James Harris — Monash University

Personal profile

Biography

Dr Harris is an Immunologist/Cell Biologist with an interest in autophagy, endocytosis, macrophage and dendritic cell biology, inflammation and host-pathogen interactions. He heads laboratory research for the Rheumatology Group with Professor Eric Morand and is focused on innate immune responses and inflammation in autoimmune diseases, including systemic lupus erythematosus (SLE, lupus), systemic sclerosis (SSc, scleroderma) and arthritis. He is also investigating the role of macrophage migration inhibitory factor (MIF) in inflammation and cell biology.

Dr Harris received a BSc (Hons) in Zoology from the University of Nottingham (UK) and his PhD in Immunology from the University of the West of England (UK). He has work as a postdoctoral fellow at the Institute for Animal Health (UK), Oxford University, University of New Mexico and Trinity College Dublin. He was also Programme Manager for the Immunology Research Centre (IRC) in Ireland. He moved to Australia and Monash in 2013.

He has publised >65 articles, with more than 12,500 citations in Google Scholar (>7,600 citations in Scopus).

Research interests

Dr Harris has an interest in innate immunity and the regulation of inflammation, particularly cytokine release by macrophages and dendritic cells. Recently, he has focused on the regulation of IL-1 family cytokines and macrophage migration inhibitory factor (MIF). In addition, he also works on the roles of autophagy in immune cells.

In addition, the Rheumatology Group has a strong interest in biomarker studies in diseases, including SLE, arthritis and scleroderma.

Community service

Scientists In Schools

Day of Immunology Organising committee (Melbourne) 2014

Monash teaching commitment

Department Convenor, MHTP, BMS3990 Research in Action

Education/Academic qualification

Immunology, PhD, University of the West of England

… → 2000

Zoology, BSc (Hons), The University of Nottingham (UK)

… → 1995

Keywords

Arthritis
Autophagy
Dendritic Cell
Immunity
Inflammation
Lupus
Macrophage
tuberculosis
innate immunity
scleroderma
MIF
Inflammasomes
IL-1

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2019

1 Active
4 Finished

Does regulation of NLRP3 by macrophage migration inhibitory factor (MIF) contribute to MS disease?

Harris, J. & Payne, N. L.

Multiple Sclerosis Research Australia

1/01/19 → 31/12/19

Project: Research

Interleukin-1b biology: mechanisms of regulation, activation and secretion

Vince, J., Masters, S. L. & Harris, J.

National Health & Medical Research Council (NHMRC)

1/01/16 → 31/12/18

Project: Research

Autophagy in Rheumatoid arthritis: effects of TNF blockade

Harris, J. & Leech, M. T.

16/12/15 → 16/12/16

Project: Research

New therapeutic targets in rheumatological diseases

Harris, J., Jones, S. & Morand, E. F.

The Rebecca L Cooper Medical Research Foundation

1/01/15 → 31/12/15

Project: Research

Targeting autophagy as a means of control of cytokine production in SLE

Morand, E. F. & Harris, J.

National Health & Medical Research Council (NHMRC)

1/01/14 → 31/12/16

Project: Research

Research Output 1998 2018

50 Article
8 Review Article
5 Chapter (Book)
2 Editorial
4 More

All-trans retinoic acid augments autophagy during intracellular bacterial infection

Coleman, M. M., Basdeo, S. A., Coleman, A. M., Ni Cheallaigh, C., Peral de Castro, C., McLaughlin, A. M., Dunne, P. J., Harris, J. & Keane, J., 1 Nov 2018, In : American Journal of Respiratory Cell and Molecular Biology. 59, 5, p. 548-556 9 p.

Research output: Contribution to journal › Article › Research › peer-review