Projects per year
Personal profile
Biography
A/Prof James McMahon is a dedicated clinician-scientist with a growing national and international reputation for excellence in Infectious Diseases. Prior to completing his PhD at Monash University in 2013, A/Prof McMahon worked as an Infectious Disease Physician at the Alfred Hospital and Monash Medical Centre. He is currently appointed as the Head of the Clinical Research Unit at the Department of Infectious Diseases (Alfred Hospital; Monash Uni).
A/Prof McMahon has received substantial competitive fellowship and grant funding totalling $50,590,729.50 to date, from (including but not limited to) NHMRC Early Career Fellowship, Australian Centre for HIV and Hepatitis Virology Research, NHMRC Program Grant, Melbourne HIV Cure Consortium, MRFF and several charitable foundations.
Research interests
A/Prof McMahon's research interests include clinical trials focused on HIV and COVID-19. Specific interests include trials in HIV Cure developing non-invasive imaging methods to locate and quantify tissue sites of HIV and clinical trials of interventions targeting the HIV reservoir with latency reversal agents and immunotherapeutics. For COVID-19 he leads an adaptive randomised trial of COVID-19 vaccine booster strategies in immunocompromised hosts and leads randomised trials of antivirals for early disease and a large prospective biobank of biological samples with matched clinical data post infection.
University Service
A/Prof McMahon is the current Vice President and President-Elect for Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM), sits on the National Clinical Evidence Taskforce committees for COVID-19 Therapeutics and National Monkeypox Taskforce.
A/Prof McMahon is the current President Elect for the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM) and is the co-convener for the 2024 conference in Sydney. He has also been invited as a reviewer for the NHMRC Ideas Grant Panel, European Research Council and the MRFF Early to Mid-Career Researchers Grant Panel.
A/Prof McMahon holds several distinguished positions across various Journals including being part of the Editorial Board on PLoS One and as an Associate Editor of AIDS Research and Therapy.
Other notable services include leading the IAS 2023 Organizing Committee and invitation to the AFAO Expert Advisory panel on strategies to end HIV in Australia by 2025.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Governance, GAICD, Company Directors Course, Australian Institute of Company Directors
Award Date: 2 Jan 2023
HIV Clinical Research, PhD, Social and behavioral factors associated with poor outcomes in patients infected with HIV on antiretroviral therapy, MONASH UNIVERSITY
Award Date: 23 Oct 2013
Epidemiology, MPH, Masters of Public Health, Tufts University
Award Date: 1 Nov 2010
Infectious Diseases, FRACP, Subspecialty Trained Infectious Diseases, Royal Australasian College of Physicians (RACP)
Award Date: 1 Nov 2008
Clinical Medicine, MBBS, Medical Degree, University of Melbourne
Award Date: 1 Dec 1999
External positions
Head Clinical Research Unit, Department of Infectious Diseases, Alfred Hospital
Infectious Diseases Physician, Alfred Hospital
Infectious Diseases Physician, Monash Health
Research area keywords
- HIV
- HIV Cure
- Infectious Diseases
- Antiretroviral Therapy
- COVID-19
- Clinical Trials
Collaborations and top research areas from the last five years
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A Phase 2 Randomized, Open-label Study to Evaluate the Safety and Efficacy of Broadly Neutralizing Antibodies (bNAbs) GS-5423 and GS-2872 in Combination With the Capsid Inhibitor Lenacapavir as Long-Acting Treatment Dosed Every 6 Months in Virologically Suppressed Adults With HIV-1 Infection
McMahon, J. & Roney, J.
13/07/23 → 12/07/25
Project: Research
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An Operationally Seamless Phase 2/3 Randomized, Open-label, Multicenter, Active-Controlled Study to Evaluate the Safety and Efficacy of Bictegravir/Lenacapavir Versus Stable Baseline Regimen in Virologically Suppressed People With HIV-1 on Stable Complex Treatment Regimens
McMahon, J. & Roney, J.
30/03/23 → 1/05/25
Project: Research
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HI-ART study: Optimising cohorts for HIV cure interventions: the role of very high CD4 T-cell counts
Lau, J., McMahon, J., Lewin, S., Rasmussen, T. A., Wright, E. & Rule, J.
1/03/23 → 31/03/25
Project: Research
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A Phase 1, Open-label, Safety and Immunogenicity Study of a Booster Dose of the Investigational CV0501 mRNA COVID-19 Vaccine in Adults at Least 18 Years Old
McMahon, J. & Roney, J.
