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Research Output 1997 2019

2019
1 Citation (Scopus)

Brentuximab vedotin in T-cell lymphoma

Van Der Weyden, C., Dickinson, M., Whisstock, J. & Prince, H. M., 2 Jan 2019, In : Expert Review of Hematology. 12, 1, p. 5-19 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 2 Jan 2019, In : ChemBioChem. 20, 1, p. 46-50 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Control of growth factor signalling by MACPF proteins

Bakopoulos, D., Whisstock, J. C. & Johnson, T. K., 28 Jun 2019, In : Biochemical Society Transactions. 47, 3, p. 801-810 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, J. E., Wu, G., Mahatmanto, T., Durek, T., Caradoc-Davies, T. T., Whisstock, J. C., Law, R. H. P. & Craik, D. J., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 552-560 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

Gorelick, S., Buckley, G., Gervinskas, G., Johnson, T. K., Handley, A., Caggiano, M. P., Whisstock, J. C., Pocock, R. & de Marco, A., 1 Jul 2019, In : eLife. 8, 15 p., e45919.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes

Yuan, Y., Ayinuola, Y. A., Singh, D., Ayinuola, O., Mayfield, J. A., Quek, A., Whisstock, J. C., Law, R. H. P., Lee, S. W., Ploplis, V. A. & Castellino, F. J., 1 Oct 2019, In : Journal of Structural Biology. 208, p. 18-29 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Structural studies of plasmin inhibition

Wu, G., Quek, A. J., Caradoc-Davies, T. T., Ekkel, S. M., Mazzitelli, B., Whisstock, J. C. & Law, R. H. P., 5 Mar 2019, In : Biochemical Society Transactions. 47, 2, p. 541-557 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Quek, A. J. H., Mazzitelli, B. A., Wu, G., Leung, E. W. W., Caradoc-Davies, T. T., Lloyd, G. J., Jeevarajah, D., Conroy, P. J., Sanderson-Smith, M., Yuan, Y., Ayinuola, Y. A., Castellino, F. J., Whisstock, J. C. & Law, R. H. P., 6 Sep 2019, In : Journal of Molecular Biology. 431, 19, p. 3804-3813 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Pang, S. S., Bayly-Jones, C., Radjainia, M., Spicer, B. A., Law, R. H. P., Hodel, A. W., Parsons, E. S., Ekkel, S. M., Conroy, P. J., Ramm, G., Venugopal, H., Bird, P. I., Hoogenboom, B. W., Voskoboinik, I., Gambin, Y., Sierecki, E., Dunstone, M. A. & Whisstock, J. C., 19 Sep 2019, In : Nature Communications. 10, 1, 9 p., 4288.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Toward Better Understanding on How Group A Streptococcus Manipulates Human Fibrinolytic System

Quek, A. J. H., Whisstock, J. C. & Law, R. H. P., 16 Aug 2019, Staphylococcus and Streptococcus. Kirmusaoglu, S. (ed.). IntechOpen Limited, 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Open Access
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2 Citations (Scopus)

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
6 Citations (Scopus)

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genome-wide screen for new components of the Drosophila melanogaster Torso receptor tyrosine kinase pathway

Johns, A. R., Henstridge, M. A., Saligari, M. J., Moore, K. A., Whisstock, J. C., Warr, C. G. & Johnson, T. K., 1 Mar 2018, In : G3: Genes, Genomes, Genetics. 8, 3, p. 761-769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, A. J., Law, R. H. P., Conroy, P. J., Noori, T., Lukoyanova, N., Saibil, H., Yagita, H., Ciccone, A., Verschoor, S., Whisstock, J. C., Trapani, J. A. & Voskoboinik, I., 7 Feb 2018, In : Cell Death and Differentiation. 25, p. 1517-1529 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
Open Access
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10 Citations (Scopus)

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Torso-like is a component of the hemolymph and regulates the insulin signaling pathway in Drosophila

