Projects per year
Personal profile
Biography
Professor James Whisstock FAHMS completed his PhD in bioinformatics and structural biology at the University of Cambridge. Since arriving at Monash University in 1997, James has established himself as one of the leading structural biologists internationally.
James was appointed as Deputy Dean Research in the Faculty of Medicine, Nursing and Health Sciences at Monash University in January 2022. Prior to this role, he held an ARC Australian Laureate Fellowship, an ARC Federation Fellowship, and an Honorary NHMRC Senior Principal Research Fellowship. Previously, he was Scientific Head of EMBL Australia (2017-2024) and the Director of the ARC Centre of Excellence in Advanced Molecular Imaging (2014-2021).
In 2024, James was named a Fellow of the Australian Academy of Health and Medical Sciences. He has also been awarded the Science Minister’s Prize in Life Sciences (2006), the Commonwealth Health Minister’s Award (2008) and the Australian Academy of Science’s Gottschalk Medal (2010).
James’ research focuses on decoding the atomic structures of complex protein molecules with a particular interest in membrane attack complex/perforin-like proteins, which play a critical role in immunity and developmental biology. His team further investigates the proteases and their inhibitors that control blood coagulation and wound remodelling.
Over the course of his career at Monash, James has contributed to the development of several key Monash technology platforms, including the establishment of the Monash Ramaciotti Cryo-Electron Microscopy platform.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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The structural basis for MPEG1 mediated assembly of immune complexes
4/03/22 → 31/12/25
Project: Research
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Exploring non-canonical roles for the ribosomal RNA genes critical for malignant transformation and cell fate
Hannan, R. (Primary Chief Investigator (PCI)), Hein, N. (Chief Investigator (CI)), Ferreira, R. (Chief Investigator (CI)), Whisstock, J. (Associate Investigator (AI)) & Ganley, A. (Associate Investigator (AI))
1/01/21 → 31/12/25
Project: Research
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Melbourne Biomolecular NMR Network
Stone, M. (Primary Chief Investigator (PCI)), Bottomley, S. (Chief Investigator (CI)), Gooley, P. R. (Chief Investigator (CI)), Langford, S. (Chief Investigator (CI)), Reynolds, E. C. (Chief Investigator (CI)), Scammells, P. (Chief Investigator (CI)), Scanlon, M. (Chief Investigator (CI)), Separovic, F. (Chief Investigator (CI)), Tuck, K. (Chief Investigator (CI)), Whisstock, J. (Chief Investigator (CI)) & Wilce, J. (Chief Investigator (CI))
Australian Research Council (ARC), University of Melbourne, Monash University
1/01/09 → …
Project: Research
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DIIRD HTTP-Whisstock
Whisstock, J. (Primary Chief Investigator (PCI))
Department of Jobs, Skills, Industry and Regions (DJSIR) (Victoria)
6/09/05 → …
Project: Research
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NHMRC 2002 Equipment - Dr J Whisstock
National Health and Medical Research Council (NHMRC) (Australia)
31/05/02 → …
Project: Research
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Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site
Cramer, D. A. T., Yin, V., Caval, T., Franc, V., Yu, D., Wu, G., Lloyd, G., Langendorf, C., Whisstock, J. C., Law, R. H. P. & Heck, A. J. R., Jan 2024, In: Molecular and Cellular Proteomics. 23, 1, 12 p., 100696.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
A High-Throughput Small-Angle X-ray Scattering Assay to Determine the Conformational Change of Plasminogen
Quek, A. J. (Leading Author), Cowieson, N. P., Caradoc-Davies, T. T., Conroy, P. J., Whisstock, J. C. (Leading Author) & Law, R. H. P. (Leading Author), Sept 2023, In: International Journal of Molecular Sciences. 24, 18, 14 p., 14258.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Automation in Cryo-FIB Preparation, from Cellular to Tissue Structural Biology
Cleeve, P., Caggiano, M. P., Dierickx, D., Whisstock, J. & de Marco, A., Aug 2023, In: Microscopy and Microanalysis. 29, S1, p. 1956 1 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access -
Design of polarity-dependent immunosensors based on the structural analysis of engineered antibodies
Islam, J., Conroy, P., Fercher, C., Kim, M., Yaari, Z., Jones, M., Bell, T. D. M., Caradoc-Davies, T., Law, R., Whisstock, J., Heller, D., Mahler, S. & Corrie, S., 18 Aug 2023, In: ACS Chemical Biology. 18, 8, p. 1863-1871 9 p.Research output: Contribution to journal › Article › Research › peer-review
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Fragment-based and structure-guided discovery of perforin inhibitors
Jose, J. (Leading Author), Law, R. H. P. (Leading Author), Leung, E. W. W., Wai, D. C. C., Akhlaghi, H., Chandrashekaran, I. R., Caradoc-Davies, T. T., Voskoboinik, I., Feutrill, J., Middlemiss, D., Jeevarajah, D., Bashtannyk-Puhalovich, T., Giddens, A. C., Lee, T. W., Jamieson, S. M. F., Trapani, J. A., Whisstock, J. C. (Leading Author), Spicer, J. A. (Leading Author) & Norton, R. S. (Leading Author), 5 Dec 2023, In: European Journal of Medicinal Chemistry. 261, 19 p., 115786.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Activities
- 10 Patents
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Biochemistry & Molecular Biology (Organisational unit)
Law, R. (Inventor), Whisstock, J. (Inventor), Quek, A. (Contributor), Hagemeyer, C. (Contributor), Martino, M. (Contributor), Wu, J. (Contributor) & Lu, A. (Contributor)
2022Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent (Provisional)
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MONASH UNIVERSITY (Organisational unit)
Whisstock, J. (Inventor), Law, R. (Inventor), Quek, A. (Inventor), Conroy, P. (Inventor) & Wu, G. (Member)
6 May 2021Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Whisstock, J. (Inventor), Law, R. (Inventor), Quek, A. (Inventor), Conroy, P. (Inventor) & Wu, G. (Member)
6 May 2021Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Whisstock, J. (Inventor), Law, R. (Inventor), Quek, A. (Inventor) & Conroy, P. (Inventor)
2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Nold, C. (Inventor), Nold, M. (Inventor), Whisstock, J. (Inventor) & Ellisdon, A. (Inventor)
12 Apr 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent