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Research Output 1999 2019

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2019

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

Harpur, C. M., Kato, Y., Dewi, S. T., Stankovic, S., Johnson, D. N., Bedoui, S., Whitney, P. G., Lahoud, M. H., Caminschi, I., Heath, W. R., Brooks, A. G. & Gebhardt, T., 1 Feb 2019, In : Journal of Immunology. 202, 3, p. 653-663 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8+ T cell development

Caminschi, I., Lahoud, M. H., Pizzolla, A. & Wakim, L. M., 21 Jan 2019, In : Mucosal Immunology. 12, p. 403-412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Holz, L. E., Prier, J. E., Freestone, D., Steiner, T. M., English, K., Johnson, D. N., Mollard, V., Cozijnsen, A., Davey, G. M., Godfrey, D. I., Yui, K., Mackay, L. K., Lahoud, M. H., Caminschi, I., McFadden, G. I., Bertolino, P., Fernandez-Ruiz, D. & Heath, W. R., 2 Oct 2018, In : Cell Reports. 25, 1, p. 68-79 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

Zeng, B., Middelberg, A. P. J., Gemiarto, A., MacDonald, K. P. A., Baxter, A. G., Talekar, M., Moi, D., Tullett, K. M., Caminschi, I., Lahoud, M. H., Mazzieri, R., Dolcetti, R. & Thomas, R., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1971-1984 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes

Macri, C., Dumont, C., Panozza, S., Lahoud, M. H., Caminschi, I., Villadangos, J. A., Johnston, A. P. R. & Mintern, J. D., Jan 2017, In : Molecular Immunology. 81, p. 143-150 8 p.

Research output: Contribution to journalArticleResearchpeer-review

CD14 is not involved in the uptake of synthetic CpG oligonucleotides

Li, J., Ahmet, F., O'Keeffe, M., Lahoud, M. H., Heath, W. R. & Caminschi, I., Jan 2017, In : Molecular Immunology. 81, p. 52-58 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells

Park, H-Y., Tan, P. S., Kavishna, R., Ker, A., Lu, J., Chan, C. E. Z., Hanson, B. J., MacAry, P. A., Caminschi, I., Shortman, K., Alonso, S. & Lahoud, M. H., 1 Dec 2017, In : npj Vaccines. 2, 1, 11 p., 33.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Local Modulation of Antigen-Presenting Cell Development after Resolution of Pneumonia Induces Long-Term Susceptibility to Secondary Infections

Roquilly, A., McWilliam, H. E. G., Jacqueline, C., Tian, Z., Cinotti, R., Rimbert, M., Wakim, L., Caminschi, I., Lahoud, M. H., Belz, G. T., Kallies, A., Mintern, J. D., Asehnoune, K. & Villadangos, J. A., 18 Jul 2017, In : Immunity. 47, 1, p. 135-147.e5 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection

Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L., 1 Apr 2017, In : Journal of Immunology. 198, 7, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

IL-12p40/IL-10 producing preCD8/Clec9A+ dendritic cells are induced in neonates upon listeria monocytogenes infection

Torres, D., Kohler, A., Delbauve, S., Caminschi, I., Lahoud, M. H., Shortman, K. & Flamand, V., 13 Apr 2016, In : PLoS Pathogens. 12, 4, 21 p., 1005561.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Liver-resident memory CD8+ T cells rorm a front-line defense against malaria liver-stage infection

Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., Li, J., Davey, G. M., Kato, Y., Devi, S., Skandari, R., Pauley, M., Manton, J. H., Godfrey, D. I., Braun, A., Tay, S. S. & 13 others, Tan, P. S., Bowen, D. G., Koch-Nolte, F., Rissiek, B., Carbone, F. R., Crabb, B. S., Lahoud, M., Cockburn, I. A., Mueller, S. N., Bertolino, P., McFadden, G. I., Caminschi, I. & Heath, W. R., 18 Oct 2016, In : Immunity. 45, 4, p. 889-902 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition

Tullett, K. M., Leal Rojas, I. M., Minoda, Y., Tan, P. S., Zhang, J-G., Smith, C., Khanna, R., Shortman, K., Caminschi, I., Lahoud, M. H. & Radford, K. J., 19 May 2016, In : JCI Insight. 1, 7, 12 p., e87102.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

