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Research Output 1997 2019

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2003
10 Citations (Scopus)

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes

Ally, N., Whisstock, J. C., Sieprawskalupa, M., Potempa, J., Le Bonniec, B. F., Travis, J. & Pike, R. N., 2003, In : Biochemistry. 42, 40, p. 11693 - 11700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Cloning and expression of the major secreted cathepsin B-Iike protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection

Law, R. H. P., Smooker, P. M., Irving, J. A., Piedrafita, D., Ponting, R., Kennedy, N. J., Whisstock, J. C., Pike, R. N. & Spithill, T. W., 2003, In : Infection and Immunity. 71, 12, p. 6921 - 6932 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Determination of the P'1, P'2 and P'3 subsite-specificity of factor Xa

Ludeman, J. P., Pike, R. N., Bromfield, K. M., Duggan, P. J., Cianci, J., Le Bonniec, B., Whisstock, J. C. & Bottomley, S. P., 2003, In : International Journal of Biochemistry and Cell Biology. 35, 2, p. 221 - 225 5 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

Welss, T., Sun, J., Irving, J. A., Blum, R., Smith, A. I., Whisstock, J. C., Pike, R. N., Von Mikecz, A., Ruzicka, T., Bird, P. I. & Abts, H. F., 2003, In : Biochemistry. 42, 24, p. 7381 - 7389 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates

O'Brien, G., Quinsey, N. S., Whisstock, J. C. & Pike, R. N., 2003, In : Biochemistry. 42, 50, p. 14939 - 14945 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability

Quinsey, N. S., Fitton, H. L., Coughlin, P. B., Whisstock, J. C., Dafforn, T. R., Carrell, R. W., Bottomley, S. P. & Pike, R. N., 2003, In : Biochemistry. 42, 34, p. 10169 - 10173 5 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

Molecules in focus: glycoprotein Ib-IX-V

Andrews, R. K., Gardiner, E. E., Shen, Y., Whisstock, J. C. & Berndt, M. C., 2003, In : International Journal of Biochemistry and Cell Biology. 35, 8, p. 1170 - 1174 5 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT

Springhetti, E. M., Istomina, N. E., Whisstock, J. C., Nikitina, T., Woodcock, C. L. & Grigoryev, S. A., 2003, In : Journal of Biological Chemistry. 278, 44, p. 43384 - 43393 10 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

The 1.5 crystal structure of a prokaryote serpin: controlling conformational change in a heated environment

Irving, J. A., Cabrita, L. D., Rossjohn, J., Pike, R. N., Bottomley, S. P. & Whisstock, J. C., 2003, In : Structure. 11, 4, p. 387 - 397 11 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

The evolution of enzyme specificity in Fasciola spp.

Irving, J. A., Spithill, T. W., Pike, R. N., Whisstock, J. C. & Smooker, P. M., 2003, In : Journal of Molecular Evolution. 57, 1, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
88 Citations (Scopus)

Antithrombin: in control of coagulation

Quinsey, N. S., Greedy, A. L., Bottomley, S. P., Whisstock, J. C. & Pike, R. N., 2004, In : International Journal of Biochemistry and Cell Biology. 36, 3, p. 386 - 389 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

CLIMS: Crystallography Laboratory Information Management System

Fulton, K. F., Ervine, S., Faux, N. G., Forster, R., Ly, W., Robilliard, L., Sonsini, J., Whelan, D., Whisstock, J. C. & Buckle, A. M., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 9, p. 1691 - 1693 3 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Computational analysis of evolution and conservation in a protein superfamily

Irving, J. A., Askew, D. J. & Whisstock, J. C., 2004, In : Methods. 32, 2, p. 73 - 92 20 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis

Silverman, G. A., Whisstock, J. C., Askew, D. J., Pak, S. C., Luke, C. J., Cataltepe, S., Irving, J. A. & Bird, P. I., 2004, In : Cellular and Molecular Life Sciences. 61, 3, p. 301 - 325 25 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Progressive multiple alignment using sequence triplet optimizations and three-residue exchange costs

Konagurthu, A., Whisstock, J. & Stuckey, P., 2004, In : Journal of Bioinformatics and Computational Biology. 2, 4, p. 719 - 745 27 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

Chow, M. K. M., Mackay, J. P., Whisstock, J. C., Scanlon, M. J. & Bottomley, S. P., 2004, In : Biochemical and Biophysical Research Communications. 322, 3, p. 387 - 394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The human serpin proteinase inhibitor-9 self-associates at physiological temperatures

Benning, L. N., Whisstock, J. C., Sun, J., Bird, P. I. & Bottomley, S. P., 2004, In : Protein Science. 13, 7, p. 1859 - 1864 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
58 Citations (Scopus)

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

Bird, C. H., Sun, J., Ung, K. S., Karambalis, D., Whisstock, J. C., Trapani, J. A. & Bird, P. I., 2005, In : Molecular and Cellular Biology. 25, 17, p. 7854 - 7867 14 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Elucidation of the substrate specificity of the C1s protease of the classical complement pathway

Kerr, F. K., O'Brien, G., Quinsey, N. S., Whisstock, J., Boyd, S. E., Garcia De La Banda, M. J., Kaiserman, D., Matthews, A. Y., Bird, P. I. & Pike, R. N., 2005, In : Journal of Biological Chemistry. 280, 47, p. 39510 - 39514 5 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Functional insights from the distribution and role of homopeptide repeat-containing proteins

Faux, N. G., Bottomley, S. P., Lesk, A. M., Irving, J. A., Morrison, J. R., Garcia De La Banda, M. J. & Whisstock, J. C., 2005, In : Genome Research. 15, 4, p. 537 - 551 15 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

PoPS: A computational tool for modeling and predicting protease specificity

Boyd, S. E., Pike, R. N., Rudy, G. B., Whisstock, J. & Garcia De La Banda, M. J., 2005, In : Journal of Bioinformatics and Computational Biology. 3, 3, p. 551 - 585 35 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
210 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

Fulton, K. F., Buckle, A. M., Cabrita, L. D., Irving, J. A., Butcher, R. E., Smith, A. I., Reeve, S. B., Lesk, A. M., Bottomley, S. P., Rossjohn, J. & Whisstock, J. C., 2005, In : Journal of Biological Chemistry. 280, 9, p. 8435 - 8442 8 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix

Law, R. H. P., Irving, J. A., Buckle, A. M., Ruzyla, K., Buzza, M. S., Bashtannyk-Puhalovich, T. A., Beddoe, T. C., Nguyen, K-N., Worrall, M. D., Bottomley, S. P., Bird, P. I., Rossjohn, J. & Whisstock, J. C., 2005, In : Journal of Biological Chemistry. 280, 23, p. 22356 - 22364 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The matrix refolded

Buckle, A. M., Devlin, G. L., Jodun, R. A., Fulton, K. F., Faux, N. G., Whisstock, J. C. & Bottomley, S. P., 2005, In : Nature Methods. 2, 1, p. 3 - 3 1 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

The murine orthologue of human antichymotrypsin: a structural paradigm for CLADE A3 serpins

Horvath, A. J., Irving, J. A., Rossjohn, J., Law, R. H. P., Bottomley, S. P., Quinsey, N. S., Pike, R. N., Coughlin, P. B. & Whisstock, J., 2005, In : Journal of Biological Chemistry. 280, 52, p. 43168 - 43178 11 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

Ivetac, I., Munday, A. D., Kisseleva, M. V., Zhang, X-M., Luff, S. E., Tiganis, T., Whisstock, J. C., Rowe, T., Majerus, P. W. & Mitchell, C. A., 2005, In : Molecular Biology of the Cell. 16, 5, p. 2218 - 2233 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
247 Citations (Scopus)

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

Paton, A. W., Beddoe, T. C., Thorpe, C. M., Whisstock, J., Wilce, M. C. J., Rossjohn, J., Talbot, U. M. & Paton, J. C., 2006, In : Nature. 443, 7111, p. 548 - 552 5 p.

Research output: Contribution to journalArticleResearchpeer-review

326 Citations (Scopus)

An overview of the serpin superfamily

Law, R. H. P., Zhang, Q., McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W., Rosado, C. J., Langendorf, C., Pike, R. N., Bird, P. I. & Whisstock, J., 2006, In : Genome Biology. 7, 5, p. 216-1 - 216-11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Hijacking of a substrate-binding protein scaffold for use in mycobacterial cell wall biosynthesis

Marland, Z., Beddoe, T. C., Zaker-Tabrizi, L., Lucet, I., Brammananth, R., Whisstock, J. C., Wilce, M. C. J., Coppel, R. L., Crellin, P. K. & Rossjohn, J., 2006, In : Journal of Molecular Biology. 359, 4, p. 983 - 997 15 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor

Shen, Y., Cranmer, S. L., Aprico, A., Whisstock, J., Jackson, S., Berndt, M. C. & Andrews, R. K., 2006, In : Journal of Biological Chemistry. 281, 36, p. 26419 - 26423 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Managing and mining protein crystallization data

Amin, A. A., Faux, N. G., Fenalti, G., Williams, G. N., Bernadou, A., Daglish, B., Keefe, K., Middleton, S., Rae, J., Tetis, K., Law, R. H. P., Fulton, K. F., Rossjohn, J., Whisstock, J. C. & Buckle, A. M., 2006, In : Proteins: Structure, Function, and Bioinformatics. 62, 1, p. 4 - 7 4 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Mechanisms of serpin dysfunction in disease

Kaiserman, D., Whisstock, J. C. & Bird, P. I., 2006, In : Expert Reviews in Molecular Medicine. 8, 31, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Molecular gymnastics: serpin structure, folding and misfolding

Whisstock, J. & Bottomley, S. P., 2006, In : Current Opinion in Structural Biology. 16, 6, p. 761 - 768 8 p.

Research output: Contribution to journalArticleResearchpeer-review

459 Citations (Scopus)

MUSTANG: a multiple structural alignment algorithm

Konagurthu, A. S., Whisstock, J. C., Stuckey, P. J. & Lesk, A. M., 2006, In : Proteins: Structure, Function, and Bioinformatics. 64, 3, p. 559 - 574 16 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

REFOLD: an analytical database of protein refolding methods

Chow, M. K. M., Amin, A. A., Fulton, K. F., Whisstock, J. C., Buckle, A. M. & Bottomley, S. P., 2006, In : Protein Expression and Purification. 46, 1, p. 166 - 171 6 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase

Hennebry, S. C., Law, R. H. P., Richardson, S. J., Buckle, A. M. & Whisstock, J. C., 2006, In : Journal of Molecular Biology. 359, 5, p. 1389 - 1399 11 p.

Research output: Contribution to journalArticleResearchpeer-review

135 Citations (Scopus)

The major human and mouse granzymes are structurally and functionally divergent

Kaiserman, D., Bird, C. H., Sun, J., Matthews, A. Y., Ung, K. S., Whisstock, J. C., Thompson, P. E., Trapani, J. A. & Bird, P. I., 2006, In : Journal of Cell Biology. 175, 4, p. 619 - 630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The REFOLD database: a tool for the optimization of protein expression and refolding.

Chow, M. K. M., Amin, A. A., Fulton, K. F., Fernando, T., Kamau, L., Batty, C., Louca, M., Ho, S., Whisstock, J. C., Bottomley, S. P. & Buckle, A. M., 2006, In : Nucleic Acids Research. 34, D-Base Issue, p. D207 - D212 6 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

McGowan, S., Buckle, A. M., Irving, J. A., Ong, P. C., Bashtannyk-Puhalovich, T. A., Kan, W-T., Henderson, K., Bulynko, Y. A., Popova, E. Y., Smith, A. I., Bottomley, S. P., Rossjohn, J., Grigoryev, S. A., Pike, R. N. & Whisstock, J. C., 2006, In : EMBO Journal. 25, 13, p. 3144 - 3155 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
190 Citations (Scopus)

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 others, Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Aeropin from the extremophile pyrobaculum aerophilum bypasses the serpin misfolding trap

Cabrita, L., Irving, J. A., Pearce, M. C., Whisstock, J. & Bottomley, S. P., 2007, In : Journal of Biological Chemistry. 282, 37, p. 26802 - 26809 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

DNA accelerates the inhibition of human cathepsin V by serpins

Ong, P. C., McGowan, S., Pearce, M. C., Irving, J. A., Kan, W-T., Grigoryev, S. A., Turk, B., Silverman, G. A., Brix, K., Bottomley, S. P., Whisstock, J. & Pike, R. N., 2007, In : Journal of Biological Chemistry. 282, 51, p. 36980 - 36986 7 p.

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

Fenalti, G., Law, R. H. P., Buckle, A. M., Langendorf, C., Tuck, K. L., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P., Wilce, M. C. J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I. R., Rowley, M. J. & Whisstock, J., 2007, In : Nature Structural and Molecular Biology. 14, 4, p. 280 - 286 7 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins

Faux, N. G., Huttley, G. A., Mahmood, K., Webb, G., Garcia De La Banda, M. J. & Whisstock, J., 2007, In : Genome Research. 17, 7, p. 1118 - 1127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

SERPINB11 is a new noninhibitory intracellular serpin: Common single nucleotide polymorphisms in the scaffold impair conformational change

Askew, D. J., Cataltepe, S., Kumar, V., Edwards, C., Pace, S. M., Howarth, R. N., Pak, S. C., Askew, Y. S., Bromme, D., Luke, C., Whisstock, J. & Silverman, G. A., 2007, In : Journal of Biological Chemistry. 282, 34, p. 24948 - 24960 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes

Scott, F. L., Sun, J. H., Whisstock, J., Kato, K. & Bird, P. I., 2007, In : Journal of Biochemistry. 142, 4, p. 435 - 442 8 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

The 1.6 angstrom crystal structure of the catalytic domain of PlyB, a bacteriophage lysin active against Bacillus anthracis

Porter, C. J., Schuch, R., Pelzek, A. J., Buckle, A. M., McGowan, S., Wilce, M. C. J., Rossjohn, J., Russell, R., Nelson, D., Fischetti, V. A. & Whisstock, J. C., 2007, In : Journal of Molecular Biology. 366, 2, p. 540 - 550 11 p.

Research output: Contribution to journalArticleResearchpeer-review