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2020

Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

Harrington, B. S., He, Y., Khan, T., Puttick, S., Conroy, P. J., Kryza, T., Cuda, T., Sokolowski, K. A., Tse, B. W. C., Robbins, K. K., Arachchige, B. J., Stehbens, S. J., Pollock, P. M., Reed, S., Weroha, S. J., Haluska, P., Salomon, C., Lourie, R., Perrin, L. C., Law, R. H. P. & 2 others, Whisstock, J. C. & Hooper, J. D., 2020, In : Theranostics. 10, 5, p. 2095-2114 20 p.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Automated cryo-lamella preparation for high-throughput in-situ structural biology

Buckley, G., Gervinskas, G., Taveneau, C., Venugopal, H., Whisstock, J. C. & de Marco, A., 1 May 2020, In : Journal of Structural Biology. 210, 2, 8 p., 107488.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

Kryza, T., Khan, T., Puttick, S., Li, C., Sokolowski, K. A., Tse, B. W. C., Cuda, T., Lyons, N., Gough, M., Yin, J., Parkin, A., Deryugina, E. I., Quigley, J. P., Law, R. H. P., Whisstock, J. C., Riddell, A. D., Barbour, A. P., Wyld, D. K., Thomas, P. A., Rose, S. & 4 others, Snell, C. E., Pajic, M., He, Y. & Hooper, J. D., 4 Mar 2020, In : Theranostics. 10, 9, p. 4116-4133 18 p.

Research output: Contribution to journalArticleResearchpeer-review

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Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

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2019

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 2 Jan 2019, In : ChemBioChem. 20, 1, p. 46-50 5 p.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, J. E., Wu, G., Mahatmanto, T., Durek, T., Caradoc-Davies, T. T., Whisstock, J. C., Law, R. H. P. & Craik, D. J., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 552-560 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

Gorelick, S., Buckley, G., Gervinskas, G., Johnson, T. K., Handley, A., Caggiano, M. P., Whisstock, J. C., Pocock, R. & de Marco, A., 1 Jul 2019, In : eLife. 8, 15 p., e45919.

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9 Citations (Scopus)

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes

Yuan, Y., Ayinuola, Y. A., Singh, D., Ayinuola, O., Mayfield, J. A., Quek, A., Whisstock, J. C., Law, R. H. P., Lee, S. W., Ploplis, V. A. & Castellino, F. J., 1 Oct 2019, In : Journal of Structural Biology. 208, p. 18-29 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Quek, A. J. H., Mazzitelli, B. A., Wu, G., Leung, E. W. W., Caradoc-Davies, T. T., Lloyd, G. J., Jeevarajah, D., Conroy, P. J., Sanderson-Smith, M., Yuan, Y., Ayinuola, Y. A., Castellino, F. J., Whisstock, J. C. & Law, R. H. P., 6 Sep 2019, In : Journal of Molecular Biology. 431, 19, p. 3804-3813 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Pang, S. S., Bayly-Jones, C., Radjainia, M., Spicer, B. A., Law, R. H. P., Hodel, A. W., Parsons, E. S., Ekkel, S. M., Conroy, P. J., Ramm, G., Venugopal, H., Bird, P. I., Hoogenboom, B. W., Voskoboinik, I., Gambin, Y., Sierecki, E., Dunstone, M. A. & Whisstock, J. C., 19 Sep 2019, In : Nature Communications. 10, 1, 9 p., 4288.

Research output: Contribution to journalArticleResearchpeer-review

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8 Citations (Scopus)

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods

Li, F., Wang, Y., Li, C., Marquez-Lago, T. T., Leier, A., Rawlings, N. D., Haffari, G., Revote, J., Akutsu, T., Chou, K-C., Purcell, A. W., Pike, R. N., Webb, G. I., Smith, A. I., Lithgow, T., Daly, R. J., Whisstock, J. C. & Song, J., 27 Nov 2019, In : Briefings in Bioinformatics. 20, 6, p. 2150-2166 17 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2018

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

Genome-wide screen for new components of the Drosophila melanogaster Torso receptor tyrosine kinase pathway

Johns, A. R., Henstridge, M. A., Saligari, M. J., Moore, K. A., Whisstock, J. C., Warr, C. G. & Johnson, T. K., 1 Mar 2018, In : G3: Genes, Genomes, Genetics. 8, 3, p. 761-769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, A. J., Law, R. H. P., Conroy, P. J., Noori, T., Lukoyanova, N., Saibil, H., Yagita, H., Ciccone, A., Verschoor, S., Whisstock, J. C., Trapani, J. A. & Voskoboinik, I., 7 Feb 2018, In : Cell Death and Differentiation. 25, p. 1517-1529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
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6 Citations (Scopus)

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

Torso-like is a component of the hemolymph and regulates the insulin signaling pathway in Drosophila

Henstridge, M. A., Aulsebrook, L., Koyama, T., Johnson, T. K., Whisstock, J. C., Tiganis, T., Mirth, C. K. & Warr, C. G., 1 Apr 2018, In : Genetics. 208, 4, p. 1523-1533 11 p.

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3 Citations (Scopus)
2017

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Westwood, J. A., Ellis, S., Danne, J., Johnson, C., Oorschot, V., Ramm, G., Tscharke, D. C., Davenport, A. J., Whisstock, J. C., Darcy, P. K., Kershaw, M. H. & Slaney, C. Y., 14 Dec 2017, In : Oncotarget. 8, 70, p. 115215-115229 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Yang, A. S. P., O'Neill, M. T., Jennison, C., Lopaticki, S., Allison, C. C., Armistead, J. S., Erickson, S. M., Rogers, K. L., Ellisdon, A. M., Whisstock, J. C., Tweedell, R. E., Dinglasan, R. R., Douglas, D. N., Kneteman, N. M. & Boddey, J. A., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3105-3116 12 p.

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27 Citations (Scopus)

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Maternal torso-like coordinates tissue folding during Drosophila gastrulation

Johnson, T. K., Moore, K. A., Whisstock, J. C. & Warr, C. G., 1 Jul 2017, In : Genetics. 206, 3, p. 1459-1468 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Real-time visualization of perforin nanopore assembly

Leung, C., Hodel, A. W., Brennan, A. J., Lukoyanova, N., Tran, S., House, C. M., Kondos, S. C., Whisstock, J. C., Dunstone, M. A., Trapani, J. A., Voskoboinik, I., Saibil, H. R. & Hoogenboom, B. W., May 2017, In : Nature Nanotechnology. 12, p. 467-473 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

House, I. G., House, C. M., Brennan, A. J., Gilan, O., Dawson, M. A., Whisstock, J. C., Law, R. H. P., Trapani, J. A. & Voskoboinik, I., 1 Oct 2017, In : EMBO Reports. 18, 10, p. 1775-1785 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The structural basis for complement inhibition by gigastasin, a protease inhibitor from the giant Amazon leech

Pang, S. S., Wijeyewickrema, L. C., Hor, L., Tan, S., Lameignere, E., Conway, E. M., Blom, A. M., Mohlin, F. C., Liu, X., Payne, R. J., Whisstock, J. C. & Pike, R. N., 1 Dec 2017, In : Journal of Immunology. 199, 11, p. 3883-3891 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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6 Citations (Scopus)
2016

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

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16 Citations (Scopus)

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

Development of the cellular immune system of Drosophila requires the membrane attack complex/perforin-like protein Torso-like

Forbes-Beadle, L., Crossman, T., Johnson, T. K., Burke, R., Warr, C. G. & Whisstock, J. C., 1 Oct 2016, In : Genetics. 204, 2, p. 675-681 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Giant MACPF/CDC pore forming toxins: A class of their own

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 1 Mar 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 3, p. 475-486 12 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Mice lacking Brinp2 or Brinp3, or both, exhibit behaviors consistent with neurodevelopmental disorders

Berkowicz, S. R., Featherby, T. J., Whisstock, J. C. & Bird, P. I., 25 Oct 2016, In : Frontiers in Behavioral Neuroscience. 10, 15 p., 196.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

