Projects per year
Personal profile
Biography
I received a BSc(Hons) (1984) from Monash University and PhD (1991) from the University of Melbourne. I have been employed by The Department of Biochemistry and Molecular Biology, Monash University since September 2002. My research employs structural biology and protein chemistry to understand critical events in autoimmunity and inflammatory diseases. The structural information is complemented by a set of skills that I have acquired over many years in molecular biology, biochemistry, biophysics and cellular immunology, thus enabling a full analysis of T cell activation upon engagement with auto-antigen bound to MHC-II.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Autoimmune Diseases
- Autoimmunity
- Structural Biology
- Rheumatoid Arthritis
- Type 1 diabetes
- Coeliacs Disease
- Multiple Sclerosis
- T cell receptors
Network
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Projects
- 2 Finished
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Defining key determinants of HLA mediated T cell tolerance and autoimmunity
1/01/19 → 31/12/22
Project: Research
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Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry-based peptide-MHC class-II tetramer staining
Patel, S., Ramnoruth, N., Wehr, P., Rossjohn, J., Reid, H. H., Campbell, K., Nel, H. J. & Thomas, R., Jan 2022, In: Clinical and Experimental Immunology. 207, 1, p. 72-83 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Human T cells recognize HLA-DP-bound peptides in two orientations
Klobuch, S., Lim, J. J., van Balen, P., Kester, M. G. D., de Klerk, W., de Ru, A. H., Pothast, C. R., Jedema, I., Drijfhout, J. W., Rossjohn, J., Reid, H. H., van Veelen, P. A., Falkenburg, J. H. F. & Heemskerk, M. H. M., 6 Dec 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 49, 9 p., e2214331119.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis
Sonigra, A., Nel, H. J., Wehr, P., Ramnoruth, N., Patel, S., van Schie, K. A., Bladen, M. W., Mehdi, A. M., Tesiram, J., Talekar, M., Rossjohn, J., Reid, H. H., Stuurman, F. E., Roberts, H., Vecchio, P., Gourley, I., Rigby, M., Becart, S., Toes, R. E. M., Scherer, H. U., & 3 others, 24 Oct 2022, In: JCI Insight. 7, 20, 18 p., e160964.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Structural bases of T cell antigen receptor recognition in celiac disease
Ciacchi, L., Reid, H. H. & Rossjohn, J., Jun 2022, In: Current Opinion in Structural Biology. 74, 10 p., 102349.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease
Ciacchi, L., Farenc, C., Dahal-Koirala, S., Petersen, J., Sollid, L. M., Reid, H. H. & Rossjohn, J., Mar 2022, In: Journal of Biological Chemistry. 298, 3, 11 p., 101619.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)