Projects per year
Personal profile
Biography
Associate Professor Jake Shortt is the Head of Haematology Research at the School of Clinical Sciences and clinical lead at Monash Haematology for leukaemia and myelodysplasia. He is Principal Investigator on a range of clinical trials for myeloid malignancies, conducted through the Monash Haematology clinical trials unit. He is also a Principal Investigator on both NHMRC and Victorian Cancer Agency funded early phase trials in multiple myeloma, conducted in collaboration with the Myeloma Research Group at the Australian Centre for Blood Diseases.
Associate Professor Shortt is the recipient of a Victorian Cancer Agency (VCA) clinical research fellowship and both NHMRC and CCV project grant funding. He was the inaugural recipient of the "Eva and Les Erdi" Snowdome Foundation/VCA grant for "New targets in haematological malignancy". His strong translational work in the School of Clinical Sciences in collaboration with the Peter MacCallum Cancer Centre is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.
In addition to his clinical and research roles, Associate Professor Shortt is an Associate Member of the Australian Academy of Health and Medical Sciences, the Chair of the Laboratory Sciences Committee of the Australasian Leukaemia and Lymphoma Group and an examiner for the Royal College of Pathologists of Australasia. He sits on the steering committees of the Australian TTP registry, the Australian Lymphoma and Related Diseases Registry and the Victorian Epigenetics Group.
Clinical activities
Associate Professor Shortt is clinical lead at Monash Health for leukaemia and myelodysplasia. He is also the Deputy Unit Head of Laboratory Haematology. He attends the Monash Haematology myeloid disorders clinic and runs a sub-specialty service for patients with chronic myeloid leukaemia. In addition to outpatient clinics, Associate Professor Shortt undertakes inpatient ward service at Monash and Alfred Health, and is Principal Investigator at Monash Health for a range of clinical trials in leukaemia and myelodysplasia.
External positions
Honorary Senior Research Scientist, Peter MacCallum Cancer Centre
1 Oct 2015 → …Consultant Haematologist, Monash Health
1 Feb 2008 → …Keywords
- Cancer Immunology
- Epigenetics
- Leukemia
- Lymphoma
- Molecular Oncology
- Myelodysplasia
- Myeloma
- Thrombotic thrombocytopenic purpura
- cMYC
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2021
- 7 Active
Single-cell genomic interrogation of poor-risk Hodgkin lymphoma to annotate intraclonal heterogeneity and evolution at relapse
1/01/18 → 31/12/19
Project: Research
Identifying New Treatments for Platinum Resistant Small Cell Lung Cancer
Gough, D. J., Watkins, D. N., Sutherland, K. & Shortt, J.
1/01/18 → 31/12/20
Project: Research
The PRECISE assay: Personalised medicine for cancer patients using next-generation sequencing
To, S. Q. G., Azad, A., Shortt, J., Wei, A., Shackleton, M. & Kenealy, M.
1/12/17 → 1/12/20
Project: Research
Exploiting and defining the immune regulatory activities of BET bromodomain inhibitors
Johnstone, R., Shortt, J., Darcy, P., Kershaw, M. & Trapani, J.
1/01/17 → 31/12/20
Project: Research
Research Output 1998 2018
A comprehensive protocol resource for performing pooled shRNA and CRISPR screens
Cluse, L. A., Nikolic, I., Knight, D., Madhamshettiwar, P. B., Luu, J., Cowley, K. J., Semple, T., Arnau, G. M., Shortt, J., Johnstone, R. W. & Simpson, K. J. 2018 Methods in Molecular Biology. Walker, J. M. (ed.). New York, NY: Humana Press, p. 201-227 27 p. (Methods in Molecular Biology; vol. 1725)Research output: Other - peer-review › Chapter (Book)
Adaptive reprogramming of NK cells in X-Linked lymphoproliferative syndrome
Opat, S., Hearps, A. C., Thia, K., Yuen, A., Rogers, B., Chachage, M., Moore, G., Shortt, J., Ryland, G., Blombery, P., Schwarer, A. P., Noori, T., Trapani, J. A., Jaworowski, A. & Voskoboinik, I. 8 Feb 2018 In : Blood. 131, 6, p. 699-702 4 p.Research output: Other - peer-review › Letter
Chronic myeloid leukaemia and tyrosine kinase inhibitor therapy: assessment and management of cardiovascular risk factors
Ross, D. M., Arthur, C., Burbury, K., Ko, B. S., Mills, A. K., Shortt, J. & Kostner, K. 1 Feb 2018 In : Internal Medicine Journal. 48, p. 5-13 9 p.Research output: Other - peer-review › Review Article
Consensus Opinion on Diagnosis and Management of Thrombotic Microangiopathy in Australia and New Zealand
Fox, L. C., Cohney, S. J., Kausman, J. Y., Shortt, J., Hughes, P. D., Wood, E. M., Isbel, N. M., de Malmanche, T., Blombery, P. & Barbour, T. D. 8 Feb 2018 (Accepted/In press) In : Nephrology. 30 p.Research output: Other - peer-review › Review Article
Open Access
Consensus Opinion on Diagnosis and Management of Thrombotic Microangiopathy in Australia and New Zealand
Fox, L. C., Cohney, S. J., Kausman, J. Y., Shortt, J., Hughes, P. D., Wood, E. M., Isbel, N. M., de Malmanche, T., Durkan, A., Hissaria, P., Blombery, P. & Barbour, T. D. 27 Mar 2018 (Accepted/In press) In : Internal Medicine Journal. 35 p.Research output: Other - peer-review › Review Article
Prizes
Albert Baikie Memorial Medal (2011)
Jake Shortt (Recipient), 2011
Prize: Prize (including medals and awards)
Joseph F Sambrook Prize for Research Excellence (2015)
Jake Shortt (Recipient), 2015
Prize: Prize (including medals and awards)
Prize for Preclinical Myeloma Research (2015)
Jake Shortt (Recipient), 2015
Prize: Prize (including medals and awards)
Activities 2005 2017
Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)
Shortt, J. (Advisor)2017 → …
Activity: Committees and working groups
Chemical Probes Portal (External organisation)
Shortt, J. (Member)2017
Activity: Membership of an advisory panel/policy group/ board
Chair - ALLG Laboratory Sciences Committee
Shortt, J. (Chair/ Co-Chair)2016
Activity: Committees and working groups
Examiner - Royal College of Pathologists of Australasia
Shortt, J. (Examiner)2016
Activity: External research and teaching