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Research Output 1997 2019

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2007
39 Citations (Scopus)

The N terminus of the serpin, tengpin, functions to trap the metastable native state

Zhang, Q., Buckle, A. M., Law, R. H. P., Pearce, M. C., Cabrita, L., Lloyd, G., Irving, J. A., Smith, A. I., Ruzyla, K., Rossjohn, J., Bottomley, S. P. & Whisstock, J., 2007, In : EMBO Reports. 8, 7, p. 658 - 663 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
23 Citations (Scopus)

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2

Steenbakkers, P. JM., Irving, J. A., Harhangi, H. R., Swinkels, W. JC., Akhmanova, A., Dijkerman, R., Jetten, M. SM., Van Der Drift, C., Whisstock, J. & Op Den Camp, H. JM., 2008, In : Mycological Research. 112, 8, p. 999 - 1006 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A structural basis for Loop C-sheet polymerization in serpins

Zhang, Q., Law, R. H. P., Bottomley, S. P., Whisstock, J. & Buckle, A. M., 2008, In : Journal of Molecular Biology. 376, 5, p. 1348 - 1359 12 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity

Fenalti, G., Hampe, C. S., Arafat, Y., Law, R. H. P., Banga, J. P., Mackay, I. R., Whisstock, J., Buckle, A. M. & Rowley, M. J., 2008, In : Diabetes. 57, 5, p. 1293 - 1301 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

Kerr, F. K., Thomas, A. R., Wijeyewickrema, L. C., Whisstock, J., Boyd, S. E., Kaiserman, D., Matthews, A. Y., Bird, P. I., Thielens, N. M., Rossi, V. & Pike, R. N., 2008, In : Molecular Immunology. 45, p. 670 - 677 7 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Federated repositories of X-ray diffraction images

Androulakis, S. G., Schmidberger, J., Bate, M. A., DeGori, R., Beitz, A., Keong, C., Cameron, B., McGowan, S., Porter, C. J., Harrison, A., Hunter, J., Martin, J. L., Kobe, B., Dobson, R. CJ., Parker, M. W., Whisstock, J., Gray, J., Treloar, A. E., Groenewegen, D., Dickson, N. & 1 others, Buckle, A. M., 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, 7, p. 810 - 814 5 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Structural biology: Serpins' mystery solved

Whisstock, J. & Bottomley, S. P., 2008, In : Nature. 455, 7217, p. 1189 - 1190 2 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism

Schmidberger, J. W., Wilce, J. A., Weightman, A. J., Whisstock, J. & Wilce, M. C. J., 2008, In : Journal of Molecular Biology. 378, 1, p. 284 - 294 11 p.

Research output: Contribution to journalArticleResearchpeer-review

174 Citations (Scopus)

The MACPF/CDC family of pore-forming toxins

Rosado, C. J., Kondos, S., Bull, T. E., Kuiper, M., Law, R. H. P., Buckle, A. M., Voskoboinik, I., Bird, P. I., Trapani, J. A., Whisstock, J. & Dunstone, M. A., 2008, In : Cellular Microbiology. 10, 9, p. 1765 - 1774 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin

Law, R. H. P., Sofian, T., Kan, W-T., Horvath, A. J., Hitchen, C. R., Langendorf, C., Buckle, A. M., Whisstock, J. & Coughlin, P. B., 2008, In : Blood. 111, p. 2049 - 2052 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
3 Citations (Scopus)

Conformational change in the chromatin remodelling protein MENT

Ong, P. C., Golding, S. J., Pearce, M. C., Irving, J. A., Grigoryev, S. A., Pike, D., Langendorf, C. G., Bashtannyk-Puhalovich, T. A., Bottomley, S. P., Whisstock, J. C., Pike, R. N. & McGowan, S., 2009, In : PLoS ONE. 4, 3 (e4727), p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Modulation of the proteolytic activity of the complement protease C1s by polyanions: Implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

