Projects per year
Personal profile
Biography
Professor James Whisstock studied for his degree and PhD at Cambridge University. He moved to Monash in 1997. Currently, James is an NHMRC Senior Principal Research Fellow and Director of the ARC Centre of Excellence in Advanced Molecular Imaging.
His research interests include structural biology and drug development around immune-related complexes; these include proteases and protease inhibitors and pore forming proteins such as perforin. From a molecular perceptive his focus includes understanding embryonic patterning in Drosophila and how the perforin-like protein Torsolike controls activation of the receptor tyrosine kinase Torso.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The structural basis for MPEG1 mediated assembly of immune complexes
1/01/22 → 31/12/24
Project: Research
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A national, multi-centre study evaluating Thrombotic Thrombocytopenia Syndrome (TTS) associated with ChAdOx1 (AZD1222) and other SARS-CoV-2 vaccines (viral vector and m-RNA)
Tran, H., Chen, V., Chunilal, S., Wood, N., Phan, T., Buttery, J., Crawford, N. W., Monagle, P. T., Passam, F., McFadyen, J., Whisstock, J., McRae, S., Pepperell, D., Tan, C. W., Bird, R. J., Járai-Szabó, F., Kleinig, T. J. & Wood, E.
Department of Health and Aged Care (Australia)
1/11/21 → 31/10/24
Project: Research
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Defining NF1 clinical variation at the microscale to discover new therapeutic targets
Ellisdon, A., Halls, M., Schittenhelm, R., Morand, E., Whisstock, J. & Sloan, E.
1/06/21 → 31/05/24
Project: Research
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Exploring non-canonical roles for the ribosomal RNA genes critical for malignant transformation and cell fate
Hannan, R., Hein, N., Ferreira, R., Whisstock, J. & Ganley, A.
1/01/21 → 31/12/25
Project: Research
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Controlling the function of pore forming perforin-like proteins in immune mediated disease
1/01/19 → 31/12/23
Project: Research
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A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen
Dickeson, S. K., Kumar, S., Sun, M. F., Mohammed, B. M., Phillips, D. R., Whisstock, J. C., Quek, A. J., Feener, E. P., Law, R. H. P. & Gailani, D., 5 May 2022, In: Blood. 139, 18, p. 2816-2829 14 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
Bayly-Jones, C., Lupton, C. J., Fritz, C., Venugopal, H., Ramsbeck, D., Wermann, M., Jäger, C., de Marco, A., Schlenzig, D., Schilling, S. & Whisstock, J. C., Dec 2022, In: Nature Communications. 13, 1, 14 p., 6178.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Macrophage self-renewal is regulated by transient expression of PDGF- and VEGF-related factor 2
Bakopoulos, D., Whisstock, J. C., Warr, C. G. & Johnson, T. K., Jul 2022, In: The FEBS Journal. 289, 13, p. 3735-3751 17 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Mining folded proteomes in the era of accurate structure prediction
Bayly-Jones, C. & Whisstock, J. C., Mar 2022, In: PLoS Computational Biology. 18, 3, 10 p., e1009930.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation
Ebrahimnezhaddarzi, S., Bird, C. H., Allison, C. C., Tuipulotu, D. E., Kostoulias, X., Macri, C., Stutz, M. D., Abraham, G., Kaiserman, D., Pang, S. S., Man, S. M., Mintern, J. D., Naderer, T., Peleg, A. Y., Pellegrini, M., Whisstock, J. C. & Bird, P. I., 26 Apr 2022, (Accepted/In press) In: Immunology and Cell Biology. 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Activities
- 10 Patents
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Biochemistry & Molecular Biology (Organisational unit)
Ruby Law (Inventor), James Whisstock (Inventor), Adam Quek (Contributor), Christoph Hagemeyer (Contributor), Mikael Martino (Contributor), Jason Wu (Contributor) & Angel Lu (Contributor)
2022Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent (Provisional)
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MONASH UNIVERSITY (Organisational unit)
James Whisstock (Inventor), Ruby Law (Inventor), Adam Quek (Inventor), Paul Conroy (Inventor) & Guojie Wu (Member)
6 May 2021Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
James Whisstock (Inventor), Ruby Law (Inventor), Adam Quek (Inventor), Paul Conroy (Inventor) & Guojie Wu (Member)
6 May 2021Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
James Whisstock (Inventor), Ruby Law (Inventor), Adam Quek (Inventor) & Paul Conroy (Inventor)
2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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MONASH UNIVERSITY (Organisational unit)
Claudia Nold (Inventor), Marcel Nold (Inventor), James Whisstock (Inventor) & Andrew Ellisdon (Inventor)
23 Mar 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent