James Harris

Personal profile

Biography

I am an Immunologist/Cell Biologist with an interest in autophagy, endocytosis, macrophage and dendritic cell biology, inflammation and host-pathogen interactions. I have previously worked on innate immunity to tuberculosis. I currently work on innate immune responses and inflammation in autoimmune diseases, including systemic lupus erythematosus (SLE, lupus) and arthritis. I am also investigating the role of macrophage migration inhibitory factor (MIF) in inflammation.

My specific interests are the role of autophagy in the regulation of cytokine secretion and inflammation, as well as its role in the response to pathogens, including Mycobacterium tuberculosis, the bacterium that causes tuberculosis in humans. I am also currently investigating the mechanisms through with macrophage migration inhibitory factor (MIF) influences inflammation, particularly in autoimmune diseases.

Our research aims are to better understand the mechanisms that control inflammation in autoimmune diseases such as SLE, arthritis and psoriasis. By gaining a clearer understanding of the molecular pathways that control inflammation, we can develop more targeted therapeutic approaches to the treatment of inflammatory disease.

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Projects 2014 2105

2 Finished
2 Active

Interleukin-1b biology: mechanisms of regulation, activation and secretion

Vince, J., Masters, S. L. & Harris, J.

National Health & Medical Research Council (NHMRC)

1/01/16 → 31/12/18

Project: Research

New therapeutic targets in rheumatological diseases

Harris, J., Jones, S. & Morand, E. F.

The Rebecca L Cooper Medical Research Foundation

1/01/15 → 31/12/05

Project: Research

Autophagy in Rheumatoid arthritis: effects of TNF blockade

Harris, J. & Leech, M. T.

16/12/15 → 16/12/16

Project: Research

Targeting autophagy as a means of control of cytokine production in SLE

Morand, E. F. & Harris, J.

National Health & Medical Research Council (NHMRC)

1/01/14 → 31/12/16

Project: Research

Research Output 1998 2018

50 Article
5 Chapter (Book)
3 Short Survey
3 Review Article
4 More

All-trans Retinoic Acid Augments Autophagy during Intracellular Bacterial Infection

Coleman, M. M., Basdeo, S. A., Coleman, A. M., Ni Cheallaigh, C., Peral de Castro, C., McLaughlin, A. M., Dunne, P. J., Harris, J. & Keane, J. 31 May 2018 (Accepted/In press) In : American Journal of Respiratory Cell and Molecular Biology. 30 p.

Research output: Contribution to journal › Article