Projects per year
Personal profile
Biography
Dr Ian Smyth is a Fellow at Monash University in Melbourne, Australia. His research interests centre on understanding the developmental mechanisms which shape the differentiation of epithelia in the mouse embryo. His group principally employs mouse genetics to identify novel factors which contribute to development of the skin and kidney, with a focus on animals models of human disease. Recent studies have also included the application of imaging and image analysis to provide insights into branching morphogenesis during organ development. He was awarded his PhD from the University of Queensland in 1999 and undertook postdoctoral training as a Wellcome Trust Traveling Research Fellow at the MRC Human Genetics Unit (Edinburgh) and Baylor College of Medicine (Houston). After a stint in London as an LRI Fellow at Cancer Research UK he returned to Australia in 2006 as an NHMRC RD Wright Fellow to establish his own laboratory in Melbourne.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Congenital Disease
- Skin and Kidney Development
Network
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Using functional genomics to diagnose ADPKD
Smyth, I., Quinlan, C. & Forbes, T.
1/08/21 → 31/07/22
Project: Research
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Dissecting the cystogenic pathway driving Polycystic Kidney Disease.
Cottle, D., Smyth, I., Combes, A., Nikolic-Paterson, D. & Rosenbluh, S.
1/03/21 → 28/02/23
Project: Research
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The cellular basis of branching morphogenesis during kidney development
Smyth, I., Combes, A., Fernandez-Gonzalez, R. & McNeill, H.
1/08/19 → 31/07/22
Project: Research
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Development of the metanephric kidney
Smyth, I. M., 2021, Current Topics in Developmental Biology. Affolter, M. (ed.). 1st ed. London UK: Elsevier, p. 111-150 40 p. (Current Topics in Developmental Biology; vol. 143).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Monkeying about with Nephron Formation
Smyth, I. M., 3 May 2021, In: Journal of the American Society of Nephrology : JASN. 32, 5, p. 1011-1013 3 p.Research output: Contribution to journal › Editorial › Other › peer-review
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ABCA12 regulates insulin secretion from β-cells
Ursino, G. M., Fu, Y., Cottle, D. L., Mukhamedova, N., Jones, L. K., Low, H., Tham, M. S., Gan, W. J., Mellett, N. A., Das, P. P., Weir, J. M., Ditiatkovski, M., Fynch, S., Thorn, P., Thomas, H. E., Meikle, P. J., Parkington, H. C., Smyth, I. M. & Sviridov, D., 4 Mar 2020, In: EMBO Reports. 21, 3, 19 p., e48692.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease
Conduit, S. E., Davies, E. M., Ooms, L. M., Gurung, R., Mcgrath, M. J., Hakim, S., Cottle, D. L., Smyth, I. M., Dyson, J. M. & Mitchell, C. A., 1 Jan 2020, In: Human Molecular Genetics. 29, 1, p. 31-48 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile9 Citations (Scopus) -
A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder
Jones, L. K., Lam, R., McKee, K. K., Aleksandrova, M., Dowling, J., Alexander, S. I., Mallawaarachchi, A., Cottle, D. L., Short, K. M., Pais, L., Miner, J. H., Mallett, A. J., Simons, C., McCarthy, H., Yurchenco, P. D. & Smyth, I. M., Nov 2020, In: Development. 147, 21, 13 p., dev189183.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Press / Media
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SBS World News coverage of 3D analysis of kidney development
Kieran Short & Ian Macleod Smyth
4/05/14
1 item of Media coverage
Press/Media: Research