• 19 Innovation Walk, Clayton Campus, Monash University

    3800 Melbourne


Accepting PhD Students

1996 …2023
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Personal profile


Dr Ian Smyth is a Fellow at Monash University in Melbourne, Australia. His research interests centre on understanding the developmental mechanisms which shape the differentiation of epithelia in the mouse embryo. His group principally employs mouse genetics to identify novel factors which contribute to development of the skin and kidney, with a focus on animals models of human disease. Recent studies have also included the application of imaging and image analysis to provide insights into branching morphogenesis during organ development. He was awarded his PhD from the University of Queensland in 1999 and undertook postdoctoral training as a Wellcome Trust Traveling Research Fellow at the MRC Human Genetics Unit (Edinburgh) and Baylor College of Medicine (Houston). After a stint in London as an LRI Fellow at Cancer Research UK he returned to Australia in 2006 as an NHMRC RD Wright Fellow to establish his own laboratory in Melbourne.

Research area keywords

  • Congenital Disease
  • Skin and Kidney Development

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Projects 2006 2023

Research Output 1996 2019

AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease

Conduit, S. E., Davies, E. M., Ooms, L. M., Gurung, R., Mcgrath, M. J., Hakim, S., Cottle, D. L., Smyth, I. M., Dyson, J. M. & Mitchell, C. A., 18 Oct 2019, (Accepted/In press) In : Human Molecular Genetics.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors

Gorinski, N., Bijata, M., Prasad, S., Wirth, A., Abdel Galil, D., Zeug, A., Bazovkina, D., Kondaurova, E., Kulikova, E., Ilchibaeva, T., Zareba-Koziol, M., Papaleo, F., Scheggia, D., Kochlamazashvili, G., Dityatev, A., Smyth, I., Krzystyniak, A., Wlodarczyk, J., Richter, D. W., Strekalova, T. & 8 others, Sigrist, S., Bang, C., Hobuß, L., Fiedler, J., Thum, T., Naumenko, V. S., Pandey, G. & Ponimaskin, E., 2 Sep 2019, In : Nature Communications. 10, 1, 14 p., 3924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

CBE1 Is a Manchette- and Mitochondria-Associated Protein With a Potential Role in Somatic Cell Proliferation

Pleuger, C., Lehti, M. S., Cooper, M., O'Connor, A. E., Merriner, D. J., Smyth, I. M., Cottle, D. L., Fietz, D., Bergmann, M. & O'Bryan, M. K., 1 Nov 2019, In : Endocrinology. 160, 11, p. 2573-2586 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Cellular and molecular determinants of normal and abnormal kidney development

Tham, M. S. & Smyth, I. M., 1 Mar 2019, In : Wiley Interdisciplinary Reviews: Developmental Biology. 8, 2, 16 p., e338.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease

Rutledge, E. A., Parvez, R. K., Short, K. M., Smyth, I. M. & McMahon, A. P., 15 Oct 2019, In : Developmental Biology. 454, 2, p. 156-169 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Press / Media