Personal profile
Biography
Professor Jake Shortt is the Head of Haematology Research in the Department of Medicine at the School of Clinical Sciences and the Clinical Director of Monash Health Haematology. He is Principal Investigator on a range of clinical trials for T-cell lymphoma and myeloid malignancies, conducted through the Monash Haematology clinical trials unit.
Professor Shortt is the recipient of a National Health & Medical Research Council Emerging Leadership Fellowship. His translational work in the School of Clinical Sciences is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.
In addition to his clinical roles, Professor Shortt co-chairs the Monash Health Research Strategy and Governance Committee, is a member of the Barry Dalgeish Centre for Myeloma and Related Blood Cancers Scientific Advisory Committee and a member of the Cancer Council Victoria Research Subcommittee.
Clinical activities
Professor Shortt is the Clinical Director of Haematology services at Monash Health. His clinical trial portfolio includes studies in chronic myeloid leukaemia, myelodysplasia and T-cell lymphoma. He attends the Monash Haematology myeloid disorders clinic and looks after Haematology inpatients at Monash Health.
External positions
Honorary Clinical Professor, University of Melbourne
1 Jan 2022 → …
Honorary Principal Fellow, University of Melbourne
31 Jan 2019 → 31 Dec 2021
Honorary Senior Research Scientist, Peter MacCallum Cancer Centre
1 Oct 2015 → …
Consultant Haematologist, Monash Health
1 Feb 2008 → …
Research area keywords
- Cancer Immunology
- Epigenetics
- Leukemia
- Lymphoma
- Molecular Oncology
- Myelodysplasia
- Myeloma
- Thrombotic thrombocytopenic purpura
- cMYC
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 5 Gender Equality
Collaborations and top research areas from the last five years
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Leveraging investigator-initiated clinical trials and novel therapeutic strategies to improve outcomes of older adults with acute myeloid leukaemia.
Chua, C. (Primary Chief Investigator (PCI)) & Shortt, J. (Supervisor)
5/01/26 → 4/01/28
Project: Research
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A Phase 3, multicenter, open label, randomized, non-comparative two-arm study of ivosidenib (IVO) monotherapy and azacitidine (AZA) monotherapy in adult patients with hypomethylating agent (HMA) naive myelodysplastic syndromes (MDS) with an isocitrate dehydrogenase-1 (IDH1) mutation (PyramIDH study).
Chua, C. (Primary Chief Investigator (PCI)) & Shortt, J. (Primary Chief Investigator (PCI))
19/02/25 → 18/02/30
Project: Research
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ASCENDANCE - ASCiminib Evaluation in Newly diagnosed CML with Dasatinib to Augment response in Complex genomic Etiology
Shortt, J. (Primary Chief Investigator (PCI))
31/10/24 → 31/10/29
Project: Research
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A Multicenter, Open-Label, First-In-Human, Multiple Expansion Cohort, Phase 1/2 Study to Evaluate the Safety and Efficacy of DR-01 in Adult Subjects with Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas
Shortt, J. (Primary Chief Investigator (PCI))
25/10/24 → 24/10/29
Project: Research
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An open-label, multi-center, roll-over study for patients who have completed a prior Novartis-sponsored sabatolimab (MBG453) study and are judged by the investigator to benefit from continued treatment with sabatolimab
Shortt, J. (Primary Chief Investigator (PCI))
5/07/24 → 4/07/29
Project: Research
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Aligning kidney function assessment in patients with cancer to global practices in internal medicine
Sandhu, G., Adattini, J., Gordon, E. A., O'Neill, N., Bagnis, C., Chambers, P., Martin, J. H., Flynn, A., Ibrahim, K., Jardine, M. J., Johnson, D. W., Jones, G. R. D., Karapetis, C. S., Kelly, A., Kichenadasse, G., Kliman, D. S., Liauw, W., Lucas, C., Mallett, A. J. & Malyszko, J. & 15 others, , Apr 2025, In: eClinicalMedicine. 82, 11 p., 103102.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
A Phase II Study of Acimtamig (AFM13) in Patients with CD30-Positive, Relapsed, or Refractory Peripheral T-cell Lymphomas
Kim, W. S., Shortt, J., Zinzani, P. L., Mikhailova, N., Radeski, D., Ribrag, V., Domenech, E. D., Sawas, A., Alexis, K., Emig, M., Elbadri, R., Hajela, P., Ravenstijn, P., Pinto, S., Garcia, L., Overesch, A., Pietzko, K. & Horwitz, S., 1 Jan 2025, In: Clinical Cancer Research. 31, 1, p. 65-73 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Link opens in a new tab Citations (Scopus) -
Integrating International Consensus Guidelines for Anticancer Drug Dosing in Kidney Dysfunction (ADDIKD) into everyday practice
Sandhu, G., Adattini, J., Armstrong Gordon, E., O'Neill, N., Bagnis, C., Boddy, A. V., Chambers, P., Flynn, A., Hamilton, B., Ibrahim, K., Johnson, D. W., Karapetis, C., Kelly, A., Kerr, K. A., Kichenadasse, G., Kliman, D. S., Kurkard, C., Liauw, W., Lucas, C. & Mallett, A. J. & 20 others, , Apr 2025, In: eClinicalMedicine. 82, 11 p., 103161.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Long-Term Transfusion Independence with Luspatercept Versus Epoetin Alfa in Erythropoiesis-Stimulating Agent-Naive, Lower-Risk Myelodysplastic Syndromes in the COMMANDS Trial
Garcia-Manero, G., Santini, V., Zeidan, A. M., Komrokji, R. S., Pozharskaya, V., Rose, S., Keeperman, K., Lai, Y., Kalsekar, S., Aggarwal, B., Miteva, D., Valcárcel, D., Fenaux, P., Shortt, J., Della Porta, M. G. & Platzbecker, U., Jul 2025, In: Advances in Therapy. 42, 7, p. 3576–3589 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Next-generation sequencing RNA fusion panel for the diagnosis of haematological malignancies
Ngo, T. Q., Goh, A. F. N., Dorwal, P., Leong, E., Shortt, J., Fedele, P. L., Gilbertson, M., Fong, C. Y., Shanmuganathan, N., Kumar, B. & Yeh, P., Apr 2025, In: Pathology. 57, 3, p. 340-347 8 p.Research output: Contribution to journal › Article › Research › peer-review
6 Link opens in a new tab Citations (Scopus)
Prizes
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Albert Baikie Memorial Medal (2011)
Shortt, J. (Recipient), 2011
Prize: Prize (including medals and awards)
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Joseph F Sambrook Prize for Research Excellence (2015)
Shortt, J. (Recipient), 2015
Prize: Prize (including medals and awards)
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Prize for Preclinical Myeloma Research (2015)
Shortt, J. (Recipient), 2015
Prize: Prize (including medals and awards)
Activities
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Cancer Council Victoria (External organisation)
Shortt, J. (Member)
2025 → …Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Deputy Chair - ALLG Scientific Advisory Committee
Shortt, J. (Chair/ Co-Chair)
2020 → 2023Activity: External Academic Engagement › Committees and working groups
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Australasian COVID19 Trial (ASCOT) Therapeutic Advisory Committee
Shortt, J. (Member)
2020 → 2022Activity: External Academic Engagement › Committees and working groups
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European Hematology Association (External organisation)
Shortt, J. (Member)
2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of networks of excellence
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Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)
Shortt, J. (Advisor)
2017 → …Activity: External Academic Engagement › Committees and working groups