If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Direct interaction between calmodulin and the grb7 RA-PH domain

Watson, G. M. & Wilce, J. A., 2 Feb 2020, In : International Journal of Molecular Sciences. 21, 4, 10 p., 1336.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain

García-Palmero, I., Shah, N., Ali, N. A., Daly, R. J., Wilce, J. A. & Villalobo, A., 15 Jul 2020, In : Archives of Biochemistry and Biophysics. 687, 8 p., 108386.

Research output: Contribution to journalArticleResearchpeer-review

2019

Evaluation of cyclic peptide inhibitors of the Grb7 breast cancer target: Small change in cargo results in large change in cellular activity

Sang, J., Kulkarni, K., Watson, G. M., Ma, X., Craik, D. J., Henriques, S. T., Poth, A., Benfield, A. H. & Wilce, J. A., 17 Oct 2019, In : Molecules. 24, 20, 19 p., 3739.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis

Shah, N., Beckham, S. A., Wilce, J. A. & Wilce, M. C. J., 6 Apr 2018, In : Nucleic Acids Research. 46, 6, p. 3169-3186 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Preparation and cellular uptake of bicyclic-peptide cargo clicked to cell penetrating peptides

Kulkarni, K., Watson, G. M., Sang, J. & Wilce, J. A., May 2018, In : Peptide Science. 110, 3, 11 p., e24037.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. Elegans

Davis, G. M., Tu, S., Anderson, J. WT., Colson, R. N., Gunzburg, M. J., Francisco, M. A., Ray, D., Shrubsole, S. P., Sobotka, J. A., Seroussi, U., Lao, R. X., Maity, T., Wu, M. Z., McJunkin, K., Morris, Q. D., Hughes, T. R., Wilce, J. A., Claycomb, J. M., Weng, Z. & Boag, P. R., 21 Dec 2018, In : eLife. 7, 29 p., e35478.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
2017

Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target

Watson, G. M., Kulkarni, K., Sang, J., Ma, X., Gunzburg, M. J., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 22 Nov 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9349-9359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis

Ramdzan, Y. M., Trubetskov, M. M., Ormsby, A. R., Newcombe, E. A., Sui, X., Tobin, M. J., Bongiovanni, M. N., Gras, S. L., Dewson, G., Miller, J. M. L., Finkbeiner, S., Moily, N. S., Niclis, J., Parish, C. L., Purcell, A. W., Baker, M. J., Wilce, J. A., Waris, S., Stojanovski, D., Böcking, T. & 4 others, Ang, C-S., Ascher, D. B., Reid, G. E. & Hatters, D. M., 2 May 2017, In : Cell Reports. 19, 5, p. 919-927 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
40 Citations (Scopus)

Insight into the selectivity of the G7-18NATE inhibitor peptide for the Grb7-SH2 domain target

Watson, G. M., Lucas, W. A. H., Gunzburg, M. J. & Wilce, J. A., 26 Sep 2017, In : Frontiers in Molecular Biosciences. 4, 8 p., 64.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Shortened penetratin cell-penetrating peptide is insufficient for cytosolic delivery of a Grb7 targeting peptide

Watson, G. M., Kulkarni, K., Brandt, R., Del Borgo, M. P., Aguilar, M-I. & Wilce, J. A., 23 Feb 2017, In : ACS Omega. 2, 2, p. 670-677 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

TIA-1 RRM23 binding and recognition of target oligonucleotides

Waris, S., Garcia-Maurino, S. M., Sivakumaran, A., Beckham, S. A., Loughlin, F. E., Gorospe, M., Diaz-Moreno, I., Wilce, M. C. J. & Wilce, J. A., 5 May 2017, In : Nucleic Acids Research. 45, 8, p. 4944-4957 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)
2016

The impact of cell-penetrating peptides on membrane bilayer structure during binding and insertion

Hirst, D. J., Lee, T-H., Kulkarni, K., Wilce, J. A. & Aguilar, M-I., Aug 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 8, p. 1841-1849 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

Gunzburg, M. J., Kulkarni, K., Watson, G. M., Ambaye, N. D., Del Borgo, M. P., Brandt, R., Pero, S. C., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 3 Jun 2016, In : Scientific Reports. 6, 13 p., 27060.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)
2015

Cooperative interplay of let-7 mimic and HuR with MYC RNA

Gunzburg, M. J., Sivakumaran, A., Pendini, N. R., Yoon, J-H., Gorospe, M., Wilce, M. C. J. & Wilce, J. A., 2015, In : Cell Cycle. 14, 17, p. 2729 - 2733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Cyclic peptides incorporating phosphotyrosine mimetics as potent and specific inhibitors of the Grb7 breast cancer target

Watson, G. M., Gunzburg, M. J., Ambaye, N. D., Lucas, W. S., Traore, D. A. K., Kulkarni, K. P., Cergol, K. M., Payne, R. J., Panjikar, S., Pero, S. C., Perlmutter, P., Wilce, M. C. & Wilce, J. A., 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7707 - 7718 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2014

Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines

Lim, R. C. C., Price, J. T. & Wilce, J. A., 2014, In : Breast Cancer Research and Treatment. 143, 3, p. 593 - 603 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist

Ambaye, N. D., Gunzburg, M. J., Traore, D. A. K., Del Borgo, M. P., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 2014, In : Acta Crystallographica. Section F: Structural Biology Communications. 70, 2, p. 182 - 186 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

RNA recognition and stress granule formation by TIA proteins

Waris, S., Wilce, M. C. & Wilce, J. A., 2014, In : International Journal of Molecular Sciences. 15, 12, p. 23377 - 23388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain

Cruz-Gallardo, I., Aroca, A., Gunzburg, M. J., Sivakumaran, A. K., Yoon, J-H. H., Angulo, J., Persson, C., Gorospe, M., Karlsson, B. G., Wilce, J. A. & Diaz-Moreno, I., 2014, In : RNA Biology. 11, 6, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2013

A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4

Perry, A. J., Wijeyewickrema, L. C., Wilmann, P. G., Gunzburg, M. J., D'Andrea, L. P., Irving, J., Pang, S. S., Duncan, R. C., Wilce, J. A., Whisstock, J. & Pike, R. N., 2013, In : The Journal of Biological Chemistry. 288, 22, p. 15821 - 15829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

Beckham, S. A., Brouwer, J. M., Roth, A., Wang, D., Sadler, A. J., John, M., Jahn-Hofmann, K., Williams, B. R. G., Wilce, J. A. & Wilce, M. C. J., 2013, In : Nucleic Acids Research. 41, 5, p. 3436 - 3445 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Design and testing of bicyclic inhibitors of Grb7 - are two cycles better than one?

Gunzburg, M. J., Ambaye, N. D., Del Borgo, M. P., Perlmutter, P. & Wilce, J. A., 2013, In : Biopolymers (Peptide Science). 100, 5, p. 543 - 549 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Distinct binding properties of TIAR RRMs and linker region

Kim, H., Headey, S. J., Yoga, Y. M. K., Scanlon, M., Gorospe, M., Wilce, M. C. J. & Wilce, J. A., 2013, In : RNA Biology. 10, 4, p. 579 - 589 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR

Schulz, S., Doller, A., Pendini, N. R., Wilce, J. A., Pfeilschifter, J. M. & Eberhardt, W., 2013, In : Cellular Signalling. 25, 12, p. 2485 - 2495 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility

O'Bryan, M. K., Clark, B., McLaughlin, E. A., D'Sylva, R., O'Donnell, L., Wilce, J. A., Sutherland, J., O'Connor, A., Whittle, B., Goodnow, C., Ormandy, C. J. & Jamsai, D., 2013, In : PLoS Genetics. 9, 7 (Art. No.: e1003628), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target

Pendini, N. R., Yap, M. Y., Traore, D. A. K., Polyak, S. W., Cowieson, N. P., Abell, A. D., Booker, G. W., Wallace, J. C., Wilce, J. A. & Wilce, M. C. J., 2013, In : Protein Science. 22, 6, p. 762 - 773 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Supramolecular self-assembly of N-acetyl-capped beta-peptides leads to nano- to macroscale fiber formation

Del Borgo, M. P., Mechler, A. I., Traore, D. A. K., Forsyth, C. M., Wilce, J. A., Wilce, M. C. J., Aguilar, M. I. & Perlmutter, P., 2013, In : Angewandte Chemie - International Edition. 52, 32, p. 8266 - 8270 5 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents

Ambaye, N. D., Gunzburg, M. J., Lim, R. C. C., Price, J. T., Wilce, M. C. J. & Wilce, J. A., 2013, In : ChemMedChem. 8, 2, p. 280 - 288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2012

Conformational stability studies of a stapled hexa-beta(3)-peptide library

Gopalan, R. D., Del Borgo, M. P., Bergman, Y. E., Unabia, S., Mulder, R. J., Wilce, M. C., Wilce, J. A., Aguilar, M. MI. & Perlmutter, P., 2012, In : Organic and Biomolecular Chemistry. 10, 9, p. 1802 - 1806 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides

Yoga, Y. M. K., Traore, D. AK., Sidiqi, M., Szeto, C., Pendini, N. R., Barker, A., Leedman, P., Wilce, J. A. & Wilce, M. C., 2012, In : Nucleic Acids Research. 40, 11, p. 5101 - 5114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity

Gunzburg, M. J., Ambaye, N. D., Del Borgo, M. P., Pero, S. C., Krag, D. N., Wilce, M. C. & Wilce, J. A., 2012, In : Journal of Molecular Recognition. 25, 1, p. 57 - 67 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Sequence requirements for RNA binding by HuR and AUF1

Barker, A., Epis, M. R., Porter, C. J., Hopkins, B. R., Wilce, M. C., Wilce, J. A., Giles, K. M. & Leedman, P. J., 2012, In : Journal of Biochemistry. 151, 4, p. 423 - 437 15 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)
2011

Benzopyrazine derivatives: a novel class of Growth Factor receptor bound protein 7 antagonists

Ambaye, N. D., Gunzburg, M. J., Lim, R. CC., Price, J. T., Wilce, M. CJ. & Wilce, J. A., 2011, In : Bioorganic & Medicinal Chemistry. 19, p. 693 - 701 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Different modes of interaction by TIAR and HuR with target RNA and DNA

Kim, H. S., Wilce, M. C. J., Yoga, Y., Pendini, N. R., Gunzburg, M. J., Cowieson, N., Wilson, G. M., Williams, B., Gorospe, M. & Wilce, J. A., 2011, In : Nucleic Acids Research. 39, 3, p. 1117 - 1130 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)
1 Citation (Scopus)

Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression

Ambaye, N., Pero, S., Gunzburg, M., Yap, M., Clayton, D., Del Borgo, M., Perlmutter, P., Aguilar, M., Shukla, G., Peletskaya, E., Cookson, M., Krag, D., Wilce, M. & Wilce, J., 2011, In : Journal of Molecular Biology. 412, 3, p. 397 - 411 15 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain

Ambaye, N. D., Lim, R. C. C., Clayton, D. J., Gunzburg, M. J., Price, J. T., Pero, S. C., Krag, D. N., Wilce, M. C. J., Aguilar, M. I., Perlmutter, P. & Wilce, J. A., 2011, In : Journal of Peptide Science. 96, 2, p. 181 - 188 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2010

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition

Theodossis, A., Guillonneau, C., Welland, A. D., Ely, L. K., Clements, C. S., Williamson, N. A., Webb, A. I., Wilce, J. A., Mulder, R. J., Dunstone, M. A., Doherty, P. C., McCluskey, J., Purcell, A. W., Turner, S. J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 12, p. 5534 - 5539 6 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide

Yap, M. Y., Wilce, M. C. J., Clayton, D. J., Perlmutter, P., Aguilar, M. I. & Wilce, J. A., 2010, In : Acta Crystallographica. Section F: Structural Biology Communications. 66, Pt 12, p. 1640 - 1643 4 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Use of SPR to study the interaction of G7-18NATE peptide with the Grb7-SH2 domain

Gunzburg, M. J., Ambaye, N. D., Hertzog, J. T., Del Borgo, M. P., Pero, S. C., Krag, D. N., Wilce, M. CJ., Aguilar, M. I., Perlmutter, P. & Wilce, J. A., 2010, In : International Journal of Peptide Research and Therapeutics. 16, 3, p. 177 - 184 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2009

Synthesis of stapled beta3-peptides through ring-closing metathesis

Bergman, Y. E., Del Borgo, M. P., Gopalan, R. D., Jalal, S., Unabia, S., Ciampini, M., Clayton, D. J., Fletcher, J. M., Mulder, R. J., Wilce, J. A., Aguilar, M. I. & Perlmutter, P., 2009, In : Organic Letters. 11, 19, p. 4438 - 4440 3 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2008
2 Citations (Scopus)

The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism

Schmidberger, J. W., Wilce, J. A., Weightman, A. J., Whisstock, J. & Wilce, M. C. J., 2008, In : Journal of Molecular Biology. 378, 1, p. 284 - 294 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The intracellular and nuclear-targeted delivery of an antiandrogen drug by carrier peptides

Hodoniczky, J., Sims, C. G., Best, W. M., Bentel, J. M. & Wilce, J. A., 2008, In : Biopolymers (Peptide Science). 90, 5, p. 595 - 603 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2007

An asymmetric structure of the bacillus subtilis replication terminator protein in complex with DNA

Vivian, J. P., Porter, C. J., Wilce, J. A. & Wilce, M. C. J., 2007, In : Journal of Molecular Biology. 370, 3, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Crystal Structures of the Substrate Free-enzyme, and Reaction Intermediate of the HAD Superfamily Member, Haloacid Dehalogenase DehIVa from Burkholderia cepacia MBA4

Schmidberger, J. W., Wilce, J. A., Tsang, J. SH. & Wilce, M. C. J., 2007, In : Journal of Molecular Biology. 368, 3, p. 706 - 717 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR

Kim, H., Kuwano, Y., Zhan, M., Pullmann Jr, R., Mazan-Mamczarz, K., Li, H., Kedersha, N., Anderson, P., Wilce, M. C. J., Gorospe, M. & Wilce, J. A., 2007, In : Molecular and Cellular Biology. 27, 19, p. 6806 - 6817 12 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation

Porter, C. J., Matthews, J. M., Mackay, J. P., Pursglove, S. E., Schmidberger, J., Leedman, P., Pero, S. C., Krag, D., Wilce, M. C. J. & Wilce, J. A., 2007, In : BMC Structural Biology. 7, 58, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

NMR analysis of G7-18NATE, a nonphosphorylated cyclic peptide inhibitor of the Grb7 adapter protein

Porter, C. J. & Wilce, J. A., 2007, In : Biopolymers (Peptide Science). 88, 2, p. 174 - 181 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)