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Research Output 1994 2019

2019

Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat

Kawada, T., Sonobe, T., Hayama, Y., Nishikawa, T., Miyamoto, T., Akiyama, T., Pearson, J. T. & Sugimachi, M., 1 May 2019, In : Autonomic Neuroscience: Basic and Clinical. 218, p. 25-30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats

Kawada, T., Akiyama, T., Sonobe, T., Shimizu, S., Hayama, Y., Pearson, J. T., Shishido, T. & Sugimachi, M., 1 Jan 2019, In : Autonomic Neuroscience: Basic and Clinical. 216, p. 39-45 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet

Sukumaran, V., Tsuchimochi, H., Sonobe, T., Shirai, M. & Pearson, J. T., 1 Jun 2019, In : The Journal of pharmacology and experimental therapeutics. 369, 3, p. 375-388 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B. & Costa, M. W., Feb 2019, In : Molecular Metabolism. 20, p. 102-114 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Drinking by amphibious fish: Convergent evolution of thirst mechanisms during vertebrate terrestrialization

Katayama, Y., Sakamoto, T., Saito, K., Tsuchimochi, H., Kaiya, H., Watanabe, T., Pearson, J. T. & Takei, Y., 12 Jan 2018, In : Scientific Reports. 8, 1, 10 p., 625.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Ghrelin Preserves Ischemia-Induced Vasodilation of Male Rat Coronary Vessels Following β-Adrenergic Receptor Blockade

Pearson, J. T., Collie, N., Lamberts, R. R., Inagaki, T., Yoshimoto, M., Umetani, K., Davis, P., Wilkins, G., Jones, P. P., Shirai, M. & Schwenke, D. O., 1 Apr 2018, In : Endocrinology. 159, 4, p. 1763-1773 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ghrelin pre-treatment attenuates local oxidative stress and end organ damage during cardiopulmonary bypass in anesthetized rats

Sukumaran, V., Tsuchimochi, H., Fujii, Y., Hosoda, H., Kangawa, K., Akiyama, T., Shirai, M., Tatsumi, E. & Pearson, J. T., 9 Mar 2018, In : Frontiers in Psychiatry. 9, 14 p., 196.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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How does the intrauterine growth restricted heart respond to angiotensin II infusion?

Zohdi, V., Black, M., Pearson, J., Kett, M., Lombardo, P., Schneider, M. & Ravingerova, T., Jul 2018, In : Journal of Molecular and Cellular Cardiology. 120, Supplement, p. 52-53 2 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Progressive decrease in coronary vascular function associated with Type 2 diabetic heart disease

Katare, R., Pearson, J. T., Lew, J. K. S., Wei, M., Tsuchimouchi, H., Du, C. K., Zhan, D. Y., Umetani, K., Shirai, M. & Schwenke, D. O., 6 Jun 2018, In : Frontiers in Physiology. 9, 11 p., 696.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Three-dimensional morphometric analysis of the renal vasculature

Khan, Z., Ngo, J. P., Le, B., Evans, R. G., Pearson, J. T., Gardiner, B. S. & Smith, D. W., 1 May 2018, In : American Journal of Physiology - Renal Physiology. 314, 5, p. F715-F725 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography

Torii, M., Fukui, T., Inoue, M., Kanao, S., Umetani, K., Shirai, M., Inagaki, T., Tsuchimochi, H., Pearson, J. T. & Toi, M., 1 Sep 2017, In : Journal of Synchrotron Radiation. 24, 5, p. 1039-1047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade

Sukumaran, V., Tsuchimochi, H., Tatsumi, E., Shirai, M. & Pearson, J. T., Nov 2017, In : Biochemical Pharmacology. 144, p. 90-99 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Beyond proof of concepts for ideal cardiac regenerative therapy

Mochizuki, N., Pearson, J. T. & Kitamura, S., 1 Sep 2017, In : Journal of Thoracic and Cardiovascular Surgery. 154, 3, p. 964-965 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation

Zhan, D-Y., Du, C-K., Akiyama, T., Morimoto, S., Shimizu, S., Kawada, T., Shirai, M. & Pearson, J. T., 1 Jul 2017, In : Autonomic Neuroscience: Basic and Clinical. 205, p. 33-40 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Correlation between diffusion tensor imaging and histological brain injury in ventilated preterm lambs

Alahmari, D. M., Barton, S. K., Galinsky, R., Nitsos, I., Atik, A. A., Farrell, M. J., Pearson, J. T. & Polglase, G. R., 2017, In : Imaging in Medicine. 9, 3, p. 67-76 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Diffusion tensor imaging colour mapping threshold for identification of ventilation-induced brain injury after intrauterine inflammation in preterm lambs

Alahmari, D. M., Skiold, B., Barton, S. K., Nitsos, I., McDonald, C., Miller, S. L., Zahra, V., Galinsky, R., Wu, Q-Z., Farrell, M. J., Moss, T. J., Hooper, S. B., Pearson, J. T. & Polglase, G. R., 5 Apr 2017, In : Frontiers in Pediatrics. 5, 70.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Diffusion tensor imaging detects ventilation-induced brain injury in preterm lambs

Alahmari, D. M., Chan, K. Y. Y., Stojanovska, V., LaRosa, D., Barton, S. K., Nitsos, I., Zahra, V., Barbuto, J., Farrell, M., Yamaoka, S., Pearson, J. T. & Polglase, G. R., 1 Dec 2017, In : PLoS ONE. 12, 12, e0188737.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways

Lew, J. K. S., Pearson, J. T., Schwenke, D. O. & Katare, R., 13 Jan 2017, In : Cardiovascular Diabetology. 16, 1, 20 p., 10.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Ghrelin, MicroRNAs, and critical limb ischemia: Hungering for a novel treatment option

Neale, J. P. H., Pearson, J. T., Katare, R. & Schwenke, D. O., 13 Dec 2017, In : Frontiers in Endocrinology. 8, 12 p., 350.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats

Kainuma, S., Miyagawa, S., Fukushima, S., Tsuchimochi, H., Sonobe, T., Fujii, Y., Pearson, J. T., Saito, A., Harada, A., Toda, K., Shirai, M. & Sawa, Y., 24 Aug 2017, In : PLoS ONE. 12, 8, 12 p., e0183323.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion

Flemmer, A. W., Thio, M., Wallace, M. J., Lee, K., Kitchen, M. J., Kerr, L., Roehr, C. C., Fouras, A., Carnibella, R., Jani, J. C., Dekoninck, P., Te Pas, A. B., Pearson, J. T. & Hooper, S. B., 1 Sep 2017, In : Pediatric Research. 82, 3, p. 536-543 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: Comparison with light microscopy

Ngo, J. P., Le, B., Khan, Z., Kett, M. M., Gardiner, B. S., Smith, D. W., Melhem, M. M., Maksimenko, A., Pearson, J. T. & Evans, R. G., Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, 12, p. 1241-1253 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Microvascular leakage in acute myocardial infarction: Characterization by histology, biochemistry, and magnetic resonance imaging

Gao, X. M., Wu, Q-Z., Kiriazis, H., Su, Y., Han, L. P., Pearson, J. T., Taylor, A. J. & Du, X-J., 15 May 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 5, p. H1068-H1075 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion

Du, C-K., Zhan, D-Y., Akiyama, T., Inagaki, T., Shishido, T., Shirai, M. & Pearson, J. T., Jan 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 1, p. H60-H67 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Furtado, M. B., Wilmanns, J. C., Chandran, A., Perera, J., Hon, O., Biben, C., Willow, T. J., Nim, H. T., Kaur, G., Simonds, S., Wu, Q., Willians, D., Salimova, E., Plachta, N., Denegre, J. M., Murray, S. A., Fatkin, D., Cowley, M., Pearson, J. T., Kaye, D. & 4 others, Ramialison, M., Harvey, R. P., Rosenthal, N. A. & Costa, M. W., 23 Mar 2017, In : JCI Insight. 2, 6, p. e88271 18 p., e88271.

