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Personal profile

Biography

I received a BSc(Hons) (1984) from Monash University and PhD (1991) from the University of Melbourne. I have been employed by The Department of Biochemistry and Molecular Biology, Monash University since September 2002. My research employs structural biology and protein chemistry to understand critical events in autoimmunity and inflammatory diseases. The structural information is complemented by a set of skills that I have acquired over many years in molecular biology, biochemistry, biophysics and cellular immunology, thus enabling a full analysis of T cell activation upon engagement with auto-antigen bound to MHC-II.

Keywords

  • Autoimmune Diseases
  • Autoimmunity
  • Structural Biology
  • Rheumatoid Arthritis
  • Type 1 diabetes
  • Coeliacs Disease
  • Multiple Sclerosis
  • T cell receptors

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Projects 2019 2022

Research Output 2001 2019

A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells

Dey, S., Vaidyanathan, R., Reza, K. K., Wang, J., Wang, Y., Nel, H. J., Law, S. C., Tyler, J., Rossjohn, J., Reid, H. H., Ibn Sina, A. A., Thomas, R. & Trau, M., 1 Apr 2019, In : Sensors and Actuators B: Chemical. 284, p. 281-288 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Ooi, J. D., Jiang, J-H., Eggenhuizen, P. J., Chua, L. L., van Timmeren, M., Loh, K. L., O’Sullivan, K. M., Gan, P. Y., Zhong, Y., Tsyganov, K., Shochet, L. R., Ryan, J., Stegeman, C. A., Fugger, L., Reid, H. H., Rossjohn, J., Heeringa, P., Holdsworth, S. R., Peleg, A. Y. & Kitching, A. R., 29 Jul 2019, In : Nature Communications. 10, 1, 14 p., 3392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease

Mayassi, T., Ladell, K., Gudjonson, H., McLaren, J. E., Shaw, D. G., Tran, M. T., Rokicka, J. J., Lawrence, I., Grenier, J. C., van Unen, V., Ciszewski, C., Dimaano, M., Sayegh, H. E., Kumar, V., Wijmenga, C., Green, P. H. R., Gokhale, R., Jericho, H., Semrad, C. E., Guandalini, S. & 7 othersDinner, A. R., Kupfer, S. S., Reid, H. H., Barreiro, L. B., Rossjohn, J., Price, D. A. & Jabri, B., 21 Feb 2019, In : Cell. 176, 5, p. 967-981 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Discriminative T-cell receptor recognition of highly homologous HLA-DQ2– bound gluten epitopes

Dahal-Koirala, S., Ciacchi, L., Petersen, J., Risnes, L. F., Neumann, R. S., Christophersen, A., Lundin, K. E. A., Reid, H. H., Qiao, S. W., Rossjohn, J. & Sollid, L. M., 18 Jan 2019, In : Journal of Biological Chemistry. 294, 3, p. 941-952 12 p.

Research output: Contribution to journalArticleResearchpeer-review

H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls

Schinkelshoek, M. S., Fronczek, R., Kooy-Winkelaar, E. M. C., Petersen, J., Reid, H. H., van der Heide, A., Drijfhout, J. W., Rossjohn, J., Lammers, G. J. & Koning, F., 15 Jul 2019, In : Journal of Neuroimmunology. 332, p. 167-175 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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