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Research Output 1997 2019

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a1 - antitrypsin polymerisation can occur by both Loop A and C sheet mechanisms

Bottomley, S. P., Hopkins, P. & Whisstock, J. C., 1998, In : Biochemical and Biophysical Research Communications. p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

244 Citations (Scopus)

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

Paton, A. W., Beddoe, T. C., Thorpe, C. M., Whisstock, J., Wilce, M. C. J., Rossjohn, J., Talbot, U. M. & Paton, J. C., 2006, In : Nature. 443, 7111, p. 548 - 552 5 p.

Research output: Contribution to journalArticleResearchpeer-review

190 Citations (Scopus)

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 others, Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Aeropin from the extremophile pyrobaculum aerophilum bypasses the serpin misfolding trap

Cabrita, L., Irving, J. A., Pearce, M. C., Whisstock, J. & Bottomley, S. P., 2007, In : Journal of Biological Chemistry. 282, 37, p. 26802 - 26809 8 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Perry, A. J., Wijeyewickrema, L. C., Wilmann, P. G., Gunzburg, M. J., D'Andrea, L. P., Irving, J., Pang, S. S., Duncan, R. C., Wilce, J. A., Whisstock, J. & Pike, R. N., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15821 - 15829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Analysis of perforin assembly by quartz crystal microbalance reveals a role for cholesterol and calcium-independent membrane binding

Stewart, S. E., Bird, C. H., Tabor, R. F., D'Angelo, M., Piantavigna, S., Whisstock, J. C., Trapani, J. A., Martin, L. L. & Bird, P. I., 2015, In : Journal of Biological Chemistry. 290, 52, p. 31101 - 31112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

A new model for pore formation by cholesterol-dependent cytolysins

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 2014, In : PLoS Computational Biology. 10, 8, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
322 Citations (Scopus)

An overview of the serpin superfamily

Law, R. H. P., Zhang, Q., McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W., Rosado, C. J., Langendorf, C., Pike, R. N., Bird, P. I. & Whisstock, J., 2006, In : Genome Biology. 7, 5, p. 216-1 - 216-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Antithrombin: in control of coagulation

Quinsey, N. S., Greedy, A. L., Bottomley, S. P., Whisstock, J. C. & Pike, R. N., 2004, In : International Journal of Biochemistry and Cell Biology. 36, 3, p. 386 - 389 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Westwood, J. A., Ellis, S., Danne, J., Johnson, C., Oorschot, V., Ramm, G., Tscharke, D. C., Davenport, A. J., Whisstock, J. C., Darcy, P. K., Kershaw, M. H. & Slaney, C. Y., 14 Dec 2017, In : Oncotarget. 8, 70, p. 115215-115229 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2

Steenbakkers, P. JM., Irving, J. A., Harhangi, H. R., Swinkels, W. JC., Akhmanova, A., Dijkerman, R., Jetten, M. SM., Van Der Drift, C., Whisstock, J. & Op Den Camp, H. JM., 2008, In : Mycological Research. 112, 8, p. 999 - 1006 8 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica

Smooker, P. M., Whisstock, J. C., Irving, J., Siyaguna, S., Spithill, T. W. & Pike, R. N., 2000, In : Protein Science. p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A structural basis for Loop C-sheet polymerization in serpins

Zhang, Q., Law, R. H. P., Bottomley, S. P., Whisstock, J. & Buckle, A. M., 2008, In : Journal of Molecular Biology. 376, 5, p. 1348 - 1359 12 p.