Research output: Contribution to journalArticleResearch

Vagal denervation inhibits the increase in pulmonary blood flow during partial lung aeration at birth

Lang, J. A. R., Pearson, J. T., Binder-Heschl, C., Wallace, M. J., Siew, M. L., Kitchen, M. J., te Pas, A. B., Lewis, R. A., Polglase, G. R., Shirai, M. & Hooper, S. B., 1 Mar 2017, In : The Journal of Physiology. 595, 5, p. 1593-1606 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model

Pearson, J. T., Yoshimoto, M., Chen, Y. C., Sultani, R., Edgley, A. J., Nakaoka, H., Nishida, M., Umetani, K., Waddingham, M. T., Jin, H. L., Zhang, Y., Kelly, D. J., Schwenke, D. O., Inagaki, T., Tsuchimochi, H., Komuro, I., Yamashita, S. & Shirai, M., 22 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 18108.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels

Furtado, M. B., Wilmanns, J., Chandran, A., Tonta, M. A., Biben, C., Eichenlaub, M. P., Coleman, H. A., Berger, S., Bouveret, R., Singh, R., Harvey, R. P., Ramialison, M. S. M., Pearson, J. T., Parkington, H. C., Rosenthal, N. A. & Da Costa, M. W., 2016, In : Differentiation. 91, 1-3, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats

Chen, Y. C., Inagaki, T., Fujii, Y., Schwenke, D. O., Tsuchimochi, H., Edgley, A. J., Umetani, K., Zhang, Y., Kelly, D. J., Yoshimoto, M., Nagai, H., Evans, R. G., Kuwahira, I., Shirai, M. & Pearson, J. T., 1 Aug 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 2, p. R426-R439 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Diffusive shunting of gases and other molecules in the renal vasculature: Physiological and evolutionary significance

Ngo, J. P., Ow, C. P. C., Gardiner, B. S., Kar, S., Pearson, J. T., Smith, D. W. & Evans, R. G., 1 Nov 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 5, p. R797-R810 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Increase in pulmonary blood flow at birth: role of oxygen and lung aeration

Lang, J. A. R., Pearson, J. T., Binder-Heschl, C., Wallace, M. J., Siew, M. L., Kitchen, M. J., Te Pas, A. B., Fouras, A., Lewis, R. A., Polglase, G. R., Shirai, M. & Hooper, S. B., 1 Mar 2016, In : The Journal of Physiology. 594, 5, p. 1389-1398 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Technical note: Contrast free angiography of the pulmonary vasculature in live mice using a laboratory x-ray source

Samarage, C. R., Carnibella, R., Preissner, M., Jones, H. D., Pearson, J. T., Fouras, A. & Dubsky, S., 1 Nov 2016, In : Medical Physics. 43, 11, p. 6017-6023 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart

Kainuma, S., Miyagawa, S., Fukushima, S., Pearson, J., Chen, Y. C., Saito, A., Harada, A., Shiozaki, M., Iseoka, H., Watabe, T., Watabe, H., Horitsugi, G., Ishibashi, M., Ikeda, H., Tsuchimochi, H., Sonobe, T., Fujii, Y., Naito, H., Umetani, K., Shimizu, T. & 10 others, Okano, T., Kobayashi, E., Daimon, T., Ueno, T., Kuratani, T., Toda, K., Takakura, N., Hatazawa, J., Shirai, M. & Sawa, Y., 2015, In : Molecular Therapy. 23, 2, p. 374 - 386 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Changes in inflammatory response during and after cardiopulmonary bypass using a rat extracorporeal circulation model

Fujii, Y., Shirai, M., Pearson, J. T., Takewa, Y. & Tatsumi, E., 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2015). Lovell, N. & Mainardi, L. (eds.). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers, p. 957-960 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

Waddingham, M. T., Edgley, A. J., Astolfo, A., Inagaki, T., Fujii, Y., Du, C-K., Zhan, D-Y., Tsuchimochi, H., Yagi, N., Pearson, J. T., Shirai, M. & Kelly, D. J., 2015, In : Cardiovascular Diabetology. 14, 1 , 13 p., 92.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Developmental programming of cardiovascular disease following intrauterine growth restriction: findings utilising a rat model of maternal protein restriction

Zohdi, V., Lim, K. J., Pearson, J. T. & Black, M. J., 2015, In : Nutrients. 7, 1, p. 119 - 152 34 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Functional and Electrical Integration of Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Myocardial Infarction Rat Heart

Higuci, T., Miyagawa, S., Pearson, J. T., Fukushima, S., Saito, A., Tsuchimochi, H., Sonobe, T., Fujii, Y., Yagi, N., Astolfo, A., Shirai, M. & Sawa, Y., 2015, In : Cell Transplantation: the regenerative medicine journal. 24, 12, p. 2479 - 2489 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Importance of tissue preparation methods in FTIR micro-spectroscopical analysis of biological tissues: 'traps for new users'

