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Research Output 1997 2019

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Article
2012
114 Citations (Scopus)

PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites

Song, J., Tan, H., Perry, A. J., Akutsu, T., Webb, G. I., Whisstock, J. C. & Pike, R. N., 2012, In : PLoS ONE. 7, 11, 23 p., e50300.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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42 Citations (Scopus)

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

Lopez, J. A., Brennan, A. J., Whisstock, J. C., Voskoboinik, I. & Trapani, J. A., 2012, In : Trends in Immunology. 33, 8, p. 406 - 412 7 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

Lo, C. Y. J., Jamsai, D., O'Connor, A. E., Borg, C. L., Clark, B., Whisstock, J. C., Field, M. C., Adams, V., Ishikawa, T., Aitken, R. J., Whittle, B., Goodnow, C. C., Ormandy, C. J. & O'Bryan, M. K., 2012, In : PLoS Genetics. 8, 10 (Art. No.: e1002969), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus

Han, X. Y., Kennan, R. M., Steer, D. L., Smith, A. I., Whisstock, J. C. & Rood, J. I., 2012, In : PLoS ONE. 7, 10, 8 p., e47932.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
53 Citations (Scopus)

The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria

Porter, C. J., Bantwal, R., Bannam, T. L., Rosado, C. J., Pearce, M. C., Adams, V. M., Lyras, D., Whisstock, J. C. & Rood, J. I., 2012, In : Molecular Microbiology. 83, 2, p. 275 - 288 14 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an n-terminal domain containing a carbohydrate-binding module

Linke, C., Siemens, N., Oehmcke, S., Radjainia, M., Law, R. HP., Whisstock, J. C., Baker, E. N. & Kreikemeyer, B., 2012, In : Journal of Biological Chemistry. 287, 45, p. 38178 - 38189 12 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

The x-ray crystal structure of full-length human plasminogen

Law, R. HP., Caradoc-Davies, T. T., Cowieson, N. P., Horvath, A. J., Quek, A. J., Amarante Da Encarnacao, J., Steer, D. L., Cowan, A. D., Zhang, Q., Lu, B. GC., Pike, R. N., Smith, A. I., Coughlin, P. B. & Whisstock, J. C., 2012, In : Cell Reports. 1, 3, p. 185 - 190 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

Kannan Sivaraman, K., Oellig, C. A., Huynh, K., Atkinson, S. C., Poreba, M., Perugini, M. A., Trenholme, K. R., Gardiner, D. L., Salvesen, G. S., Drag, M., Dalton, J. P., Whisstock, J. C. & McGowan, S., 2012, In : Journal of Molecular Biology. 422, 4, p. 495 - 507 13 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

X-ray crystal structure of the streptococcal specific phage lysin PlyC

McGowan, S., Buckle, A. M., Mitchell, M. S., Hoopes, J. T., Gallagher, D. T., Heselpoth, R. D., Shen, Y., Reboul, C. F., Law, R. HP., Fischetti, V. A., Whisstock, J. C. & Nelson, D. C., 2012, In : Proceedings of the National Academy of Sciences. 109, 31, p. 12752 - 12757 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013
17 Citations (Scopus)

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Perry, A. J., Wijeyewickrema, L. C., Wilmann, P. G., Gunzburg, M. J., D'Andrea, L. P., Irving, J., Pang, S. S., Duncan, R. C., Wilce, J. A., Whisstock, J. & Pike, R. N., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15821 - 15829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

Byrne, H., Conroy, P., Whisstock, J. & O'Kennedy, R., 2013, In : Trends in Biotechnology. 31, 11, p. 621 - 632 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

Li, S-H., Reinke, A. A., Sanders, K. L., Emal, C. D., Whisstock, J., Stuckey, J. A. & Lawrence, D. A., 2013, In : Proceedings of the National Academy of Sciences. 110, 51, p. 4941 - 4949 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
54 Citations (Scopus)

