If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Professor James Whisstock studied for his degree and PhD at Cambridge University. He moved to Monash in 1997. Currently, James is an NHMRC Senior Principal Research Fellow and Director of the ARC Centre of Excellence in Advanced Molecular Imaging.

His research interests include structural biology and drug development around immune-related complexes; these include proteases and protease inhibitors and pore forming proteins such as perforin. From a molecular perceptive his focus includes understanding embryonic patterning in Drosophila and how the perforin-like protein Torsolike controls activation of the receptor tyrosine kinase Torso.

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

New generation direct electron detector for cryo-electron microscopy

Ramm, G., Whisstock, J., Lucet, I., Boecking, T., Landsberg, M. J., Alexandrov, K., Dunstone, M., Curmi, P. M. G., Lawrence, M. C., Lithgow, T., Watterson, D., Sexton, P. & Hankamer, B. D.

3/07/202/07/21

Project: Research

ACCS: The Australian Characterisation Commons at Scale

Goscinski, W., Bonnington, P., Quenette, S., Abbott, D., Abramson, D., Ali, R., Andrade, J., Barth, M., Betbeder-Matibet, L., Beves, J., Bond, C., Boyd, B., Bryant, G., Cairney, J., Colmer, T., Egan, G., Etheridge, J., Frazier, J., Galloway, G., Gentle, I., Gilbert, A., Gray, M., Hilder, E., Janke, A., Johnstone, T., Kemp, C., Lay, P., Love, S., Martinez, P. A., Mehnert, A., Moffat, B., Mulvaney, P., Raston, C. L., Thordarson, P., Weyland, M., Oijen, A. V., Sexton, P., Sullivan, R., Ward, N., Warr, G., Wepf, R., Wilson, L., Whisstock, J. & Yen, L.

University of South Australia, Flinders University, Massive, Monash University, National Imaging Facility, Queensland Cyber Infrastructure Foundation Ltd (QCIF), RMIT University, University of New South Wales, University of Queensland , University of Sydney, University of Western Australia, University of Wollongong

7/02/207/02/23

Project: Research

Confocal and single molecule microscopes for Systems Microscopy

Gaus, K., Lock, J., Ebrahimi Warkiani, M., Gunning, P. W., Whan, R. M., Whisstock, J., Richardson, H., Meunier, F., James, D. E., King, N., Godfrey, D. I., Gleeson, P. A., Rigby, P., Lee, W. M. & Rogers, K. L.

23/04/1831/12/20

Project: Other

Research Output

Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

Harrington, B. S., He, Y., Khan, T., Puttick, S., Conroy, P. J., Kryza, T., Cuda, T., Sokolowski, K. A., Tse, B. W. C., Robbins, K. K., Arachchige, B. J., Stehbens, S. J., Pollock, P. M., Reed, S., Weroha, S. J., Haluska, P., Salomon, C., Lourie, R., Perrin, L. C., Law, R. H. P. & 2 others, Whisstock, J. C. & Hooper, J. D., 2020, In : Theranostics. 10, 5, p. 2095-2114 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Automated cryo-lamella preparation for high-throughput in-situ structural biology

Buckley, G., Gervinskas, G., Taveneau, C., Venugopal, H., Whisstock, J. C. & de Marco, A., 1 May 2020, In : Journal of Structural Biology. 210, 2, 8 p., 107488.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

Kryza, T., Khan, T., Puttick, S., Li, C., Sokolowski, K. A., Tse, B. W. C., Cuda, T., Lyons, N., Gough, M., Yin, J., Parkin, A., Deryugina, E. I., Quigley, J. P., Law, R. H. P., Whisstock, J. C., Riddell, A. D., Barbour, A. P., Wyld, D. K., Thomas, P. A., Rose, S. & 4 others, Snell, C. E., Pajic, M., He, Y. & Hooper, J. D., 4 Mar 2020, In : Theranostics. 10, 9, p. 4116-4133 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

PhosTransfer: a deep transfer learning framework for kinase-specific phosphorylation site prediction in hierarchy

Xu, Y., Wilson, C., Leier, A., Marquez-Lago, T. T., Whisstock, J. & Song, J., 2020, Advances in Knowledge Discovery and Data Mining: 24th Pacific-Asia Conference, PAKDD 2020 Singapore, May 11–14, 2020 Proceedings, Part II. Lauw, H. W., Wong, R. C-W., Ntoulas, A., Lim, E-P., Ng, S-K. & Pan, S. J. (eds.). Cham Switzerland: Springer, p. 384-395 12 p. (Lecture Notes in Computer Science; vol. 12085 ).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Open Access
File