Personal profile


Associate Professor Jake Shortt is the Head of Haematology Research at the School of Clinical Sciences and clinical lead at Monash Haematology for leukaemia and myelodysplasia. He is Principal Investigator on a range of clinical trials for myeloid malignancies, conducted through the Monash Haematology clinical trials unit. He is also a Principal Investigator on both NHMRC and Victorian Cancer Agency funded early phase trials in multiple myeloma, conducted in collaboration with the Myeloma Research Group at the Australian Centre for Blood Diseases. 

Associate Professor Shortt is the recipient of a Victorian Cancer Agency (VCA) clinical research fellowship and both NHMRC and CCV project grant funding. He was the inaugural recipient of the "Eva and Les Erdi" Snowdome Foundation/VCA grant for "New targets in haematological malignancy". His strong translational work in the School of Clinical Sciences in collaboration with the Peter MacCallum Cancer Centre is focused on strategies incorporating epigenetic drugs with immunotherapy in haematological cancers, particularly lymphoma and multiple myeloma. He heads the Blood Cancer Therapeutics laboratory within the Monash Health Translation Precinct, facilitating bench-to-bedside research in order to progress these new treatments into the haematology clinic.  

In addition to his clinical and research roles, Associate Professor Shortt is an Associate Member of the Australian Academy of Health and Medical Sciences, the Chair of the Laboratory Sciences Committee of the Australasian Leukaemia and Lymphoma Group and an examiner for the Royal College of Pathologists of Australasia. He sits on the steering committees of the Australian TTP registry, the Australian Lymphoma and Related Diseases Registry and the Victorian Epigenetics Group. 


Clinical activities

Associate Professor Shortt is clinical lead at Monash Health for leukaemia and myelodysplasia. He is also the Deputy Unit Head of Laboratory Haematology. He attends the Monash Haematology myeloid disorders clinic and runs a sub-specialty service for patients with chronic myeloid leukaemia. In addition to outpatient clinics, Associate Professor Shortt undertakes inpatient ward service at Monash and Alfred Health, and is Principal Investigator at Monash Health for a range of clinical trials in leukaemia and myelodysplasia.

External positions

Honorary Senior Research Scientist, Peter MacCallum Cancer Centre

1 Oct 2015 → …

Consultant Haematologist, Monash Health

1 Feb 2008 → …


  • Cancer Immunology
  • Epigenetics
  • Leukemia
  • Lymphoma
  • Molecular Oncology
  • Myelodysplasia
  • Myeloma
  • Thrombotic thrombocytopenic purpura
  • cMYC

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2021

Research Output 1998 2017

A chemical probe toolbox for dissecting the cancer epigenome

Shortt, J., Ott, C. J., Johnstone, R. W. & Bradner, J. E. 1 Mar 2017 In : Nature Reviews Cancer. 17, 3, p. 160-183 24 p.

Research output: Research - peer-reviewReview Article

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

Hogg, S. J., Vervoort, S. J., Deswal, S., Ott, C. J., Li, J., Cluse, L. A., Beavis, P. A., Darcy, P. K., Martin, B. P., Spencer, A., Traunbauer, A. K., Sadovnik, I., Bauer, K., Valent, P., Bradner, J. E., Zuber, J., Shortt, J. & Johnstone, R. W. 28 Feb 2017 In : Cell Reports. 18, 9, p. 2162-2174 13 p.

Research output: Research - peer-reviewArticle

Open Access

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Lefebure, M. , Tothill, R. W. , Kruse, E. , Hawkins, E. D. , Shortt, J. , Matthews, G. M. , Gregory, G. P. , Martin, B. P. , Kelly, M. J. , Todorovski, I. , Doyle, M. A. , Lupat, R. , Li, J. , Schroeder, J. , Wall, M. , Craig, S. , Poortinga, G. , Cameron, D. , Bywater, M. , Kats, L. & 6 others Gearhart, M. D., Bardwell, V. J., Dickins, R. A., Hannan, R. D., Papenfuss, A. T. & Johnstone, R. W. 6 Mar 2017 In : Nature Communications. 8, 14581

Research output: Research - peer-reviewArticle

Open Access

High rates of potentially infectious exposures between immunocompromised patients and their companion animals: an unmet need for education

Gurry, G. A., Campion, V., Premawardena, C., Woolley, I., Shortt, J., Bowden, D. K., Kaplan, Z. & Dendle, C. 1 Mar 2017 In : Internal Medicine Journal. 47, 3, p. 333-335 3 p.

Research output: Research - peer-reviewArticle

Nilotinib dose-optimization in newly diagnosed chronic myeloid leukaemia in chronic phase: Final results from ENESTxtnd

Hughes, T. P., Munhoz, E., Aurelio Salvino, M., Ong, T. C., Elhaddad, A., Shortt, J., Quach, H., Pavlovsky, C., Louw, V. J., Shih, L-Y., Turkina, A. G., Meillon, L., Jin, Y., Acharya, S., Dalal, D. & Lipton, J. H. 2017 (Accepted/In press) In : British Journal of Haematology. 10 p.

Research output: Research - peer-reviewArticle

Open Access


Albert Baikie Memorial Medal (2011)

Jake Shortt (Recipient), 2011

Prize: Prize (including medals and awards)

Joseph F Sambrook Prize for Research Excellence (2015)

Jake Shortt (Recipient), 2015

Prize: Prize (including medals and awards)

Presidential Award (2013)

Jake Shortt (Recipient), 2013

Prize: Prize (including medals and awards)

Prize for Preclinical Myeloma Research (2015)

Jake Shortt (Recipient), 2015

Prize: Prize (including medals and awards)

Activities 2005 2017

  • 5 Committees and working groups
  • 5 Membership of an advisory panel/policy group/ board
  • 3 Submissions to industry or govt committees, commissions and inquiries
  • 1 External research and teaching

Steering Committee - A trial of tranexamic acid for low platelet counts (TREATT)

Shortt, J. (Advisor)
2017 → …

Activity: Committees and working groups

Chemical Probes Portal (External organisation)

Shortt, J. (Member)

Activity: Membership of an advisory panel/policy group/ board

Standing Research Sub-Committee

Shortt, J. (Member)

Activity: Committees and working groups

Chair - ALLG Laboratory Sciences Committee

Shortt, J. (Chair/ Co-Chair)

Activity: Committees and working groups

Examiner - Royal College of Pathologists of Australasia

Shortt, J. (Examiner)

Activity: External research and teaching