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Research Output 2010 2017

2017

Analysis of Clinical HIV-1 Strains with Resistance to Maraviroc Reveals Strain-Specific Resistance Mutations, Variable Degrees of Resistance, and Minimal Cross-Resistance to Other CCR5 Antagonists

Flynn, J. K., Ellenberg, P. C., Duncan, R., Ellett, A., Zhou, J., Sterjovski, J., Cashin, K., Borm, K., Gray, L. R., Lewis, M., Jubb, B., Westby, M., Lee, B., Lewin, S., Churchill, M., Roche, M. J. & Gorry, P. R., 1 Dec 2017, In : AIDS Research and Human Retroviruses. 33, 12, p. 1220-1235 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc

Borm, K., Jakobsen, M. R., Cashin, K., Flynn, J. K., Ellenberg, P., Ostergaard, L., Lee, B., Churchill, M. J., Roche, M. & Gorry, P. R., 3 Nov 2016, In : Retrovirology. 13, 1, 13 p., 74.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Molecular gymnastics: Mechanisms of HIV-1 resistance to CCR5 antagonists and impact on virus phenotypes

Roche, M., Borm, K., Flynn, J. K., Lewin, S. R., Churchill, M. J. & Gorry, P. R., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1091-1106 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2015

Role of macrophages in the immunopathogenesis of HIV-1 infection

Flynn, J. K. & Gorry, P. R., 1 Jan 2015, Global Virology I-Identifying and Investigating Viral Diseases. Shapshak, P., Sinnott, J. T., Somboonwit, C. & Kuhn, J. H. (eds.). New York NY USA: Springer, p. 723-744 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

T cell therapies-are T memory stem cells the answer?

Flynn, J. K. & Gorry, P. R., 1 Oct 2015, In : Annals of Translational Medicine. 3, 17, 251.

Research output: Contribution to journalEditorialOtherpeer-review

2014

Detection of HCV-specific IFN-gamma responses in HCV antibody and HCV RNA negative injecting drug users

Flynn, J. K., Sacks-Davis, R., Higgs, P. G., Aitken, C. K., Moneer, S., Suppiah, V., Tracy, S. L., Ffrench, R. A., Bowden, S., Drummer, H. E., George, J., Bharadwaj, M. & Hellard, M. E., 2014, In : Hepatitis Monthly. 14, 1 (Art. ID: e14678), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Differences in coreceptor specificity contribute to alternative tropism of HIV-1 subtype C for CD4+ T-cell subsets, including stem cell memory T-cells

Cashin, K., Paukovics, G., Jakobsen, M. R., Østergaard, L., Churchill, M. J., Gorry, P. R. & Flynn, J. K., 12 Nov 2014, In : Retrovirology. 11, 1, 6 p., 97.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Is the central nervous system a reservoir of HIV-1?

Gray, L. R., Roche, M., Flynn, J. K., Wesselingh, S. L., Gorry, P. R. & Churchill, M. J., 2014, In : Current Opinion in HIV and AIDS. 9, 6, p. 552-558 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Quantifying susceptibility of CD4+ stem memory T-cells to infection by laboratory adapted and clinical HIV-1 strains

Flynn, J. K., Paukovics, G., Cashin, K., Borm, K., Ellett, A. M., Roche, M. J., Jakobsen, M. R., Churchill, M. J. & Gorry, P. R., 2014, In : Viruses. 6, 2, p. 709 - 726 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Stem memory T cells (TSCM)—their role in cancer and HIV immunotherapies

Flynn, J. K. & Gorry, P. R., 2014, In : Clinical and Translational Immunology. 3, 7, 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy

Devaud, C., Westwood, J. A., John, L. B., Flynn, J. K., Paquet-Fifield, S., Duong, C. P. M., Yong, C. SM., Pegram, H. J., Stacker, S. A., Achen, M. G., Stewart, T. J., Snyder, L., Teng, M., Smyth, M. J., Darcy, P. K. & Kershaw, M. H., 2014, In : Molecular Therapy. 22, 1, p. 18 - 27 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Roche, M. J., Salimi, H., Duncan, R. C., Wilkinson, B., Chikere, K., Moore, M. S., Webb, N., Zappi, H., Sterjovski, J., Flynn, J. K., Ellett, A., Gray, L. R., Lee, B., Jubb, B., Westby, M., Ramsland, P. A., Lewin, S. R., Payne, R. J., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art. No.: 43), p. 1 - 20 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitro usage of alternative coreceptors during progressive HIV-1 subtype C infection