Zohdi, V., Whelan, D. R., Wood, B. R., Pearson, J. T., Bambery, K. R. & Black, M. J., 2015, In : PLoS ONE. 10, 2, 11 p., e0116491.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pulmonary macrophages attenuate hypoxic pulmonary vasoconstriction via β3 AR/iNOS pathway in rats exposed to chronic intermittent hypoxia

Nagai, H., Kuwahira, I., Schwenke, D. O., Tsuchimochi, H., Nara, A., Ogura, S., Sonobe, T., Inagaki, T., Fujii, Y., Yamaguchi, R., Wingenfeld, L., Umetani, K., Shimosawa, T., Yoshida, K., Uemura, K., Pearson, J. T. & Shirai, M., 2015, In : PLoS ONE. 10, 7, 20 p., e0131923.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography

Sonobe, T., Tsuchimochi, H., Schwenke, D. O., Pearson, J. T. & Shirai, M., 2015, In : Cardiovascular Diabetology. 14, 1, 10 p., 51.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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When early life growth restriction in rats is followed by attenuated postnatal growth: effects on cardiac function in adulthood

Zohdi, V., Pearson, J. T., Kett, M. M., Lombardo, P. P., Schneider, M. E. & Black, M. J., 2015, In : European Journal of Nutrition. 54, 5, p. 743 - 750 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

beta2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats

Nagai, H., Kuwahira, I., Schwenke, D. O., Tsuchimochi, H., Nara, A., Inagaki, T., Ogura, S., Fujii, Y., Umetani, K., Shimosawa, T., Yoshida, K., Pearson, J. T., Uemura, K. & Shirai, M., 2014, In : PLoS ONE. 9, 10, 9 p., e110693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair

Furtado, M. B., Da Costa, M., Pranoto, E. M. A., Salimova, E., Pinto, R. I. A., Lam, N. T., Park, A., Snider, P., Chandran, A., Harvey, R. P., Boyd, R. L., Conway, S., Pearson, J. T., Kaye, D. M. & Rosenthal, N. A., 2014, In : Circulation Research. 114, 9, p. 1422 - 1434 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Early detection of ventilation-induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: An in vivo study in preterm lambs

Skiold, B., Wu, Q-Z., Hooper, S. B., Davis, P. G., McIntyre, R., Tolcos, M., Pearson, J. T., Vreys, R., Egan, G. F., Barton, S. K., Cheong, J. L. Y. & Polglase, G., 2014, In : PLoS ONE. 9, 4, 8 p., e95804.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia

Shirai, M., Tsuchimochi, H., Nagai, H., Gray, E., Pearson, J. T., Sonobe, T., Yoshimoto, M., Inagaki, T., Fujii, Y., Umetani, K., Kuwahira, I. & Schwenke, D. O., 2014, In : Basic Research in Cardiology. 109, 5, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Vascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney

Ngo, J., Kar, S., Kett, M. M., Gardiner, B. S., Pearson, J. T., Smith, D. W., Ludbrook, J., Bertram, J. F. & Evans, R. G., 2014, In : American Journal of Physiology - Renal Physiology. 307, 10, p. 1111 - 1122 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ventilation/perfusion mismatch during lung aeration at birth

Lang, J., Pearson, J. T., Te Pas, A. B., Wallace, M. J., Siew, M. L-L., Kitchen, M. J., Fouras, A., Lewis, R., Wheeler, K., Polglase, G., Shirai, M., Sonobe, T. & Hooper, S. B., 2014, In : Journal of Applied Physiology. 117, 5, p. 535 - 543 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013

A comparative study of cerebral microcirculation during pulsatile and nonpulsatile selective cerebral perfusion: assessment by synchrotron radiation microangiography

Inamori, S., Shirai, M., Yahagi, N., Pearson, J. T., Fujii, Y., Umetani, K., Kobayashi, Y., Okura, Y., Yakehiro, M. & Minamiyama, M., 2013, In : ASAIO Journal. 59, 4, p. 374 - 379 6 p.

Research output: Contribution to journalArticleResearchpeer-review