28/09/22 → 31/12/23
Project: Research
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PROPHECY: Profiling immune RespOnses in Paediatric and High risk populations to SARS-CoV-2
McMahon, J., van Zelm, M., Khoury, G., Drummer, H., Mulley, W., Holland, A., Woolley, I., Ojaimi, S., Rogers, B., Hoi, A., Trauer, J., Sparrow, M., Licciardi, P. V., Giles, E., Curtis, D., Crawford, N. W., Leech, M., Westall, G., O'Hehir, R., Jones, A., Morand, E., Bosco, J. J. & Turner, S.
Monash University, Alfred Health, Monash Health, Murdoch Children's Research Institute, Burnet Institute (Australia), Spleen Australia, National Association of People with HIV Australia (NAPWHA) Incorporated, Musculoskeletal Australia , Safer Care Victoria (SCV)
1/06/22 → 30/05/26
Project: Research
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HIV treatment-as-prevention and its effect on incidence of HIV among cisgender gay, bisexual, and other men who have sex with men in Australia: a 10-year longitudinal cohort study
Callander, D., McManus, H., Gray, R. T., Grulich, A. E., Carr, A., Hoy, J., Donovan, B., Fairley, C. K., Holt, M., Templeton, D. J., Liaw, S. T., McMahon, J. H., Asselin, J., Petoumenos, K., Hellard, M., Pedrana, A., Elliott, J., Keen, P., Costello, J., Keane, R., & 3 others , Jun 2023, In: The Lancet HIV. 10, 6, p. e385-e393 9 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
How do we enhance protective immunity to COVID-19 in lung transplant recipients?
Griffin, D. W. J. & McMahon, J. H., 1 Jan 2023, In: European Respiratory Journal. 61, 1, 2 p., 2201723.Research output: Contribution to journal › Editorial › Other › peer-review
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Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations
Habel, J. R., Chua, B. Y., Kedzierski, L., Selva, K. J., Damelang, T., Haycroft, E. R., Nguyen, T. H. O., Koay, H. F., Nicholson, S., McQuilten, H. A., Jia, X., Allen, L. F., Hensen, L., Zhang, W., van de Sandt, C. E., Neil, J. A., Pragastis, K., Lau, J. S. Y., Jumarang, J., Allen, E. K., & 34 others , 2023, In: JCI Insight. 8, 7, 21 p., e167157.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Long-acting cabotegravir PrEP: a time for cautious optimism
Griffin, D. WJ., Hoy, J. F. & McMahon, J. H., Dec 2023, In: The Lancet HIV. 10, 12, p. E756-E757 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Meningococcal Vaccine in Mali and Gambia
Griffin, D. W. J., Hoy, J. F., McMahon, J. H., Clarke, E., Alderson, M. R. & Tapia, M. D., 2023, In: The New England Journal of Medicine. 389, 6, p. 577 1 p.Research output: Contribution to journal › Letter › Other › peer-review
Prizes
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Alfred Infectious Diseased Clinical Research Unit Nursing Excellence Award
McMahon, James (Recipient), 2022
Prize: Other distinction
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Best poster ASHM Conference 2011
McMahon, James (Recipient), 2011
Prize: Prize (including medals and awards)
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Burnet Prize for Infectious Diseases Research for analysis of unstructured treatment interruptions to antiretroviral therapy in low to middle income countries
McMahon, James (Recipient), 2016
Prize: Prize (including medals and awards)
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Burnet Prize for Infectious Diseases Research for presentation on Neurotoxicity with High-dose Disulfiram and Vorinostat used for latency reversal
McMahon, James (Recipient), 2019
Prize: Prize (including medals and awards)
Activities
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Monash Medical Centre (External organisation)
James McMahon (Member)
2021Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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External Grant Reviewer - MRC UK
James McMahon (Reviewer)
2020Activity: External Academic Engagement › Grant review responsibilities
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Burnet Institute HIV Elimination Committee
James McMahon (Member)
2020Activity: External Academic Engagement › Peer review panel or committee
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Rare Cancers Rare Diseases Unmet Need (RCRDUN), Clinical Trial Grant Panel
James McMahon (Member)
2020Activity: External Academic Engagement › Peer review panel or committee
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AIDS Research and Therapy (Journal)
James McMahon (Associate editor)
2020Activity: Publication peer-review and editorial work types › Editorial responsibility
Press/Media
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HIV Cure Trials - JOY FM Saturday Magazine
21/10/23
1 item of Media coverage
Press/Media: Profile/Interview
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“There’s a lot of hope”: Courage and community drive latest efforts in HIV cure research
11/10/23
1 Media contribution
Press/Media: Article/Feature
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Multi-institutional consortium attracts $6.3 million MRFF grant to profile COVID-19 vaccine responses in our most vulnerable patient populations across the lifespan.
Gabriela Khoury, Menno van Zelm, Heidi Drummer, Benjamin Rogers & James McMahon
1/09/22
1 item of Media coverage
Press/Media: Profile/Interview