Cashin, K., Jakobsen, M. R., Sterjovski, J., Roche, M. J., Ellett, A., Flynn, J. K., Borm, K., Gouillou, M., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art. No.: 98), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Longitudinal analysis of CCR5 and CXCR4 usage in a cohort of antiretroviral therapy-naive subjects with progressive HIV-1 subtype C infection

Jakobsen, M. R., Cashin, K., Roche, M., Sterjovski, J., Ellett, A., Borm, K., Flynn, J. K., Erikstrup, C., Gouillou, M., Gray, L. R., Saksena, N. K., Wang, B., Purcell, D. F., Kallestrup, P., Zinyama-Gutsire, R., Gomo, E., Ullum, H., Ostergaard, L., Lee, B., Ramsland, P. A. & 2 othersChurchill, M. & Gorry, P. R., 2013, In : PLoS ONE. 8, 6, 13 p., e65950.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment

Flynn, J. K., Dore, G. J., Hellard, M., Yeung, B., Rawlinson, W., White, P. A., Kaldor, J. M., Lloyd, A. & Ffrench, R. A., 2013, In : Journal of Gastroenterology and Hepatology. 28, 11, p. 1770 - 1781 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets

Flynn, J. K., Paukovics, G., Moore, M. S., Ellett, A., Gray, L. R., Duncan, R., Salimi, H., Jubb, B., Westby, M., Purcell, D. F. J., Lewin, S. R., Lee, B., Churchill, M., Gorry, P. R. & Roche, M. J., 2013, In : Virology. 422, 1, p. 51 - 58 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Impaired hepatitis C virus (HCV)-specific interferon-gamma responses in individuals with HIV who acquire HCV infection: correlation with CD4(+) T-cell counts

Flynn, J. K., Dore, G. J., Matthews, G., Hellard, M., Yeung, B., Rawlinson, W., White, P. A., Kaldor, J. M., Lloyd, A. & Ffrench, R. A., 2012, In : Journal of Infectious Diseases. 206, 10, p. 1568 - 1576 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Oncolytic virus and anti-4-1BB combination therapy elicits strong antitumor immunity against established cancer

John, L. B., Howland, L. J., Flynn, J. K., West, A. C., Devaud, C., Duong, C. P. M., Stewart, T. J., Westwood, J. A., Guo, Z. S., Bartlett, D. L., Smyth, M. J., Kershaw, M. H. & Darcy, P. K., 2012, In : Cancer Research. 72, 7, p. 1651 - 1660 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

Early IL-10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users

Flynn, J. K., Dore, G. J., Hellard, M., Yeung, B., Rawlinson, W. D., White, P. A., Kaldor, J. M., Lloyd, A. R., Ffrench, R. A. & ATAHC Study Group, Aug 2011, In : Journal of Viral Hepatitis. 18, 8, p. 549-561 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection

Grebely, J., Petoumenos, K., Hellard, M., Matthews, G. V., Suppiah, V., Applegate, T., Yeung, B., Marks, P., Rawlinson, W., Lloyd, A. R., Booth, D., Kaldor, J. M., George, J., Dore, G. J., Marks, P., Haber, P. S., Ffrench, R., White, P., Day, C., van Beek, I. & 31 othersMcCaughan, G., Madden, A., Dolan, K., Farrell, G. C., Crofts, N., Sievert, W., Baker, D., Acraman, B., Amin, J., Doab, A., Carroll, T., Nguyen, O., von Bibra, S., Teutsch, S., Li, H., Oon, A., Cameron, B., Jacka, B., Pan, Y., Flynn, J., Goy, K., Shaw, D., Sasadeusz, J., Crawford, D., Phung, N., Bloch, M. T., Hughes, B. M., Mollison, L., Roberts, S., Desmond, P. & ATAHC Study Group, 22 Nov 2010, In : Hepatology. 52, 4, p. 1216-1224 9 p.

Research output: Contribution to journalArticleResearchpeer-review