20002011
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Personal profile

Biography

Inusha has over 15 years of experience in molecular and cellular biology with significant academic and industrial experience in pharmaceutical and diagnostic sectors.

 

Inusha graduated in Medical Biochemistry with honours from University of Leicester, UK and obtained her PhD in Oncology from University College London. Her doctoral research focused on study of DNA damage and repair. Following her PhD, Inusha spent several years working as a postdoctoral fellow at University College London and University of Cambridge studying mechanisms of oncogenesis. Then she worked for GlaxoSmithKline in UK as a Principle Scientist for six years working on antibody engineering, developing antibody based novel bio therapeutic agents. Following her move to Australia, she worked for Minifab and was responsible for development of highly sensitive microfluidic based point-of-care diagnostic assays.

 

After spending many years in pharmaceutical and diagnostic sectors, in 2017, Inusha moved back to academia and joined James Whisstock group at Monash university. She is currently working on a number of projects and her main focus is development of antibodies and novel antibody formats using phage display technology. These antibodies are used for structural studies, proof of concept studies in animal models and development of novel therapeutics for a number of diseases.

Education/Academic qualification

Oncology, PhD, University College London

1 Oct 19971 Jun 2001

Medical Biochemistry, BSc. Hons, University of Leicester

1 Oct 19921 Jun 1996

Research Output 2000 2011

39 Citations (Scopus)

Common and overlapping oncogenic pathways contribute to the evolution of acute myeloid leukemias

Kvinlaug, B. T., Chan, W. I., Bullinger, L., Ramaswami, M., Sears, C., Foster, D., Lazic, S. E., Okabe, R., Benner, A., Lee, B. H., De Silva, I., Valk, P. J. M., Delwel, R., Armstrong, S. A., Döhner, H., Gilliland, D. G. & Huntly, B. J. P., 15 Jun 2011, In : Cancer Research. 71, 12, p. 4117-4129 13 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Continuous MLL-ENL expression is necessary to establish a "Hox code" and maintain immortalization of hematopoietic progenitor cells

Horton, S. J., Grier, D. G., McGonigle, G. J., Thompson, A., Morrow, M., De Silva, I., Moulding, D. A., Kioussis, D., Lappin, T. R. J., Brady, H. J. M. & Williams, O., 15 Oct 2005, In : Cancer Research. 65, 20, p. 9245-9252 8 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136

Clingen, P. H., De Silva, I. U., McHugh, P. J., Ghadessy, F. J., Tilby, M. J., Thurston, D. E. & Hartley, J. A., 2 Sep 2005, In : Nucleic Acids Research. 33, 10, p. 3283-3291 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin

De Silva, I. U., McHugh, P. J., Clingen, P. H. & Hartley, J. A., 1 Sep 2002, In : Nucleic Acids Research. 30, 17, p. 3848-3856 9 p.

Research output: Contribution to journalArticleResearchpeer-review

356 Citations (Scopus)

Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells

De Silva, I. U., McHugh, P. J., Clingen, P. H. & Hartley, J. A., 1 Jan 2000, In : Molecular and Cellular Biology. 20, 21, p. 7980-7990 11 p.

Research output: Contribution to journalArticleResearchpeer-review