Projects per year
Personal profile
Biography
I received a BSc(Hons) (1984) from Monash University and PhD (1991) from the University of Melbourne. I have been employed by The Department of Biochemistry and Molecular Biology, Monash University since September 2002. My research employs structural biology and protein chemistry to understand critical events in autoimmunity and inflammatory diseases. The structural information is complemented by a set of skills that I have acquired over many years in molecular biology, biochemistry, biophysics and cellular immunology, thus enabling a full analysis of T cell activation upon engagement with auto-antigen bound to MHC-II.
Research area keywords
- Autoimmune Diseases
- Autoimmunity
- Structural Biology
- Rheumatoid Arthritis
- Type 1 diabetes
- Coeliacs Disease
- Multiple Sclerosis
- T cell receptors
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Projects
- 1 Active
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Defining key determinants of HLA mediated T cell tolerance and autoimmunity
1/01/19 → 31/12/22
Project: Research
Research output
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A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Ting, Y. T., Dahal-Koirala, S., Kim, H. S. K., Qiao, S. W., Neumann, R. S., Lundin, K. E. A., Petersen, J., Reid, H. H., Sollid, L. M. & Rossjohn, J., 11 Feb 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3063-3073 11 p.Research output: Contribution to journal › Article › Research › peer-review
7 Citations (Scopus) -
Expression and purification of recombinant mouse CRISP4 using a baculovirus system
Gaikwad, A. S., Lee Loh, K., O'Connor, A. E., Reid, H. H. & O'Bryan, M. K., 1 Mar 2020, In : Protein Expression and Purification. 167, 6 p., 105543.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility
Wirasinha, R. C., Davies, A. R., Srivastava, M., Sheridan, J. M., Sng, X. Y. X., Delmonte, O. M., Dobbs, K., Loh, K. L., Miosge, L. A., Lee, C. E., Chand, R., Chan, A., Yap, J. Y., Keller, M. D., Chen, K., Rossjohn, J., La Gruta, N. L., Vinuesa, C. G., Reid, H. H., Lionakis, M. S. & 5 others, , 27 Oct 2020, In : Journal of Experimental Medicine. 218, 2, 19 p., e20200476.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease
Petersen, J., Ciacchi, L., Tran, M. T., Loh, K. L., Kooy-Winkelaar, Y., Croft, N. P., Hardy, M. Y., Chen, Z., McCluskey, J., Anderson, R. P., Purcell, A. W., Tye-Din, J. A., Koning, F., Reid, H. H. & Rossjohn, J., Jan 2020, In : Nature Structural & Molecular Biology. 27, p. 49-61 13 p.Research output: Contribution to journal › Article › Research › peer-review
20 Citations (Scopus) -
A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1
Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, , 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.Research output: Contribution to journal › Article › Research › peer-review
36 Citations (Scopus)