Henstridge, M. A., Aulsebrook, L., Koyama, T., Johnson, T. K., Whisstock, J. C., Tiganis, T., Mirth, C. K. & Warr, C. G., 1 Apr 2018, In : Genetics. 208, 4, p. 1523-1533 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods

Li, F., Wang, Y., Li, C., Marquez-Lago, T. T., Leier, A., Rawlings, N. D., Haffari, G., Revote, J., Akutsu, T., Chou, K-C., Purcell, A. W., Pike, R. N., Webb, G. I., Smith, A. I., Lithgow, T., Daly, R. J., Whisstock, J. C. & Song, J., 2018, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bby077.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
1 Citation (Scopus)

An essential role of maspin in embryogenesis and tumor suppression — Letter

Whisstock, J. C. & Bird, P. I., 15 Sep 2017, In : Cancer Research. 77, 18, 1 p.

Research output: Contribution to journalLetterOtherpeer-review

2 Citations (Scopus)

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

An ultrastructural investigation of tumors undergoing regression mediated by immunotherapy

Westwood, J. A., Ellis, S., Danne, J., Johnson, C., Oorschot, V., Ramm, G., Tscharke, D. C., Davenport, A. J., Whisstock, J. C., Darcy, P. K., Kershaw, M. H. & Slaney, C. Y., 14 Dec 2017, In : Oncotarget. 8, 70, p. 115215-115229 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Cell Traversal Activity Is Important for Plasmodium falciparum Liver Infection in Humanized Mice

Yang, A. S. P., O'Neill, M. T., Jennison, C., Lopaticki, S., Allison, C. C., Armistead, J. S., Erickson, S. M., Rogers, K. L., Ellisdon, A. M., Whisstock, J. C., Tweedell, R. E., Dinglasan, R. R., Douglas, D. N., Kneteman, N. M. & Boddey, J. A., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3105-3116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Maternal torso-like coordinates tissue folding during Drosophila gastrulation

Johnson, T. K., Moore, K. A., Whisstock, J. C. & Warr, C. G., 1 Jul 2017, In : Genetics. 206, 3, p. 1459-1468 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Perforin-A key (shaped) weapon in the immunological arsenal

Spicer, B. A., Conroy, P. J., Law, R. H. P., Voskoboinik, I. & Whisstock, J. C., Dec 2017, In : Seminars in Cell and Developmental Biology. 72, p. 117-123 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

20 Citations (Scopus)

Real-time visualization of perforin nanopore assembly

Leung, C., Hodel, A. W., Brennan, A. J., Lukoyanova, N., Tran, S., House, C. M., Kondos, S. C., Whisstock, J. C., Dunstone, M. A., Trapani, J. A., Voskoboinik, I., Saibil, H. R. & Hoogenboom, B. W., May 2017, In : Nature Nanotechnology. 12, p. 467-473 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

House, I. G., House, C. M., Brennan, A. J., Gilan, O., Dawson, M. A., Whisstock, J. C., Law, R. H. P., Trapani, J. A. & Voskoboinik, I., 1 Oct 2017, In : EMBO Reports. 18, 10, p. 1775-1785 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The structural basis for complement inhibition by gigastasin, a protease inhibitor from the giant Amazon leech

Pang, S. S., Wijeyewickrema, L. C., Hor, L., Tan, S., Lameignere, E., Conway, E. M., Blom, A. M., Mohlin, F. C., Liu, X., Payne, R. J., Whisstock, J. C. & Pike, R. N., 1 Dec 2017, In : Journal of Immunology. 199, 11, p. 3883-3891 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Understanding CD30 biology and therapeutic targeting: a historical perspective providing insight into future directions

van der Weyden, C. A., Pileri, S. A., Feldman, A. L., Whisstock, J. & Prince, H. M., 8 Sep 2017, In : Blood Cancer Journal. 7, 9, 10 p., e603.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
15 Citations (Scopus)

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

5 Citations (Scopus)

Development of the cellular immune system of Drosophila requires the membrane attack complex/perforin-like protein Torso-like

