Ian Smith

Professor

1985 …2020
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Research Output 1985 2019

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2008

Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression

Burchill, L., Velkoska, E., Dean, R. G., Lew, R. A., Smith, A. I., Levidiotis, V. & Burrell, L. M., 2008, In : Experimental Physiology. 93, 5, p. 622 - 630 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues

Jokubaitis, V. J., Sinka, L., Driessen, R., Whitty, G., Haylock, D. N., Bertoncello, I., Smith, A. I., Peault, B., Tavian, M. & Simmons, P. J., 2008, In : Blood. 111, 8, p. 4055 - 4063 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor

Lew, R. A., Warner, F. J., Hanchapola, I., Yarski, M. A., Manohar, J., Burrell, L. M. & Smith, A. I., 2008, In : Experimental Physiology. 93, 5, p. 685 - 693 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids

Foulds, L. M., Boysen, R. I., Crane, M., Yang, Y., Muir, J. A., Smith, A. I., de Kretser, D. M., Hearn, M. T. W. & Hedger, M. P., 2008, In : Biology of Reproduction. 79, 3, p. 525 - 536 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurotoxins from Australo-Papuan elapids: A biochemical and pharmacological perspective

Kuruppu, D. M. S., Smith, A. I., Isbister, G. K. & Hodgson, W. C., 2008, In : Critical Reviews in Toxicology. 38, 1, p. 73 - 86 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Quenched fluorescent peptide substrates tools for the discovery of novel biomarkers

Lai, Z. W., Hanchapola, I. & Smith, A. I., 2008, In : Chimica Oggi. 26, 2, p. 18 - 21 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Using differential solubilization and 2-D gel electrophoresis to visualize increased numbers of proteins in the human cortex and caudate nucleus and putamen

Dean, B., Pavey, G. & Smith, A. I., 2008, In : Proteomics - Clinical Applications. 2, 9, p. 1281 - 1289 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

?-Amino acid-containing hybrid peptides - New opportunities in peptidomimetics

Aguilar, M. I., Purcell, A. W., Devi, R., Lew, R. A., Rossjohn, J., Smith, A. I. & Perlmutter, P., 2007, In : Organic and Biomolecular Chemistry. 5, 18, p. 2884 - 2890 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 others, Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterisation of endothelin converting enzyme-1 shedding from endothelial cells

Kuruppu, D. M. S., Reeve, S. B. & Smith, A. I., 2007, In : FEBS Letters. 581, 23, p. 4501 - 4506 6 p.

Research output: Contribution to journalArticleResearchpeer-review

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

Fenalti, G., Law, R. H. P., Buckle, A. M., Langendorf, C., Tuck, K. L., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P., Wilce, M. C. J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I. R., Rowley, M. J. & Whisstock, J., 2007, In : Nature Structural and Molecular Biology. 14, 4, p. 280 - 286 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a Campylobacter jejuni protein that cross-reacts with cholera toxin

Albert, M. J., Haridas, S., Steer, D. L., Dhaunsi, G. S., Smith, A. I. & Adler, B., 2007, In : Infection and Immunity. 75, 6, p. 3070 - 3073 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The N terminus of the serpin, tengpin, functions to trap the metastable native state

Zhang, Q., Buckle, A. M., Law, R. H. P., Pearce, M. C., Cabrita, L., Lloyd, G., Irving, J. A., Smith, A. I., Ruzyla, K., Rossjohn, J., Bottomley, S. P. & Whisstock, J., 2007, In : EMBO Reports. 8, 7, p. 658 - 663 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis

Herath, C. B., Warner, F. J., Lubel, J. S., Dean, R. G., Jia, Z., Lew, R. A., Smith, A. I., Burrell, L. M. & Angus, P. W., 2007, In : Journal of Hepatology. 47, 3, p. 387 - 395 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Characterization of angiotensin converting enzyme-2 (ACE2) in human urine

Lew, R. A., Warner, F. J., Hanchapola, I. & Smith, A. I., 2006, In : International Journal of Peptide Research and Therapeutics. 12, 3, p. 283 - 289 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Developmental expression of ACE2 in the SHR kidney: A role in hypertension?

Tikellis, C., Cooper, M. E., Bialkowski, K., Johnston, C. I., Burns, W. C., Lew, R. A., Smith, A. I. & Thomas, M. C., 12 Jul 2006, In : Kidney International. 70, 1, p. 34-41 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and pharmacological characterisation of hostoxin-1, a postsynaptic neurotoxin from the venom of the Stephen's banded snake (Hoplocephalus stephensi)

Tan, L. C., Kuruppu, D. M. S., Smith, A. I., Reeve, S. B. & Hodgson, W. C., 2006, In : Neuropharmacology. 51, 4, p. 782 - 788 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxylepitoxin-1, a reversible neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus)

Clarke, C., Kuruppu, D. M. S., Reeve, S. B., Smith, A. I. & Hodgson, W. C., 2006, In : Peptides. 27, 11, p. 2655 - 2660 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1

Smith, A. I., Lew, R. A., Thomas, W. G. & Tochon-Danguy, N., 2006, In : International Journal of Peptide Research and Therapeutics. 12, 3, p. 291 - 295 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin

Wilson, K. M., Smith, A. I. & Phillips, D. J., 2006, In : Molecular and Cellular Endocrinology. 253, 1-2, p. 30 - 35 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities

Autelitano, D. J., Rajic, A., Smith, A. I., Berndt, M. C., Ilag, L. L. & Vadas, M., 2006, In : Drug Discovery Today. 11, 7/8, p. 306 - 314 9 p.

Research output: Contribution to journalArticleResearchpeer-review

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

McGowan, S., Buckle, A. M., Irving, J. A., Ong, P. C., Bashtannyk-Puhalovich, T. A., Kan, W-T., Henderson, K., Bulynko, Y. A., Popova, E. Y., Smith, A. I., Bottomley, S. P., Rossjohn, J., Grigoryev, S. A., Pike, R. N. & Whisstock, J. C., 2006, In : EMBO Journal. 25, 13, p. 3144 - 3155 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells

Warner, F. J., Lew, R. A., Smith, A. I., Lambert, D. W., Hooper, N. M. & Turner, A. J., 2005, In : Journal of Biological Chemistry. 280, 47, p. 39353 - 39362 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2

Paizis, G., Tikellis, C., Cooper, M. E., Schembri, J. M., Lew, R. A., Smith, A. I., Shaw, T., Warner, F. J., Zuilli, A., Burrell, L. M. & Angus, P. W., 2005, In : Gut. 54, 12, p. 1790 - 1796 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin

Buzza, M. S., Zamurs, L., Sun, J., Bird, C. H., Smith, A. I., Trapani, J. A., Froelich, C. J., Nice, E. C. & Bird, P. I., 2005, In : Journal of Biological Chemistry. 280, 25, p. 23549 - 23558 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and characterisation of acanmyotoxin-2 and acanmyotoxin-3, myotoxins from the venom of the death adder Acanthophis sp. Seram

Hart, A. J., Smith, A. I., Reeve, S. B. & Hodgson, W. C., 2005, In : Biochemical Pharmacology. 70, 12, p. 1807 - 1813 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and pharmacological characterization of cannitoxin, a presynaptic neurotoxin from the venom of the Papuan Taipan (Oxyuranus scutellatus canni)

Kuruppu, D. M. S., Reeve, S. B., Banerjee, Y., Kini, R. M., Smith, A. I. & Hodgson, W. C., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 3, p. 1196 - 1202 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Myocardial infarction increases ACE2 expression in rat and humans

Burrell, L. M., Risvanis, J., Kubota, E., Dean, R. G., Macdonald, P. S., Lu, S., Tikellis, C., Grant, S. L., Lew, R. A., Smith, A. I., Cooper, M. E. & Johnston, C. I., 2005, In : European Heart Journal. 26, 4, p. 369 - 375 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer

Ahmed, N., Oliva, K. T., Barker, G., Hoffmann, P., Reeve, S. B., Smith, A. I., Quinn, M. A. & Rice, G. E., 2005, In : Proteomics. 5, 17, p. 4625 - 4636 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

Fulton, K. F., Buckle, A. M., Cabrita, L. D., Irving, J. A., Butcher, R. E., Smith, A. I., Reeve, S. B., Lesk, A. M., Bottomley, S. P., Rossjohn, J. & Whisstock, J. C., 2005, In : Journal of Biological Chemistry. 280, 9, p. 8435 - 8442 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide

Blanchfield, J. T., Lew, R. A., Smith, A. I. & Toth, I., 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 6, p. 1609 - 1612 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)

Lambert, D. W., Yarski, M. A., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M. & Turner, A. J., 2005, In : Journal of Biological Chemistry. 280, 34, p. 30113 - 30119 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Identification of angiotensin converting enzyme 2 in the rodent retina

Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Thomas, M. C., Lew, R. A., Yarski, M. A., Smith, A. I. & Cooper, M. E., 2004, In : Current Eye Research. 29, 6, p. 419 - 427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a Novel Apolipoprotein, ApoN, in Ovarian Follicular Fluid

O'Bryan, M. K., Foulds, L. M., Cannon, J. F., Winnall, W. R., Muir, J. A., Sebire, K. L., Smith, A. I., Keah, H-H. H., Hearn, M. T. W., de Kretser, D. M. & Hedger, M. P., 2004, In : Endocrinology. 145, 11, p. 5231 - 5242 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer

Ahmed, N., Barker, G., Oliva, K. T., Hoffmann, P., Riley, C., Reeve, S. B., Smith, A. I., Kemp, B. E., Quinn, M. A. & Rice, G. E., 2004, In : British Journal of Cancer. 91, 1, p. 129 - 140 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The Novel Angiotensin-Converting Enzyme (ACE) Homolog, ACE2, Is Selectively Expressed by Adult Leydig Cells of the Testis

Douglas, G. C., O'Bryan, M. K., Hedger, M. P., Lee, D. K. L., Yarski, M. A., Smith, A. I. & Lew, R., 2004, In : Endocrinology. 145, 10, p. 4703 - 4711 9 p.

Research output: Contribution to journalArticleResearchpeer-review

What's new in the renin-angiotensin system?

Smith, A. I. & Turner, A. J., 2004, In : Cellular and Molecular Life Sciences. 61, 21, p. 2675 - 2676 2 p.

Research output: Contribution to journalArticleOther

2003

Albumin fragments in normal rat urine are derived from rapidly degraded filtered albumin

Clavant, S. P., Greive, K. A., Nikolovski, J., Reeve, S. B., Smith, A. I. & Comper, W. D., 2003, In : Nephrology. 8, 2, p. 72 - 79 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endopeptidases 3.4.24.15 and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism

Norman, M. U., Reeve, S. B., Dive, V., Smith, A. I. & Lew, R. A., 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 6, p. 1978 - 1984 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

Welss, T., Sun, J., Irving, J. A., Blum, R., Smith, A. I., Whisstock, J. C., Pike, R. N., Von Mikecz, A., Ruzicka, T., Bird, P. I. & Abts, H. F., 2003, In : Biochemistry. 42, 24, p. 7381 - 7389 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature

Norman, M. U., Lew, R., Smith, A. I. & Hickey, M. J., 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 6, p. 1942 - 1948 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteases and proteolytic processing in the nervous system: key targets for drug development

Small, D. H. & Smith, A. I., 2003, In : Journal of Neuroscience Research. 74, 3, p. 339 - 341 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulators of the neuropeptide-degrading enzyme, EC 3.4.24.15 (thimet oligopeptidase), in cerebrospinal fluid

Shrimpton, C. N., Wolfson, A. J., Smith, A. I. & Lew, R. A., 2003, In : Journal of Neuroscience Research. 74, 3, p. 474 - 478 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Amino Acids: Versatile Peptidomimetics

Steer, D., Lew, R., Perlmutter, P., Smith, A. I. & Aguilar, M. I., 2002, In : Current Medicinal Chemistry. 9, 8, p. 811 - 822 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of the 49-kDa autoantigen associated with lymphocytic hypophysitis as α-enolase

O'Dwyer, D. T., Ian Smith, A., Matthew, M. L., Andronicos, N. M., Ranson, M., Robinson, P. J. & Crock, P. A., 28 Feb 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 2, p. 752-757 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of -amino acids

Steer, D., Lew, R., Perlmutter, P., Smith, A. I. & Aguilar, M. I., 2002, In : Biochemistry. 41, 35, p. 10819 - 10826 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16: potential roles in vascular physiology

Norman, M. U., Smith, A. I. & Hickey, M. J., 2002, In : Letters in Peptide Science. 8, p. 195 - 199 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Soluble metalloendopeptidases and neuroendocrine signaling

Shrimpton, C. N., Smith, A. I. & Lew, R. A., 2002, In : Endocrine Reviews. 23, 5, p. 647 - 664 18 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of -amino acids in the design of protease and peptidase inhibitors

Steer, D. L., Lew, R. A., Perlmutter, P., Smith, A. I. & Aguilar, M. I., 2002, In : Letters in Peptide Science. 8, p. 241 - 246 6 p.

Research output: Contribution to journalArticleResearchpeer-review