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Personal profile


Professor James Whisstock studied for his degree and PhD at Cambridge University. He moved to Monash in 1997. Currently, James is an NHMRC Senior Principal Research Fellow and Director of the ARC Centre of Excellence in Advanced Molecular Imaging.

His research interests include structural biology and drug development around immune-related complexes; these include proteases and protease inhibitors and pore forming proteins such as perforin. From a molecular perceptive his focus includes understanding embryonic patterning in Drosophila and how the perforin-like protein Torsolike controls activation of the receptor tyrosine kinase Torso.

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Projects 2000 2023

Confocal and single molecule microscopes for Systems Microscopy

Gaus, K., Lock, J., Ebrahimi Warkiani, M., Gunning, P. W., Whan, R. M., Whisstock, J., Richardson, H., Meunier, F., james, D., King, N., Godfrey, D. I., Gleeson, P., Rigby, P., Lee, W. M. & Rogers, K. L.


Project: Other

Immunobiology and Immunotherapy of Cancer

Joseph, T. & Whisstock, J.


Project: Research

Research Output 1997 2018

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 17 Sep 2018, (Accepted/In press) In : ChemBioChem. 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Genome-wide screen for new components of the Drosophila melanogaster Torso receptor tyrosine kinase pathway

Johns, A. R., Henstridge, M. A., Saligari, M. J., Moore, K. A., Whisstock, J. C., Warr, C. G. & Johnson, T. K., 1 Mar 2018, In : G3: Genes, Genomes, Genetics. 8, 3, p. 761-769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, J. E., Wu, G., Mahatmanto, T., Durek, T., Caradoc-Davies, T. T., Whisstock, J. C., Law, R. H. P. & Craik, D. J., 6 Dec 2018, (Accepted/In press) In : Journal of Medicinal Chemistry. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin

Brennan, A. J., Law, R. H. P., Conroy, P. J., Noori, T., Lukoyanova, N., Saibil, H., Yagita, H., Ciccone, A., Verschoor, S., Whisstock, J. C., Trapani, J. A. & Voskoboinik, I., 7 Feb 2018, (Accepted/In press) In : Cell Death and Differentiation. 13 p.

Research output: Contribution to journalArticleResearchpeer-review