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Research Output 1997 2019

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2019

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 17 Sep 2018, (Accepted/In press) In : ChemBioChem. 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genome-wide screen for new components of the Drosophila melanogaster Torso receptor tyrosine kinase pathway

Johns, A. R., Henstridge, M. A., Saligari, M. J., Moore, K. A., Whisstock, J. C., Warr, C. G. & Johnson, T. K., 1 Mar 2018, In : G3: Genes, Genomes, Genetics. 8, 3, p. 761-769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, J. E., Wu, G., Mahatmanto, T., Durek, T., Caradoc-Davies, T. T., Whisstock, J. C., Law, R. H. P. & Craik, D. J., 6 Dec 2018, (Accepted/In press) In : Journal of Medicinal Chemistry. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, A. J., Law, R. H. P., Conroy, P. J., Noori, T., Lukoyanova, N., Saibil, H., Yagita, H., Ciccone, A., Verschoor, S., Whisstock, J. C., Trapani, J. A. & Voskoboinik, I., 7 Feb 2018, In : Cell Death and Differentiation. 25, p. 1517-1529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Torso-like is a component of the hemolymph and regulates the insulin signaling pathway in Drosophila

Henstridge, M. A., Aulsebrook, L., Koyama, T., Johnson, T. K., Whisstock, J. C., Tiganis, T., Mirth, C. K. & Warr, C. G., 1 Apr 2018, In : Genetics. 208, 4, p. 1523-1533 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods

Li, F., Wang, Y., Li, C., Marquez-Lago, T. T., Leier, A., Rawlings, N. D., Haffari, G., Revote, J., Akutsu, T., Chou, K-C., Purcell, A. W., Pike, R. N., Webb, G. I., Smith, A. I., Lithgow, T., Daly, R. J., Whisstock, J. C. & Song, J., 2018, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bby077.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Westwood, J. A., Ellis, S., Danne, J., Johnson, C., Oorschot, V., Ramm, G., Tscharke, D. C., Davenport, A. J., Whisstock, J. C., Darcy, P. K., Kershaw, M. H. & Slaney, C. Y., 14 Dec 2017, In : Oncotarget. 8, 70, p. 115215-115229 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Yang, A. S. P., O'Neill, M. T., Jennison, C., Lopaticki, S., Allison, C. C., Armistead, J. S., Erickson, S. M., Rogers, K. L., Ellisdon, A. M., Whisstock, J. C., Tweedell, R. E., Dinglasan, R. R., Douglas, D. N., Kneteman, N. M. & Boddey, J. A., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3105-3116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

Maternal torso-like coordinates tissue folding during Drosophila gastrulation

Johnson, T. K., Moore, K. A., Whisstock, J. C. & Warr, C. G., 1 Jul 2017, In : Genetics. 206, 3, p. 1459-1468 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Real-time visualization of perforin nanopore assembly

Leung, C., Hodel, A. W., Brennan, A. J., Lukoyanova, N., Tran, S., House, C. M., Kondos, S. C., Whisstock, J. C., Dunstone, M. A., Trapani, J. A., Voskoboinik, I., Saibil, H. R. & Hoogenboom, B. W., May 2017, In : Nature Nanotechnology. 12, p. 467-473 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

House, I. G., House, C. M., Brennan, A. J., Gilan, O., Dawson, M. A., Whisstock, J. C., Law, R. H. P., Trapani, J. A. & Voskoboinik, I., 1 Oct 2017, In : EMBO Reports. 18, 10, p. 1775-1785 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The structural basis for complement inhibition by gigastasin, a protease inhibitor from the giant Amazon leech

Pang, S. S., Wijeyewickrema, L. C., Hor, L., Tan, S., Lameignere, E., Conway, E. M., Blom, A. M., Mohlin, F. C., Liu, X., Payne, R. J., Whisstock, J. C. & Pike, R. N., 1 Dec 2017, In : Journal of Immunology. 199, 11, p. 3883-3891 9 p.

Research output: Contribution to journalArticleResearchpeer-review

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

Development of the cellular immune system of Drosophila requires the membrane attack complex/perforin-like protein Torso-like

Forbes-Beadle, L., Crossman, T., Johnson, T. K., Burke, R., Warr, C. G. & Whisstock, J. C., 1 Oct 2016, In : Genetics. 204, 2, p. 675-681 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Giant MACPF/CDC pore forming toxins: A class of their own

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 1 Mar 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 3, p. 475-486 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mice lacking Brinp2 or Brinp3, or both, exhibit behaviors consistent with neurodevelopmental disorders

Berkowicz, S. R., Featherby, T. J., Whisstock, J. C. & Bird, P. I., 25 Oct 2016, In : Frontiers in Behavioral Neuroscience. 10, 15 p., 196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Smoothing a rugged protein folding landscape by sequence-based redesign

Porebski, B. T., Keleher, S., Hollins, J. J., Nickson, A. A., Marijanovic, E. M., Borg, N. A., Costa, M. G. S., Pearce, M. A., Dai, W., Zhu, L., Irving, J. A., Hoke, D. E., Kass, I., Whisstock, J. C., Bottomley, S. P., Webb, G. I., McGowan, S. & Buckle, A. M., 26 Sep 2016, In : Scientific Reports. 6, 14 p., 33958.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