Li, J., Ahmet, F., Sullivan, L. C., Brooks, A. G., Kent, S. J., De Rose, R., Salazar, A. M., Reis e Sousa, C., Shortman, K., Lahoud, M. H., Heath, W. R. & Caminschi, I., 2015, In : European Journal of Immunology. 45, 3, p. 854 - 864 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

Wakim, L., Smith, J. R., Caminschi, I., Lahoud, M. H. & Villadangos, J. A., 2015, In : Mucosal Immunology. 8, 5, p. 1060 - 1071 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination

Reuter, A., Panozza, S. E., Macri, C., Dumont, C., Li, J., Liu, H., Segura, E., Vega-Ramos, J., Gupta, N., Caminschi, I., Villadangos, J. A., Johnston, A. P. R. & Mintern, J. D., 2015, In : Journal of Immunology. 194, 6, p. 2696-2705 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting antigen to Clec9A primes follicular Th cell memory responses capable of robust recall

Kato, Y., Zaid, A., Davey, G. M., Mueller, S. N., Nutt, S. L., Zotos, D., Tarlinton, D., Shortman, K., Lahoud, M. H., Heath, W. R. & Caminschi, I., 2015, In : Journal of Immunology. 195, 3, p. 1006 - 1014 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo

Ding, Y., Wilkinson, A. R. J., Idris, A., Fancke, B. R., O'Keeffe, M., Khalil, D., Ju, X., Lahoud, M. H., Caminschi, I., Shortman, K., Rodwell, R. L., Vuckovic, S. & Radford, K. J., 2014, In : Journal of Immunology. 192, 4, p. 1982 - 1989 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

DEC-205 is a cell surface receptor for CpG oligonucleotides

Caminschi, I., Meuter, S. & Heath, W. R., Mar 2013, In : OncoImmunology. 2, 3, e23128.

Research output: Contribution to journalArticleResearchpeer-review

DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats

Wang, Y., Wang, Y. M., Wang, Y., Zheng, G., Zhang, G. Y., Zhou, J. J., Tan, T. K., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Lahoud, M. H., Caminschi, I., Harris, D. C. & Alexander, S. I., Feb 2013, In : Kidney International. 83, 2, p. 223-232 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Evolution of B cell responses to Clec9A-targeted antigen

Park, H-Y., Light, A., Lahoud, M., Caminschi, I., Tarlinton, D. M. & Shortman, K., 2013, In : Journal of Immunology. 191, 10, p. 4919 - 4925 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: Potential therapeutic implications

Gagné, V., Marois, L., Levesque, J. M., Galarneau, H., Lahoud, M. H., Caminschi, I., Naccache, P. H., Tessier, P. & Fernandes, M. J. G., 9 Jul 2013, In : Arthritis Research and Therapy. 15, 4, 15 p., R73.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly

Zeng, B. J., Chuan, Y. P., O'Sullivan, B., Caminschi, I., Lahoud, M. H., Thomas, R. & Middelberg, A. P. J., 25 Nov 2013, In : Small. 9, 22, p. 3736-3742 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation

Moffat, J. M., Segura, E., Khoury, G., Caminschi, I., Cameron, P. U., Lewin, S. R., Villadangos, J. A. & Mintern, J., 2013, In : European Journal of Immunology. 43, 3, p. 595 - 605 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

Gatto, D., Wood, K., Caminschi, I., Murphy-Durland, D., Schofield, P., Christ, D., Karupiah, G. & Brink, R., May 2013, In : Nature Immunology. 14, 5, p. 446-453 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3-/- mice

Caminschi, I., Vremec, D., Ahmet, F., Lahoud, M. H., Villadangos, J. A., Murphy, K. M., Heath, W. R. & Shortman, K., Feb 2012, In : Molecular Immunology. 50, 1-2, p. 9-17 9 p.

Research output: Contribution to journalArticleResearchpeer-review

DEC-205 is a cell surface receptor for CpG oligonucleotides

Lahoud, M. H., Ahmet, F., Zhang, J-G., Meuter, S., Policheni, A. N., Kitsoulis, S., Lee, C-N., O'Keeffe, M., Sullivan, L. C., Brooks, A. G., Berry, R., Rossjohn, J., Mintern, J. D., Vega-Ramos, J., Villadangos, J. A., Nicola, N. A., Nussenzweig, M. C., Stacey, K. J., Shortman, K., Heath, W. R. & 1 others, Caminschi, I., 2012, In : Proceedings of the National Academy of Sciences. 109, 40, p. 16270 - 16275 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

Zhang, J-G., Czabotar, P. E., Policheni, A. N., Caminschi, I., Wan, S. S., Kitsoulis, S., Tullett, K. M., Robin, A. Y., Brammananth, R., van Delft, M. F., Lu, J., O'Reilly, L. A., Josefsson, E. C., Kile, B. T., Chin, W. J., Mintern, J. D., Olshina, M. A., Wong, W., Baum, J., Wright, M. D. & 7 others, Huang, D. C. S., Mohandas, N., Coppel, R. L., Colman, P. M., Nicola, N. A., Shortman, K. & Lahoud, M. H., 2012, In : Immunity. 36, 4, p. 646-657 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen

Desch, A. N., Randolph, G. J., Murphy, K. M., Gautier, E. L., Kedl, R. M., Lahoud, M. H., Caminschi, I., Shortman, K., Henson, P. M. & Jakubzick, C. V., 29 Aug 2011, In : Journal of Experimental Medicine. 208, 9, p. 1789-1797 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

Idoyaga, J., Lubkin, A., Fiorese, C., Lahoud, M. H., Caminschi, I., Huang, Y., Rodriguez, A., Clausen, B. E., Park, C. G., Trumpfheller, C. & Steinmana, R. M., 8 Feb 2011, In : Proceedings of the National Academy of Sciences. 108, 6, p. 2384-2389 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype

Lahoud, M. H., Ahmet, F., Kitsoulis, S., Wan, S. S., Vremec, D., Lee, C-N., Phipson, B., Shi, W., Smyth, G. K., Lew, A. M., Kato, Y., Mueller, S. N., Davey, G. M., Heath, W. R., Shortman, K. & Caminschi, I., 15 Jul 2011, In : Journal of Immunology. 187, 2, p. 842-850 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

Bedoui, S., Whitney, P. G., Waithman, J., Eidsmo, L., Wakim, L., Caminschi, I., Allan, R. S., Wojtasiak, M., Shortman, K., Carbone, F. R., Brooks, A. G. & Heath, W. R., 2009, In : Nature Immunology. 10, 5, p. 488-495 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential migration of epidermal and dermal dendritic cells during skin infection

Eidsmo, L., Allan, R. S., Caminschi, I., van Rooijen, N., Heath, W. R. & Carbone, F. R., 1 Mar 2009, In : Journal of Immunology. 182, 5, p. 3165-3172 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response

Lee, C., Kolesnik, T. B., Caminschi, I., Chakravorty, A., Carter, A. W., Alexander, W. S., Jones, J., Anderson, G. P. & Nicholson, S. E., Jun 2009, In : Clinical and Experimental Allergy. 39, 6, p. 897-907 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses

Lahoud, M., Proietto, A. I., Ahmet, F., Kitsoulis, S., Eidsmo, L., Wu, L., Sathe, P., Pietersz, S., Chang, H-W., Walker, I., Maraskovsky, E., Braley, H., Lew, A. M., Wright, M. D., Heath, W. R., Shortman, K. & Caminschi, I., 2009, In : Journal of Immunology. 182, 12, p. 7587 - 7594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

Caminschi, I., Proietto, A. I., Ahmet, F., Kitsoulis, S., Teh, J. S., Lo, J. C. Y., Rizzitelli, A., Wu, L., Vremec, D., van Dommelen, S. LH., Campbell, I. K., Maraskovsky, E., Braley, H., Davey, G. M., Mottram, P. L., van de Velde, N. C., Jensen, K., Lew, A. M., Wright, M. D., Heath, W. R. & 2 others, Shortman, K. & Lahoud, M. H., 2008, In : Blood. 112, 8, p. 3264 - 3273 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells

Vremec, D., O'Keeffe, M., Hochrein, H., Fuchsberger, M., Caminschi, I., Lahoud, M. & Shortman, K., 1 Feb 2007, In : Blood. 109, 3, p. 1165-1173 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

Caminschi, I., Ahmet, F., Heger, K., Brady, J., Nutt, S. L., Vremec, D., Pietersz, S., Lahoud, M. H., Schofield, L. D., Hansen, D. S., O'Keeffe, M., Smyth, M. J., Bedoui, S., Davey, G. M., Villadangos, J. A., Heath, W. R. & Shortman, K., 29 Oct 2007, In : Journal of Experimental Medicine. 204, 11, p. 2579-2590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN

Caminschi, I., Corbett, A., Zahra, C., Lahoud, M., Lucas, K., Sofi, M., Vremec, D., Gramberg, T., Pohlmann, S., Curtis, J., Handman, E., van Dommelen, S. LH., Fleming, P., Degli-Esposti, M., Shortman, K. & Wright, M. D., 2006, In : International Immunology. 18, 5, p. 741 - 753 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE

Caminschi, I., Vandenabeele, S., Sofi, M., McKnight, A. J., Ward, N., Brodnicki, T. C., Toy, T., Lahoud, M., Maraskovsky, E., Shortman, K. & Wright, M. D., 2006, In : Dna Sequence. 17, 1, p. 8 - 14 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Signal regulatory protein molecules are differentially expressed, by CD8- dendritic cells

Lahoud, M. H., Proietto, A. I., Gartlan, K., Kitsoulis, S., Curtis, J., Wettenhall, J., Sofi, M., Daunt, C. P., O'Keeffe, M., Caminschi, I., Satterley, K., Rizzitelli, A., Schnorrer, P., Hinohara, A., Yamaguchi, Y., Wu, L., Smyth, G. K., Handman, E., Shortman, K. & Wright, M. D., 2006, In : Journal of Immunology. 177, 1, p. 372 - 382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger"

Corbett, A., Caminschi, I., McKenzie, B., Brady, J. L., Wright, M. D., Mottram, P. L., Hogarth, P. M., Hodder, A. N., Zhan, Y., Tarlinton, D. M., Shortman, K. & Lew, A. M., 2005, In : European Journal of Immunology. 35, 10, p. 2815 - 2825 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Mouse Plasmacytoid Cells: Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8+ Dendritic Cells Only after Microbial Stimulus

O'Keeffe, M., Hochrein, H., Vremec, D., Caminschi, I., Miller, J. L., Anders, M. L., Wu, L., Mahoud, M. H., Henri, S., Scott, B. M., Hertzog, P. J., Tatarczuch, L. & Shortman, K., 2002, In : Journal of Experimental Medicine. 196, 10, p. 1307 - 1319 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

c-Rel regulates interleukin 12 p70 expression in CD8+ dendritic cells by specifically inducing p35 gene transcription

Grumont, R., Hochrein, H., O'Keeffe, M., Gugasyan, R., White, C., Caminschi, I., Cook, W. & Gerondakis, S., 15 Oct 2001, In : Journal of Experimental Medicine. 194, 8, p. 1021-1031 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8α- splenic dendritic cells

Caminschi, I., Lucas, K. M., O’keeffe, M. A., Hochrein, H., Laâbi, Y., Brodnicki, T. C., Lew, A. M., Shortman, K. & Wright, M. D., 1 Jan 2001, In : Molecular Immunology. 38, 5, p. 365-373 9 p., 1027.

Research output: Contribution to journalArticleResearchpeer-review

Molecular cloning of F4/80-like-receptor, a seven-span membrane protein expressed differentially by dendritic cell and monocyte-macrophage subpopulations

Caminschi, I., Lucas, K. M., O'Keeffe, M. A., Hochrein, H., Laâbi, Y., Köntgen, F., Lew, A. M., Shortman, K. & Wright, M. D., 1 Oct 2001, In : Journal of Immunology. 167, 7, p. 3570-3576 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

CD30 prevents T cell responses to non-lymphoid tissues

Heath, W. R., Kurts, C., Caminschi, I., Carbone, F. R. & Miller, J. F., 1999, In : Immunological Reviews. p. 23 - 29 7 p.

Research output: Contribution to journalArticleResearchpeer-review