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Personal profile

Biography

Our laboratory investigates the role of dendritic cells in immunity with the intent of applying this knowledge to the design of immunotherapies.

I have received my PhD from The University of Western Australia, investigating the role of IL-12 in evoking anti-tumour immunity. My interest in harnessing the immune system to combat disease has led to my post-doctoral studies on dendritic cells in the laboratory of Prof Shortman at The Walter and Eliza Hall Institute. I investigated the heterogeneous nature of dendritic cells and their role in orchestrating the adaptive immune response. My analysis of dendritic cell subsets by screening for differentially expressed genes has led to the discovery of many novel genes. These molecules have allowed the dissection of the unique immune functions of dendritic cell subpopulations and provided targets for immunotherapy. In 2012, I established my own laboratory, where I continued my research on dendritic cell biology with a view that understanding the molecules that govern the specialised functions of dendritic cells will open the way to novel immunotherapies.

 

Research area keywords

  • adjuvants
  • dendritic cells
  • humoral immunity
  • non-human primates
  • vaccines
  • antigen presentation/processing
  • antigen-presenting cells
  • vaccination

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Projects 2014 2022

New strategies to improve personalized immunotherapy of breast cancer

Dolcetti, R., Caminschi, I., Mazzieri, R., Brown, M. A., Woodward, N. & Bennett, I.

National Breast Cancer Foundation

31/03/1831/03/21

Project: Other

Protecting against malaria through liver-resident memory T cells

Fernandez-Ruiz, D., Mackay, L. K., Mueller, S. N., Caminschi, I., Bertolino, P. & Bowen, D. G.

1/01/1831/12/21

Project: Research

The regulatory role of Clec12A in antigen presentation and inflammatory disease

Lahoud, M., Begun, J., Caminschi, I. & Shortman, K. D.

1/01/1831/12/22

Project: Research

Research Output 1999 2019

3 Citations (Scopus)

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

Harpur, C. M., Kato, Y., Dewi, S. T., Stankovic, S., Johnson, D. N., Bedoui, S., Whitney, P. G., Lahoud, M. H., Caminschi, I., Heath, W. R., Brooks, A. G. & Gebhardt, T., 1 Feb 2019, In : Journal of Immunology. 202, 3, p. 653-663 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8+ T cell development

Caminschi, I., Lahoud, M. H., Pizzolla, A. & Wakim, L. M., 21 Jan 2019, In : Mucosal Immunology. 12, p. 403-412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Holz, L. E., Prier, J. E., Freestone, D., Steiner, T. M., English, K., Johnson, D. N., Mollard, V., Cozijnsen, A., Davey, G. M., Godfrey, D. I., Yui, K., Mackay, L. K., Lahoud, M. H., Caminschi, I., McFadden, G. I., Bertolino, P., Fernandez-Ruiz, D. & Heath, W. R., 2 Oct 2018, In : Cell Reports. 25, 1, p. 68-79 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

Zeng, B., Middelberg, A. P. J., Gemiarto, A., MacDonald, K. P. A., Baxter, A. G., Talekar, M., Moi, D., Tullett, K. M., Caminschi, I., Lahoud, M. H., Mazzieri, R., Dolcetti, R. & Thomas, R., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1971-1984 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes

Macri, C., Dumont, C., Panozza, S., Lahoud, M. H., Caminschi, I., Villadangos, J. A., Johnston, A. P. R. & Mintern, J. D., Jan 2017, In : Molecular Immunology. 81, p. 143-150 8 p.

Research output: Contribution to journalArticleResearchpeer-review