Projects per year
Personal profile
Biography
I received a BSc(Hons) (1984) from Monash University and PhD (1991) from the University of Melbourne. I have been employed by The Department of Biochemistry and Molecular Biology, Monash University since September 2002. My research employs structural biology and protein chemistry to understand critical events in autoimmunity and inflammatory diseases. The structural information is complemented by a set of skills that I have acquired over many years in molecular biology, biochemistry, biophysics and cellular immunology, thus enabling a full analysis of T cell activation upon engagement with auto-antigen bound to MHC-II.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Autoimmune Diseases
- Autoimmunity
- Structural Biology
- Rheumatoid Arthritis
- Type 1 diabetes
- Coeliacs Disease
- Multiple Sclerosis
- T cell receptors
Network
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Projects
- 1 Active
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Defining key determinants of HLA mediated T cell tolerance and autoimmunity
1/01/19 → 31/12/22
Project: Research
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T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Tran, M. T., Faridi, P., Lim, J. J., Ting, Y. T., Onwukwe, G., Bhattacharjee, P., Jones, C. M., Tresoldi, E., Cameron, F. J., La Gruta, N. L., Purcell, A. W., Mannering, S. I., Rossjohn, J. & Reid, H. H., 25 Aug 2021, In: Nature Communications. 12, 1, 13 p., 5110.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR
Lim, J. J., Jones, C. M., Loh, T. J., Ting, Y. T., Zareie, P., Loh, K. L., Felix, N. J., Suri, A., McKinnon, M., Stevenaert, F., Sharma, R. K., Klareskog, L., Malmström, V., Baker, D. G., Purcell, A. W., Reid, H. H., La Gruta, N. L. & Rossjohn, J., 30 Apr 2021, In: Science Immunology. 6, 58, 16 p., eabe0896.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Ting, Y. T., Dahal-Koirala, S., Kim, H. S. K., Qiao, S. W., Neumann, R. S., Lundin, K. E. A., Petersen, J., Reid, H. H., Sollid, L. M. & Rossjohn, J., 11 Feb 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3063-3073 11 p.Research output: Contribution to journal › Article › Research › peer-review
18 Citations (Scopus) -
Expression and purification of recombinant mouse CRISP4 using a baculovirus system
Gaikwad, A. S., Lee Loh, K., O'Connor, A. E., Reid, H. H. & O'Bryan, M. K., 1 Mar 2020, In: Protein Expression and Purification. 167, 6 p., 105543.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility
Wirasinha, R. C., Davies, A. R., Srivastava, M., Sheridan, J. M., Sng, X. Y. X., Delmonte, O. M., Dobbs, K., Loh, K. L., Miosge, L. A., Lee, C. E., Chand, R., Chan, A., Yap, J. Y., Keller, M. D., Chen, K., Rossjohn, J., La Gruta, N. L., Vinuesa, C. G., Reid, H. H., Lionakis, M. S. & 5 others, , 27 Oct 2020, In: Journal of Experimental Medicine. 218, 2, 19 p., e20200476.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus)