Projects per year
Personal profile
Biography
Professor Jake Shortt is the Head of Haematology Research at the School of Clinical Sciences and clinical lead at Monash Haematology for myeloid leukaemia, myelodysplasia and T-cell lymphoma. He is Principal Investigator on a range of clinical trials for T-cell lymphoma and myeloid malignancies, conducted through the Monash Haematology clinical trials unit.
Professor Shortt is the recipient of a Medical Research Future Fund Career Development Fellowship as part of the Next Generation Clinical Researchers Program. His strong translational work in the School of Clinical Sciences is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.
In addition to his clinical and research roles, Professor Shortt is the Chair of the Laboratory Sciences Working Party of the Australasian Leukaemia and Lymphoma Group (ALLG) and Deputy Chair of the ALLG Scientific Advisory Committee.
Clinical activities
Professor Shortt is clinical lead at Monash Health for myeloid leukaemia, myelodysplasia and T-cell lymphoma. He is also the Deputy Unit Head of Laboratory Haematology. He attends the Monash Haematology myeloid disorders clinic and looks after Haematology inpatients at Monash Health. Professor Shortt is the Principal Investigator at Monash Health for a range of clinical trials in leukaemia, myelodysplasia, myeloproliferative disorders and T-cell lymphoma.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Clinical Professor, University of Melbourne
1 Jan 2022 → …
Honorary Principal Fellow, University of Melbourne
31 Jan 2019 → 31 Dec 2021
Honorary Senior Research Scientist, Peter MacCallum Cancer Centre
1 Oct 2015 → …
Consultant Haematologist, Monash Health
1 Feb 2008 → …
Research area keywords
- Cancer Immunology
- Epigenetics
- Leukemia
- Lymphoma
- Molecular Oncology
- Myelodysplasia
- Myeloma
- Thrombotic thrombocytopenic purpura
- cMYC
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Myelodysplasia Advancing Strategies in Therapy (MYDAS-T) platform trial
16/01/23 → 15/01/28
Project: Research
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ctDNA to monitor non-genomic evolution in peripheral T-cell lymphoma.
Yeh, P., Shortt, J. & Chandrananda, D.
1/01/23 → 31/12/25
Project: Research
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High risk of infection in ‘real-world’ patients receiving ibrutinib, idelalisib or venetoclax for mature B-cell leukaemia/lymphoma
Tey, A., Schwarer, J., Raffa, R., Shi, E., Paul, E., Opat, S., Dendle, C. & Shortt, J., May 2023, In: European Journal of Haematology. 110, 5, p. 540-547 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
BET Inhibition Enhances TNF-Mediated Antitumor Immunity
Wellinger, L. C., Hogg, S. J., Newman, D. M., Friess, T., Geiss, D., Michie, J., Ramsbottom, K. M., Bacac, M., Fauti, T., Marbach, D., Jarassier, L., Thienger, P., Paehler, A., Cluse, L. A., Kearney, C. J., Vervoort, S. J., Trapani, J. A., Oliaro, J., Shortt, J., Ruefli-Brasse, A., & 2 others, Jan 2022, In: Cancer Immunology Research. 10, 1, p. 87-107 21 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Diagnosis, management and follow up of peripheral T-cell lymphomas: a consensus practice statement from the Australasian Lymphoma Alliance
Hapgood, G., Latimer, M., Lee, S. T., Kuss, B., Lade, S., Tobin, J. W. D., Purtill, D., Campbell, B. A., Prince, H. M., Hawkes, E. A., Shortt, J. & Radeski, D., Oct 2022, In: Internal Medicine Journal. 52, 10, p. 1806-1817 12 p.Research output: Contribution to journal › Article › Other › peer-review
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Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer
Hogg, S. J., Motorna, O., Kearney, C. J., Derrick, E. B., House, I. G., Todorovski, I., Kelly, M. J., Zethoven, M., Bromberg, K. D., Lai, A., Beavis, P. A., Shortt, J., Johnstone, R. W. & Vervoort, S. J., Dec 2022, In: Clinical Epigenetics. 14, 1, 15 p., 96.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Early and Deep Molecular Responses Achieved with Frontline Asciminib in Chronic Phase CML - Interim Results from ALLG CML13 Ascend-CML
Yeung, D. T., Shanmuganathan, N., Reynolds, J., Branford, S., Walia, M. K., Yong, A. S. M., Shortt, J., Burbury, K. L., Viiala, N., Cunningham, I., Ross, D. M., Harrup, R. A., Wright, M., Forsyth, C. J., D'Souza, A. B., Filshie, R. J. A., Browett, P. J., Lane, S. W., Grove, C. S., Grigg, A. P., & 1 others, 15 Nov 2022, In: Blood. 140, Supplement 1, p. 192-194 3 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Prizes
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Albert Baikie Memorial Medal (2011)
Shortt, Jake (Recipient), 2011
Prize: Prize (including medals and awards)
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Joseph F Sambrook Prize for Research Excellence (2015)
Shortt, Jake (Recipient), 2015
Prize: Prize (including medals and awards)
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Prize for Preclinical Myeloma Research (2015)
Shortt, Jake (Recipient), 2015
Prize: Prize (including medals and awards)
Activities
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Deputy Chair - ALLG Scientific Advisory Committee
Jake Shortt (Chair/ Co-Chair)
2020 → 2023Activity: External Academic Engagement › Committees and working groups
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Australasian COVID19 Trial (ASCOT) Therapeutic Advisory Committee
Jake Shortt (Member)
2020 → 2022Activity: External Academic Engagement › Committees and working groups
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European Hematology Association (External organisation)
Jake Shortt (Member)
2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of networks of excellence
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Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)
Jake Shortt (Advisor)
2017 → …Activity: External Academic Engagement › Committees and working groups
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Standing Research Sub-Committee - Cancer Council Victoria
Jake Shortt (Member)
2017Activity: External Academic Engagement › Committees and working groups