Forbes-Beadle, L., Crossman, T., Johnson, T. K., Burke, R., Warr, C. G. & Whisstock, J. C., 1 Oct 2016, In : Genetics. 204, 2, p. 675-681 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Giant MACPF/CDC pore forming toxins: A class of their own

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 1 Mar 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 3, p. 475-486 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Mice lacking Brinp2 or Brinp3, or both, exhibit behaviors consistent with neurodevelopmental disorders

Berkowicz, S. R., Featherby, T. J., Whisstock, J. C. & Bird, P. I., 25 Oct 2016, In : Frontiers in Behavioral Neuroscience. 10, 15 p., 196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Smoothing a rugged protein folding landscape by sequence-based redesign

Porebski, B. T., Keleher, S., Hollins, J. J., Nickson, A. A., Marijanovic, E. M., Borg, N. A., Costa, M. G. S., Pearce, M. A., Dai, W., Zhu, L., Irving, J. A., Hoke, D. E., Kass, I., Whisstock, J. C., Bottomley, S. P., Webb, G. I., McGowan, S. & Buckle, A. M., 26 Sep 2016, In : Scientific Reports. 6, 14 p., 33958.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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48 Citations (Scopus)

Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens

Wisniewski, J. A., Traore, D. A. K., Bannam, T. L., Lyras, D., Whisstock, J. C. & Rood, J. I., 1 Mar 2016, In : Molecular Microbiology. 99, 5, p. 884-896 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
3 Citations (Scopus)

Analysis of perforin assembly by quartz crystal microbalance reveals a role for cholesterol and calcium-independent membrane binding

Stewart, S. E., Bird, C. H., Tabor, R. F., D'Angelo, M., Piantavigna, S., Whisstock, J. C., Trapani, J. A., Martin, L. L. & Bird, P. I., 2015, In : Journal of Biological Chemistry. 290, 52, p. 31101 - 31112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during danio rerio development

Giousoh, A., Rodrigues Vaz, R., Bryson-Richardson, R. J., Whisstock, J. C., Verkade, H. M. & Bird, P. I., 2015, In : Gene Expression Patterns. 18, 1-2, p. 37 - 43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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52 Citations (Scopus)

GlycoMine: a machine learning-based approach for predicting N-, C- and O-linked glycosylation in the human proteome

Li, F., Li, C., Wang, M., Webb, G. I., Zhang, Y., Whisstock, J. C. & Song, J., 2015, In : Bioinformatics. 31, 9, p. 1411 - 1419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

155 Citations (Scopus)

IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, C. A., Lo, C. Y-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P. M., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, C. W. J., Ellisdon, A. M., Rotterd, B., Azam, T., Mangan, N., Rossello, F. J., Whisstock, J., Bufler, P., Garlanda, C., Mantovani, A. A., Dinarello, C. A. & 1 others, Nold, M. F., 2015, In : Nature Immunology. 16, 4, p. 354 - 365 12 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

Perforin and granzymes: function, dysfunction and human pathology

Voskoboinik, I., Whisstock, J. C. & Trapani, J. A., 2015, In : Nature Reviews Immunology. 15, 6, p. 388 - 400 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Preferential acquisition and activation of plasminogen glycoform II by PAM positive group A streptococcal isolates

De Oliveira, D. M. P., Law, R. H. P., Ly, D., Cook, S. M., Quek, A. J., McArthur, J. D., Whisstock, J. C. & Sanderson-Smith, M. L., 2015, In : Biochemistry. 54, 25, p. 3960 - 3968 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolase

Cork, A. J., Ericsson, D. J., Law, R. H. P., Casey, L. W., Valkov, E., Bertozzi, C., Stamp, A., Jovcevski, B., Aquilina, J. A., Whisstock, J. C., Walker, M. J. & Kobe, B., 2015, In : PLoS ONE. 10, 3, 18 p., e0121764.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
Open Access
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