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Personal profile


Professor James Whisstock studied for his degree and PhD at Cambridge University. He moved to Monash in 1997. Currently, James is an NHMRC Senior Principal Research Fellow and Director of the ARC Centre of Excellence in Advanced Molecular Imaging.

His research interests include structural biology and drug development around immune-related complexes; these include proteases and protease inhibitors and pore forming proteins such as perforin. From a molecular perceptive his focus includes understanding embryonic patterning in Drosophila and how the perforin-like protein Torsolike controls activation of the receptor tyrosine kinase Torso.

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Projects 2000 2023

Confocal and single molecule microscopes for Systems Microscopy

Gaus, K., Lock, J., Ebrahimi Warkiani, M., Gunning, P. W., Whan, R. M., Whisstock, J., Richardson, H., Meunier, F., james, D., King, N., Godfrey, D. I., Gleeson, P., Rigby, P., Lee, W. M. & Rogers, K. L.


Project: Other

Immunobiology and Immunotherapy of Cancer

Joseph, T. & Whisstock, J.


Project: Research

Research Output 1997 2019

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy

Gorelick, S., Buckley, G. A., Gervinskas, G., Johnson, T. K., Handley, A., Caggiano, M., Whisstock, J., Pocock, R. & de Marco, A., 1 Jul 2019, In : eLife. 8, 15 p., e45919.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural studies of plasmin inhibition

Wu, G., Quek, A. J., Caradoc-Davies, T. T., Ekkel, S. M., Mazzitelli, B., Whisstock, J. C. & Law, R. H. P., 5 Mar 2019, (Accepted/In press) In : Biochemical Society Transactions. 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterising the Subsite Specificity of Urokinase-Type Plasminogen Activator and Tissue-Type Plasminogen Activator using a Sequence-Defined Peptide Aldehyde Library

Li, C. Y., de Veer, S. J., Law, R. H. P., Whisstock, J. C., Craik, D. J. & Swedberg, J. E., 17 Sep 2018, (Accepted/In press) In : ChemBioChem. 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3

Traore, D. A. K., Wisniewski, J. A., Flanigan, S. F., Conroy, P. J., Panjikar, S., Mok, Y-F., Lao, C., Griffin, M. D. W., Adams, V., Rood, J. I. & Whisstock, J. C., 13 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access