Research output: Contribution to journalArticleResearchpeer-review

273 Citations (Scopus)

A structural basis for the selection of dominant T cell receptors in antiviral immunity

Kjer-Nielsen, L., Clements, C. S., Purcell, A. W., Brooks, A. G., Whisstock, J. C., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2003, In : Immunity. 18, 1, p. 53 - 64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Byrne, H., Conroy, P., Whisstock, J. & O'Kennedy, R., 2013, In : Trends in Biotechnology. 31, 11, p. 621 - 632 12 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)

Automatic generation of protein structure cartoons with Pro-origami

Stivala, A., Wybrow, M., Wirth, A., Whisstock, J. & Stuckey, P., 2011, In : Bioinformatics. 27, 23, p. 3315 - 3316 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A versatile monoclonal antibody specific to human SERPINB5

Teoh, S. SY., Wang, H., Risbridger, G. P., Whisstock, J. C. & Bird, P. I., 2012, In : Hybridoma. 31, 5, p. 333 - 339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Harbut, M., Velmourougane, G., Dalal, S., Reiss, G., Whisstock, J., Onder, O., Brisson, D., McGowan, S., Klemba, M. & Greenbaum, D., 2011, In : Proceedings of the National Academy of Sciences. 108, 34, p. E526 - E534 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Bioinformatic approaches for predicting substrates of proteases

Song, J., Tan, H., Boyd, S. E., Shen, H., Mahmood, K., Webb, G., Akutsu, T., Whisstock, J. & Pike, R., 2011, In : Journal of Bioinformatics and Computational Biology. 9, 1, p. 149 - 178 30 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during danio rerio development

Giousoh, A., Rodrigues Vaz, R., Bryson-Richardson, R. J., Whisstock, J. C., Verkade, H. M. & Bird, P. I., 2015, In : Gene Expression Patterns. 18, 1-2, p. 37 - 43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?

Duncan, E. J., Johnson, T. K., Whisstock, J., Warr, C. G. & Dearden, P. K., 2014, In : Current Opinion in Insect Science. 1, p. 45 - 51 7 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

Song, J., Tan, H., Shen, H., Mahmood, K., Boyd, S. E., Webb, G., Akutsu, T. & Whisstock, J., 2010, In : Bioinformatics. 26, 6, p. 752 - 760 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets

Wang, M., Zhao, X-M., Tan, H., Akutsu, T., Whisstock, J. & Song, J., 2014, In : Bioinformatics. 30, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

Bird, C. H., Sun, J., Ung, K. S., Karambalis, D., Whisstock, J. C., Trapani, J. A. & Bird, P. I., 2005, In : Molecular and Cellular Biology. 25, 17, p. 7854 - 7867 14 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Yang, A. S. P., O'Neill, M. T., Jennison, C., Lopaticki, S., Allison, C. C., Armistead, J. S., Erickson, S. M., Rogers, K. L., Ellisdon, A. M., Whisstock, J. C., Tweedell, R. E., Dinglasan, R. R., Douglas, D. N., Kneteman, N. M. & Boddey, J. A., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3105-3116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 2 Jan 2019, In : ChemBioChem. 20, 1, p. 46-50 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin invloved in virulence

Guerin, J-L., Gelfi, J., Camus, C., Delverdier, M., Whisstock, J. C., Amardeihl, M-F., Py, R., Bertagnole, S. & Messud-Petit, F., 2001, In : Journal of General Virology. 82, p. 1407-1417 11 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity

Nandurkar, H., Caldwell, K. K., Whisstock, J. C., Layton, M. J., Gaudet, E. A., Norris, F. A., Majerus, P. W. & Mitchell, C. A., 2001, In : Proceedings of the National Academy of Sciences. 98, 17, p. 9499 - 9504 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
10 Citations (Scopus)

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

Ally, N., Whisstock, J. C., Sieprawskalupa, M., Potempa, J., Le Bonniec, B. F., Travis, J. & Pike, R. N., 2003, In : Biochemistry. 42, 40, p. 11693 - 11700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Cleaved antitrypsin polymers at atomic resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B. F., Parker, M. W. & Bottomley, S. P., 13 Mar 2000, In : Protein Science. 9, 2, p. 417-420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cleaved antitrypsin polymers at atominc resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B., Parker, M. W. & Bottomley, S. P., 2000, In : Protein Science. p. 417 - 420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