Murray-Rust, T. A., Kerr, F. K., Thomas, A. R., Wu, T. J-T., Yongqing, T., Ong, P. C., Quinsey, N. S., Whisstock, J. C., Wagenaar-Bos, I. C., Freeman, C. & Pike, R. N., 2009, In : Biochemical Journal. 422, 2, p. 295 - 303 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Prodepth: Predict residue depth by support vector regression approach from protein sequences only

Song, J., Tan, H., Mahmood, K., Law, R. H. P., Buckle, A. M., Webb, G., Akutsu, T. & Whisstock, J., 2009, In : PLoS ONE. 4, 9 (e7072), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

97 Citations (Scopus)

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

McGowan, S., Porter, C. J., Lowther, J., Stack, C. M., Golding, S. J., Skinner-Adams, T. S., Trenholme, K. R., Teuscher, F., Donnelly, S. M., Grembecka, J., Mucha, A., Kafarski, P., DeGori, R., Buckle, A. M., Gardiner, D. L., Whisstock, J. C. & Dalton, J. P., 2009, In : Proceedings of the National Academy of Sciences. 106, 8, p. 2537 - 2542 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural determinants of GAD antigenicity

Arafat, Y., Fenalti, G., Whisstock, J., Mackay, I. R., Garcia De La Banda, M. J., Rowley, M. J. & Buckle, A. M., 2009, In : Molecular Immunology. 47, 2-3, p. 493 - 505 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Structural mechanisms of inactivation in scabies mite serine protease paralogues

Fischer, K., Langendorf, C., Irving, J. A., Reynolds, S., Willis, C., Beckham, S. A., Law, R. H. P., Yang, S., Bashtannyk-Puhalovich, T. A., McGowan, S., Whisstock, J., Pike, R. N., Kemp, D. J. & Buckle, A. M., 2009, In : Journal of Molecular Biology. 390, 4, p. 635 - 645 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

Kaiserman, D., Buckle, A. M., Van Damme, P., Irving, J. A., Law, R. H. P., Matthews, A. Y., Bashtannyk-Puhalovich, T. A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J. C. & Bird, P. I., 2009, In : Proceedings of the National Academy of Sciences. 106, 14, p. 5587 - 5592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

Chia, J., Yeo, K. P., Whisstock, J., Dunstone, M. A., Trapani, J. A. & Voskoboinik, I., 2009, In : Proceedings of the National Academy of Sciences. 106, 24, p. 9809 - 9814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

The molecular basis for perforin oligomerization and transmembrane pore assembly

Baran, K., Dunstone, M. A., Chia, J., Ciccone, A., Browne, K. A., Clarke, C. J. P., Lukoyanova, N., Saibil, H., Whisstock, J., Voskoboinik, I. & Trapani, J. A., 2009, In : Immunity. 30, 5, p. 684 - 695 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The performance of perforin-like proteins

Whisstock, J., May 2009, In : Australian Life Scientist. 6, 3, p. 34-35 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
103 Citations (Scopus)

Cascleave: towards more accurate prediction of caspase substrate cleavage sites

Song, J., Tan, H., Shen, H., Mahmood, K., Boyd, S. E., Webb, G., Akutsu, T. & Whisstock, J., 2010, In : Bioinformatics. 26, 6, p. 752 - 760 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus

Wong, W., Kennan, R. M., Rosado, C. J., Rood, J. I., Whisstock, J. & Porter, C. J., 2010, In : Acta Crystallographica. Section F: Structural Biology Communications. 66, 3, p. 289 - 293 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

EGM: Encapsulated gene-by-gene matching to identify gene orthologs and homologous segments in genomes

Mahmood, K., Konagurthu, A. S., Song, J., Buckle, A. M., Webb, G. I. & Whisstock, J. C., 2010, In : Bioinformatics. 26, 17, p. 2076 - 2084 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Maspin (SERPINB5) is an obligate intracellular serpin

