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Research Output 2010 2019

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2019

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

Newson, J., Scott, N. E., Chung, I. Y. W., Lung, T. W. F., Giogha, C., Gan, J., Wang, N., Strugnell, R., Brown, N. F., Cygler, M., Pearson, J. & Hartland, E., 1 Jun 2019, In : Molecular & Cellular Proteomics. 18, 6, p. 1138-1156 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Distinct roles of the antiapoptotic effectors NleB and NleF from enteropathogenic Escherichia coli

Pollock, G. L., Oates, C. V. L., Giogha, C., Lung, T. W. F., Ong, S. Y., Pearson, J. S. & Hartland, E. L., 1 Apr 2017, In : Infection and Immunity. 85, 4, 12 p., e01071-16.

Research output: Contribution to journalArticleResearchpeer-review

Down the rabbit hole: Is necroptosis truly an innate response to infection?

Pearson, J. S. & Murphy, J. M., 1 Aug 2017, In : Cellular Microbiology. 19, 8, e12750.

Research output: Contribution to journalArticleOtherpeer-review

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Pearson, J. S., Giogha, C., Mühlen, S., Nachbur, U., Pham, C. L. L., Zhang, Y., Hildebrand, J. M., Oates, C. V., Lung, T. W. F., Ingle, D. J., Dagley, L. F., Bankovacki, A., Petrie, E. J., Schroeder, G. N., Crepin, V. F., Frankel, G., Masters, S. L., Vince, J., Murphy, J. M., Sunde, M. & 3 others, Webb, A. I., Silke, J. & Hartland, E. L., 13 Jan 2017, In : Nature Microbiology. 2, 10 p., 16258.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD)

Scott, N. E., Giogha, C., Pollock, G. L., Kennedy, C. L., Webb, A. I., Williamson, N. A., Pearson, J. S. & Hartland, E. L., 2017, In : Journal of Biological Chemistry. 292, 42, p. 17337-17350 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The type III effector NleD from enteropathogenic Escherichia coli differentiates between host substrates p38 and JNK

Creuzburg, K., Giogha, C., Lung, T. W. F., Scott, N. E., Mühlen, S., Hartland, E. L. & Pearson, J. S., Feb 2017, In : Infection and Immunity. 85, 2, 16 p., e00620-16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Evolution of atypical enteropathogenic E. Coli by repeated acquisition of LEE pathogenicity island variants

Ingle, D. J., Tauschek, M., Edwards, D. J., Hocking, D. M., Pickard, D. J., Azzopardi, K. I., Amarasena, T. H., Bennett-Wood, V. R., Pearson, J. S., Tamboura, B., Antonio, M., Ochieng, J. B., Oundo, J., Mandomando, I., Qureshi, S. M., Ramamurthy, T., Hossain, A., Kotloff, K. L., Nataro, J. P., Dougan, G. & 3 others, Levine, M. M., Robins-Browne, R. M. & Holt, K. E., 18 Jan 2016, In : Nature Microbiology. 1, 2, 9 p., 15010.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ

Zhang, Y., Mühlen, S., Oates, C. V., Pearson, J. S. & Hartland, E. L., 16 Sep 2016, In : Journal of Biological Chemistry. 291, 38, p. 20149-20162 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mutagenesis and functional analysis of the bacterial arginine glycosyltransferase effector NleB1 from enteropathogenic Escherichia coli

Wong Fok Lung, T., Giogha, C., Creuzburg, K., Ong, S. Y., Pollock, G. L., Zhang, Y., Fung, K. Y., Pearson, J. S. & Hartland, E. L., May 2016, In : Infection and Immunity. 84, 5, p. 1346-1360 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2015

A surprising sweetener from enteropathogenic Escherichia coli

Pearson, J. S. & Hartland, E. L., 26 Jan 2015, In : Gut Microbes. 5, 6, p. 766-769 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli

Giogha, C., Wong Fok Lung, T., Mühlen, S., Pearson, J. S. & Hartland, E. L., Dec 2015, In : Cellular Microbiology. 17, 12, p. 1766-1778 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 19 Dec 2014, In : Nature Communications. 5, 10 p., 5887.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The inflammatory response during enterohemorrhagic Escherichia coli infection

Pearson, J. S. & Hartland, E. L., 15 Aug 2014, In : Microbiology spectrum. 2, 4, 14 p., EHEC-0012-2013.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection

Pallett, M. A., Berger, C. N., Pearson, J. S., Hartland, E. L. & Frankel, G., Nov 2014, In : Infection and Immunity. 82, 11, p. 4878-4888 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

A type III effector antagonizes death receptor signalling during bacterial gut infection

Pearson, J. S., Giogha, C., Ong, S. Y., Kennedy, C. L., Kelly, M., Robinson, K. S., Lung, T. W. F., Mansell, A. S., Riedmaier, P., Oates, C. VL., Zaid, A., Muhlen, S., Crepin, V. F., Marches, O., Ang, C-S., Williamson, N. A., O'Reilly, L. A., Bankovacki, A., Nachbur, U., Infusini, G. & 5 others, Webb, A. I., Silke, J., Strasser, A., Frankel, G. M. & Hartland, E. L., 2013, In : Nature. 501, 7466, p. 247-251 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the ospz promoter in shigella flexneri and its regulation by virb and h-ns

Basta, D. W., Pew, K. L., Immak, J. A., Park, H. S., Picker, M. A., Wigley, A. F., Hensley, C. T., Pearson, J. S., Hartland, E. L. & Wing, H. J., Jun 2013, In : Journal of Bacteriology. 195, 11, p. 2562-2572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

Pearson, J. S., Riedmaier, P., Marchès, O., Frankel, G. & Hartland, E. L., Apr 2011, In : Molecular Microbiology. 80, 1, p. 219-230 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., 2010, In : PLoS Pathogens. 6, 5 (e1000898), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review