• 19 Innovation Walk, Clayton Campus, Monash University

    3800 Melbourne


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Personal profile


Dr Ian Smyth is a Fellow at Monash University in Melbourne, Australia. His research interests centre on understanding the developmental mechanisms which shape the differentiation of epithelia in the mouse embryo. His group principally employs mouse genetics to identify novel factors which contribute to development of the skin and kidney, with a focus on animals models of human disease. Recent studies have also included the application of imaging and image analysis to provide insights into branching morphogenesis during organ development. He was awarded his PhD from the University of Queensland in 1999 and undertook postdoctoral training as a Wellcome Trust Traveling Research Fellow at the MRC Human Genetics Unit (Edinburgh) and Baylor College of Medicine (Houston). After a stint in London as an LRI Fellow at Cancer Research UK he returned to Australia in 2006 as an NHMRC RD Wright Fellow to establish his own laboratory in Melbourne.


  • Congenital Disease
  • Skin and Kidney Development

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Projects 2006 2021

Research Output 1996 2019

Cellular and molecular determinants of normal and abnormal kidney development

Tham, M. S. & Smyth, I. M., 1 Mar 2019, In : Wiley Interdisciplinary Reviews: Developmental Biology. 8, 2, 16 p., e338.

Research output: Contribution to journalArticleResearchpeer-review

Branching morphogenesis in the developing kidney 1 is not impacted by nephron formation or integration

Short, K. M., Combes, A. N., Lisnyak, V., Lefevre, J. G., Jones, L. K., Little, M. H., Hamilton, N. A. & Smyth, I. M., 31 Jul 2018, In : eLife. 7, 11 p., e38992.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number

Combes, A. N., Wilson, S., Phipson, B., Binnie, B. B., Ju, A., Lawlor, K. T., Cebrian, C., Walton, S. L., Smyth, I. M., Moritz, K. M., Kopan, R., Oshlack, A. & Little, M. H., Mar 2018, In : Kidney International. 93, 3, p. 589-598 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In : Cell death & disease. 9, 11, 12 p., 1072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Seminars in cell and developmental biology

Smyth, I. M. & Bertram, J. F., 23 Nov 2018, (Accepted/In press) In : Seminars in Cell and Developmental Biology. 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Press / Media

SBS World News coverage of 3D analysis of kidney development

Kieran Short & Ian Smyth


1 item of media coverage

Press/Media: Research