Projects per year
Personal profile
Biography
Our laboratory investigates the role of dendritic cells in immunity with the intent of applying this knowledge to the design of immunotherapies.
I have received my PhD from The University of Western Australia, investigating the role of IL-12 in evoking anti-tumour immunity. My interest in harnessing the immune system to combat disease has led to my post-doctoral studies on dendritic cells in the laboratory of Prof Shortman at The Walter and Eliza Hall Institute. I investigated the heterogeneous nature of dendritic cells and their role in orchestrating the adaptive immune response. My analysis of dendritic cell subsets by screening for differentially expressed genes has led to the discovery of many novel genes. These molecules have allowed the dissection of the unique immune functions of dendritic cell subpopulations and provided targets for immunotherapy. In 2012, I established my own laboratory, where I continued my research on dendritic cell biology with a view that understanding the molecules that govern the specialised functions of dendritic cells will open the way to novel immunotherapies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- adjuvants
- dendritic cells
- humoral immunity
- non-human primates
- vaccines
- antigen presentation/processing
- antigen-presenting cells
- vaccination
Network
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A bispecific antibody to synergise checkpoint blockers in oncology
Robert, R., Mackay, C., Caminschi, I. & Cowley, M.
1/01/21 → 31/12/23
Project: Research
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The regulatory role of Clec12A in antigen presentation and inflammatory disease
Lahoud, M., Begun, J., Caminschi, I. & Shortman, K. D.
1/01/18 → 31/12/23
Project: Research
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New strategies to improve personalized immunotherapy of breast cancer
Dolcetti, R., Caminschi, I., Mazzieri, R., Brown, M. A., Woodward, N. & Bennett, I.
National Breast Cancer Foundation
31/03/18 → 1/06/22
Project: Other
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Protecting against malaria through liver-resident memory T cells
Fernandez-Ruiz, D., Mackay, L. K., Mueller, S. N., Caminschi, I., Bertolino, P. & Bowen, D. G.
1/01/18 → 31/12/21
Project: Research
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Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells
Valencia-Hernandez, A. M., Zillinger, T., Ge, Z., Tan, P. S., Cozijnsen, A., I. McFadden, G., Lahoud, M. H., Caminschi, I., Barchet, W., Heath, W. R. & Fernandez-Ruiz, D., 27 Jan 2023, In: Vaccine. 41, 5, p. 1094-1107 14 p.Research output: Contribution to journal › Article › Research › peer-review
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Marginal zone B cells acquire dendritic cell functions by trogocytosis
Schriek, P., Ching, A. C., Moily, N. S., Moffat, J., Beattie, L., Steiner, T. M., Hosking, L. M., Thurman, J. M., Holers, V. M., Ishido, S., Lahoud, M. H., Caminschi, I., Heath, W. R., Mintern, J. D. & Villadangos, J. A., 11 Feb 2022, In: Science. 375, 6581, 12 p., eabf7470.Research output: Contribution to journal › Article › Research › peer-review
20 Citations (Scopus) -
Splenic Dendritic Cells and Macrophages Drive B Cells to Adopt a Plasmablast Cell Fate
McNamara, H. A., Lahoud, M. H., Cai, Y., Durrant-Whyte, J., O’Connor, J. H., Caminschi, I. & Cockburn, I. A., 12 Apr 2022, In: Frontiers in Immunology. 13, 15 p., 825207.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86
Liu, H., Wilson, K. R., Firth, A. M., Macri, C., Schriek, P., Blum, A. B., Villar, J., Wormald, S., Shambrook, M., Xu, B., Lim, H. J., McWilliam, H. E. G., Hill, A. F., Edgington-Mitchell, L. E., Caminschi, I., Lahoud, M. H., Segura, E., Herold, M. J., Villadangos, J. A. & Mintern, J. D., 11 Apr 2022, In: Nature Communications. 13, 1, 15 p., 1934.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Elucidating the motif for cpg oligonucleotide binding to the dendritic cell receptor dec-205 leads to improved adjuvants for liver-resident memory
Li, J., Panetta, F., O'Keeffe, M., Rojas, I. M. L., Radford, K. J., Zhang, J-G., Fernandez-Ruiz, D., Davey, G. M., Gully, B. S., Tullett, K. M., Rossjohn, J., Berry, R., Lee, C. N., Lahoud, M. H., Heath, W. R. & Caminschi, I., 1 Oct 2021, In: Journal of Immunology. 207, 7, p. 1836-1847 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)