Projects per year
Personal profile
Biography
Associate Professor Jake Shortt is the Head of Haematology Research at the School of Clinical Sciences and clinical lead at Monash Haematology for leukaemia and myelodysplasia. He is Principal Investigator on a range of clinical trials for myeloid malignancies, conducted through the Monash Haematology clinical trials unit. He is also a Principal Investigator on academically-funded and investigator-initiated trials in multiple myeloma and lymphoma.
Associate Professor Shortt is the recipient of a Medical Research Future Fund Career Development Fellowship as part of the Next Generation Clinical Researchers Program. His strong translational work in the School of Clinical Sciences is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.
In addition to his clinical and research roles, Associate Professor Shortt is an Associate Member of the Australian Academy of Health and Medical Sciences, the Chair of the Laboratory Sciences Committee of the Australasian Leukaemia and Lymphoma Group and an examiner for the Royal College of Pathologists of Australasia. He sits on the steering committees of the Australian TTP registry, the Australian Lymphoma and Related Diseases Registry and the Victorian Epigenetics Group.
Clinical activities
Associate Professor Shortt is clinical lead at Monash Health for leukaemia and myelodysplasia. He is also the Deputy Unit Head of Laboratory Haematology. He attends the Monash Haematology myeloid disorders clinic and runs a sub-specialty service for patients with chronic myeloid leukaemia. In addition to outpatient clinics, Associate Professor Shortt undertakes inpatient ward service at Monash Health, and is Principal Investigator at Monash Health for a range of clinical trials in leukaemia and myelodysplasia.
External positions
Honorary Senior Research Scientist, Peter MacCallum Cancer Centre
1 Oct 2015 → …Consultant Haematologist, Monash Health
1 Feb 2008 → …Honorary Principal Fellow, The University of Melbourne
31 Jan 0001 → …Keywords
- Cancer Immunology
- Epigenetics
- Leukemia
- Lymphoma
- Molecular Oncology
- Myelodysplasia
- Myeloma
- Thrombotic thrombocytopenic purpura
- cMYC
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2024
A Phase 3, Open-Label, Randomized Study To Compare The Efficacy And Safety Of Luspatercept (Ace-536) Versus Epoetin Alfa For The Treatment Of Anemia Due To Ipss-R Very Low, Low Or Intermediate Risk Myelodysplastic Syndromes (Mds) In Esa NaïveSubjects Who Require Red Blood Cell Transfusions (The“Commands”Trial)
18/01/19 → 17/01/24
Project: Research
Improving survival in myelofibrosis
Perkins, A. C., Ross, D., Lane, S., Forsyth, C., Wei, A., Curtis, D. J., Shortt, J., Erber, W. N. & Stevenson, W. S.
The Department of Health (Comm)
3/01/19 → 31/12/23
Project: Research
Next Generation Targeting of DNA-Methylation in Poor Risk Lymphoid Cancer
1/01/19 → 31/12/22
Project: Research
A feasibility randomised controlled pilot trial of weekly-interval red cell transfusion schedule in myelodysplastic syndromes: REDDSW2 pilot study
Mo, A., Wood, E. M., McQuilten, Z., Stanworth, S., Wallis, J., Shortt, J., Opat, S., Daly, J. & Hodgson, C. L.
9/05/18 → 8/05/19
Project: Research
Research Output 1998 2019
Dose-adjusted EPOCH-R therapy in MYC-rearranged diffuse large B-cell lymphoma: not yet the standard of care
Casan, J. ML., Barraclough, A., Shortt, J. & Hawkes, E. A., 1 Mar 2019, In : The Lancet Haematology. 6, 3, p. e119 1 p.Research output: Contribution to journal › Letter › Research › peer-review
A comprehensive protocol resource for performing pooled shRNA and CRISPR screens
Cluse, L. A., Nikolic, I., Knight, D., Madhamshettiwar, P. B., Luu, J., Cowley, K. J., Semple, T., Arnau, G. M., Shortt, J., Johnstone, R. W. & Simpson, K. J., 2018, Methods in Molecular Biology. Walker, J. M. (ed.). New York, NY: Humana Press, p. 201-227 27 p. (Methods in Molecular Biology; vol. 1725).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
Adaptive reprogramming of NK cells in X-Linked lymphoproliferative syndrome
Opat, S., Hearps, A. C., Thia, K., Yuen, A., Rogers, B., Chachage, M., Moore, G., Shortt, J., Ryland, G., Blombery, P., Schwarer, A. P., Noori, T., Trapani, J. A., Jaworowski, A. & Voskoboinik, I., 8 Feb 2018, In : Blood. 131, 6, p. 699-702 4 p.Research output: Contribution to journal › Letter › Other › peer-review
Chronic myeloid leukaemia and tyrosine kinase inhibitor therapy: assessment and management of cardiovascular risk factors
Ross, D. M., Arthur, C., Burbury, K., Ko, B. S., Mills, A. K., Shortt, J. & Kostner, K., 1 Feb 2018, In : Internal Medicine Journal. 48, p. 5-13 9 p.Research output: Contribution to journal › Review Article › Other › peer-review
Combination of Nilotinib and Pegylated Interferon Alfa-2b Results in High Molecular Response Rates in Chronic Phase CML: Interim Results of the ALLG CML 11 Pinnacle Study: Blood 2018 132:459
Yeung, D. T., Grigg, A. P., Shanmuganathan, N., Cunningham, I., Shortt, J., Rowlings, P., Reynolds, J., Cushion, R., Harrup, R., Ross, D. M., Kipp, D., Mills, A. K., Arthur, C., Schwarer, A. P., Jackson, K., Viiala, N., Weinkove, R., Yong, A., White, D. L., Branford, S. & 1 others, Nov 2018, In : Blood. 132, Suppl 1, p. 459-459 1 p.Research output: Contribution to journal › Meeting Abstract › Other › peer-review
Prizes
Albert Baikie Memorial Medal (2011)
Jake Shortt (Recipient), 2011
Prize: Prize (including medals and awards)
Joseph F Sambrook Prize for Research Excellence (2015)
Jake Shortt (Recipient), 2015
Prize: Prize (including medals and awards)
Prize for Preclinical Myeloma Research (2015)
Jake Shortt (Recipient), 2015
Prize: Prize (including medals and awards)
Activities 2005 2017
Standing Research Sub-Committee
Jake Shortt (Member)2017
Activity: External Academic Engagement › Committees and working groups
Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)
Jake Shortt (Advisor)2017 → …
Activity: External Academic Engagement › Committees and working groups
Chemical Probes Portal (External organisation)
Jake Shortt (Member)2017
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Chair - ALLG Laboratory Sciences Committee
Jake Shortt (Chair/ Co-Chair)2016
Activity: External Academic Engagement › Committees and working groups
eviQ Haematology Reference Committee
Jake Shortt (Member)2016 → 2019
Activity: External Academic Engagement › Committees and working groups