Dr James (Jim) Harris is an Immunologist/Cell Biologist with interests in inflammation, autophagy, macrophage and dendritic cell biology, autoimmunity and host-pathogen interactions. He is an adjunct Senior Research Fellow in the School of Clinical Sciences at Monash Health.

Dr Harris received a BSc (Hons) in Zoology from the University of Nottingham, UK and his PhD in Immunology (in fish) from the University of the West of England, UK. He has worked as a postdoctoral fellow at the Institute for Animal Health, UK (on cows), Oxford University, UK (on human cells), University of New Mexico, USA (on mouse cells and bacteria) and Trinity College Dublin (on all sorts). He was also Programme Manager for the Immunology Research Centre (IRC) in Ireland, a €10 million Science Foundation Ireland-funded cluster of immunology research groups. He moved to Australia and Monash in 2013.

Jim has an interest in innate immunity and more specifically the regulation of inflammation, particularly cytokine release by innate immune cells. Recently, he has focused largely on the regulation of IL-1 family cytokines and macrophage migration inhibitory factor (MIF), demonstrating a specific role for MIF in the activation of the NLRP3 inflammasome (Nat Commun 2018). He also works on the roles of autophagy in immune cells, particularly myeloid cells. In this context, he has published studies on the role of cytokines in regulating autophagy (Immunity 2007) and on the regulation of cytokine release by autophagy (J Biol Chem 2011, J Immunol 2012, Autophagy 2016, Immunol Cell Biol 2022).

Along with his interest in the cellular and molecular mechanisms involved in the regulation of inflammation and immunity, Jim has developed a strong interest in immune cell responses to virus infection and is working with colleagues at RMIT and CSIRO to investigate how inflammation is regulated in infected macrophages. This work will include investigations of cells infected with Influenza A and SARS-CoV-2.

Scientists In Schools

Day of Immunology Organising committee (Melbourne) 2014

Department Convenor, MHTP, BMS3990 Research in Action