• 19 Innovation Walk, Clayton Campus, Monash University

    3800 Melbourne


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Personal profile


Dr Ian Smyth is a Fellow at Monash University in Melbourne, Australia. His research interests centre on understanding the developmental mechanisms which shape the differentiation of epithelia in the mouse embryo. His group principally employs mouse genetics to identify novel factors which contribute to development of the skin and kidney, with a focus on animals models of human disease. Recent studies have also included the application of imaging and image analysis to provide insights into branching morphogenesis during organ development. He was awarded his PhD from the University of Queensland in 1999 and undertook postdoctoral training as a Wellcome Trust Traveling Research Fellow at the MRC Human Genetics Unit (Edinburgh) and Baylor College of Medicine (Houston). After a stint in London as an LRI Fellow at Cancer Research UK he returned to Australia in 2006 as an NHMRC RD Wright Fellow to establish his own laboratory in Melbourne.


  • Congenital Disease
  • Skin and Kidney Development

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Projects 2006 2020

Research Output 1996 2018

Branching morphogenesis in the developing kidney 1 is not impacted by nephron formation or integration

Short, K. M., Combes, A. N., Lisnyak, V., Lefevre, J. G., Jones, L. K., Little, M. H., Hamilton, N. A. & Smyth, I. M., 31 Jul 2018, In : eLife. 7, 11 p., e38992.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number

Combes, A. N., Wilson, S., Phipson, B., Binnie, B. B., Ju, A., Lawlor, K. T., Cebrian, C., Walton, S. L., Smyth, I. M., Moritz, K. M., Kopan, R., Oshlack, A. & Little, M. H., Mar 2018, In : Kidney International. 93, 3, p. 589-598 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In : Cell death & disease. 9, 11, 12 p., 1072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities

Grabow, S., Kueh, A. J., Ke, F., Vanyai, H. K., Sheikh, B. N., Dengler, M. A., Chiang, W., Eccles, S., Smyth, I. M., Jones, L. K., De Sauvage, F. J., Scott, M., Whitehead, L., Voss, A. K. & Strasser, A., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3285-3295 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

BJD Research Letter: A profile of lipid dysregulation in Harlequin Ichthyosis

Ip, S. C. I., Cottle, D. L., Jones, L. K., Weir, J. M., Kelsell, D. P., O'Toole, E. A., Meikle, P. J. & Smyth, I. M., Nov 2017, In : British Journal of Dermatology. 177, 5, p. e217-e219 3 p.

Research output: Contribution to journalLetterResearchpeer-review

Press / Media