Projects per year
Personal profile
Biography
Dr Ian Smyth is a Fellow at Monash University in Melbourne, Australia. His research interests centre on understanding the developmental mechanisms which shape the differentiation of epithelia in the mouse embryo. His group principally employs mouse genetics to identify novel factors which contribute to development of the skin and kidney, with a focus on animals models of human disease. Recent studies have also included the application of imaging and image analysis to provide insights into branching morphogenesis during organ development. He was awarded his PhD from the University of Queensland in 1999 and undertook postdoctoral training as a Wellcome Trust Traveling Research Fellow at the MRC Human Genetics Unit (Edinburgh) and Baylor College of Medicine (Houston). After a stint in London as an LRI Fellow at Cancer Research UK he returned to Australia in 2006 as an NHMRC RD Wright Fellow to establish his own laboratory in Melbourne.
Keywords
- Congenital Disease
- Skin and Kidney Development
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Projects 2006 2020
Modulating inflammation as a therapy for Harlequin Ichthyosis
Smyth, I. M., Cottle, D. L., Nold, M. F. & Nold, C. A.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
NHMRC Research Fellowship
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/20
Project: Research
Applying functional genomics to kidney disease
Smyth, I. M., Little, M., Simons, C., Mallett, A. & Alexander, S. I.
1/01/16 → 31/12/19
Project: Other
Ultramicroscope II: 3D Fluorescence Light-Sheet Microscopy from Macro Structure to Cellular Resolution.
Smyth, I. M., Merson, T. D., Bertram, J. F., Cole, T. J., O'Bryan, M. K., Oldfield, B. J., Medcalf, R. L., Rosa, M. G., McGlinn, E., Mitchell, C. A., Daly, R. J., Karagiannis, T. C., Kaslin, V. J. M., Warr, C., Bowman, J. L. & Harper, I. S.
1/11/16 → 31/12/17
Project: Research
Morphological development of the kidney - a paradigm for organogenesis.
Smyth, I. M., Hamilton, N. & Henkelman, M.
Australian Research Council (ARC), Monash University, The University of Queensland , University of Toronto
4/03/16 → 31/12/18
Project: Research
Research Output 1996 2018
Branching morphogenesis in the developing kidney 1 is not impacted by nephron formation or integration
Short, K. M., Combes, A. N., Lisnyak, V., Lefevre, J. G., Jones, L. K., Little, M. H., Hamilton, N. A. & Smyth, I. M., 31 Jul 2018, In : eLife. 7, 11 p., e38992.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number
Combes, A. N., Wilson, S., Phipson, B., Binnie, B. B., Ju, A., Lawlor, K. T., Cebrian, C., Walton, S. L., Smyth, I. M., Moritz, K. M., Kopan, R., Oshlack, A. & Little, M. H., Mar 2018, In : Kidney International. 93, 3, p. 589-598 10 p.Research output: Contribution to journal › Article › Research › peer-review
Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In : Cell death & disease. 9, 11, 12 p., 1072.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities
Grabow, S., Kueh, A. J., Ke, F., Vanyai, H. K., Sheikh, B. N., Dengler, M. A., Chiang, W., Eccles, S., Smyth, I. M., Jones, L. K., De Sauvage, F. J., Scott, M., Whitehead, L., Voss, A. K. & Strasser, A., 18 Sep 2018, In : Cell Reports. 24, 12, p. 3285-3295 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
BJD Research Letter: A profile of lipid dysregulation in Harlequin Ichthyosis
Ip, S. C. I., Cottle, D. L., Jones, L. K., Weir, J. M., Kelsell, D. P., O'Toole, E. A., Meikle, P. J. & Smyth, I. M., Nov 2017, In : British Journal of Dermatology. 177, 5, p. e217-e219 3 p.Research output: Contribution to journal › Letter › Research › peer-review
Press / Media
SBS World News coverage of 3D analysis of kidney development
Kieran Matthew Short & Ian Macleod Smyth
4/05/14
1 item of media coverage
Press/Media: Research