Projects per year
Personal profile
Biography
Prof Henry Ma is Director of Neurology and Stroke at Monash Health (2015-) and Adjunct Associate Professor of Medicine at Monash University (2015-). He was previously Director of Physician Training at Monash Health. Prof Ma is a senior member of the National Examiner Panel and Adult Medicine Division Basic Training Committee for the Royal Australasian College of Physician (RACP). He undertook his doctoral thesis on imaging of ischaemic penumbra with Profs Donnan and Davis. Prof Ma's work on persistence of penumbra beyond the traditional 3-hour time-frame has generated the idea for the EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND)-IV trial. He presented the final result for the EXTEND-IV trial at the World Congress of Stroke in October 2018. Prof Ma is a clinician and educator and has been instrumental in setting up the Australasian Stroke Academy (ASA) to educate and train the new generation of stroke physicians. He currently serves as Associate Editor of the journals Stroke and Frontiers in Neurology.
Prof Ma has been instrumental in setting up collaborative multicentre clinical trials and observational studies as evidenced by his high productivity, role as co-chair of the Australian Stroke Trial Network (ASTN). He is a keen advocate in the use of amnion stem cell in neurological diseases such as stroke and multiple sclerosis. He is a chief investigator on a NHMRC sponsored Phase 1 amnion stem cell trial of stroke (I-ACT), starting in February 2019. His major research skill is in the clinical trials and penumbral imaging. He is Principal Coordinator of the multicentre trial of the clot-busting drug tissue plasminogen activator, EXTEND-IV. The trial is being conducted in Australia, Europe and Asia. The success of this trial has led to change in guidelines in Europe and Australia. Prof Ma's role in ASTN puts him in an ideal position to promote this trial to other sites in Phases II and III. He plays a key role in evaluation of biomarkers and immune dysfunction using data from START-EXTEND trial.
In addition to Stroke research activities, Prof Ma has been setting up Department of Neurology as an academic unit with strength in Epilepsy, Movement Disorders, Neuroimmunology/ Multiple Sclerosis, Neuro-degenerative medicine, Behavioural Neurology, Neuro-ophthalmology, Neuro-otology and Neuro-oncology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 11 Sustainable Cities and Communities
Collaborations and top research areas from the last five years
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TENACITY – A Phase III, prospective, randomized, open-label, blinded endpoint assessment (PROBE) to assess efficacy and safety of i.v. tenecteplase vs standard of care in patients with acute ischemic stroke (including wake-up stroke), last known well >4.5 h with imaging evidence of salvageable ischemic tissue
Ma, H. (Primary Chief Investigator (PCI))
2/06/26 → 1/06/31
Project: Research
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A multicenter, double-blinded, placebo-controlled, single ascending dose, two-part, randomized, phase 2 clinical trial to assess safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BB-031 in acute ischemic stroke (AIS) patients
Ma, H. (Primary Chief Investigator (PCI))
22/01/25 → 21/01/30
Project: Research
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A phase 2b, multinational, randomized, double-blind study to investigate the efficacy and safety of redasemtide (S-005151) compared with placebo in adult participants with acute ischemic stroke who are not eligible for tissue plasminogen activator or thrombectomy
Ma, H. (Primary Chief Investigator (PCI))
12/08/24 → 11/08/29
Project: Research
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FRONTIER-AP: Randomized controlled trial of thrombectomy versus standard medical therapy for stroke with medium sized vessel occlusion: Frontier-AP
Phan, T. (Primary Chief Investigator (PCI)), Yan, B. (Chief Investigator (CI)), Mitchell, P. J. (Chief Investigator (CI)), Ma, H. (Chief Investigator (CI)), Churilov, L. (Chief Investigator (CI)), Gao, L. (Chief Investigator (CI)), Parsons, M. (Chief Investigator (CI)), Blackberry, I. (Chief Investigator (CI)), Balabanski, A. (Chief Investigator (CI)) & Davis, S. M. (Chief Investigator (CI))
1/07/24 → 30/06/29
Project: Research
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A Phase II, Multicenter, Double Blinded, Randomized, Placebo Controlled, Parallel-Group, Single-Dose Study to Determine the Safety, Preliminary Efficacy, and Pharmacokinetics of ARG-007 in Acute Ischemic Stroke Patients
Ma, H. (Primary Chief Investigator (PCI))
25/06/24 → 24/06/29
Project: Research
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Extending the time window for tenecteplase by effective reperfusion of penumbral tissue in patients with large vessel occlusion: Rationale and design of a multicenter, prospective, randomized, open-label, blinded-endpoint, controlled phase 3 trial
Yogendrakumar, V., Campbell, B. C. V., Churilov, L., Garcia-Esperon, C., Choi, P. M. C., Cordato, D. J., Guha, P., Sharma, G., Chen, C., McDonald, A., Thijs, V., Mamun, A., Dos Santos, A., Balabanski, A. H., Kleinig, T. J., Butcher, K. S., Devlin, M. J., O’Rourke, F., Donnan, G. A. & Davis, S. M. & 4 others, , Mar 2025, In: International Journal of Stroke. 20, 3, p. 367-372 6 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
Framingham Risk Score Prediction at 12 Months in the STANDFIRM Randomized Control Trial
Phan, T. G., Srikanth, V. K., Cadilhac, D. A., Nelson, M., Kim, J., Olaiya, M. T., Fitzgerald, S. M., Bladin, C., Gerraty, R., Ma, H., Thrift, A. G. & on behalf of PGDipBiostat the Shared Team Approach Between Nurses, Doctors for Improved Risk Factor Management (STANDFIRM) Collaborators, 20 May 2025, In: Journal of the American Heart Association. 14, 10, 13 p., e040254.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Identifying hotspots of seizure-related hospital admissions in Australia
Muthusamy, S., Phan, A. L. G., Seneviratne, U., Beare, R., Srikanth, V., Ma, H. & Phan, T. G., Jul 2025, In: Seizure. 129, p. 70-76 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Sanctuary sites in cortical stroke
Thirugnanachandran, T., Ma, H., Vuong, J., Singhal, S., Slater, L. A. & Phan, T., 30 Sept 2025, In: Frontiers in Neurology. 16, 9 p., 1606666.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Systematic review and meta-analysis of audits measuring antithrombotic therapy within forty-eight hours for ischemic stroke
Lim, A., Phillips, G., Chan, W., Albrefkany, S., Kim-Blackmore, J., Ma, H. & Phan, T., Feb 2025, In: Journal of Stroke and Cerebrovascular Diseases. 34, 2, 9 p., 108213.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access