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Personal profile

External positions

Director of Cardiac Physiology, National Cerebral and Cardiovascular Center

1 Apr 2016 → …

Research area keywords

  • heart failure therapeutics
  • coronary circulation
  • diabetes
  • hypertension

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Projects 2005 2019

Research Output 1994 2019

Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat

Kawada, T., Sonobe, T., Hayama, Y., Nishikawa, T., Miyamoto, T., Akiyama, T., Pearson, J. T. & Sugimachi, M., 1 May 2019, In : Autonomic Neuroscience: Basic and Clinical. 218, p. 25-30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats

Kawada, T., Akiyama, T., Sonobe, T., Shimizu, S., Hayama, Y., Pearson, J. T., Shishido, T. & Sugimachi, M., 1 Jan 2019, In : Autonomic Neuroscience: Basic and Clinical. 216, p. 39-45 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction

Nagano, K., Kwon, C., Ishida, J., Hashimoto, T., Kim, J. D., Kishikawa, N., Murao, M., Kimura, K., Kasuya, Y., Kimura, S., Chen, Y-C., Tsuchimochi, H., Shirai, M., Pearson, J. T. & Fukamizu, A., 1 Nov 2019, In : Journal of Biochemistry. 166, 5, p. 383-392 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model

Waddingham, M. T., Sonobe, T., Tsuchimochi, H., Edgley, A. J., Sukumaran, V., Chen, Y. C., Hansra, S. S., Schwenke, D. O., Umetani, K., Aoyama, K., Yagi, N., Kelly, D. J., Gaderi, S., Herwig, M., Kolijn, D., Mügge, A., Paulus, W. J., Ogo, T., Shirai, M., Hamdani, N. & 1 others, Pearson, J. T., 1 Dec 2019, In : Journal of Molecular and Cellular Cardiology. 137, p. 119-131 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File