CLIMS: Crystallography Laboratory Information Management System

Fulton, K. F., Ervine, S., Faux, N. G., Forster, R., Ly, W., Robilliard, L., Sonsini, J., Whelan, D., Whisstock, J. C. & Buckle, A. M., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 9, p. 1691 - 1693 3 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Cloning and expression of the major secreted cathepsin B-Iike protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection

Law, R. H. P., Smooker, P. M., Irving, J. A., Piedrafita, D., Ponting, R., Kennedy, N. J., Whisstock, J. C., Pike, R. N. & Spithill, T. W., 2003, In : Infection and Immunity. 71, 12, p. 6921 - 6932 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Computational analysis of evolution and conservation in a protein superfamily

Irving, J. A., Askew, D. J. & Whisstock, J. C., 2004, In : Methods. 32, 2, p. 73 - 92 20 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Conformational change in the chromatin remodelling protein MENT

Ong, P. C., Golding, S. J., Pearce, M. C., Irving, J. A., Grigoryev, S. A., Pike, D., Langendorf, C. G., Bashtannyk-Puhalovich, T. A., Bottomley, S. P., Whisstock, J. C., Pike, R. N. & McGowan, S., 2009, In : PLoS ONE. 4, 3 (e4727), p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Conformational changes in serpins: 1. The native and cleaved conformations of alpha1-antitrypsin

Whisstock, J. C., Skinner, R., Carrell, R. W. & Lesk, A. M., 2000, In : Journal of Molecular Biology. p. 685 - 699 15 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin

Whisstock, J. C., Pike, R. N., Jin, L., Skinner, R., Pei, X. Y., Carrell, R. W. & Lesk, A. M., 2000, In : Journal of Molecular Biology. p. 1287 - 1305 19 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling

Myers, M., Davies, J. M., Tong, J. C., Whisstock, J. C., Scealy, M., Mackay, I. R. & Rowley, M. J., 2000, In : Journal of Immunology. p. 3830 - 3838 9 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity

Fenalti, G., Hampe, C. S., Arafat, Y., Law, R. H. P., Banga, J. P., Mackay, I. R., Whisstock, J., Buckle, A. M. & Rowley, M. J., 2008, In : Diabetes. 57, 5, p. 1293 - 1301 9 p.

Research output: Contribution to journalArticleResearchpeer-review

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

4 Citations (Scopus)

Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus

Wong, W., Kennan, R. M., Rosado, C. J., Rood, J. I., Whisstock, J. & Porter, C. J., 2010, In : Acta Crystallographica. Section F: Structural Biology Communications. 66, 3, p. 289 - 293 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Determination of the P'1, P'2 and P'3 subsite-specificity of factor Xa

Ludeman, J. P., Pike, R. N., Bromfield, K. M., Duggan, P. J., Cianci, J., Le Bonniec, B., Whisstock, J. C. & Bottomley, S. P., 2003, In : International Journal of Biochemistry and Cell Biology. 35, 2, p. 221 - 225 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Development of the cellular immune system of Drosophila requires the membrane attack complex/perforin-like protein Torso-like

Forbes-Beadle, L., Crossman, T., Johnson, T. K., Burke, R., Warr, C. G. & Whisstock, J. C., 1 Oct 2016, In : Genetics. 204, 2, p. 675-681 7 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

DNA accelerates the inhibition of human cathepsin V by serpins

Ong, P. C., McGowan, S., Pearce, M. C., Irving, J. A., Kan, W-T., Grigoryev, S. A., Turk, B., Silverman, G. A., Brix, K., Bottomley, S. P., Whisstock, J. & Pike, R. N., 2007, In : Journal of Biological Chemistry. 282, 51, p. 36980 - 36986 7 p.

Research output: Contribution to journalArticleResearchpeer-review