New insights into the structure and function of the plasminogen/plasmin system

Law, R. H. P., Abu-ssaydeh, D. & Whisstock, J., 2013, In : Current Opinion in Structural Biology. 23, 6, p. 836 - 841 6 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Lopez, J., Susanto, O., Jenkins, M., Lukoyanova, N., Sutton, V. R., Law, R. H. P., Johnston, A., Bird, C. H., Bird, P. I., Whisstock, J., Trapani, J. A., Saibil, H. & Voskoboinik, I., 2013, In : Blood. 121, 14, p. 2659 - 2668 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Structural and functional analysis of the pore-forming toxin NetB from clostridium perfringens

Yan, X., Porter, C. J., Hardy, S. P., Steer, D., Smith, A. I., Quinsey, N. S., Hughes, V., Cheung, J. K., Keyburn, A. L., Kaldhusdal, M., Moore, R. J., Bannam, T. L., Whisstock, J. C. & Rood, J. I., 2013, In : mBio. 4, 1, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural biology: Torqueing about pores

Whisstock, J. & Dunstone, M. A., 2013, In : Nature Chemical Biology. 9, 10, p. 605 - 606 2 p.

Research output: Contribution to journalArticleOther

6 Citations (Scopus)

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Langendorf, C. G., Tuck, K. L., Key, T., Fenalti, G., Pike, R. N., Rosado, C. J., Wong, A. SM., Buckle, A. M., Law, R. H. P. & Whisstock, J., 2013, In : Bioscience Reports. 33, 1 (Art # A13), p. 137 - 149 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) syndrome

Yongqing, T., Wilmann, P. G., Reeve, S. B., Coetzer, T. H., Smith, A. I., Whisstock, J., Pike, R. N. & Wijeyewickrema, L. C., 2013, In : Journal of Biological Chemistry. 288, 31, p. 22399 - 22407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing

Johnson, T. K., Crossman, T., Foote, K., Henstridge, M. A., Saligari, M. J., Forbes Beadle, L. J., Herr, A., Whisstock, J. & Warr, C. G., 2013, In : Proceedings of the National Academy of Sciences. 110, 36, p. 14688 - 14692 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014
19 Citations (Scopus)

A new model for pore formation by cholesterol-dependent cytolysins

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 2014, In : PLoS Computational Biology. 10, 8, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?

Duncan, E. J., Johnson, T. K., Whisstock, J., Warr, C. G. & Dearden, P. K., 2014, In : Current Opinion in Insect Science. 1, p. 45 - 51 7 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets

Wang, M., Zhao, X-M., Tan, H., Akutsu, T., Whisstock, J. & Song, J., 2014, In : Bioinformatics. 30, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster

Ellisdon, A. M., Zhang, Q., Bennett, M. A., Johnson, T. K., Warr, C. G., Law, R. H. P. & Whisstock, J. C., 2014, In : BMC Structural Biology. 14, 1, p. 1 - 8 8 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Maspin is not required for embryonic development or tumour suppression

Teoh, S. S. Y., Vieusseux, J. L., Prakash, M. D., Berkowicz, S. R., Luu, J., Bird, C. H., Law, R. H. P., Rosado, C. J., Price, J. T., Whisstock, J. C. & Bird, P. I., 2014, In : Nature Communications. 5, (Art. No.: 3164), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Reconciling the structural attributes of avian antibodies

Conroy, P., Law, R. H. P., Gilgunn, S., Hearty, S., Caradoc-Davies, T. T., Lloyd, G., O'Kennedy, R. & Whisstock, J., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15384 - 15392 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The perforin pore facilitates the delivery of cationic cargos

Stewart, S. E., Kondos, S., Matthews, A. Y., D'Angelo, M., Dunstone, M. A., Whisstock, J., Trapani, J. A. & Bird, P. I., 2014, In : Journal of Biological Chemistry. 289, 13, p. 9172 - 9181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori

Pang, S. S., Nguyen, T. S., Perry, A. J., Day, C. J., Panjikar, S., Tiralongo, J., Whisstock, J. & Kwok, T., 2014, In : Journal of Biological Chemistry. 289, 10, p. 6332 - 6340 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like

Henstridge, M. A., Johnson, T. K., Warr, C. G. & Whisstock, J., 2014, In : Nature Communications. 5, 3419, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2015
3 Citations (Scopus)

Analysis of perforin assembly by quartz crystal microbalance reveals a role for cholesterol and calcium-independent membrane binding

