 4, p. 495 - 507 13 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

X-ray crystal structure of the streptococcal specific phage lysin PlyC

McGowan, S., Buckle, A. M., Mitchell, M. S., Hoopes, J. T., Gallagher, D. T., Heselpoth, R. D., Shen, Y., Reboul, C. F., Law, R. HP., Fischetti, V. A., Whisstock, J. C. & Nelson, D. C., 2012, In : Proceedings of the National Academy of Sciences. 109, 31, p. 12752 - 12757 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011
88 Citations (Scopus)

Automatic generation of protein structure cartoons with Pro-origami

Stivala, A., Wybrow, M., Wirth, A., Whisstock, J. & Stuckey, P., 2011, In : Bioinformatics. 27, 23, p. 3315 - 3316 2 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Harbut, M., Velmourougane, G., Dalal, S., Reiss, G., Whisstock, J., Onder, O., Brisson, D., McGowan, S., Klemba, M. & Greenbaum, D., 2011, In : Proceedings of the National Academy of Sciences. 108, 34, p. E526 - E534 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Bioinformatic approaches for predicting substrates of proteases

Song, J., Tan, H., Boyd, S. E., Shen, H., Mahmood, K., Webb, G., Akutsu, T., Whisstock, J. & Pike, R., 2011, In : Journal of Bioinformatics and Computational Biology. 9, 1, p. 149 - 178 30 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence

Alonzo III, F., Xayarath, B., Whisstock, J. & Freitag, N., 2011, In : Molecular Microbiology. 80, 6, p. 1530 - 1548 19 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Molecular basis of α 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

Yamasaki, M., Sendall, T. J., Pearce, M. C., Whisstock, J. C. & Huntington, J. A., Oct 2011, In : EMBO Reports. 12, 10, p. 1011-1017 7 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Protection from endogenous perforin: Glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes

Brennan, A., Chia, J., Browne, K., Ciccone, A., Ellis, S. L., Lopez, J., Susanto, O., Verschoor, S., Yagita, H., Whisstock, J., Trapani, J. & Voskoboinik, I., 2011, In : Immunity. 34, 6, p. 879 - 892 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction

Wong, W., Wijeyewickrema, L. C., Kennan, R. M., Reeve, S. B., Steer, D. L., Reboul, C., Smith, A. I., Pike, R. N., Rood, J. I., Whisstock, J. C. & Porter, C. J., 2011, In : Journal of Biological Chemistry. 286, 49, p. 42180 - 42187 8 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase

Velmourougane, G., Harbut, M. B., Dalal, S., McGowan, S., Oellig, C., Meinhardt, N., Whisstock, J. C., Klemba, M. & Greenbaum, D. C., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1655 - 1666 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
102 Citations (Scopus)

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

Song, J., Tan, H., Shen, H., Mahmood, K., Boyd, S. E., Webb, G., Akutsu, T. & Whisstock, J., 2010, In : Bioinformatics. 26, 6, p. 752 - 760 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus

Wong, W., Kennan, R. M., Rosado, C. J., Rood, J. I., Whisstock, J. & Porter, C. J., 2010, In : Acta Crystallographica. Section F: Structural Biology Communications. 66, 3, p. 289 - 293 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

EGM: Encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes

Mahmood, K., Konagurthu, A. S., Song, J., Buckle, A. M., Webb, G. I. & Whisstock, J. C., 2010, In : Bioinformatics. 26, 17, p. 2076 - 2084 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Maspin (SERPINB5) is an obligate intracellular serpin

Teoh, S., Whisstock, J. & Bird, P. I., 2010, In : Journal of Biological Chemistry. 285, 14, p. 10862 - 10869 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers

Huntington, J. A. & Whisstock, J., 2010, In : Biological Chemistry. 391, 8, p. 973 - 982 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Mrgrid: A portable grid based molecular replacement pipeline

Schmidberger, J. W., Bate, M., Reboul, C. F., Androulakis, S. G., Phan, J. M. N., Whisstock, J., Goscinski, W., Abramson, D. A. & Buckle, A. M., 2010, In : PLoS ONE. 5, 4 (e10049), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

MUSTANG-MR structural sieving server: Applications in protein structural analysis and crystallography

Konagurthu, A. S., Reboul, C. F., Schmidberger, J. W., Irving, J. A., Lesk, A. M., Stuckey, P. J., Whisstock, J. C. & Buckle, A. M., 2010, In : PLoS ONE. 5, 4 (e10048), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

115 Citations (Scopus)

Perforin: structure, function, and role in human immunopathology

Voskoboinik, I., Dunstone, M. A., Baran, K., Whisstock, J. & Trapani, J. A., 2010, In : Immunological Reviews. 235, 1, p. 35 - 54 20 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Skinner-Adams, T. S., Stack, C. M., Trenholme, K. R., Brown, C. L., Grembecka, J., Lowther, J., Mucha, A., Drag, M., Kafarski, P., McGowan, S., Whisstock, J., Gardiner, D. L. & Dalton, J. P., 2010, In : Trends in Biochemical Sciences. 35, p. 53 - 61 8 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems

Silverman, G. A., Whisstock, J. C., Bottomley, S. P., Huntington, J. A., Kaiserman, D., Luke, C. J., Pak, S. C., Reichhart, J. -M. & Bird, P. I., 2010, In : Journal of Biological Chemistry. 285, 32, p. 24299 - 24305 7 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

Whisstock, J. C., Silverman, G. A., Bird, P. I., Bottomley, S. P., Kaiserman, D., Luke, C. J., Pak, S. C., Reichhart, J. -M. & Huntington, J. A., 2010, In : Journal of Biological Chemistry. 285, 32, p. 24307 - 24312 6 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

McGowan, S., Oellig, C., Birru, W. A., Caradoc-Davies, T. T., Stack, C. M., Lowther, J., Skinner-Adams, T. S., Mucha, A., Kafarski, P., Grembecka, J., Trenholme, K. R., Buckle, A. M., Gardiner, D. L., Dalton, J. P. & Whisstock, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 6, p. 2449 - 2454 6 p.

Research output: Contribution to journalArticleResearchpeer-review

225 Citations (Scopus)

The structural basis for membrane binding and pore formation by lymphocyte perforin

Law, R. H. P., Lukoyanova, N., Voskoboinik, I., Caradoc-Davies, T. T., Baran, K., Dunstone, M. A., D'Angelo, M., Orlova, E. V., Coulibaly, F. J., Verschoor, S., Browne, K. A., Ciccone, A., Kuiper, M. J., Bird, P. I., Trapani, J. A., Saibil, H. R. & Whisstock, J. C., 2010, In : Nature. 468, 7322, p. 447 - 451 5 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

The structure and function of mammalian membrane-attack complex/perforin-like proteins

Kondos, S., Hatfaludi, T. Z., Voskoboinik, I., Trapani, J. A., Law, R. HP., Whisstock, J. C. & Dunstone, M. A., 2010, In : Tissue Antigens. 76, 5, p. 341 - 351 11 p.

Research output: Contribution to journalArticleResearchpeer-review