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Personal profile


Professor James Whisstock studied for his degree and PhD at Cambridge University. He moved to Monash in 1997. Currently, James is an NHMRC Senior Principal Research Fellow and Director of the ARC Centre of Excellence in Advanced Molecular Imaging.

His research interests include structural biology and drug development around immune-related complexes; these include proteases and protease inhibitors and pore forming proteins such as perforin. From a molecular perceptive his focus includes understanding embryonic patterning in Drosophila and how the perforin-like protein Torsolike controls activation of the receptor tyrosine kinase Torso.

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Projects 2000 2023

Confocal and single molecule microscopes for Systems Microscopy

Gaus, K., Lock, J., Ebrahimi Warkiani, M., Gunning, P. W., Whan, R. M., Whisstock, J., Richardson, H., Meunier, F., james, D., King, N., Godfrey, D. I., Gleeson, P., Rigby, P., Lee, W. M. & Rogers, K. L.


Project: Other

Immunobiology and Immunotherapy of Cancer

Joseph, T. & Whisstock, J.


Project: Research

Research Output 1997 2019

Brentuximab vedotin in T-cell lymphoma

Van Der Weyden, C., Dickinson, M., Whisstock, J. & Prince, H. M., 2 Jan 2019, In : Expert Review of Hematology. 12, 1, p. 5-19 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 2 Jan 2019, In : ChemBioChem. 20, 1, p. 46-50 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Control of growth factor signalling by MACPF proteins

Bakopoulos, D., Whisstock, J. C. & Johnson, T. K., 28 Jun 2019, In : Biochemical Society Transactions. 47, 3, p. 801-810 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, J. E., Wu, G., Mahatmanto, T., Durek, T., Caradoc-Davies, T. T., Whisstock, J. C., Law, R. H. P. & Craik, D. J., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 552-560 9 p.

Research output: Contribution to journalArticleResearchpeer-review