Stewart, S. E., Bird, C. H., Tabor, R. F., D'Angelo, M., Piantavigna, S., Whisstock, J. C., Trapani, J. A., Martin, L. L. & Bird, P. I., 2015, In : Journal of Biological Chemistry. 290, 52, p. 31101 - 31112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during danio rerio development

Giousoh, A., Rodrigues Vaz, R., Bryson-Richardson, R. J., Whisstock, J. C., Verkade, H. M. & Bird, P. I., 2015, In : Gene Expression Patterns. 18, 1-2, p. 37 - 43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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52 Citations (Scopus)

GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome

Li, F., Li, C., Wang, M., Webb, G. I., Zhang, Y., Whisstock, J. C. & Song, J., 2015, In : Bioinformatics. 31, 9, p. 1411 - 1419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

155 Citations (Scopus)

IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, C. A., Lo, C. Y-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P. M., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, C. W. J., Ellisdon, A. M., Rotterd, B., Azam, T., Mangan, N., Rossello, F. J., Whisstock, J., Bufler, P., Garlanda, C., Mantovani, A. A., Dinarello, C. A. & 1 others, Nold, M. F., 2015, In : Nature Immunology. 16, 4, p. 354 - 365 12 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

Perforin and granzymes: function, dysfunction and human pathology

Voskoboinik, I., Whisstock, J. C. & Trapani, J. A., 2015, In : Nature Reviews Immunology. 15, 6, p. 388 - 400 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Preferential acquisition and activation of plasminogen glycoform II by PAM positive group A streptococcal isolates

De Oliveira, D. M. P., Law, R. H. P., Ly, D., Cook, S. M., Quek, A. J., McArthur, J. D., Whisstock, J. C. & Sanderson-Smith, M. L., 2015, In : Biochemistry. 54, 25, p. 3960 - 3968 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase

Cork, A. J., Ericsson, D. J., Law, R. H. P., Casey, L. W., Valkov, E., Bertozzi, C., Stamp, A., Jovcevski, B., Aquilina, J. A., Whisstock, J. C., Walker, M. J. & Kobe, B., 2015, In : PLoS ONE. 10, 3, 18 p., e0121764.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
Open Access
File
20 Citations (Scopus)

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini

Johnson, T. K., Henstridge, M. A., Herr, A. K., Moore, K. A., Whisstock, J. & Warr, C. G., 2015, In : Nature Communications. 6, p. 1-6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2016
15 Citations (Scopus)

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

5 Citations (Scopus)

Development of the cellular immune system of Drosophila requires the membrane attack complex/perforin-like protein Torso-like

Forbes-Beadle, L., Crossman, T., Johnson, T. K., Burke, R., Warr, C. G. & Whisstock, J. C., 1 Oct 2016, In : Genetics. 204, 2, p. 675-681 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Giant MACPF/CDC pore forming toxins: A class of their own

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 1 Mar 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 3, p. 475-486 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Mice lacking Brinp2 or Brinp3, or both, exhibit behaviors consistent with neurodevelopmental disorders

Berkowicz, S. R., Featherby, T. J., Whisstock, J. C. & Bird, P. I., 25 Oct 2016, In : Frontiers in Behavioral Neuroscience. 10, 15 p., 196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Smoothing a rugged protein folding landscape by sequence-based redesign

Porebski, B. T., Keleher, S., Hollins, J. J., Nickson, A. A., Marijanovic, E. M., Borg, N. A., Costa, M. G. S., Pearce, M. A., Dai, W., Zhu, L., Irving, J. A., Hoke, D. E., Kass, I., Whisstock, J. C., Bottomley, S. P., Webb, G. I., McGowan, S. & Buckle, A. M., 26 Sep 2016, In : Scientific Reports. 6, 14 p., 33958.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
48 Citations (Scopus)

Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

Wisniewski, J. A., Traore, D. A. K., Bannam, T. L., Lyras, D., Whisstock, J. C. & Rood, J. I., 1 Mar 2016, In : Molecular Microbiology. 99, 5, p. 884-896 13 p.

Research output: Contribution to journalArticleResearchpeer-review