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Personal profile

Biography

Postdoctoral Fellow, Interventional Immunology in Neonatal Diseases

Ritchie Centre

Hudson Institute of Medical Research

 

I trained for 3 years as a Medical-Technical Assistant at the School for Health and Social Affairs in Meiningen, Germany before studying biochemistry/molecular biology at the Friedrich-Schiller-University, Jena, Germany. After graduating in 2008, I applied for a PhD Fellowship at the Pharmazentrum Frankfurt (Centre for Pharmacology and Toxicology, head of department Prof. J. Pfeilschifter) at the Goethe University in Frankfurt am Main, Germany. In July 2008, I was awarded a competitive three year PhD Fellowship by the Deutsche Forschungsgemeinschaft (the German equivalent of the NHMRC). Under supervision of Prof. Heiko Mühl, I studied the expression regulation and function of interleukin-22 and completed my PhD in Theoretical Medicine in February 2012. Following my interests in cytokine biology and in the role of cytokines in inflammatory diseases especially of neonates, I joined the group of Dr. Marcel Nold and Dr. Claudia Nold at the Ritchie Centre in April 2012. Since then, I work on IL-37 and IL-38 and their potential in becoming new therapeutics for inflammatory diseases.

Research area keywords

  • Cytokines
  • Immune System Disorders
  • Immune system
  • Immunology
  • Inflammation
  • Inflammatory diseases
  • Premature babies
  • autoimmune diseases/drug therapy/genetics/immunology
  • calcimycin/pharmacology
  • calcium ionophores/ph

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Research Output 2010 2020

Molecular signature of interleukin-22 in colon carcinoma cells and organoid models

Rudloff, I., Jardé, T., Bachmann, M., Elgass, K. D., Kerr, G., Engel, R., Richards, E., Oliva, K., Wilkins, S., McMurrick, P. J., Abud, H. E., Mühl, H. & Nold, M. F., Feb 2020, In : Translational Research. 216, p. 1-22 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus

Jones, S. A., Cantsilieris, S., Fan, H., Cheng, Q., Russ, B. E., Tucker, E. J., Harris, J., Rudloff, I., Nold, M., Northcott, M., Dankers, W., Toh, A. E. J., White, S. J. & Morand, E. F., 1 Dec 2019, In : Scientific Reports. 9, 1, 9 p., 15433.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells

Rudloff, I., Cho, S. X., Lao, J. C., Ngo, D., McKenzie, M., Nold-Petry, C. A. & Nold, M. F., 1 Apr 2017, In : Journal of leukocyte biology. 101, 4, p. 901-911 11 p.

Research output: Contribution to journalArticleResearchpeer-review