Ian Smith

Professor

1985 …2020
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Research Output 1985 2019

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2001

A Novel Viper Venom Metalloproteinase, Alborhagin, Is an Agonist at the Platelet Collagen Receptor GPVI

Andrews, R. K., Gardiner, E. E., Asazuma, N., Berlanga, O., Tulasne, D., Nieswandtll, B., Smith, A. I., Berndt, M. C. & Watson, S. P., 27 Jul 2001, In : Journal of Biological Chemistry. 276, 30, p. 28092-28097 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Immuno-unreactive albumin excretion increases in streptozotocin diabetic rats

Greive, K. A., Eppel, G. A., Reeve, S., Smith, A. I., Jerums, G. & Comper, W. D., 1 Jan 2001, In : American Journal of Kidney Diseases. 38, 1, p. 144-152 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Immuno-unreactive albumin excretion increases in streptozotocin diabteic rats

Greive, K. A., Eppel, G., Reeve, S. B., Smith, A. I., Jerums, G. & Comper, W. D., 2001, In : American Journal of Kidney Diseases. 38, 1, p. 144 - 152 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

Sun, J. H., Whisstock, J. C., Harriott, P., Walker, B., Novak, A. J., Thompson, P. E., Smith, A. I. & Bird, P. I., 2001, In : Journal of Biological Chemistry. 276, 18, p. 15177 - 15184 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Substrate analogs incorporating beta-amino acids: potential application for peptidase inhibition.

Lew, R. A., Boulos, E., Stewart, K. M., Perlmutter, P., Harte, M. F., Bond, S., Reeve, S. B., Norman, M. U., Lew, M. J., Aguilar, M. I. & Smith, A. I., 1 Jul 2001, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15, 9, p. 1664-1666 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Substrate analogs incorporting -amino acids: potential application for peptidase inhibition

Lew, R. A., Boulos, E., Stewart, K. M., Perlmutter, P., Harte, M. F., Bond, S., Reeve, S. B., Norman, M. U., Lew, M. J., Aguilar, M-I. & Smith, A. I., 2001, In : FASEB Journal. 15, 9, p. 1664 - 1666 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Synapsin I identified as a novel brain-specific autoantigen

Gitlits, V. M., Sentry, J. W., Matthew, M. L., Smith, A. I. & Toh, B. H., 2001, In : Journal of Investigative Medicine. 49, 3, p. 276 - 283 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The viper venom metalloproteinase-disintegrin, Alborhagin, is an agonist at the platelet collagen receptor GPVI

Andrews, R. K., Gardiner, E. E., Asazuma, N., Berlanga, O., Nieswandt, B., Smith, A. I., Watson, S. P., Tulasne, D. & Berndt, M. C., 2001, In : Journal of Molecular Biology. 276, p. 28092* - 28097 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

A novel stable inhibitor on endopeptidases EC 3.4.24.15 and 3.4.24.16 potentiates bradykinin-induced hypotension

Smith, A. I., Lew, R. A., Shrimpton, C. N., Evans, R. G. & Abbenante, G., 2000, In : Hypertension. p. 626 - 630 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Bradykinin Analogues with beta-Amino Acid Substitutions Reveal Subtle Differences in Substrate Specificity Between the Endopeptidases Ec 3.4.24.15 and EC 3.4.24.16

Lew, R., Boulos, E., Stewart, K. M., Perlmutter, P. P., Harte, M. F., Bond, S., Aguilar, M-I. & Smith, A. I., 2000, In : Journal of Peptide Science. p. 440 - 445 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Bradykinin analogues with β-amino acid substitutions reveal subtle differences in substrate specificity between the endopeptidases EC 3.4.24. 15 and EC 3.4.24.16

Lew, R. A., Boulos, E., Stewart, K. M., Perlmutter, P., Harte, M. F., Bond, S., Aguilar, M. I. & Ian Smith, A., 5 Oct 2000, In : Journal of Peptide Science. 6, 9, p. 440-445 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and Synthesis of Inhibitors Incorporating beta-Amino Acids of Metalloendopeptidase EC 3.4.24.15

Steer, D., Lew, R., Perlmutter, P. P., Smith, A. I. & Aguilar, M., 2000, In : Journal of Peptide Science. p. 470 - 477 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and synthesis of inhibitors incorporating β-amino acids of metalloendopeptidase EC 3.4.24.15

Steer, D. L., Lew, R. A., Perlmutter, P., Smith, A. I. & Aguilar, M. I., 7 Oct 2000, In : Journal of Peptide Science. 6, 9, p. 470-477 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Development and characterization of novel potent and stable inhibitors of endopeptidase EC 3.4.24.15

Shrimpton, C. N., Abbenante, G., Lew, R. & Smith, A. I., 2000, In : Biochemical Journal. 345, Pt 2, p. 351 - 356 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Human thyroid peroxidase: Mapping of autoantibodies, conformational epitopes to the enzyme surface

Gardas, A., Watson, P. F., Hobby, P., Smith, A., Weetman, A. P., Sutton, B. J. & Banga, J. P., 1 Jan 2000, In : Redox Report. 5, 4, p. 237-241 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuropeptidases regulating gonadal function

Smith, A. I., Shrimpton, C. N., Norman, U. M., Clarke, I. J., Wolfson, A. J. & Lew, R. A., 2000, In : Biochemical Society Transactions. 28, 4, p. 430-434 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric oxide mediated modulation of norepinephrine transport: Identification of a potential target for S-nitrosylation

Kaye, D. M., Gruskin, S., Smith, A. I. & Esler, M. D., 1 Jan 2000, In : British Journal of Pharmacology. 130, 5, p. 1060-1064 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation

Tullai, J. W., Cummins, P. M., Pabon, A., Roberts, J. L., Lopingco, M. C., Shrimpton, C. N., Smith, A. I., Martignetti, J. A., Ferro, E. S. & Glucksman, M. J., 24 Nov 2000, In : Journal of Biological Chemistry. 275, 47, p. 36514-36522 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1999

Conformational analysis of an EP24.15 inhibitor by NMR and molecular modelling

Anderson, R. J., Clark, B. P., Hewage, C. M., Ian Smith, A. & Mackay, S. P., 1 Jan 1999, In : Letters in Peptide Science. 6, 5-6, p. 395-402 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Conformational analysis of endopeptidase 24.15 inhibitors - Generation of possible active site conformers

Anderson, R. J., Clark, B. P., Hewage, C. M., Mackay, S. P. & Smith, A. I., 1 Dec 1999, In : Journal of Pharmacy and Pharmacology. 51, SUPPL., 1 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of calcium in the release of EC 3.4.24.15 and EC 3.4.24.16 from endothelial cells

Ursula Norman, M., Ian Smith, A. & Lew, R. A., 1 Jan 1999, In : Letters in Peptide Science. 6, 5-6, p. 349-352 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Endothelin interactions with brain dopamine systems

Webber, K. M., Wallace, C. A., Ian Smith, A. & Van Den Buuse, M., 1 Jan 1998, In : Journal of Cardiovascular Pharmacology. 31, SUPPL. 1

Research output: Contribution to journalArticleResearchpeer-review

Haemorphin peptides may be endogenous ligands for brain angiotensin AT4 receptors

Moeller, I., Siew Yeen Chai, Y. C., Smith, I., Lew, R. & Mendelsohn, F. A. O., 12 Nov 1998, In : Clinical and Experimental Pharmacology and Physiology. 25

Research output: Contribution to journalArticleResearchpeer-review

Purification, characterisation and distribution of ovine neuronal nitric oxide synthase

Crack, P. J., Tetaz, T. & Smith, A. I., 1 Dec 1998, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 120, 4, p. 727-733 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments

Mok, S. S., Evin, G., Li, Q. X., Smith, A. I., Beyreuther, K., Masters, C. L. & Small, D. H., 7 Jan 1997, In : Biochemistry. 36, 1, p. 156-163 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Autoantibodies to evolutionarily conserved epitopes of enolase in a patient with discoid lupus erythematosus

Gitlits, V. M., Sentry, J. W., Matthew, M. L., Smith, A. I. & Toh, B-H. H., 1997, In : Immunology. p. 362 - 368 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Endopeptidase EC 3.4.24.15 presence in the rat median eminence and hypophysial portal blood and its modulation of the luteinizing hormone surge

Wu, T. J., Pierotti, A. R., Jakubowski, M., Sheward, W. J., Glucksman, M. J., Smith, A. I., King, J. C., Fink, G. & Roberts, J. L., 1 Nov 1997, In : Journal of Neuroendocrinology. 9, 11, p. 813-822 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptidases that degrade gonadotropin-releasing hormone: Influence on LH secretion in the ewe

Lew, R. A., Cowley, M., Clarke, I. J. & Smith, A. I., 1 Sep 1997, In : Journal of Neuroendocrinology. 9, 9, p. 707-712 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Post-secretory processing of peptide signals: A novel mechanism for the regulation of peptide hormone receptors

Smith, A. I., Clarke, I. J. & Lew, R. A., 1 Jan 1997, In : Biochemical Society Transactions. 25, 3, p. 1011-1014 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The characterization, localization and regulation of endothelin in ovine pars intermedia

Mansour, V. M., Clarke, I. J. & Smith, A. I., 14 May 1997, In : Regulatory Peptides. 70, 1, p. 55-65 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain

Moeller, I., Lew, R. A., Mendelsohn, F. A. O., Smith, A. I., Brennan, M. E., Tetaz, T. J. & Chai, S. Y., 1 Jun 1997, In : Journal of Neurochemistry. 68, 6, p. 2530-2537 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The involvement of nitric oxide in the secretion of β-endorphin from the pituitary intermediate lobe of the rat

Crack, P. J., Autelitano, D. J. & Smith, A. I., 27 Jun 1997, In : Brain Research. 761, 1, p. 113-120 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Thiol activation and stabilization of endopeptidase EC 3.4.24.15 in the central nervous system

Shrimpton, C. N., Smith, A. I. & Wolfson, A. J., 1 Dec 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticleResearchpeer-review

Thiol activation of endopeptidase EC 3.4.24.15: A novel mechanism for the regulation of catalytic activity

Shrimpton, C. N., Glucksman, M. J., Lew, R. A., Tullai, J. W., Margulies, E. H., Roberts, J. L. & Smith, A. I., 5 Aug 1997, In : Journal of Biological Chemistry. 272, 28, p. 17395-17399 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1996

Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation

Andrews, R. K., Kroll, M. H., Ward, C. M., Rose, J. W., Scarborough, R. M., Smith, A. I., López, J. A. & Berndt, M. C., 2 Oct 1996, In : Biochemistry. 35, 38, p. 12629-12639 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of methods for purification of membrane associated gonadotropin-releasing hormone binding proteins

Flanagan, C. A., Tetaz, T., Smith, A. I. & Millar, R. P., 1 Mar 1996, In : Biomedical Chromatography. 10, 2, p. 83-88 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential activation of endopeptidase EC 3.4.24.15 toward natural and synthetic substrates by metal ions

Wolfson, A. J., Shrimpton, C. N., Lew, R. A. & Smith, A. I., 4 Dec 1996, In : Biochemical and Biophysical Research Communications. 229, 1, p. 341-348 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of jumper ant (Myrmecia pilosula) venom allergens: Post-translational processing of allergen gene products

Donovan, G. R., Street, M. D., Tetaz, T., Smith, A. I., Alewood, D., Alewood, P., Sutherland, S. K. & Baldo, B. A., 14 Sep 1996, In : Biochemistry and Molecular Biology International. 39, 5, p. 877-885 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Factor H co-purifies with thrombospondin isolated from platelet secretate

Carron, J. A., Bates, R. C., Smith, A. I., Tetoz, T., Arellano, A., Gordon, D. L. & Burns, G. F., 17 Apr 1996, In : Biochimica et Biophysica Acta - General Subjects. 1289, 3, p. 305-311 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of bradykinin receptors in the renal effects of inhibition of angiotensin converting enzyme and endopeptidases 24.11 and 24.15 in conscious rabbits

Tomoda, F., Lew, R. A., Smith, A. I., Madden, A. C. & Evans, R. G., 1996, In : British Journal of Pharmacology. 119, 2, p. 365-373 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic inhibitors of endopeptidase EC 3.4.24.15: Potency and stability in vitro and in vivo

Lew, R. A., Tomoda, F., Evans, R. G., Lakat, L., Boublik, J. H., Pipolo, L. A. & Smith, A. I., 1996, In : British Journal of Pharmacology. 118, 5, p. 1269-1277 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1995

Characterisation of neurons with nitric oxide synthase immunoreactivity that project to prevertebral ganglia

Anderson, C. R., Furness, J. B., Woodman, H. L., Edwards, S. L., Crack, P. J. & Smith, A. I., 8 Apr 1995, In : Journal of the Autonomic Nervous System. 52, 2-3, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Combination of High-Performance Liquid Chromatography and Radioimmunoassay for Characterization of Peptide-Processing Pathways

Smith, A. I. & Lew, R. A., 1 Jan 1995, In : Methods in Neurosciences. 23, C, p. 125-139 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of ovarian steroids on hypothalamic opioid receptor subtypes in ovariectomized ewes: Regional changes in density and affinity

Shen, P. J., Smith, A. I., Evans, R. G. & Clarke, I. J., 1995, In : Journal of Endocrinology. 145, 3, p. 559-567 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Intracellular Production of βA4 Amyloid of Alzheimer's Disease: Modulation by Phosphoramidon and Lack of Coupling to the Secretion of the Amyloid Precursor Protein

Fuller, S. J., Storey, E., Qiao-Xin, L., Smith, A. I., Beyreuther, K. & Masters, C. L., 1 Jan 1995, In : Biochemistry. 34, 25, p. 8091-8098 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Measurement, distribution, and subcellular localization of peptide-amidating activity

Lew, R. A. & Smith, A. I., 1 Jan 1995, In : Methods in Neurosciences. 23, C, p. 219-236 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of angiotensin converting enzyme in the vascular effects of an endopeptidase 24.15 inhibitor

Telford, S. E., Smith, A. I., Lew, R. A., Perich, R. B., Madden, A. C. & Evans, R. G., 1995, In : British Journal of Pharmacology. 114, 6, p. 1185-1192 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Substrate specificity differences between recombinant rat testes endopeptidase EC 3.4.24.15 and the native brain enzyme

Lew, R. A., Hey, N. J., Tetaz, T. J., Glucksman, M. J., Roberts, J. L. & Ian Smith, A., 26 Apr 1995, In : Biochemical and Biophysical Research Communications. 209, 3, p. 788-795 8 p.

Research output: Contribution to journalArticleResearchpeer-review