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8 Citations (Scopus)

Smoothing a rugged protein folding landscape by sequence-based redesign

Porebski, B. T., Keleher, S., Hollins, J. J., Nickson, A. A., Marijanovic, E. M., Borg, N. A., Costa, M. G. S., Pearce, M. A., Dai, W., Zhu, L., Irving, J. A., Hoke, D. E., Kass, I., Whisstock, J. C., Bottomley, S. P., Webb, G. I., McGowan, S. & Buckle, A. M., 26 Sep 2016, In : Scientific Reports. 6, 14 p., 33958.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

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55 Citations (Scopus)

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

Wisniewski, J. A., Traore, D. A. K., Bannam, T. L., Lyras, D., Whisstock, J. C. & Rood, J. I., 1 Mar 2016, In : Molecular Microbiology. 99, 5, p. 884-896 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2015

Analysis of perforin assembly by quartz crystal microbalance reveals a role for cholesterol and calcium-independent membrane binding

Stewart, S. E., Bird, C. H., Tabor, R. F., D'Angelo, M., Piantavigna, S., Whisstock, J. C., Trapani, J. A., Martin, L. L. & Bird, P. I., 2015, In : The Journal of Biological Chemistry. 290, 52, p. 31101 - 31112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during danio rerio development

Giousoh, A., Rodrigues Vaz, R., Bryson-Richardson, R. J., Whisstock, J. C., Verkade, H. M. & Bird, P. I., 2015, In : Gene Expression Patterns. 18, 1-2, p. 37 - 43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

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58 Citations (Scopus)

GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome

Li, F., Li, C., Wang, M., Webb, G. I., Zhang, Y., Whisstock, J. C. & Song, J., 2015, In : Bioinformatics. 31, 9, p. 1411 - 1419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, C. A., Lo, C. Y-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P. M., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, C. W. J., Ellisdon, A. M., Rotterd, B., Azam, T., Mangan, N., Rossello, F. J., Whisstock, J., Bufler, P., Garlanda, C., Mantovani, A. A., Dinarello, C. A. & 1 others, Nold, M. F., 2015, In : Nature Immunology. 16, 4, p. 354 - 365 12 p.

Research output: Contribution to journalArticleResearchpeer-review

188 Citations (Scopus)

Perforin and granzymes: function, dysfunction and human pathology

Voskoboinik, I., Whisstock, J. C. & Trapani, J. A., 2015, In : Nature Reviews Immunology. 15, 6, p. 388 - 400 13 p.

Research output: Contribution to journalArticleResearchpeer-review

271 Citations (Scopus)

Preferential acquisition and activation of plasminogen glycoform II by PAM positive group A streptococcal isolates

De Oliveira, D. M. P., Law, R. H. P., Ly, D., Cook, S. M., Quek, A. J., McArthur, J. D., Whisstock, J. C. & Sanderson-Smith, M. L., 2015, In : Biochemistry. 54, 25, p. 3960 - 3968 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase

Cork, A. J., Ericsson, D. J., Law, R. H. P., Casey, L. W., Valkov, E., Bertozzi, C., Stamp, A., Jovcevski, B., Aquilina, J. A., Whisstock, J. C., Walker, M. J. & Kobe, B., 2015, In : PLoS ONE. 10, 3, 18 p., e0121764.

Research output: Contribution to journalArticleResearchpeer-review

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6 Citations (Scopus)

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : The Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
29 Citations (Scopus)

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini

Johnson, T. K., Henstridge, M. A., Herr, A. K., Moore, K. A., Whisstock, J. & Warr, C. G., 2015, In : Nature Communications. 6, p. 1-6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)
2014

A new model for pore formation by cholesterol-dependent cytolysins

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 2014, In : PLoS Computational Biology. 10, 8, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?

Duncan, E. J., Johnson, T. K., Whisstock, J., Warr, C. G. & Dearden, P. K., 2014, In : Current Opinion in Insect Science. 1, p. 45 - 51 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)