Personal profile
Biography
Postdoctoral Fellow, Interventional Immunology in Neonatal Diseases
Ritchie Centre
Hudson Institute of Medical Research
I trained for 3 years as a Medical-Technical Assistant at the School for Health in Meiningen, Germany, before studying biochemistry/molecular biology at the Friedrich-Schiller-University, Jena, Germany. After graduating in 2008, I applied for a PhD Fellowship at the Pharmazentrum Frankfurt (Centre for Pharmacology and Toxicology, head of department Prof. J. Pfeilschifter) at the Goethe University in Frankfurt am Main, Germany. In July 2008, I was awarded a competitive three year PhD Fellowship by the Deutsche Forschungsgemeinschaft (the German equivalent of the NHMRC). Under supervision of Prof. Heiko Mühl, I studied the expression regulation and function of interleukin-22 and completed my PhD in Theoretical Medicine in February 2012. In April 2012, I was recruited to the Nold Laboratory at the Ritchie Centre, Hudson Institute of Medical Research and Department of Paediatrics, Monash University. With extensive expertise in cytokine biology, I currently investigate the function and therapeutic potential of novel immune modulators of the interleukin (IL-)1 family, namely IL-1 receptor antagonist and the more recently discovered IL‑37 and IL‑38. With a strong interest in promoting the translation of basic science into applied interventional immunology, I also explore the role of these cytokines in clinically relevant models of diseases such as bronchopulmonary dysplasia (BPD), systemic lupus erythematosus (lupus, SLE) and viral infections. The ultimate goal of my research is to influence clinical practice through the development of improved treatments for severe inflammatory conditions.
Education/Academic qualification
Theoretical Medicine, PhD, Investigations of the molecular expression regulation and biological function of Interleukin-22
Award Date: 7 Feb 2012
Immunology, German Diploma (equiv. M.Sc.), Analysis of the Role of SOCS3 for the Regulation of Proliferation, Migration and Invasion of Trophoblasts
Award Date: 24 Jul 2008
Research area keywords
- Cytokines
- Immune System Disorders
- Immune system
- Immunology
- Inflammation
- Inflammatory diseases
- Premature babies
- autoimmune diseases/drug therapy/genetics/immunology
- interleukins
- bronchopulmonary dysplasia
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cho, S. X., Rudloff, I., Ellisdon, A. M., Nold-Petry, C. A. & Nold, M. F., Feb 2024, In: Cellular & Molecular Immunology. 21, 2, p. 201-202 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Understanding respiratory microbiome-immune system interactions in health and disease
Di Simone, S. K., Rudloff, I., Nold-Petry, C. A., Forster, S. C. & Nold, M. F., 11 Jan 2023, In: Science Translational Medicine. 15, 678, 15 p., eabq5126.Research output: Contribution to journal › Review Article › Research › peer-review
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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
Bujotzek, A., Tiefenthaler, G., Lariviere, L., D'Andrea, L., Marquez, E. A., Rudloff, I., Cho, S. X., Deen, N. S., Richter, W., Regenass-Lechner, F., Poehler, A., Whisstock, J. C., Sydow-Andersen, J., Reiser, X., Schuster, S., Neubauer, J., Hoepfl, S., Richter, K., Nold, M. F. & Nold-Petry, C. A. & 2 others, , 21 Apr 2022, In: Cell Chemical Biology. 29, 4, p. 586-596.e4 15 p.Research output: Contribution to journal › Article › Research › peer-review
18 Link opens in a new tab Citations (Scopus) -
Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants
Lao, J. C., Bui, C. B., Pang, M. A., Cho, S. X., Rudloff, I., Elgass, K., Schröder, J., Maksimenko, A., Mangan, N. E., Starkey, M. R., Skuza, E. M., Sun, Y. B. Y., Beker, F., Collins, C. L., Kamlin, O. F., König, K., Malhotra, A., Tan, K., Theda, C. & Young, M. J. & 10 others, , 6 Apr 2022, In: Science Translational Medicine. 14, 639, 17 p., eaaz8454.Research output: Contribution to journal › Article › Research › peer-review
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Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
Santarelli, D. M., Vincent, F. B., Rudloff, I., Nold, C. A., Nold, M. F. & Russo, M., 23 Jul 2021, In: Frontiers in Immunology. 12, 11 p., 708425.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile12 Link opens in a new tab Citations (Scopus)