19982020

Research output per year

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Personal profile

Biography

Associate Professor Jake Shortt is the Head of Haematology Research at the School of Clinical Sciences and clinical lead at Monash Haematology for leukaemia and myelodysplasia. He is Principal Investigator on a range of clinical trials for myeloid malignancies, conducted through the Monash Haematology clinical trials unit. He is also a Principal Investigator on academically-funded and investigator-initiated trials in multiple myeloma and lymphoma.

Associate Professor Shortt is the recipient of a Medical Research Future Fund Career Development Fellowship as part of the Next Generation Clinical Researchers Program. His strong translational work in the School of Clinical Sciences is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.  

In addition to his clinical and research roles, Associate Professor Shortt is the Chair of the Laboratory Sciences Committee of the Australasian Leukaemia and Lymphoma Group and sits on the steering committees of the Australian TTP registry, the Australian Lymphoma and Related Diseases Registry and the Victorian Epigenetics Group. 

 

Clinical activities

Associate Professor Shortt is clinical lead at Monash Health for leukaemia and myelodysplasia. He is also the Deputy Unit Head of Laboratory Haematology. He attends the Monash Haematology myeloid disorders clinic and runs a sub-specialty service for patients with chronic myeloid leukaemia. In addition to outpatient clinics, Associate Professor Shortt undertakes inpatient ward service at Monash Health, and is Principal Investigator at Monash Health for a range of clinical trials in leukaemia and myelodysplasia.

External positions

Honorary Principal Fellow, University of Melbourne

31 Jan 2019 → …

Honorary Senior Research Scientist, Peter MacCallum Cancer Centre

1 Oct 2015 → …

Consultant Haematologist, Monash Health

1 Feb 2008 → …

Research area keywords

  • Cancer Immunology
  • Epigenetics
  • Leukemia
  • Lymphoma
  • Molecular Oncology
  • Myelodysplasia
  • Myeloma
  • Thrombotic thrombocytopenic purpura
  • cMYC

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

Prolonged administration of low-dose cytarabine and thioguanine in elderly patients with acute myeloid leukaemia (AML) achieves high complete remission rates and prolonged survival

Arthur, C., Jeffrey, A., Yip, E., Katsioulas, V., Nalpantidis, A., Kerridge, I., Greenwood, M., Coyle, L., Mackinlay, N., Fay, K., Enjeti, A., Shortt, J. & Stevenson, W., 20 Mar 2020, In : Leukemia and Lymphoma. 61, 4, p. 831-839 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors

Hilton-Proctor, J. P., Ilyichova, O., Zheng, Z., Jennings, I. G., Johnstone, R. W., Shortt, J., Mountford, S. J., Scanlon, M. J. & Thompson, P. E., 1 Apr 2020, In : European Journal of Medicinal Chemistry. 191, 112120.

Research output: Contribution to journalArticleResearchpeer-review

Acute myelomonocytic leukemia demonstrating erythrophagocytosis on cerebral spinal fluid cytology

Yuen, H. L. A. & Shortt, J., 1 Jan 2019, In : Journal of Applied Hematology. 10, 1, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

Phillips, D. C., Jin, S., Gregory, G. P., Zhang, Q., Xue, J., Zhao, X., Chen, J., Tong, Y., Zhang, H., Smith, M., Tahir, S. K., Clark, R. F., Penning, T. D., Devlin, J. R., Shortt, J., Hsi, E. D., Albert, D. H., Konopleva, M., Johnstone, R. W., Leverson, J. D. & 1 others, Souers, A. J., 11 Dec 2019, (Accepted/In press) In : Leukemia. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytarabine-based induction immunochemotherapy in the front-line treatment of older patients with mantle cell lymphoma

Ratnasingam, S., Casan, J., Shortt, J., Hawkes, E., Gilbertson, M., McQuilten, Z., Grigoriadis, G., Htun, K. T., Htet, S. M., Campbell, P., Chai, K. L., Quach, H., Patil, S. & Opat, S., 19 Sep 2019, In : Scientific Reports. 9, 1, 7 p., 13544.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Prizes

Albert Baikie Memorial Medal (2011)

Shortt, Jake (Recipient), 2011

Prize: Prize (including medals and awards)

Joseph F Sambrook Prize for Research Excellence (2015)

Shortt, Jake (Recipient), 2015

Prize: Prize (including medals and awards)

Presidential Award (2013)

Shortt, Jake (Recipient), 2013

Prize: Prize (including medals and awards)

Prize for Preclinical Myeloma Research (2015)

Shortt, Jake (Recipient), 2015

Prize: Prize (including medals and awards)

Activities

European Hematology Association (External organisation)

Jake Shortt (Member)

2018

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of networks of excellence

Standing Research Sub-Committee - Cancer Council Victoria

Jake Shortt (Member)

2017

Activity: External Academic EngagementCommittees and working groups

Chemical Probes Portal (External organisation)

Jake Shortt (Member)

2017

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)

Jake Shortt (Advisor)

2017 → …

Activity: External Academic EngagementCommittees and working groups

Scientific Reports (Journal)

Jake Shortt (Editorial board member)

1 Jun 20161 May 2017

Activity: Publication peer-review and editorial work typesEditorial responsibility