Projects per year
Personal profile
Biography
Our laboratory investigates the role of dendritic cells in immunity with the intent of applying this knowledge to the design of immunotherapies.
I have received my PhD from The University of Western Australia, investigating the role of IL-12 in evoking anti-tumour immunity. My interest in harnessing the immune system to combat disease has led to my post-doctoral studies on dendritic cells in the laboratory of Prof Shortman at The Walter and Eliza Hall Institute. I investigated the heterogeneous nature of dendritic cells and their role in orchestrating the adaptive immune response. My analysis of dendritic cell subsets by screening for differentially expressed genes has led to the discovery of many novel genes. These molecules have allowed the dissection of the unique immune functions of dendritic cell subpopulations and provided targets for immunotherapy. In 2012, I established my own laboratory, where I continued my research on dendritic cell biology with a view that understanding the molecules that govern the specialised functions of dendritic cells will open the way to novel immunotherapies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- adjuvants
- dendritic cells
- humoral immunity
- non-human primates
- vaccines
- antigen presentation/processing
- antigen-presenting cells
- vaccination
Network
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A bispecific antibody to synergise checkpoint blockers in oncology
Robert, R., Mackay, C., Caminschi, I. & Cowley, M.
1/01/21 → 31/12/23
Project: Research
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New strategies to improve personalized immunotherapy of breast cancer
Dolcetti, R., Caminschi, I., Mazzieri, R., Brown, M. A., Woodward, N. & Bennett, I.
National Breast Cancer Foundation
31/03/18 → 1/06/22
Project: Other
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The regulatory role of Clec12A in antigen presentation and inflammatory disease
Lahoud, M., Begun, J., Caminschi, I. & Shortman, K. D.
1/01/18 → 31/12/22
Project: Research
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Protecting against malaria through liver-resident memory T cells
Fernandez-Ruiz, D., Mackay, L. K., Mueller, S. N., Caminschi, I., Bertolino, P. & Bowen, D. G.
1/01/18 → 31/12/21
Project: Research
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The cryo-EM structure of the endocytic receptor DEC-205
Gully, B. S., Venugopal, H., Fulcher, A. J., Fu, Z., Li, J., Deuss, F. A., Llerena, C., Heath, W. R., Lahoud, M. H., Caminschi, I., Rossjohn, J. & Berry, R., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 12 p., 100127.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice
Valencia-Hernandez, A. M., Ng, W. Y., Ghazanfari, N., Ghilas, S., de Menezes, M. N., Holz, L. E., Huang, C., English, K., Naung, M., Tan, P. S., Tullett, K. M., Steiner, T. M., Enders, M. H., Beattie, L., Chua, Y. C., Jones, C. M., Cozijnsen, A., Mollard, V., Cai, Y., Bowen, D. G. & 15 others, , 10 Jun 2020, In: Cell Host & Microbe. 27, 6, p. 950-962 13 p.Research output: Contribution to journal › Article › Research › peer-review
22 Citations (Scopus) -
Display of native antigen on cDC1 that have spatial access to both T and B cells underlies efficient humoral vaccination
Kato, Y., Steiner, T. M., Park, H-Y., Hitchcock, R. O., Zaid, A., Hor, J. L., Devi, S., Davey, G. M., Vremec, D., Tullett, K. M., Tan, P. S., Ahmet, F., Mueller, S. N., Alonso, S., Tarlinton, D. M., Ploegh, H. L., Kaisho, T., Beattie, L., Manton, J. H., Fernandez-Ruiz, D. & 4 others, , 1 Oct 2020, In: Journal of Immunology. 205, 7, p. 1842-1856 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile10 Citations (Scopus) -
Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria
Holz, L. E., Chua, Y. C., de Menezes, M. N., Anderson, R. J., Draper, S. L., Compton, B. J., Chan, S. T. S., Mathew, J., Li, J., Kedzierski, L., Wang, Z., Beattie, L., Enders, M. H., Ghilas, S., May, R., Steiner, T. M., Lange, J., Fernandez-Ruiz, D., Valencia-Hernandez, A. M., Osmond, T. L. & 17 others, , 26 Jun 2020, In: Science Immunology. 5, 48, 13 p.Research output: Contribution to journal › Article › Research › peer-review
19 Citations (Scopus) -
Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141+dendritic cells to activate naïve and memory NY-ESO-1-specific CD8+T cells
Masterman, K-A., Haigh, O. L., Tullett, K. M., Leal-Rojas, I. M., Walpole, C., Pearson, F. E., Cebon, J., Schmidt, C., O'Brien, L., Rosendahl, N., Daraj, G., Caminschi, I., Gschweng, E. H., Hollis, R. P., Kohn, D. B., Lahoud, M. H. & Radford, K. J., 30 Jul 2020, In: Journal for ImmunoTherapy of Cancer. 8, 2, 11 p., e000691.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile13 Citations (Scopus)