Projects per year
Personal profile
Biography
Dr Ian Smyth is a Fellow at Monash University in Melbourne, Australia. His research interests centre on understanding the developmental mechanisms which shape the differentiation of epithelia in the mouse embryo. His group principally employs mouse genetics to identify novel factors which contribute to development of the skin and kidney, with a focus on animals models of human disease. Recent studies have also included the application of imaging and image analysis to provide insights into branching morphogenesis during organ development. He was awarded his PhD from the University of Queensland in 1999 and undertook postdoctoral training as a Wellcome Trust Traveling Research Fellow at the MRC Human Genetics Unit (Edinburgh) and Baylor College of Medicine (Houston). After a stint in London as an LRI Fellow at Cancer Research UK he returned to Australia in 2006 as an NHMRC RD Wright Fellow to establish his own laboratory in Melbourne.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Congenital Disease
- Skin and Kidney Development
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cilia biology: an emerging frontier.
Mitchell, C., Smyth, I. & Davies, M.
1/03/25 → 29/02/28
Project: Research
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The KidGen National Kidney Genomics Program – improving genomic outcomes for Australian families with genetic kidney disease
Mallett, A. J. (Primary Chief Investigator (PCI)), Alexander, S. (Chief Investigator (CI)), Little, M. (Chief Investigator (CI)), Simons, C. (Chief Investigator (CI)), Smyth, I. (Chief Investigator (CI)), Mallawaarachchi, A. (Chief Investigator (CI)), Quinlan, C. (Chief Investigator (CI)), Deveson, I. (Chief Investigator (CI)), Forbes, T. (Chief Investigator (CI)), Jayasinghe, K. (Chief Investigator (CI)), MacArthur, D. (Associate Investigator (AI)), Stark, Z. L. (Associate Investigator (AI)), Patel, C. V. (Associate Investigator (AI)), Braithwaite, J. (Associate Investigator (AI)), Bennetts, B. (Associate Investigator (AI)), McCarthy, H. J. (Associate Investigator (AI)), Sundaram, M. (Associate Investigator (AI)), Faull, R. J. (Associate Investigator (AI)), Jose, M. D. (Associate Investigator (AI)) & Chakera, A. (Associate Investigator (AI))
Department of Health and Aged Care (Australia)
1/06/21 → 31/05/25
Project: Research
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Dissecting the cystogenic pathway driving Polycystic Kidney Disease.
Cottle, D. (Primary Chief Investigator (PCI)), Smyth, I. (Chief Investigator (CI)), Combes, A. (Chief Investigator (CI)), Nikolic-Paterson, D. (Chief Investigator (CI)) & Rosenbluh, S. (Chief Investigator (CI))
1/03/21 → 28/02/26
Project: Research
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Pharmacokinetic assessment and optimisation of a new therapy for PKD
Smyth, I. (Primary Chief Investigator (PCI)), Cottle, D. (Chief Investigator (CI)), Powell, A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Baell, J. (Chief Investigator (CI)) & Zhao, Y. (Chief Investigator (CI))
Project: Research
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Inhibiting cyst formation in Polycystic Kidney Disease with Targeted Protein Degraders (TPDs)
Smyth, I. (Primary Chief Investigator (PCI)), Cottle, D. (Chief Investigator (CI)), Baell, J. (Chief Investigator (CI)) & Zhao, Y. (Chief Investigator (CI))
Project: Research
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Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice
Tham, M. S. (Leading Author), Cottle, D. L. (Leading Author), Zylberberg, A. K. (Leading Author), Short, K. M., Jones, L. K., Chan, P., Conduit, S. E., Dyson, J. M., Mitchell, C. A. & Smyth, I. M. (Leading Author), 2024, In: Nature Communications. 15, 1, 18 p., 371.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Modulating inflammation with interleukin 37 treatment ameliorates murine Autosomal Dominant Polycystic Kidney Disease
Zylberberg, A. K., Cottle, D. L. (Leading Author), Runting, J., Rodrigues, G., Tham, M. S., Jones, L. K., Cumming, H. E., Short, K. M., Zaph, C. & Smyth, I. M. (Leading Author), Apr 2024, In: Kidney International. 105, 4, p. 731-743 13 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
Patrick, R., Naval-Sanchez, M., Deshpande, N., Huang, Y., Zhang, J., Chen, X., Yang, Y., Tiwari, K., Esmaeili, M., Tran, M., Mohamed, A. R., Wang, B., Xia, D., Ma, J., Bayliss, J., Wong, K., Hun, M. L., Sun, X., Cao, B. & Cottle, D. L. & 28 others, , 6 Aug 2024, In: Cell Metabolism. 36, 8, p. 1858-1881 48 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Vascular cells improve functionality of human cardiac organoids
Voges, H. K., Foster, S., Reynolds, L. T., Parker, B. L., Devilee, L., Quaife-Ryan, G. A., Fortuna, P. R. J., Mathieson, E., Fitzsimmons, R., Lor, M., Batho, C., Reid, J., Pocock, M., Friedmand, C. E., Mizikovsky, D., Francois, M., Palpant, N. J., Needham, E. J., Peralta, M. & del Monte Nieto, G. & 16 others, , 30 May 2023, In: Cell Reports. 42, 5, 22 p., 112322.Research output: Contribution to journal › Article › Research › peer-review
Open Access47 Citations (Scopus) -
Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse
Jhala, G., Krishnamurthy, B., Brodnicki, T. C., Ge, T., Akazawa, S., Selck, C., Trivedi, P. M., Pappas, E. G., Mackin, L., Principe, N., Brémaud, E., De George, D. J., Boon, L., Smyth, I., Chee, J., Kay, T. W. H. & Thomas, H. E., 26 Apr 2022, In: Cell Reports. 39, 4, 21 p., 110747.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus)
Press/Media
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New Monash biotech company receives funding to halt the progression of Polycystic Kidney Disease
Denny Cottle, Ian Smyth, Paul Stupple & Yichao Zhao
30/05/23
1 item of Media coverage
Press/Media: Blogs, Podcasts and Social Media › Social Media Article
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SBS World News coverage of 3D analysis of kidney development
Kieran Short & Ian Macleod Smyth
4/05/14
1 item of Media coverage
Press/Media: Research