Jake Shortt

Assoc Professor

1998 …2024
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Personal profile


Associate Professor Jake Shortt is the Head of Haematology Research at the School of Clinical Sciences and clinical lead at Monash Haematology for leukaemia and myelodysplasia. He is Principal Investigator on a range of clinical trials for myeloid malignancies, conducted through the Monash Haematology clinical trials unit. He is also a Principal Investigator on academically-funded and investigator-initiated trials in multiple myeloma and lymphoma.

Associate Professor Shortt is the recipient of a Medical Research Future Fund Career Development Fellowship as part of the Next Generation Clinical Researchers Program. His strong translational work in the School of Clinical Sciences is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.  

In addition to his clinical and research roles, Associate Professor Shortt is the Chair of the Laboratory Sciences Committee of the Australasian Leukaemia and Lymphoma Group and sits on the steering committees of the Australian TTP registry, the Australian Lymphoma and Related Diseases Registry and the Victorian Epigenetics Group. 


Clinical activities

Associate Professor Shortt is clinical lead at Monash Health for leukaemia and myelodysplasia. He is also the Deputy Unit Head of Laboratory Haematology. He attends the Monash Haematology myeloid disorders clinic and runs a sub-specialty service for patients with chronic myeloid leukaemia. In addition to outpatient clinics, Associate Professor Shortt undertakes inpatient ward service at Monash Health, and is Principal Investigator at Monash Health for a range of clinical trials in leukaemia and myelodysplasia.

External positions

Honorary Principal Fellow, University of Melbourne

31 Jan 2019 → …

Honorary Senior Research Scientist, Peter MacCallum Cancer Centre

1 Oct 2015 → …

Consultant Haematologist, Monash Health

1 Feb 2008 → …

Research area keywords

  • Cancer Immunology
  • Epigenetics
  • Leukemia
  • Lymphoma
  • Molecular Oncology
  • Myelodysplasia
  • Myeloma
  • Thrombotic thrombocytopenic purpura
  • cMYC

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2024

Research Output 1998 2019

Dose-adjusted EPOCH-R therapy in MYC-rearranged diffuse large B-cell lymphoma: not yet the standard of care

Casan, J. ML., Barraclough, A., Shortt, J. & Hawkes, E. A., 1 Mar 2019, In : The Lancet Haematology. 6, 3, p. e119 1 p.

Research output: Contribution to journalLetterOtherpeer-review

Rapid and Durable Complete Remission of Refractory AITL with Azacitidine Treatment in Absence of TET2 Mutation or Concurrent MDS

Gregory, G., Dickinson, M. J., Yannakou, C., Wong, J., Blombery, P. A., Corboy, G., Kats, L., Crozier, T., Kumar, B., Prince, M., Opat, S. S. & Shortt, J., Apr 2019, In : HemaSphere. 3, 2, 4 p., e187.

Research output: Contribution to journalLetterOtherpeer-review

The natural history of vascular and other complications in patients treated with nilotinib for chronic myeloid leukemia

Minson, A. G., Cummins, K., Fox, L., Costello, B., Yeung, D., Cleary, R., Forsyth, C., Tatarczuch, M., Burbury, K., Motorna, O., Shortt, J., Fleming, S., McQuillan, A., Schwarer, A., Harrup, R., Holmes, A., Ratnasingam, S., Chan, K-L., Hsu, W-H., Ashraf, A. & 2 others, Putt, F. & Grigg, A., 9 Apr 2019, In : Blood Advances. 3, 7, p. 1084-1091 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A comprehensive protocol resource for performing pooled shRNA and CRISPR screens

Cluse, L. A., Nikolic, I., Knight, D., Madhamshettiwar, P. B., Luu, J., Cowley, K. J., Semple, T., Arnau, G. M., Shortt, J., Johnstone, R. W. & Simpson, K. J., 2018, Methods in Molecular Biology. Walker, J. M. (ed.). New York, NY: Humana Press, p. 201-227 27 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Adaptive reprogramming of NK cells in X-Linked lymphoproliferative syndrome

Opat, S., Hearps, A. C., Thia, K., Yuen, A., Rogers, B., Chachage, M., Moore, G., Shortt, J., Ryland, G., Blombery, P., Schwarer, A. P., Noori, T., Trapani, J. A., Jaworowski, A. & Voskoboinik, I., 8 Feb 2018, In : Blood. 131, 6, p. 699-702 4 p.

Research output: Contribution to journalLetterOtherpeer-review


Albert Baikie Memorial Medal (2011)

Jake Shortt (Recipient), 2011

Prize: Prize (including medals and awards)

Joseph F Sambrook Prize for Research Excellence (2015)

Jake Shortt (Recipient), 2015

Prize: Prize (including medals and awards)

Presidential Award (2013)

Jake Shortt (Recipient), 2013

Prize: Prize (including medals and awards)

Prize for Preclinical Myeloma Research (2015)

Jake Shortt (Recipient), 2015

Prize: Prize (including medals and awards)

Activities 2005 2017

  • 5 Committees and working groups
  • 5 Membership of an advisory panel/policy group/ board
  • 3 Submissions to industry or govt committees, commissions and inquiries
  • 1 External research and teaching

Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)

Jake Shortt (Advisor)
2017 → …

Activity: External Academic EngagementCommittees and working groups

Standing Research Sub-Committee

Jake Shortt (Member)

Activity: External Academic EngagementCommittees and working groups

Chemical Probes Portal (External organisation)

Jake Shortt (Member)

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Examiner - Royal College of Pathologists of Australasia

Jake Shortt (Examiner)

Activity: External Academic EngagementExternal research and teaching

Chair - ALLG Laboratory Sciences Committee

Jake Shortt (Chair/ Co-Chair)

Activity: External Academic EngagementCommittees and working groups