Ian Smith


1986 …2020
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Personal profile


Professor Ian Smith completed his first degree in Newcastle upon Tyne England and moved to Australia in 1984 to complete his PhD at Prince Henrys Institute Melbourne and Monash University. In 1991 Ian moved to the Baker Heart Research Institute and was Associate Director until his move to Monash University in 2004.

Ian is currently Vice-Provost (Research & Research Infrastructure) and has responsibility for the oversight and management of the universities research alliances and research infrastructure as well as developing and implementing strategies to meet future university infrastructure needs in these areas.

Ian is an accomplished medical researcher and is recognized as a leader in his field. His research applies proteomics technologies to study the proteases involved in the generation and metabolism of peptide regulators involved in both brain and cardiovascular function This research has resulted in over 250 publications and many patents. Ian receives regular invitations to speak at international meetings, many as a plenary speaker. His research has had a direct impact on human health and has led to changes in clinical practice. Ian was a co-founder of a proteomics-based, publicly listed, biotechnology company and he continues to collaborate and consult widely with the pharmaceutical and biotechnology industry. Ian serves on six international editorial boards and over the years he has held office-bearing positions in a number of national and international societies and has had an active involvement in the organisation of numerous national and international scientific meetings. Finally, he has held and continues to hold, a variety of national and international senior government and non- government advisory board/committee memberships. 


  • ECE
  • Vascular Peptides
  • Vascular Tone
  • Protease Inhibitors
  • Endothelin
  • Angiotensin
  • ACE
  • Proteomics
  • Proteases
  • Peptides
  • Mass Spectrometry

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Projects 2002 2020

Research Output 1986 2019

Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer’s Disease

Sikanyika, N. L., Parkington, H. C., Smith, A. I. & Kuruppu, S., 15 Jun 2019, In : Neurochemical Research. 44, 6, p. 1289-1296 8 p.

Research output: Contribution to journalArticleResearchpeer-review

iFeature: a python package and web server for features extraction and selection from protein and peptide sequences

Chen, Z., Zhao, P., Li, F., Leier, A., Marquez-Lago, T., Wang, Y., Webb, G. I., Smith, A. I., Daly, R. J., Chou, K-C. & Song, J., 15 Jul 2018, In : Bioinformatics. 34, 14, p. 2499-2502 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Large-scale comparative assessment of computational predictors for lysine post-translational modification sites

Chen, Z., Liu, X., Li, F., Li, C., Marquez-Lago, T., Leier, A., Akutsu, T., Webb, G. I., Xu, D., Smith, A. I., Li, L., Chou, K-C. & Song, J., 4 Oct 2018, (Accepted/In press) In : Briefings in Bioinformatics. 24 p., bby089.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Quokka: A comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

Li, F., Li, C., Marquez-Lago, T. T., Leier, A., Akutsu, T., Purcell, A. W., Smith, A. I., Lithgow, T., Daly, R. J., Song, J. & Chou, K-C., 15 Dec 2018, In : Bioinformatics. 34, 24, p. 4223-4231 9 p., bty522.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy

Giam, B., Chu, P. Y., Kuruppu, S., Smith, A. I., Horlock, D., Murali, A., Kiriazis, H., Du, X-J., Kaye, D. M. & Rajapakse, N. W., 1 Dec 2018, In : Experimental Physiology. 103, 12, p. 1593-1602 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Press / Media