Wisniewski, J. A., Traore, D. A. K., Bannam, T. L., Lyras, D., Whisstock, J. C. & Rood, J. I., 1 Mar 2016, In : Molecular Microbiology. 99, 5, p. 884-896 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Analysis of perforin assembly by quartz crystal microbalance reveals a role for cholesterol and calcium-independent membrane binding

Stewart, S. E., Bird, C. H., Tabor, R. F., D'Angelo, M., Piantavigna, S., Whisstock, J. C., Trapani, J. A., Martin, L. L. & Bird, P. I., 2015, In : Journal of Biological Chemistry. 290, 52, p. 31101 - 31112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during danio rerio development

Giousoh, A., Rodrigues Vaz, R., Bryson-Richardson, R. J., Whisstock, J. C., Verkade, H. M. & Bird, P. I., 2015, In : Gene Expression Patterns. 18, 1-2, p. 37 - 43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome

Li, F., Li, C., Wang, M., Webb, G. I., Zhang, Y., Whisstock, J. C. & Song, J., 2015, In : Bioinformatics. 31, 9, p. 1411 - 1419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, C. A., Lo, C. Y-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P. M., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, C. W. J., Ellisdon, A. M., Rotterd, B., Azam, T., Mangan, N., Rossello, F. J., Whisstock, J., Bufler, P., Garlanda, C., Mantovani, A. A., Dinarello, C. A. & 1 othersNold, M. F., 2015, In : Nature Immunology. 16, 4, p. 354 - 365 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin and granzymes: function, dysfunction and human pathology

Voskoboinik, I., Whisstock, J. C. & Trapani, J. A., 2015, In : Nature Reviews Immunology. 15, 6, p. 388 - 400 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Preferential acquisition and activation of plasminogen glycoform II by PAM positive group A streptococcal isolates

De Oliveira, D. M. P., Law, R. H. P., Ly, D., Cook, S. M., Quek, A. J., McArthur, J. D., Whisstock, J. C. & Sanderson-Smith, M. L., 2015, In : Biochemistry. 54, 25, p. 3960 - 3968 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase

Cork, A. J., Ericsson, D. J., Law, R. H. P., Casey, L. W., Valkov, E., Bertozzi, C., Stamp, A., Jovcevski, B., Aquilina, J. A., Whisstock, J. C., Walker, M. J. & Kobe, B., 2015, In : PLoS ONE. 10, 3, 18 p., e0121764.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini

Johnson, T. K., Henstridge, M. A., Herr, A. K., Moore, K. A., Whisstock, J. & Warr, C. G., 2015, In : Nature Communications. 6, p. 1-6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

A new model for pore formation by cholesterol-dependent cytolysins

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 2014, In : PLoS Computational Biology. 10, 8, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Capturing embryonic development from metamorphosis: how did the terminal patterning signalling pathway of Drosophila evolve?

Duncan, E. J., Johnson, T. K., Whisstock, J., Warr, C. G. & Dearden, P. K., 2014, In : Current Opinion in Insect Science. 1, p. 45 - 51 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets

Wang, M., Zhao, X-M., Tan, H., Akutsu, T., Whisstock, J. & Song, J., 2014, In : Bioinformatics. 30, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster

Ellisdon, A. M., Zhang, Q., Bennett, M. A., Johnson, T. K., Warr, C. G., Law, R. H. P. & Whisstock, J. C., 2014, In : BMC Structural Biology. 14, 1, p. 1 - 8 8 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Maspin is not required for embryonic development or tumour suppression

Teoh, S. S. Y., Vieusseux, J. L., Prakash, M. D., Berkowicz, S. R., Luu, J., Bird, C. H., Law, R. H. P., Rosado, C. J., Price, J. T., Whisstock, J. C. & Bird, P. I., 2014, In : Nature Communications. 5, (Art. No.: 3164), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Reconciling the structural attributes of avian antibodies

Conroy, P., Law, R. H. P., Gilgunn, S., Hearty, S., Caradoc-Davies, T. T., Lloyd, G., O'Kennedy, R. & Whisstock, J., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15384 - 15392 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The perforin pore facilitates the delivery of cationic cargos

Stewart, S. E., Kondos, S., Matthews, A. Y., D'Angelo, M., Dunstone, M. A., Whisstock, J., Trapani, J. A. & Bird, P. I., 2014, In : Journal of Biological Chemistry. 289, 13, p. 9172 - 9181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The three-dimensional structure of the extracellular adhesion domain of the sialic acid-binding adhesin SabA from Helicobacter pylori

Pang, S. S., Nguyen, T. S., Perry, A. J., Day, C. J., Panjikar, S., Tiralongo, J., Whisstock, J. & Kwok, T., 2014, In : Journal of Biological Chemistry. 289, 10, p. 6332 - 6340 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like

Henstridge, M. A., Johnson, T. K., Warr, C. G. & Whisstock, J., 2014, In : Nature Communications. 5, 3419, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Perry, A. J., Wijeyewickrema, L. C., Wilmann, P. G., Gunzburg, M. J., D'Andrea, L. P., Irving, J., Pang, S. S., Duncan, R. C., Wilce, J. A., Whisstock, J. & Pike, R. N., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15821 - 15829 9 p.

Research output: Contribution to journalArticleResearchpeer-review