Teoh, S., Whisstock, J. & Bird, P. I., 2010, In : Journal of Biological Chemistry. 285, 14, p. 10862 - 10869 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Molecular contortionism - on the physical limits of serpin 'loop-sheet' polymers

Huntington, J. A. & Whisstock, J., 2010, In : Biological Chemistry. 391, 8, p. 973 - 982 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Mrgrid: A portable grid based molecular replacement pipeline

Schmidberger, J. W., Bate, M., Reboul, C. F., Androulakis, S. G., Phan, J. M. N., Whisstock, J., Goscinski, W., Abramson, D. A. & Buckle, A. M., 2010, In : PLoS ONE. 5, 4 (e10049), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

MUSTANG-MR structural sieving server: Applications in protein structural analysis and crystallography

Konagurthu, A. S., Reboul, C. F., Schmidberger, J. W., Irving, J. A., Lesk, A. M., Stuckey, P. J., Whisstock, J. C. & Buckle, A. M., 2010, In : PLoS ONE. 5, 4 (e10048), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)

Perforin: structure, function, and role in human immunopathology

Voskoboinik, I., Dunstone, M. A., Baran, K., Whisstock, J. & Trapani, J. A., 2010, In : Immunological Reviews. 235, 1, p. 35 - 54 20 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

Skinner-Adams, T. S., Stack, C. M., Trenholme, K. R., Brown, C. L., Grembecka, J., Lowther, J., Mucha, A., Drag, M., Kafarski, P., McGowan, S., Whisstock, J., Gardiner, D. L. & Dalton, J. P., 2010, In : Trends in Biochemical Sciences. 35, p. 53 - 61 8 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems

Silverman, G. A., Whisstock, J. C., Bottomley, S. P., Huntington, J. A., Kaiserman, D., Luke, C. J., Pak, S. C., Reichhart, J. -M. & Bird, P. I., 2010, In : Journal of Biological Chemistry. 285, 32, p. 24299 - 24305 7 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

Whisstock, J. C., Silverman, G. A., Bird, P. I., Bottomley, S. P., Kaiserman, D., Luke, C. J., Pak, S. C., Reichhart, J. -M. & Huntington, J. A., 2010, In : Journal of Biological Chemistry. 285, 32, p. 24307 - 24312 6 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

McGowan, S., Oellig, C., Birru, W. A., Caradoc-Davies, T. T., Stack, C. M., Lowther, J., Skinner-Adams, T. S., Mucha, A., Kafarski, P., Grembecka, J., Trenholme, K. R., Buckle, A. M., Gardiner, D. L., Dalton, J. P. & Whisstock, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 6, p. 2449 - 2454 6 p.

Research output: Contribution to journalArticleResearchpeer-review

226 Citations (Scopus)

The structural basis for membrane binding and pore formation by lymphocyte perforin

Law, R. H. P., Lukoyanova, N., Voskoboinik, I., Caradoc-Davies, T. T., Baran, K., Dunstone, M. A., D'Angelo, M., Orlova, E. V., Coulibaly, F. J., Verschoor, S., Browne, K. A., Ciccone, A., Kuiper, M. J., Bird, P. I., Trapani, J. A., Saibil, H. R. & Whisstock, J. C., 2010, In : Nature. 468, 7322, p. 447 - 451 5 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

The structure and function of mammalian membrane-attack complex/perforin-like proteins

Kondos, S., Hatfaludi, T. Z., Voskoboinik, I., Trapani, J. A., Law, R. HP., Whisstock, J. C. & Dunstone, M. A., 2010, In : Tissue Antigens. 76, 5, p. 341 - 351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates

Kennan, R. M., Wong, W., Dhungyel, O., Han, X., Wong, D. M., Parker, D., Rosado, C. J., Law, R. HP., McGowan, S., Reeve, S. B., Levina, V., Powers, G. A., Pike, R. N., Bottomley, S. P., Smith, A. I., Marsh, I., Whittington, R. J., Whisstock, J., Porter, C. J. & Rood, J. I., 2010, In : PLoS Pathogens. 6, 11, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., 2010, In : PLoS Pathogens. 6, 5 (e1000898), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions

Langendorf, C., Key, T., Fenalti, G., Kan, W-T., Buckle, A. M., Caradoc-Davies, T. T., Tuck, K. L., Law, R. H. P. & Whisstock, J., 2010, In : PLoS ONE. 5, 2, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
89 Citations (Scopus)

Automatic generation of protein structure cartoons with Pro-origami

Stivala, A., Wybrow, M., Wirth, A., Whisstock, J. & Stuckey, P., 2011, In : Bioinformatics. 27, 23, p. 3315 - 3316 2 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

Harbut, M., Velmourougane, G., Dalal, S., Reiss, G., Whisstock, J., Onder, O., Brisson, D., McGowan, S., Klemba, M. & Greenbaum, D., 2011, In : Proceedings of the National Academy of Sciences. 108, 34, p. E526 - E534 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Bioinformatic approaches for predicting substrates of proteases

Song, J., Tan, H., Boyd, S. E., Shen, H., Mahmood, K., Webb, G., Akutsu, T., Whisstock, J. & Pike, R., 2011, In : Journal of Bioinformatics and Computational Biology. 9, 1, p. 149 - 178 30 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence

Alonzo III, F., Xayarath, B., Whisstock, J. & Freitag, N., 2011, In : Molecular Microbiology. 80, 6, p. 1530 - 1548 19 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Molecular basis of α 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

Yamasaki, M., Sendall, T. J., Pearce, M. C., Whisstock, J. C. & Huntington, J. A., Oct 2011, In : EMBO Reports. 12, 10, p. 1011-1017 7 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Protection from endogenous perforin: Glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes

Brennan, A., Chia, J., Browne, K., Ciccone, A., Ellis, S. L., Lopez, J., Susanto, O., Verschoor, S., Yagita, H., Whisstock, J., Trapani, J. & Voskoboinik, I., 2011, In : Immunity. 34, 6, p. 879 - 892 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction

Wong, W., Wijeyewickrema, L. C., Kennan, R. M., Reeve, S. B., Steer, D. L., Reboul, C., Smith, A. I., Pike, R. N., Rood, J. I., Whisstock, J. C. & Porter, C. J., 2011, In : Journal of Biological Chemistry. 286, 49, p. 42180 - 42187 8 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase

Velmourougane, G., Harbut, M. B., Dalal, S., McGowan, S., Oellig, C., Meinhardt, N., Whisstock, J. C., Klemba, M. & Greenbaum, D. C., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1655 - 1666 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
2 Citations (Scopus)

A versatile monoclonal antibody specific to human SERPINB5

Teoh, S. SY., Wang, H., Risbridger, G. P., Whisstock, J. C. & Bird, P. I., 2012, In : Hybridoma. 31, 5, p. 333 - 339 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs

Mahmood, K., Webb, G. I., Song, J., Whisstock, J. C. & Konagurthu, A. S., 2012, In : Nucleic Acids Research. 40, 6 (Art. ID: e44), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
42 Citations (Scopus)

Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum

Poreba, M., McGowan, S., Skinner-Adams, T. S., Trenholme, K. R., Gardiner, D. L., Whisstock, J. C., To, J., Salvesen, G. S., Dalton, J. P. & Drag, M., 2012, In : PLoS ONE. 7, 2, 8 p., e31938.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

D'Angelo, M., Dunstone, M. A., Whisstock, J. C., Trapani, J. & Bird, P. I., 2012, In : BMC Evolutionary Biology. 12, Art. ID: 59, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
18 Citations (Scopus)

Predicting giant transmembrane beta-barrel architecture

Reboul, C. F., Mahmood, K., Whisstock, J. C. & Dunstone, M. A., 2012, In : Bioinformatics. 28, 10, p. 1299 - 1302 4 p.

Research output: Contribution to journalArticleResearchpeer-review